The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction

Cell Metabolism

Volumn 19, Issue 4, 2014, Pages 653-666

  Prentice, Kacey J ^a   Luu, Lemieux ^a   Allister, Emma M ^a   Liu, Ying ^a   Jun, Lucy S ^c   Sloop, Kyle W ^c   Hardy, Alexandre B ^a   Wei, Li ^d   Jia, Weiping ^d   Fantus, I George ^a,b   Sweet, Douglas H ^e   Sweeney, Gary ^f   Retnakaran, Ravi ^b   Dai, Feihan F ^a   Wheeler, Michael B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c ELI LILLY AND COMPANY   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; FATTY ACID; FURAN; TRANSCRIPTION FACTOR; 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPANOIC ACID; FURAN DERIVATIVE; INSULIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE INTOLERANCE; GLUCOSE UTILIZATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SYNTHESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; HUMAN; METABOLISM; METABOLOMICS; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; FURANS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; METABOLOMICS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; OXIDATIVE STRESS; PROPIONATES; TRANSCRIPTION FACTORS;

EID: 84897556949     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.03.008     Document Type: Article

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