-
1
-
-
84925285641
-
What do drug transporters really do?
-
Nigam SK: What do drug transporters really do? Nat Rev Drug Discov 14: 29-44, 2015
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 29-44
-
-
Nigam, S.K.1
-
2
-
-
84865578333
-
Drug transport by Organic Anion Transporters (OATs)
-
Burckhardt G: Drug transport by Organic Anion Transporters (OATs). Pharmacol Ther 136: 106-130, 2012
-
(2012)
Pharmacol Ther
, vol.136
, pp. 106-130
-
-
Burckhardt, G.1
-
3
-
-
84879397236
-
How much do we know about drug handling by SLC and ABC drug transporters in children?
-
Nigam SK, Bhatnagar V: How much do we know about drug handling by SLC and ABC drug transporters in children? Clin Pharmacol Ther 94: 27-29, 2013
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 27-29
-
-
Nigam, S.K.1
Bhatnagar, V.2
-
4
-
-
34547208011
-
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
-
Nigam SK, Bush KT, Bhatnagar V: Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3: 443-448, 2007
-
(2007)
Nat Clin Pract Nephrol
, vol.3
, pp. 443-448
-
-
Nigam, S.K.1
Bush, K.T.2
Bhatnagar, V.3
-
5
-
-
75349105185
-
Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
-
VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 31: 1-71, 2010
-
(2010)
Biopharm Drug Dispos
, vol.31
, pp. 1-71
-
-
Vanwert, A.L.1
Gionfriddo, M.R.2
Sweet, D.H.3
-
6
-
-
58149357521
-
Update on the molecular physiology of organic anion transporters
-
Ahn SY, Bhatnagar V: Update on the molecular physiology of organic anion transporters. Curr Opin Nephrol Hypertens 17: 499-505, 2008
-
(2008)
Curr Opin Nephrol Hypertens
, vol.17
, pp. 499-505
-
-
Ahn, S.Y.1
Bhatnagar, V.2
-
7
-
-
84919784518
-
The organic anion transporter (OAT) family: A systems biology perspective
-
Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W: The organic anion transporter (OAT) family: A systems biology perspective. Physiol Rev 95: 83-123, 2015
-
(2015)
Physiol Rev
, vol.95
, pp. 83-123
-
-
Nigam, S.K.1
Bush, K.T.2
Martovetsky, G.3
Ahn, S.Y.4
Liu, H.C.5
Richard, E.6
Bhatnagar, V.7
Wu, W.8
-
8
-
-
84884698943
-
Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
-
Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, Nigam SK: Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos 41: 1825-1834, 2013
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 1825-1834
-
-
Wu, W.1
Jamshidi, N.2
Eraly, S.A.3
Liu, H.C.4
Bush, K.T.5
Palsson, B.O.6
Nigam, S.K.7
-
9
-
-
84888404447
-
Hepatocyte nuclear factors 4a and 1a regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters
-
Martovetsky G, Tee JB, Nigam SK: Hepatocyte nuclear factors 4a and 1a regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol 84: 808-823, 2013
-
(2013)
Mol Pharmacol
, vol.84
, pp. 808-823
-
-
Martovetsky, G.1
Tee, J.B.2
Nigam, S.K.3
-
10
-
-
84869119273
-
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules
-
Masereeuw R, Russel FG: Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules. AAPS J 14: 883-894, 2012
-
(2012)
AAPS J
, vol.14
, pp. 883-894
-
-
Masereeuw, R.1
Russel, F.G.2
-
11
-
-
84927163741
-
Overview of drug transporter families
-
2nd Ed., edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons, Inc
-
You G, Morris ME: Overview of drug transporter families. In: Drug Transporters: Molecular Characterization and Role in Drug Disposition, 2nd Ed., edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons, Inc., 2014, pp 1-6
-
(2014)
Drug Transporters: Molecular Characterization and Role in Drug Disposition
, pp. 1-6
-
-
You, G.1
Morris, M.E.2
-
12
-
-
84927130771
-
Organic anion transporters
-
2nd Ed., edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons, Inc
-
Bush KT, Nagle M, Truong DM, Bhatnagar V, Kaler G, Eraly SA, Wu W, Nigam SK: Organic anion transporters. In: Drug Transporters: Molecular Characterization and Role in Drug Disposition, 2nd Ed., edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons, Inc., 2014, pp 25-42
-
(2014)
Drug Transporters: Molecular Characterization and Role in Drug Disposition
, pp. 25-42
-
-
Bush, K.T.1
Nagle, M.2
Truong, D.M.3
Bhatnagar, V.4
Kaler, G.5
Eraly, S.A.6
Wu, W.7
Nigam, S.K.8
-
13
-
-
84875181483
-
The SLC22 family with transporters of organic cations, anions and zwitterions
-
Koepsell H: The SLC22 family with transporters of organic cations, anions and zwitterions. Mol AspectsMed 34: 413-435, 2013
-
(2013)
Mol Aspectsmed
, vol.34
, pp. 413-435
-
-
Koepsell, H.1
-
14
-
-
33646165531
-
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
-
Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK: Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281: 5072-5083, 2006
-
(2006)
J Biol Chem
, vol.281
, pp. 5072-5083
-
-
Eraly, S.A.1
Vallon, V.2
Vaughn, D.A.3
Gangoiti, J.A.4
Richter, K.5
Nagle, M.6
Monte, J.C.7
Rieg, T.8
Truong, D.M.9
Long, J.M.10
Barshop, B.A.11
Kaler, G.12
Nigam, S.K.13
-
15
-
-
0030940999
-
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
-
Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK: Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272: 6471-6478, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 6471-6478
-
-
Lopez-Nieto, C.E.1
You, G.2
Bush, K.T.3
Barros, E.J.4
Beier, D.R.5
Nigam, S.K.6
-
16
-
-
0030781076
-
Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney
-
Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272: 30088-30095, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 30088-30095
-
-
Sweet, D.H.1
Wolff, N.A.2
Pritchard, J.B.3
-
17
-
-
84872257350
-
Renal transporters in drug development
-
Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM: Renal transporters in drug development. Annu Rev Pharmacol Toxicol 53: 503-529, 2013
-
(2013)
Annu Rev Pharmacol Toxicol
, vol.53
, pp. 503-529
-
-
Morrissey, K.M.1
Stocker, S.L.2
Wittwer, M.B.3
Xu, L.4
Giacomini, K.M.5
-
18
-
-
33645909146
-
Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins
-
Miyazaki H, Anzai N, Ekaratanawong S, Sakata T, Shin HJ, Jutabha P, Hirata T, He X, Nonoguchi H, Tomita K, Kanai Y, Endou H: Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J Am Soc Nephrol 16: 3498-3506, 2005
-
(2005)
J am Soc Nephrol
, vol.16
, pp. 3498-3506
-
-
Miyazaki, H.1
Anzai, N.2
Ekaratanawong, S.3
Sakata, T.4
Shin, H.J.5
Jutabha, P.6
Hirata, T.7
He, X.8
Nonoguchi, H.9
Tomita, K.10
Kanai, Y.11
Endou, H.12
-
19
-
-
0028063302
-
Drug excretion mediated by a new prototype of polyspecific transporter
-
Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372: 549-552, 1994
-
(1994)
Nature
, vol.372
, pp. 549-552
-
-
Gründemann, D.1
Gorboulev, V.2
Gambaryan, S.3
Veyhl, M.4
Koepsell, H.5
-
20
-
-
0028285029
-
Molecular cloning and characterization of a novel liver-specific transport protein
-
Simonson GD, Vincent AC, Roberg KJ, Huang Y, Iwanij V: Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107: 1065-1072, 1994
-
(1994)
J Cell Sci
, vol.107
, pp. 1065-1072
-
-
Simonson, G.D.1
Vincent, A.C.2
Roberg, K.J.3
Huang, Y.4
Iwanij, V.5
-
21
-
-
78649665012
-
-
edited by Fromm MF, Kim RB, Berlin, Heidelberg, Springer
-
Burckhardt G, Burckhardt BC: In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. In:Drug Transporters., edited by Fromm MF, Kim RB, Berlin, Heidelberg, Springer, 2011, pp 29-104
-
(2011)
Vitro and in Vivo Evidence of the Importance of Organic Anion Transporters (Oats) in Drug Therapy. In:Drug Transporters.
, pp. 29-104
-
-
Burckhardt, G.1
Burckhardt, B.C.2
-
22
-
-
39149136890
-
Membrane transporters in drug disposition
-
You G: Membrane transporters in drug disposition. Pharm Res 25: 441-443, 2008
-
(2008)
Pharm Res
, vol.25
, pp. 441-443
-
-
You, G.1
-
23
-
-
1342287145
-
The molecular pharmacology of organic anion transporters: From DNA to FDA?
-
Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK: The molecular pharmacology of organic anion transporters: From DNA to FDA? Mol Pharmacol 65: 479-487, 2004
-
(2004)
Mol Pharmacol
, vol.65
, pp. 479-487
-
-
Eraly, S.A.1
Bush, K.T.2
Sampogna, R.V.3
Bhatnagar, V.4
Nigam, S.K.5
-
24
-
-
72049089059
-
Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
-
Saito H: Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications. Pharmacol Ther 125: 79-91, 2010
-
(2010)
Pharmacol Ther
, vol.125
, pp. 79-91
-
-
Saito, H.1
-
25
-
-
0034880349
-
The organic anion transporter family: From physiology to ontogeny and the clinic
-
Sweet DH, Bush KT, Nigam SK: The organic anion transporter family: From physiology to ontogeny and the clinic. Am J Physiol Renal Physiol 281: F197-F205, 2001
-
(2001)
Am J Physiol Renal Physiol
, vol.281
, pp. F197-F205
-
-
Sweet, D.H.1
Bush, K.T.2
Nigam, S.K.3
-
26
-
-
84871983440
-
Renal organic anion transporters (SLC22 family): Expression, regulation, roles in toxicity, and impact on injury and disease
-
Wang L, Sweet DH: Renal organic anion transporters (SLC22 family): Expression, regulation, roles in toxicity, and impact on injury and disease. AAPS J 15: 53-69, 2013
-
(2013)
AAPS J
, vol.15
, pp. 53-69
-
-
Wang, L.1
Sweet, D.H.2
-
27
-
-
84927154577
-
Regulatory science perspectives on transporter studies in drug development
-
2n Ed, edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons
-
Lee SC, Zhang L, Huang SM: Regulatory science perspectives on transporter studies in drug development. In: Drug Transporters: Molecular Characterization and Role in Drug Disposition, 2n Ed, edited by You G, Morris ME, Hoboken, NJ, John Wiley & Sons, 2014, pp 473-487
-
(2014)
Drug Transporters: Molecular Characterization and Role in Drug Disposition
, pp. 473-487
-
-
Lee, S.C.1
Zhang, L.2
Huang, S.M.3
-
28
-
-
84865415281
-
-
MD, U.S. Food and Drug Administration, Drug-Drug Interaction Working Group, Center for Drug Evaluation and Research (CDER)
-
U.S. Food and Drug Administration: Guidance for Industry: Drug Interaction Studies—Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations. Rockville, MD, U.S. Food and Drug Administration, Drug-Drug Interaction Working Group, Center for Drug Evaluation and Research (CDER), 2012, pp 1-75
-
(2012)
Guidance for Industry: Drug Interaction Studies—Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations. Rockville
, pp. 1-75
-
-
U.S. Food and Drug Administration1
-
29
-
-
84863177864
-
Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients
-
Ciarimboli G, Lancaster CS, Schlatter E, Franke RM, Sprowl JA, Pavenstädt H, Massmann V, Guckel D, Mathijssen RH, Yang W, Pui CH, Relling MV, Herrmann E, Sparreboom A: Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients. Clin Cancer Res 18: 1101-1108, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1101-1108
-
-
Ciarimboli, G.1
Lancaster, C.S.2
Schlatter, E.3
Franke, R.M.4
Sprowl, J.A.5
Pavenstädt, H.6
Massmann, V.7
Guckel, D.8
Mathijssen, R.H.9
Yang, W.10
Pui, C.H.11
Relling, M.V.12
Herrmann, E.13
Sparreboom, A.14
-
30
-
-
78650514267
-
Prediction of fluoroquinolone-induced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion
-
Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y: Prediction of fluoroquinolone-induced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther 89: 81-88, 2011
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 81-88
-
-
Imamura, Y.1
Murayama, N.2
Okudaira, N.3
Kurihara, A.4
Okazaki, O.5
Izumi, T.6
Inoue, K.7
Yuasa, H.8
Kusuhara, H.9
Sugiyama, Y.10
-
31
-
-
84875174656
-
Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K
-
Motohashi H, Inui K: Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med 34: 661-668, 2013
-
(2013)
Mol Aspects Med
, vol.34
, pp. 661-668
-
-
Motohashi, H.1
Inui, K.2
-
32
-
-
71449118407
-
Interaction of organic cations with organic anion transporters
-
Ahn SY, Eraly SA, Tsigelny I, Nigam SK: Interaction of organic cations with organic anion transporters. J Biol Chem 284: 31422-31430, 2009
-
(2009)
J Biol Chem
, vol.284
, pp. 31422-31430
-
-
Ahn, S.Y.1
Eraly, S.A.2
Tsigelny, I.3
Nigam, S.K.4
-
33
-
-
84861152254
-
A role for the organic anion transporter OAT3 in renal creatinine secretion in mice
-
Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T: A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol 302: F1293-F1299, 2012
-
(2012)
Am J Physiol Renal Physiol
, vol.302
, pp. F1293-F1299
-
-
Vallon, V.1
Eraly, S.A.2
Rao, S.R.3
Gerasimova, M.4
Rose, M.5
Nagle, M.6
Anzai, N.7
Smith, T.8
Sharma, K.9
Nigam, S.K.10
Rieg, T.11
-
34
-
-
84905508974
-
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
-
Lepist EI, Zhang X, Hao J, Huang J, Kosaka A, Birkus G, Murray BP, Bannister R, Cihlar T, Huang Y, Ray AS: Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat. Kidney Int 86: 350-357, 2014
-
(2014)
Kidney Int
, vol.86
, pp. 350-357
-
-
Lepist, E.I.1
Zhang, X.2
Hao, J.3
Huang, J.4
Kosaka, A.5
Birkus, G.6
Murray, B.P.7
Bannister, R.8
Cihlar, T.9
Huang, Y.10
Ray, A.S.11
-
35
-
-
84872696364
-
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor
-
Reese MJ, Savina PM, Generaux GT, Tracey H, Humphreys JE, Kanaoka E, Webster LO, Harmon KA, Clarke JD, Polli JW: In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Drug Metab Dispos 41: 353-361, 2013
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 353-361
-
-
Reese, M.J.1
Savina, P.M.2
Generaux, G.T.3
Tracey, H.4
Humphreys, J.E.5
Kanaoka, E.6
Webster, L.O.7
Harmon, K.A.8
Clarke, J.D.9
Polli, J.W.10
-
36
-
-
84894054261
-
Bcrp1;Mdr1a/b;Mrp2 Combination knockout mice: Altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites
-
Vlaming ML, Teunissen SF, van de Steeg E, van Esch A, Wagenaar E, Brunsveld L, de Greef TF, Rosing H, Schellens JH, Beijnen JH, Schinkel AH: Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites. Mol Pharmacol 85: 520-530, 2014
-
(2014)
Mol Pharmacol
, vol.85
, pp. 520-530
-
-
Vlaming, M.L.1
Teunissen, S.F.2
Van De Steeg, E.3
Van Esch, A.4
Wagenaar, E.5
Brunsveld, L.6
De Greef, T.F.7
Rosing, H.8
Schellens, J.H.9
Beijnen, J.H.10
Schinkel, A.H.11
-
37
-
-
63449139456
-
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
-
Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G: Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323: 1718-1722, 2009
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
Weng, Y.4
Chittaboina, S.5
Zhuo, R.6
Harrell, P.M.7
Trinh, Y.T.8
Zhang, Q.9
Urbatsch, I.L.10
Chang, G.11
-
38
-
-
0033559052
-
A novel putative transporter maps to the osteosclerosis (Oc) mutation and is not expressed in the oc mutant mouse
-
Brady KP, Dushkin H, Förnzler D, Koike T, Magner F, Her H, Gullans S, Segre GV, Green RM, Beier DR: A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56: 254-261, 1999
-
(1999)
Genomics
, vol.56
, pp. 254-261
-
-
Brady, K.P.1
Dushkin, H.2
Förnzler, D.3
Koike, T.4
Magner, F.5
Her, H.6
Gullans, S.7
Segre, G.V.8
Green, R.M.9
Beier, D.R.10
-
39
-
-
44949088665
-
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
-
Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK: Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol 294: F867-F873, 2008
-
(2008)
Am J Physiol Renal Physiol
, vol.294
, pp. F867-F873
-
-
Vallon, V.1
Rieg, T.2
Ahn, S.Y.3
Wu, W.4
Eraly, S.A.5
Nigam, S.K.6
-
40
-
-
35348889668
-
SweetDH: Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G
-
Vanwert AL, Bailey RM, SweetDH: Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G. Am J Physiol Renal Physiol 293: F1332-F1341, 2007
-
(2007)
Am J Physiol Renal Physiol
, vol.293
, pp. F1332-F1341
-
-
Vanwert, A.L.1
Bailey, R.M.2
-
41
-
-
78650936423
-
Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
-
Nagle MA, Truong DM, Dnyanmote AV, Ahn SY, Eraly SA, Wu W, Nigam SK: Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J Biol Chem 286: 243-251, 2011
-
(2011)
J Biol Chem
, vol.286
, pp. 243-251
-
-
Nagle, M.A.1
Truong, D.M.2
Dnyanmote, A.V.3
Ahn, S.Y.4
Eraly, S.A.5
Wu, W.6
Nigam, S.K.7
-
42
-
-
43749115381
-
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
-
Truong DM, Kaler G, Khandelwal A, Swaan PW, Nigam SK: Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283: 8654-8663, 2008
-
(2008)
J Biol Chem
, vol.283
, pp. 8654-8663
-
-
Truong, D.M.1
Kaler, G.2
Khandelwal, A.3
Swaan, P.W.4
Nigam, S.K.5
-
43
-
-
0022625981
-
Disposition of bumetanide in the isolated perfused rat kidney: Effects of probenecid and dose response
-
Bekersky I, Popick AC: Disposition of bumetanide in the isolated perfused rat kidney: effects of probenecid and dose response. Am J Cardiol 57: 33A-37A, 1986
-
(1986)
Am J Cardiol
, vol.57
, pp. 33A-37A
-
-
Bekersky, I.1
Popick, A.C.2
-
44
-
-
0021164580
-
Effect of furosemide administration on glomerular and tubular dynamics in the rat
-
Tucker BJ, Blantz RC: Effect of furosemide administration on glomerular and tubular dynamics in the rat. Kidney Int 26: 112-121, 1984
-
(1984)
Kidney Int
, vol.26
, pp. 112-121
-
-
Tucker, B.J.1
Blantz, R.C.2
-
45
-
-
24344442157
-
Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations
-
Burnell JM, Kirby WM: Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations. J Clin Invest 30: 697-700, 1951
-
(1951)
J Clin Invest
, vol.30
, pp. 697-700
-
-
Burnell, J.M.1
Kirby, W.M.2
-
46
-
-
0015790836
-
Treatment of gonorrhoea with procaine penicillin plus probenecid
-
Lesi_nski J, Dzierzanowska D, Szymczak M, Linda H, Wiśniewska C, Nawara A, Winogrodzka A: Treatment of gonorrhoea with procaine penicillin plus probenecid. Br J Vener Dis 49: 358-361, 1973
-
(1973)
Br J Vener Dis
, vol.49
, pp. 358-361
-
-
Lesi_Nski, J.1
Dzierzanowska, D.2
Szymczak, M.3
Linda, H.4
Wiśniewska, C.5
Nawara, A.6
Winogrodzka, A.7
-
47
-
-
84858792470
-
The history and future of probenecid
-
Robbins N, Koch SE, Tranter M, Rubinstein J: The history and future of probenecid. Cardiovasc Toxicol 12: 1-9, 2012
-
(2012)
Cardiovasc Toxicol
, vol.12
, pp. 1-9
-
-
Robbins, N.1
Koch, S.E.2
Tranter, M.3
Rubinstein, J.4
-
48
-
-
0037333435
-
Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells
-
Aslamkhan AG, Han YH, Yang XP, Zalups RK, Pritchard JB: Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharmacol 63: 590-596, 2003
-
(2003)
Mol Pharmacol
, vol.63
, pp. 590-596
-
-
Aslamkhan, A.G.1
Han, Y.H.2
Yang, X.P.3
Zalups, R.K.4
Pritchard, J.B.5
-
49
-
-
70349618596
-
Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride
-
DiGiusto G, Anzai N, Ruiz ML, Endou H, Torres AM: Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride. Arch Toxicol 83: 887-897, 2009
-
(2009)
Arch Toxicol
, vol.83
, pp. 887-897
-
-
Digiusto, G.1
Anzai, N.2
Ruiz, M.L.3
Endou, H.4
Torres, A.M.5
-
50
-
-
84872064733
-
Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining
-
Engström K, Ameer S, Bernaudat L, Drasch G, Baeuml J, Skerfving S, Bose-O’Reilly S, Broberg K: Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining. Environ Health Perspect 121: 85-91, 2013
-
(2013)
Environ Health Perspect
, vol.121
, pp. 85-91
-
-
Engström, K.1
Ameer, S.2
Bernaudat, L.3
Drasch, G.4
Baeuml, J.5
Skerfving, S.6
Bose-O’reilly, S.7
Broberg, K.8
-
51
-
-
3543093902
-
Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: Role of basolateral transporter organic anion transporter 1
-
Zalups RK, Ahmad S: Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: Role of basolateral transporter organic anion transporter 1. J Am Soc Nephrol 15: 2023-2031, 2004
-
(2004)
J am Soc Nephrol
, vol.15
, pp. 2023-2031
-
-
Zalups, R.K.1
Ahmad, S.2
-
52
-
-
79960666822
-
Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
-
Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam SK: Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem 286: 26391-26395, 2011
-
(2011)
J Biol Chem
, vol.286
, pp. 26391-26395
-
-
Torres, A.M.1
Dnyanmote, A.V.2
Bush, K.T.3
Wu, W.4
Nigam, S.K.5
-
53
-
-
69449105950
-
Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy
-
Bakhiya N, Arlt VM, Bahn A, Burckhardt G, Phillips DH, Glatt H: Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology 264: 74-79, 2009
-
(2009)
Toxicology
, vol.264
, pp. 74-79
-
-
Bakhiya, N.1
Arlt, V.M.2
Bahn, A.3
Burckhardt, G.4
Phillips, D.H.5
Glatt, H.6
-
54
-
-
65449118063
-
Fifty years of research in Balkan endemic nephropathy: Where are we now?
-
Stefanovi_c V, Polenakovi_c M: Fifty years of research in Balkan endemic nephropathy: Where are we now? Nephron Clin Pract 112: c51-c56, 2009
-
(2009)
Nephron Clin Pract
, vol.112
, pp. c51-c56
-
-
Stefanovi_C, V.1
Polenakovi_C, M.2
-
55
-
-
17744363092
-
Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells
-
Balachandran P, Wei F, Lin RC, Khan IA, Pasco DS: Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells. Kidney Int 67: 1797-1805, 2005
-
(2005)
Kidney Int
, vol.67
, pp. 1797-1805
-
-
Balachandran, P.1
Wei, F.2
Lin, R.C.3
Khan, I.A.4
Pasco, D.S.5
-
56
-
-
45749152051
-
Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid
-
Nakagawa H, Hirata T, Terada T, Jutabha P, Miura D, Harada KH, Inoue K, Anzai N, Endou H, Inui K, Kanai Y, Koizumi A: Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid. Basic Clin Pharmacol Toxicol 103: 1-8, 2008
-
(2008)
Basic Clin Pharmacol Toxicol
, vol.103
, pp. 1-8
-
-
Nakagawa, H.1
Hirata, T.2
Terada, T.3
Jutabha, P.4
Miura, D.5
Harada, K.H.6
Inoue, K.7
Anzai, N.8
Endou, H.9
Inui, K.10
Kanai, Y.11
Koizumi, A.12
-
57
-
-
77956402544
-
Metabolomic profiling of uremic solutes in CKD patients
-
Toyohara T, Akiyama Y, Suzuki T, Takeuchi Y, Mishima E, Tanemoto M, Momose A, Toki N, Sato H, Nakayama M, Hozawa A, Tsuji I, Ito S, Soga T, Abe T: Metabolomic profiling of uremic solutes in CKD patients. Hypertens Res 33: 944-952, 2010
-
(2010)
Hypertens Res
, vol.33
, pp. 944-952
-
-
Toyohara, T.1
Akiyama, Y.2
Suzuki, T.3
Takeuchi, Y.4
Mishima, E.5
Tanemoto, M.6
Momose, A.7
Toki, N.8
Sato, H.9
Nakayama, M.10
Hozawa, A.11
Tsuji, I.12
Ito, S.13
Soga, T.14
Abe, T.15
-
58
-
-
69249116923
-
The role of EUTox in uremic toxin research
-
Vanholder R, Abou-Deif O, Argiles A, Baurmeister U, Beige J, Brouckaert P, Brunet P, Cohen G, DeDeyn PP, Drüeke TB, Fliser D, Glorieux G, Herget-Rosenthal S, Hörl WH, Jankowski J, Jörres A, Massy ZA, Mischak H, Perna AF, Rodriguez-Portillo JM, Spasovski G, Stegmayr BG, Stenvinkel P, Thornalley PJ, Wanner C, Wiecek A: The role of EUTox in uremic toxin research. Semin Dial 22: 323-328, 2009
-
(2009)
Semin Dial
, vol.22
, pp. 323-328
-
-
Vanholder, R.1
Abou-Deif, O.2
Argiles, A.3
Baurmeister, U.4
Beige, J.5
Brouckaert, P.6
Brunet, P.7
Cohen, G.8
Dedeyn, P.P.9
Drüeke, T.B.10
Fliser, D.11
Glorieux, G.12
Herget-Rosenthal, S.13
Hörl, W.H.14
Jankowski, J.15
Jörres, A.16
Massy, Z.A.17
Mischak, H.18
Perna, A.F.19
Rodriguez-Portillo, J.M.20
Spasovski, G.21
Stegmayr, B.G.22
Stenvinkel, P.23
Thornalley, P.J.24
Wanner, C.25
Wiecek, A.26
more..
-
60
-
-
84887570558
-
From the gastrointestinal tract (GIT) to the kidneys: Live bacterial cultures (probiotics) mediating reductions of uremic toxin levels via free radical signaling
-
Vitetta L, Linnane AW, Gobe GC: From the gastrointestinal tract (GIT) to the kidneys: Live bacterial cultures (probiotics) mediating reductions of uremic toxin levels via free radical signaling. Toxins (Basel) 5: 2042-2057, 2013
-
(2013)
Toxins (Basel)
, vol.5
, pp. 2042-2057
-
-
Vitetta, L.1
Linnane, A.W.2
Gobe, G.C.3
-
61
-
-
79958226930
-
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
-
Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK: Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res 10: 2842-2851, 2011
-
(2011)
J Proteome Res
, vol.10
, pp. 2842-2851
-
-
Wikoff, W.R.1
Nagle, M.A.2
Kouznetsova, V.L.3
Tsigelny, I.F.4
Nigam, S.K.5
-
62
-
-
84899083735
-
The kidney and uremic toxin removal: Glomerulus or tubule?
-
Masereeuw R, Mutsaers HA, Toyohara T, Abe T, Jhawar S, Sweet DH, Lowenstein J: The kidney and uremic toxin removal: Glomerulus or tubule? Semin Nephrol 34: 191-208, 2014
-
(2014)
Semin Nephrol
, vol.34
, pp. 191-208
-
-
Masereeuw, R.1
Mutsaers, H.A.2
Toyohara, T.3
Abe, T.4
Jhawar, S.5
Sweet, D.H.6
Lowenstein, J.7
-
63
-
-
72049086464
-
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation
-
Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, Terasaki T, Goto J, Ito S, Hishinuma T, Rubera I, Tauc M, Fujii-Kuriyama Y, Yabuuchi H, Moriyama Y, Soga T, Abe T: SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol 20: 2546-2555, 2009
-
(2009)
J am Soc Nephrol
, vol.20
, pp. 2546-2555
-
-
Toyohara, T.1
Suzuki, T.2
Morimoto, R.3
Akiyama, Y.4
Souma, T.5
Shiwaku, H.O.6
Takeuchi, Y.7
Mishima, E.8
Abe, M.9
Tanemoto, M.10
Masuda, S.11
Kawano, H.12
Maemura, K.13
Nakayama, M.14
Sato, H.15
Mikkaichi, T.16
Yamaguchi, H.17
Fukui, S.18
Fukumoto, Y.19
Shimokawa, H.20
Inui, K.21
Terasaki, T.22
Goto, J.23
Ito, S.24
Hishinuma, T.25
Rubera, I.26
Tauc, M.27
Fujii-Kuriyama, Y.28
Yabuuchi, H.29
Moriyama, Y.30
Soga, T.31
Abe, T.32
more..
-
64
-
-
79960137204
-
Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics
-
Reyes M, Benet LZ: Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. J Pharm Sci 100: 3831-3842, 2011
-
(2011)
J Pharm Sci
, vol.100
, pp. 3831-3842
-
-
Reyes, M.1
Benet, L.Z.2
-
65
-
-
79954998791
-
Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis
-
Wu W, Dnyanmote AV, Nigam SK: Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis. Mol Pharmacol 79: 795-805, 2011
-
(2011)
Mol Pharmacol
, vol.79
, pp. 795-805
-
-
Wu, W.1
Dnyanmote, A.V.2
Nigam, S.K.3
-
66
-
-
62649151803
-
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
-
Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G: Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A 106: 3698-3703, 2009
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3698-3703
-
-
Wikoff, W.R.1
Anfora, A.T.2
Liu, J.3
Schultz, P.G.4
Lesley, S.A.5
Peters, E.C.6
Siuzdak, G.7
-
67
-
-
80052406750
-
Linkage of organic anion transporter-1 to metabolic pathways through integrated “omics”-driven network and functional analysis
-
Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BO, Nigam SK: Linkage of organic anion transporter-1 to metabolic pathways through integrated “omics”-driven network and functional analysis. J Biol Chem286: 31522-31531, 2011
-
(2011)
J Biol Chem286
, pp. 31522-31531
-
-
Ahn, S.Y.1
Jamshidi, N.2
Mo, M.L.3
Wu, W.4
Eraly, S.A.5
Dnyanmote, A.6
Bush, K.T.7
Gallegos, T.F.8
Sweet, D.H.9
Palsson, B.O.10
Nigam, S.K.11
-
68
-
-
43049121374
-
Multiple organic anion transporters contribute to net renal excretion of uric acid
-
Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK: Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 33: 180-192, 2008
-
(2008)
Physiol Genomics
, vol.33
, pp. 180-192
-
-
Eraly, S.A.1
Vallon, V.2
Rieg, T.3
Gangoiti, J.A.4
Wikoff, W.R.5
Siuzdak, G.6
Barshop, B.A.7
Nigam, S.K.8
-
69
-
-
69549103730
-
Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis
-
Ahn SY, Nigam SK: Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol 76: 481-490, 2009
-
(2009)
Mol Pharmacol
, vol.76
, pp. 481-490
-
-
Ahn, S.Y.1
Nigam, S.K.2
-
70
-
-
0030772953
-
Kidney-specific expression of a novel mouse organic cation transporter-like protein
-
Mori K, Ogawa Y, Ebihara K, Aoki T, Tamura N, Sugawara A, Kuwahara T, Ozaki S, Mukoyama M, Tashiro K, Tanaka I, Nakao K: Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett 417: 371-374, 1997
-
(1997)
FEBS Lett
, vol.417
, pp. 371-374
-
-
Mori, K.1
Ogawa, Y.2
Ebihara, K.3
Aoki, T.4
Tamura, N.5
Sugawara, A.6
Kuwahara, T.7
Ozaki, S.8
Mukoyama, M.9
Tashiro, K.10
Tanaka, I.11
Nakao, K.12
-
71
-
-
84882448261
-
Urate transporters in the genomic era
-
Sakurai H: Urate transporters in the genomic era. Curr Opin Nephrol Hypertens 22: 545-550, 2013
-
(2013)
Curr Opin Nephrol Hypertens
, vol.22
, pp. 545-550
-
-
Sakurai, H.1
-
72
-
-
84873567973
-
The kidney in hyperuricemia and gout
-
Mount DB: The kidney in hyperuricemia and gout. Curr Opin Nephrol Hypertens 22: 216-223, 2013
-
(2013)
Curr Opin Nephrol Hypertens
, vol.22
, pp. 216-223
-
-
Mount, D.B.1
-
74
-
-
0037427506
-
Organic anion and cation transporters occur in pairs of similar and similarly expressed genes
-
Eraly SA, Hamilton BA, Nigam SK: Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun 300: 333-342, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 333-342
-
-
Eraly, S.A.1
Hamilton, B.A.2
Nigam, S.K.3
-
75
-
-
84863750420
-
Organic anion and cation SLC22 “drug” transporter (Oat1, Oat3, andOct1) regulation during development and maturation of the kidney proximal tubule
-
Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK: Organic anion and cation SLC22 “drug” transporter (Oat1, Oat3, andOct1) regulation during development and maturation of the kidney proximal tubule. PLoS One 7: e40796, 2012
-
(2012)
Plos One
, vol.7
-
-
Gallegos, T.F.1
Martovetsky, G.2
Kouznetsova, V.3
Bush, K.T.4
Nigam, S.K.5
-
76
-
-
53049092262
-
Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells
-
Maeda A, Tsuruoka S, Kanai Y, Endou H, Saito K, Miyamoto E, Fujimura A: Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells. Eur J Pharmacol 596: 166-172, 2008
-
(2008)
Eur J Pharmacol
, vol.596
, pp. 166-172
-
-
Maeda, A.1
Tsuruoka, S.2
Kanai, Y.3
Endou, H.4
Saito, K.5
Miyamoto, E.6
Fujimura, A.7
-
77
-
-
0041831237
-
Novel aspects of renal organic anion transporters
-
Eraly SA, Blantz RC, Bhatnagar V, Nigam SK: Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens 12: 551-558, 2003
-
(2003)
Curr Opin Nephrol Hypertens
, vol.12
, pp. 551-558
-
-
Eraly, S.A.1
Blantz, R.C.2
Bhatnagar, V.3
Nigam, S.K.4
-
78
-
-
0033514320
-
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
-
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM: Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99: 552-557, 1999
-
(1999)
Circulation
, vol.99
, pp. 552-557
-
-
Fromm, M.F.1
Kim, R.B.2
Stein, C.M.3
Wilkinson, G.R.4
Roden, D.M.5
-
79
-
-
0021705472
-
Quinidine-induced digoxin toxicity after discontinuing digoxin in a patient with renal failure
-
Nigam SK, Burton ME, Vasko MR: Quinidine-induced digoxin toxicity after discontinuing digoxin in a patient with renal failure. Clin Pharm 3: 662-664, 1984
-
(1984)
Clin Pharm
, vol.3
, pp. 662-664
-
-
Nigam, S.K.1
Burton, M.E.2
Vasko, M.R.3
-
80
-
-
77649216536
-
International Transporter Consortium: Membrane transporters in drug development
-
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L; International Transporter Consortium: Membrane transporters in drug development. Nat Rev Drug Discov 9: 215-236, 2010
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
Huang, S.M.2
Tweedie, D.J.3
Benet, L.Z.4
Brouwer, K.L.5
Chu, X.6
Dahlin, A.7
Evers, R.8
Fischer, V.9
Hillgren, K.M.10
Hoffmaster, K.A.11
Ishikawa, T.12
Keppler, D.13
Kim, R.B.14
Lee, C.A.15
Niemi, M.16
Polli, J.W.17
Sugiyama, Y.18
Swaan, P.W.19
Ware, J.A.20
Wright, S.H.21
Yee, S.W.22
Zamek-Gliszczynski, M.J.23
Zhang, L.24
more..
-
81
-
-
79957453890
-
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1)
-
Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK: Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem 19: 3320-3340, 2011
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 3320-3340
-
-
Kouznetsova, V.L.1
Tsigelny, I.F.2
Nagle, M.A.3
Nigam, S.K.4
-
82
-
-
33745444581
-
Analyses of 59 regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)
-
Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK: Analyses of 59 regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet 51: 575-580, 2006
-
(2006)
J Hum Genet
, vol.51
, pp. 575-580
-
-
Bhatnagar, V.1
Xu, G.2
Hamilton, B.A.3
Truong, D.M.4
Eraly, S.A.5
Wu, W.6
Nigam, S.K.7
-
83
-
-
31644434086
-
Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]
-
Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK: Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int 68: 1491-1499, 2005
-
(2005)
Kidney Int
, vol.68
, pp. 1491-1499
-
-
Xu, G.1
Bhatnagar, V.2
Wen, G.3
Hamilton, B.A.4
Eraly, S.A.5
Nigam, S.K.6
-
84
-
-
33745831231
-
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters
-
Choudhuri S, Klaassen CD: Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 25: 231-259, 2006
-
(2006)
Int J Toxicol
, vol.25
, pp. 231-259
-
-
Choudhuri, S.1
Klaassen, C.D.2
-
85
-
-
70349091471
-
Genetic variation in the proximal promoter of ABC and SLC superfamilies: Liver and kidney specific expression and promoter activity predict variation
-
Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM: Genetic variation in the proximal promoter of ABC and SLC superfamilies: Liver and kidney specific expression and promoter activity predict variation. PLoS One 4: e6942, 2009
-
(2009)
Plos One
, vol.4
-
-
Hesselson, S.E.1
Matsson, P.2
Shima, J.E.3
Fukushima, H.4
Yee, S.W.5
Kobayashi, Y.6
Gow, J.M.7
Ha, C.8
Ma, B.9
Poon, A.10
Johns, S.J.11
Stryke, D.12
Castro, R.A.13
Tahara, H.14
Choi, J.H.15
Chen, L.16
Picard, N.17
Sjödin, E.18
Roelofs, M.J.19
Ferrin, T.E.20
Myers, R.21
Kroetz, D.L.22
Kwok, P.Y.23
Giacomini, K.M.24
more..
-
86
-
-
79951675822
-
Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide
-
Han YF, Fan XH, Wang XJ, Sun K, Xue H, Li WJ, Wang YB, Chen JZ, Zhen YS, Zhang WL, Zhou X, Hui R: Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide. Am J Hypertens 24: 340-346, 2011
-
(2011)
Am J Hypertens
, vol.24
, pp. 340-346
-
-
Han, Y.F.1
Fan, X.H.2
Wang, X.J.3
Sun, K.4
Xue, H.5
Li, W.J.6
Wang, Y.B.7
Chen, J.Z.8
Zhen, Y.S.9
Zhang, W.L.10
Zhou, X.11
Hui, R.12
-
87
-
-
84881614134
-
Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)
-
Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM: Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci 102: 3451-3457, 2013
-
(2013)
J Pharm Sci
, vol.102
, pp. 3451-3457
-
-
Yee, S.W.1
Nguyen, A.N.2
Brown, C.3
Savic, R.M.4
Zhang, Y.5
Castro, R.A.6
Cropp, C.D.7
Choi, J.H.8
Singh, D.9
Tahara, H.10
Stocker, S.L.11
Huang, Y.12
Brett, C.M.13
Giacomini, K.M.14
-
88
-
-
20244389716
-
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)
-
Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM: Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics 15: 201-209, 2005
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 201-209
-
-
Fujita, T.1
Brown, C.2
Carlson, E.J.3
Taylor, T.4
De La Cruz, M.5
Johns, S.J.6
Stryke, D.7
Kawamoto, M.8
Fujita, K.9
Castro, R.10
Chen, C.W.11
Lin, E.T.12
Brett, C.M.13
Burchard, E.G.14
Ferrin, T.E.15
Huang, C.C.16
Leabman, M.K.17
Giacomini, K.M.18
-
89
-
-
84873081171
-
Polymorphisms in the methotrexate transport pathway: A new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia
-
Lopez-Lopez E, Ballesteros J, Piñan MA, Sanchez de Toledo J, Garcia de Andoin N, Garcia-Miguel P, Navajas A, Garcia-Orad A: Polymorphisms in the methotrexate transport pathway: A new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia. Pharmacogenet Genomics 23: 53-61, 2013
-
(2013)
Pharmacogenet Genomics
, vol.23
, pp. 53-61
-
-
Lopez-Lopez, E.1
Ballesteros, J.2
Piñan, M.A.3
De Sanchez Toledo, J.4
De Garcia Andoin, N.5
Garcia-Miguel, P.6
Navajas, A.7
Garcia-Orad, A.8
-
90
-
-
67651235787
-
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
-
Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM: Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics 19: 497-504, 2009
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 497-504
-
-
Chen, Y.1
Li, S.2
Brown, C.3
Cheatham, S.4
Castro, R.A.5
Leabman, M.K.6
Urban, T.J.7
Chen, L.8
Yee, S.W.9
Choi, J.H.10
Huang, Y.11
Brett, C.M.12
Burchard, E.G.13
Giacomini, K.M.14
-
91
-
-
84885063981
-
A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
-
Christensen MM, Pedersen RS, Stage TB, Brasch-Andersen C, Nielsen F, Damkier P, Beck-Nielsen H, Brøsen K: A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin. Pharmacogenet Genomics 23: 526-534, 2013
-
(2013)
Pharmacogenet Genomics
, vol.23
, pp. 526-534
-
-
Christensen, M.M.1
Pedersen, R.S.2
Stage, T.B.3
Brasch-Andersen, C.4
Nielsen, F.5
Damkier, P.6
Beck-Nielsen, H.7
Brøsen, K.8
-
92
-
-
70349440952
-
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity
-
Filipski KK, Mathijssen RH, Mikkelsen TS, Schinkel AH, Sparreboom A: Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin Pharmacol Ther 86: 396-402, 2009
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 396-402
-
-
Filipski, K.K.1
Mathijssen, R.H.2
Mikkelsen, T.S.3
Schinkel, A.H.4
Sparreboom, A.5
-
93
-
-
79251494151
-
Effect of drugs on renal development
-
Schreuder MF, Bueters RR, Huigen MC, Russel FG, Masereeuw R, van den Heuvel LP: Effect of drugs on renal development. Clin J Am Soc Nephrol 6: 212-217, 2011
-
(2011)
Clin J am Soc Nephrol
, vol.6
, pp. 212-217
-
-
Schreuder, M.F.1
Bueters, R.R.2
Huigen, M.C.3
Russel, F.G.4
Masereeuw, R.5
Van Den Heuvel, L.P.6
-
94
-
-
0034004157
-
Developmentally regulated expression of organic ion transporters NKT (OAT1),OCT1, NLT (OAT2), and Roct
-
Pavlova A, Sakurai H, Leclercq B, Beier DR, Yu AS, Nigam SK: Developmentally regulated expression of organic ion transporters NKT (OAT1),OCT1, NLT (OAT2), and Roct. AmJ Physiol Renal Physiol 278: F635-F643, 2000
-
(2000)
Amj Physiol Renal Physiol
, vol.278
, pp. F635-F643
-
-
Pavlova, A.1
Sakurai, H.2
Leclercq, B.3
Beier, D.R.4
Yu, A.S.5
Nigam, S.K.6
-
95
-
-
33644499212
-
Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models
-
Sweet DH, Eraly SA, Vaughn DA, Bush KT, Nigam SK: Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int 69: 837-845, 2006
-
(2006)
Kidney Int
, vol.69
, pp. 837-845
-
-
Sweet, D.H.1
Eraly, S.A.2
Vaughn, D.A.3
Bush, K.T.4
Nigam, S.K.5
-
96
-
-
79959313678
-
Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney
-
Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam SK: Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol 80: 147-154, 2011
-
(2011)
Mol Pharmacol
, vol.80
, pp. 147-154
-
-
Sweeney, D.E.1
Vallon, V.2
Rieg, T.3
Wu, W.4
Gallegos, T.F.5
Nigam, S.K.6
-
97
-
-
0014702319
-
Maturation of renal organic acid transport: Substrate stimulation by penicillin and p-aminohippurate (PAH)
-
Hirsch GH, Hook JB: Maturation of renal organic acid transport: Substrate stimulation by penicillin and p-aminohippurate (PAH). J Pharmacol Exp Ther 171: 103-108, 1970
-
(1970)
J Pharmacol Exp Ther
, vol.171
, pp. 103-108
-
-
Hirsch, G.H.1
Hook, J.B.2
-
98
-
-
0017348754
-
Development of mechanisms for drug excretion
-
Hook JB, Hewitt WR: Development of mechanisms for drug excretion. Am J Med 62: 497-506, 1977
-
(1977)
Am J Med
, vol.62
, pp. 497-506
-
-
Hook, J.B.1
Hewitt, W.R.2
-
99
-
-
84927765622
-
Expression of drug transporters in human kidney: Impact of sex, age, and ethnicity
-
Joseph S, Nicolson TJ, Hammons G, Word B, Green-Knox B, Lyn-Cook B: Expression of drug transporters in human kidney: Impact of sex, age, and ethnicity. Biol Sex Differ 6: 4, 2015
-
(2015)
Biol Sex Differ
, vol.6
, pp. 4
-
-
Joseph, S.1
Nicolson, T.J.2
Hammons, G.3
Word, B.4
Green-Knox, B.5
Lyn-Cook, B.6
-
100
-
-
2642572647
-
Aging biology and geriatric clinical pharmacology
-
McLean AJ, Le Couteur DG: Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56: 163-184, 2004
-
(2004)
Pharmacol Rev
, vol.56
, pp. 163-184
-
-
McLean, A.J.1
Le Couteur, D.G.2
-
101
-
-
0036233041
-
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney
-
Deguchi T, Ohtsuki S, Otagiri M, Takanaga H, Asaba H, Mori S, Terasaki T: Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int 61: 1760-1768, 2002
-
(2002)
Kidney Int
, vol.61
, pp. 1760-1768
-
-
Deguchi, T.1
Ohtsuki, S.2
Otagiri, M.3
Takanaga, H.4
Asaba, H.5
Mori, S.6
Terasaki, T.7
-
102
-
-
0037040390
-
Interaction of human organic anion transporters with various cephalosporin antibiotics
-
Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol 438: 137-142, 2002
-
(2002)
Eur J Pharmacol
, vol.438
, pp. 137-142
-
-
Takeda, M.1
Babu, E.2
Narikawa, S.3
Endou, H.4
-
103
-
-
0023923417
-
Biochemical mechanisms of cephaloridine nephrotoxicity
-
Goldstein RS, Smith PF, Tarloff JB, Contardi L, Rush GF, Hook JB: Biochemical mechanisms of cephaloridine nephrotoxicity. Life Sci 42: 1809-1816, 1988
-
(1988)
Life Sci
, vol.42
, pp. 1809-1816
-
-
Goldstein, R.S.1
Smith, P.F.2
Tarloff, J.B.3
Contardi, L.4
Rush, G.F.5
Hook, J.B.6
-
104
-
-
79957591114
-
Tenofovir renal proximal tubular toxicity is regulated byOAT1 and MRP4 transporters
-
Kohler JJ, Hosseini SH, Green E, Abuin A, Ludaway T, Russ R, Santoianni R, Lewis W: Tenofovir renal proximal tubular toxicity is regulated byOAT1 and MRP4 transporters. Lab Invest 91: 852-858, 2011
-
(2011)
Lab Invest
, vol.91
, pp. 852-858
-
-
Kohler, J.J.1
Hosseini, S.H.2
Green, E.3
Abuin, A.4
Ludaway, T.5
Russ, R.6
Santoianni, R.7
Lewis, W.8
-
105
-
-
34447544972
-
The metabolic basis of solute transport
-
7th Ed., edited by Brenner BM, Philadelphia, Saunders
-
Kone BC: The metabolic basis of solute transport. In: Brenner and Rector’s The Kidney, 7th Ed., edited by Brenner BM, Philadelphia, Saunders, 2004, pp 231-260
-
(2004)
Brenner and Rector’s the Kidney
, pp. 231-260
-
-
Kone, B.C.1
-
106
-
-
0025072492
-
Bulk isolation of renal PCT and PST. II. Differential responses to anoxia or hypoxia
-
Ruegg CE, Mandel LJ: Bulk isolation of renal PCT and PST. II. Differential responses to anoxia or hypoxia. Am J Physiol 259: F176-F185, 1990
-
(1990)
Am J Physiol
, vol.259
, pp. F176-F185
-
-
Ruegg, C.E.1
Mandel, L.J.2
-
107
-
-
41149136735
-
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP
-
Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM: Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol 73: 1151-1158, 2008
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1151-1158
-
-
Cropp, C.D.1
Komori, T.2
Shima, J.E.3
Urban, T.J.4
Yee, S.W.5
More, S.S.6
Giacomini, K.M.7
-
108
-
-
33644841714
-
Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells
-
Zhou F, Illsley NP, You G: Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. Eur J Pharm Sci 27: 518-523, 2006
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 518-523
-
-
Zhou, F.1
Illsley, N.P.2
You, G.3
-
109
-
-
33750821441
-
Olfactorymucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions
-
Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M, Wu W, Eraly SA, Nigam SK: Olfactorymucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun 351: 872-876, 2006
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 872-876
-
-
Kaler, G.1
Truong, D.M.2
Sweeney, D.E.3
Logan, D.W.4
Nagle, M.5
Wu, W.6
Eraly, S.A.7
Nigam, S.K.8
-
110
-
-
77954611799
-
A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules
-
Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y: A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. J Biol Chem 285: 22141-22151, 2010
-
(2010)
J Biol Chem
, vol.285
, pp. 22141-22151
-
-
Shiraya, K.1
Hirata, T.2
Hatano, R.3
Nagamori, S.4
Wiriyasermkul, P.5
Jutabha, P.6
Matsubara, M.7
Muto, S.8
Tanaka, H.9
Asano, S.10
Anzai, N.11
Endou, H.12
Yamada, A.13
Sakurai, H.14
Kanai, Y.15
-
111
-
-
57749119509
-
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin-and clathrindependent pathway
-
Zhang Q, Hong M, Duan P, Pan Z, Ma J, You G: Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin-and clathrindependent pathway. J Biol Chem283: 32570-32579, 2008
-
(2008)
J Biol Chem283
, pp. 32570-32579
-
-
Zhang, Q.1
Hong, M.2
Duan, P.3
Pan, Z.4
Ma, J.5
You, G.6
-
112
-
-
84946739389
-
Shared ligands between organic anion transporters (Oat1 and Oat6) and odorant receptors
-
Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, Nigam SK: Shared ligands between organic anion transporters (Oat1 and Oat6) and odorant receptors. Drug Metab Dispos 43: 1-9, 2015
-
(2015)
Drug Metab Dispos
, vol.43
, pp. 1-9
-
-
Wu, W.1
Bush, K.T.2
Liu, H.C.3
Zhu, C.4
Abagyan, R.5
Nigam, S.K.6
-
113
-
-
84951128933
-
Evolutionary analysis and classification of OATs, OCTs, OCTNs and other SLC22 transporters: Structurefunction implications and analysis of sequence motifs
-
in press
-
Zhu C, Nigam KB, Date RC, Springer SA, Bush KT, Saier MH Jr, Wu W, Nigam SK: Evolutionary analysis and classification of OATs, OCTs, OCTNs and other SLC22 transporters: Structurefunction implications and analysis of sequence motifs. PLoS One 2015, in press
-
(2015)
Plos One
-
-
Zhu, C.1
Nigam, K.B.2
Date, R.C.3
Springer, S.A.4
Bush, K.T.5
Saier, M.H.6
Wu, W.7
Nigam, S.K.8
|