Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approachs

Journal of Pharmacology and Experimental Therapeutics

Volumn 359, Issue 1, 2016, Pages 215-229

  Liu, Henry C ^a   Goldenberg, Anne ^b   Chen, Yuchen ^b   Lun, Christina ^b   Wu, Wei ^b   Bush, Kevin T ^b   Balac, Natasha ^d,e   Rodriguez, Paul ^d   Abagyan, Ruben ^b   Nigam, Sanjay K ^b,c,f  

^a San Diego   (United States)

^b Department of Pediatrics ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; AMPHOLYTE; BUMETANIDE; CATION; CEFADROXIL; CLEMASTINE; DIFLUNISAL; DRUG METABOLITE; FENOFIBRIC ACID; HALOPERIDOL; INDOMETACIN; LIGAND; LOSARTAN; LOXOPROFEN; NAPROXEN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1 LIGAND; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 3 LIGAND; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 1 LIGAND; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 2 LIGAND; QUINIDINE; ROSIGLITAZONE; SILIBININ; TOLBUTAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; ZIDOVUDINE; CARRIER PROTEIN; DRUG; ORGANIC ANION TRANSPORTER; PROTEIN BINDING;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG INTERACTION; DRUG PROTEIN BINDING; DRUG SCREENING; IN VITRO STUDY; LABORATORY TEST; MACHINE LEARNING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; VIRTUAL REALITY; BIOLOGY; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; MOLECULAR MODEL; PH; PROCEDURES; PROTEIN CONFORMATION;

COMPUTATIONAL BIOLOGY; HYDROGEN-ION CONCENTRATION; MACHINE LEARNING; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORTER 1; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84988661387     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.116.232660     Document Type: Article

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