Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the Remote Sensing and Signaling Hypothesis

Molecular Pharmacology

Volumn 79, Issue 5, 2011, Pages 795-805

  Wu, Wei ^a   Dnyanmote, Ankur V ^a   Nigam, Sanjay K ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE; CYCLIC GMP; PROSTAGLANDIN; SEX HORMONE; URIC ACID;

ANTIOXIDANT ACTIVITY; BODY FLUID; CEREBROSPINAL FLUID; DRUG TRANSPORT; EPIGENETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CARNITINE; HUMANS; INTESTINES; MICE; SIGNAL TRANSDUCTION; URIC ACID;

EID: 79954998791     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.070607     Document Type: Review

References (77)

1. Ahn SY, Eraly SA, Tsigelny I, and Nigam SK (2009) Interaction of organic cations with organic anion transporters. J Biol Chem 284:31422-31430.
2. Ahn SY and Nigam SK (2009) Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol 76:481-490.
3. Barros SA, Srimaroeng C, Perry JL, Walden R, Dembla-Rajpal N, Sweet DH, and Pritchard JB (2009) Activation of protein kinase Czeta increases OAT1 (SLC22A6) - and OAT3 (SLC22A8)-mediated transport. J Biol Chem 284:2672-2679.
4. Benet LZ, Izumi T, Zhang Y, Silverman JA, and Wacher VJ (1999) Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. J Control Release 62:25-31. (Pubitemid 29486478)
5. Bruyere A, Decleves X, Bouzom F, Ball K, Marques C, Treton X, Pocard M, Valleur P, Bouhnik Y, Panis Y, et al. (2010) Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first-pass. Mol Pharm 7:1596-1607.
6. Cheeseman C (2009) Solute carrier family 2, member 9 and uric acid homeostasis. Curr Opin Nephrol Hypertens 18:428-432.
7. Cheng X and Klaassen CD (2009) Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos 37:2178-2185.
8. Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, and Giacomini KM (2008) Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMPMol Pharmacol 73:1151-1158.
9. Davidson J, Abul HT, Milton AS, and Rotondo D (2001) Cytokines and cytokine inducers stimulate prostaglandin E2 entry into the brain. Pflugers Arch 442:526-533. (Pubitemid 32673318)
10. De la Cruz O, Blekhman R, Zhang X, Nicolae D, Firestein S, and Gilad y (2009) A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes. Mol Biol Evol 26:491-494.
11. Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372:1953-1961.
12. Di Giusto G, Anzai N, Endou H, and Torres AM (2008) Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow. Pharmacology 81:127-136. (Pubitemid 351182687)
13. Döring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, et al. (2008) SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet 40:430-436. (Pubitemid 351454014)
14. Dreisbach AW (2009) The influence of chronic renal failure on drug metabolism and transport. Clin Pharmacol Ther 86:553-556.
15. Duan P and You G (2009) Novobiocin is a potent inhibitor for human organic anion transporters.Drug Metab Dispos 37:1203-1210.
16. Duan P and You G (2010) Short-term regulation of organic anion transporters. Pharmacol Ther 125:55-61.
17. Elbaz A and Moisan F (2008) Update in the epidemiology of Parkinson's disease. Curr Opin Neurol 21:454-460.
18. Eraly SA, Blantz RC, Bhatnagar V, and Nigam SK (2003a) Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens 12:551-558. (Pubitemid 37083117)
19. Eraly SA, Hamilton BA, and Nigam SK (2003b) Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun 300:333-342. (Pubitemid 38379656)
20. Eraly SA, Monte JC, and Nigam SK (2004) Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 18:12-24. (Pubitemid 39319482)
21. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, and Nigam SK (2008) Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 33:180-192. (Pubitemid 351629526)
22. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, et al. (2006) Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281:5072-5083. (Pubitemid 43847773)
23. Feldmesser E, Olender T, Khen M, Yanai I, Ophir R, and Lancet D (2006) Widespread ectopic expression of olfactory receptor genes. BMC Genomics 7:121.
24. Foti MC and Amorati R (2009) Non-phenolic radical-trapping antioxidants. J Pharm Pharmacol 61:1435-1448.
25. Grube M, Meyer Zu Schwabedissen H, Draber K, Präger D, Möritz KU, Linnemann K, Fusch C, Jedlitschky G, and Kroemer HK (2005) Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 33:31-37. (Pubitemid 40023511)
26. Gutgesell A, Ringseis R, Brandsch C, Stangl GI, Hirche F, and Eder K (2009) Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Metabolism 58:226-232.
27. Hagos Y, Stein D, Ugele B, Burckhardt G, and Bahn A (2007) Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol 18:430-439. (Pubitemid 46193309)
28. He L, Vasiliou K, and Nebert DW (2009) Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics 3:195-206.
29. Heinig M and Johnson RJ (2006) Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleve Clin J Med 73:1059-1064. (Pubitemid 44883981)
30. Hsu FF, Nodari F, Kao LF, Fu X, Holekamp TF, Turk J, and Holy TE (2008) Structural characterization of sulfated steroids that activate mouse pheromonesensing neurons. Biochemistry 47:14009-14019.
31. Hu QH, Jiao RQ, Wang X, Lv YZ, and Kong LD (2010) Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice. J Ethnopharmacol 128:685-692.
32. Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, Iseki S, and Tsuji A (2008) Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart. Drug Metab Pharmacokinet 23:207-215.
33. Jonker JW, Wagenaar E, Van Eijl S, and Schinkel AH (2003) Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23:7902-7908.
34. Kaler G, Truong DM, Khandelwal A, Nagle M, Eraly SA, Swaan PW, and Nigam SK (2007) Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem 282:23841-23853.
35. Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M, Wu W, Eraly SA, and Nigam SK (2006) Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun 351:872-876. (Pubitemid 44715866)
36. Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, and Schuster VL (1995) Identification and characterization of a prostaglandin transporter. Science 268:866-869.
37. Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, and Tsuji A (2006) Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Mol Pharmacol 70829-837.
38. Keebaugh AC and Thomas JW (2010) The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles. Mol Biol Evol27:1359-1369.
39. Klaassen CD and Aleksunes LM (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62:1-96.
40. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, et al. (2009) Meta-analysis of 28, 141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5:e1000504.
41. Komatsuda A, Iwamoto K, Wakui H, Sawada K, and Yamaguchi A (2006) Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in northern Japan and review of the literature. Ren Fail28:223-227. (Pubitemid 43995105)
42. Kwok B, Yamauchi A, Rajesan R, Chan L, Dhillon U, Gao W, Xu H, Wang B, Takahashi S, Semple J, et al. (2006) Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A. Am J Physiol Regul Integr Comp Physiol 290:R793-R802.
43. Li S, Sanna S, Maschio A, Busonero F, Usala G, Mulas A, Lai S, Dei M, Orrù M, Albai G, et al. (2007) The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3:e194.
44. Lin JH, Chiba M, Chen IW, Nishime JA, deLuna FA, Yamazaki M, and Lin YJ (1999) Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction. Drug Metab Dispos 27:1187-1193. (Pubitemid 29463606)
45. Meeks JP, Arnson HA, and Holy TE (2010) Representation and transformation of sensory information in the mouse accessory olfactory system. Nat Neurosci 13:723-730.
46. Miller DS (2010) Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol Sci 31:246-254.
47. Monte JC, Nagle MA, Eraly SA, and Nigam SK (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429-436. (Pubitemid 39221116)
48. Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, et al. (1999) Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21:91-94. (Pubitemid 29036290)
49. Nigam S and Lieberthal W (2000) Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair. Am J Physiol Renal Physiol 279:F3-F11. (Pubitemid 30619542)
50. Nigam SK, Bush KT, and Bhatnagar V (2007) Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3:443-448. (Pubitemid 47123587)
51. Nyhan WL (1968) Lesch-Nyhan syndrome. Summary of clinical features. Fed Proc 27:1034-1041.
52. Pavlova A, Sakurai H, Leclercq B, Beier DR, Yu AS, and Nigam SK (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol 278:F635-F643. (Pubitemid 30215242)
53. Puig JG and Martínez MA (2008) Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol 20:187-191. (Pubitemid 351339891)
54. Rebouche CJ and Seim H (1998) Carnitine metabolism and its regulation in microorganisms and mammals. Annu Rev Nutr 18:39-61. (Pubitemid 28366860)
55. Sachs L, Batra KL, and Zimmermann B (2009) Medical implications of hyperuricemia. Med Health R I92:353-355.
56. Sanchez-Moreno C, Dashe JF, Scott T, Thaler D, Folstein MF, and Martin A (2004) Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke 35:163-168. (Pubitemid 38057613)
57. Sandor A, Pecsuvac K, Kerner J, and Alkonyi I (1982) On carnitine content of the human breast milk. Pediatr Res 16:89-91. (Pubitemid 12212096)
58. Sauvant C, Holzinger H, and Gekle M (2006) Prostaglandin E2 inhibits its own renal transport by down-regulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol 17:46-53.
59. Schlatter E, Mönnich V, Cetinkaya I, Mehrens T, Ciarimboli G, Hirsch JR, Popp C, and Koepsell H (2002) The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP. J Membr Biol 189:237-244. (Pubitemid 36930160)
60. Schnabolk GW, Gupta B, Mulgaonkar A, Kulkarni M, and Sweet DH (2010) Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles. J Pharmacol Exp Ther 334:927-935.
61. Serkova NJ, Christians U, and Benet LZ (2004) Biochemical mechanisms of cyclosporin neurotoxicity. Mol Interv 4:97-107.
62. Shekhawat PS, Srinivas SR, Matern D, Bennett MJ, Boriack R, George V, Xu H, Prasad PD, Roon P, and Ganapathy V (2007) Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2 (-/-)) mice. Mol Genet Metab92:315-324. (Pubitemid 350123730)
63. Shi XD, Li GC, Qian ZX, Jin ZQ, and Song y (2008) Randomized and controlled clinical study of modified prescriptions of Simiao Pill in the treatment of acute gouty arthritis. Chin J Integr Med 14:17-22. (Pubitemid 351488144)
64. Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, et al. (2010) A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. J Biol Chem 285:22141-22151.
65. Srimaroeng C, Perry JL, and Pritchard JB (2008) Physiology, structure, and regulation of the cloned organic anion transporters. Xenobiotica 38:889-935.
66. Sun H, Frassetto L, and Benet LZ (2006) Effects of renal failure on drug transport and metabolism. Pharmacol Ther 109:1-11. (Pubitemid 41740811)
67. Sweet DH, Eraly SA, Vaughn DA, Bush KT, and Nigam SK (2006) Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int 69:837-845.
68. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943. (Pubitemid 34951703)
69. Takahashi R, Asai T, Murakami H, Murakami R, Tsuzuki M, Numaguchi Y, Matsui H, Murohara T, and Okumura K (2007) Pressure overload-induced cardiomyopathy in heterozygous carrier mice of carnitine transporter gene mutation. Hypertension 50:497-502. (Pubitemid 47312235)
70. Tanaka Y, Chen C, Maher JM, and Klaassen CD (2008) Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). Toxicol Sci 101:171-178. (Pubitemid 350239021)
71. Truong DM, Kaler G, Khandelwal A, Swaan PW, and Nigam SK (2008) Multi-level analysis of organic anion transporters 1,3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283:8654-8663.
72. Vasiliou V, Vasiliou K, and Nebert DW (2009) Human ATP-binding cassette (ABC) transporter family. Hum Genomics 3:281-290.
73. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, et al. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40:437-442. (Pubitemid 351450879)
74. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, and Siuzdak G (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 106:3698-3703.
75. Wright AF, Rudan I, Hastie ND, and Campbell H (2010) A 'complexity' of urate transporters. Kidney Int 78:446-452.
76. Wu W, Baker ME, Eraly SA, Bush KT, and Nigam SK (2009) Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics 38:116-124.
77. Zhang X, De la Cruz O, Pinto JM, Nicolae D, Firestein S, and Gilad y (2007) Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray. Genome Biol8:R86.