Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected black South Africans: A pilot study

AIDS Research and Human Retroviruses

Volumn 29, Issue 7, 2013, Pages 1031-1039

  Sinxadi, Phumla Z ^a   Dave, Joel A ^a   Samuels, David C ^b   Heckmann, Jeannine M ^a   Maartens, Gary ^a   Levitt, Naomi S ^a   Wester, C William ^b   Haas, David W ^b   Hulgan, Todd ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; LOPINAVIR PLUS RITONAVIR; MITOCHONDRIAL DNA; NEVIRAPINE; THYMIDINE DERIVATIVE; TRIACYLGLYCEROL;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG INDUCED DISEASE; FEMALE; GENOMICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTRIGLYCERIDEMIA; MAJOR CLINICAL STUDY; MALE; MOLECULAR PHYLOGENY; NEGRO; PHYLOGENETIC TREE; PILOT STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOUTH AFRICA; TREATMENT DURATION;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANTI-HIV AGENTS; CROSS-SECTIONAL STUDIES; DNA, MITOCHONDRIAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME, MITOCHONDRIAL; HIV INFECTIONS; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; HYPERTRIGLYCERIDEMIA; MALE; METABOLIC DISEASES; PILOT PROJECTS; POLYNEUROPATHIES; SOUTH AFRICA;

EID: 84879163885     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0373     Document Type: Article

References (37)

1. Kohler JJ and Lewis W: A brief overview of mitochondrial toxicity from NRTIs. Environ Mol Mutagen 2007;48:166-172.
2. Falutz J: HIV infection, body composition changes and related metabolic complications: Contributing factors and evolving management strategies. Curr Opin Clin Nutr Metab Care 2011;14:255-260.
3. Karamchand L, Dawood H, and Chuturgoon AA: Lymphocyte mitochondrial depolarization and apoptosis in HIV-1-infected HAART patients. J Acquir Immune Defic Syndr 2008;48:381-388.
4. Viengchareun S, Caron M, Auclair M, et al.: Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes. Antivir Ther 2007;12:919-929.
5. Wallace DC, Brown MD, and Lott MT: Mitochondrial DNA variation in human evolution and disease. Gene 1999;238: 211-230.
6. Saxena R, de Bakker PIW, Singer K, Mootha V, Burtt N, Hirshchorn M, et al.: Comprehensive association testing of common mitochondrial DNA variation. Am J Hum Genet 2006;76:54-61.
7. Grady B, Samuels DC, Robbins GK, Selph B, Canter JA, Pollard RB, et al.: Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS Clinical Trials Group Study 384. J Acquir Immune Defic Syndr 2011;58:363-370.
8. Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, Poole JC, Lautenberger J, Sezgin E, et al.: Mitochondrial DNA haplogroups influence AIDS progression. AIDS 2008;22: 2429-2439.
9. Micheloud D, Berenguer J, Guzmán-Fulgencio M, Campos Y, Garcia-Á lvarez M, Catalán P, et al.: European mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV coinfection. J Acquir Immune Defic Syndr 2011;58:371-378.
10. Hulgan T, Haubrich R, Riddler SA, Tebas P, Ritchie MD, McComsey GA, Haas DW, and Canter JA: European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS 2011;25:37-47.
11. Hulgan T, Tebas P, Canter JA, Mulligan K, Haas DW, Dubé M, Grinspoon S, et al.: Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy. JID 2008;197: 858-866.
12. Hendrickson SL, Kingsley LA, Ruiz-Pesini E, Poole JC, Jacobson LP, Palella FJ, et al.: Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy. JAIDS 2009;51:111-116.
13. Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, et al.: Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: An adult AIDS clinical trials group study. AIDS 2005;19:1341-1349.
14. Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer W, et al.: The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenom J 2008;8:71-77.
15. Canter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, et al. for the ACTG 384 and New Work Concept Sheet 273 Study Teams: African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. JID 2010;201:1703-1707.
16. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, et al.: Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet 2001;109:521-525.
17. Lal S, Madhavan M, and Heng CK: The association of mitochondrial DNA 5178 C>A polymorphism with plasma lipid levels among three ethnic groups. Ann Hum Genet 2005;69:639-644.
18. Park KS, Chan JC, Chuang LM, Suzuki S, Araki E, Nanjo K, et al.: A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia 2008;51:602-608.
19. Dahmani Y, Marcuello A, Diez-Sanchez C, Ruiz-Pesini E, Montoya J, and Lopez-Perez J: Association of human mitochondrial DNA variants with plasma LDL levels. Mitochondrion 2008;8:247-253.
20. Feder J, Ovadia O, Blech I Cohen J, WainsteinJ, Harman-Boehm I, et al.: Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes. BMC Genet 2009;10:doi:10.1186/1471-2350-10-60.
21. UNAIDS report 2010. http://www.unaids.org/documents/20101123-FS-SSA-em- en.pdf. August 1, 2011.
22. Dave JA, Lambert EV, Badri M, West S, Maartens G, and Levitt NS: Effect of nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy on dysglycaemia and insulin sensitivity in South African HIV-infected patients. J Acquir Immune Defic Syndr 2011;57:284-289.
23. Maritz J, Benatar M, Dave J, Harrison TB, Badri M, Levitt NS, and Heckmann JM: HIV neuropathy in South Africans: Frequency, characteristics, and risk factors. Muscle Nerve 2010;41:599-606.
24. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2008;31:S55-S60.
25. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2489-2497.
26. McComsey GA and Yau L: Asymptomatic hyperlactataemia: Predictive value, natural history and correlates. Antiviral Ther 2004;9:205-221.
27. van Oven M and Kayser M: Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 2009;30(2):E386-E394. http://www.phylotree .org.
28. Gonder MK, Mortensen HM, Reed FA, de Sousa A, and Tishkoff SA: Whole-mtDNA genome sequence analysis of ancient African lineages. Mol Biol Evol 2007;24:757-768.
29. van der Walt EM, Smuts I, Taylor RW, Elson JL, Turnbull DM, Louw R, and van der Westhuizen FH: Characterization of mtDNA variation in a cohort of South African paediatric patients with mitochondrial disease. Eur J Hum Genet 2012;20:650-656.
30. Montes ML, Pulido F, Barros C, Condes E, Rubio R, Cepeda C, et al.: Lipid disorders in antiretroviral-näve patients with lopinavir-ritonavir based HAART: Frequency, characterization and risk factors. JAC 2005;55:800-804.
31. Hegele RA, Zinman B, Hanley JG, Harris S, and Connelly PW: A common mtDNA polymorphism associated with variation in plasma triglyceride concentration. Am J Hum Genet 1997;60:1552-1555.
32. Maechler P and Wollheim CB: Mitochondrial function in normal and diabetics ß-cells. Nature 2001;414:807-812.
33. Park KS, Chan JC, Chuang L-M, Suzuki S, Araki E, Nanjo K, et al.: A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologica 2008;58:602-608.
34. Poulton J, Luan J, Macaulay V, Hennings S,Mitchell J, and Wareham J: Type 2 diabetes is associated with a common mitochondrial variant: Evidence from a population-based case-control study. Hum Mol Genet 2002;11:1581-1583.
35. Hocqueloux L, Alberti C, Feugeas J-P, Lafaurie M, Lukasiewicz E, Bagnard G, et al.: Prevalence, risk factors and outcome of hyperlactataemia in HIV-infected patients. HIV Med 2003;4:18-23.
36. Arenas-Pinto A, Weller I, Ekong R, Grant A, Karstaedt A, Reiss P, et al.: Common inherited mitochondrial DNA mutations and nucleoside reverse transcriptase inhibitorinduced severe hyperlactataemia in HIV-infected adults: An exploratory study. Antivir Ther 2012;17:275-282.
37. De Luca A, Nasi M, Di Giambenedetto S, Cozzi-Lepri A, Pinti M, Marzochetti A, et al.: Mitochondrial DNA haplogroups and incidence of lipodystrophy in HIV infected patients on long-term antiretroviral therapy. J Acquir Immune Defic Syndr 2012;59:113-120.