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Volumn 4, Issue , 2011, Pages 273-282

Is obesity in women protective against osteoporosis?

Author keywords

Adipocytes; Body mass index; Bone mineral density; Fat mass; Fractures

Indexed keywords

ADIPONECTIN; AROMATASE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RESISTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR;

EID: 84985905232     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S11920     Document Type: Review
Times cited : (108)

References (138)
  • 1
    • 6944255415 scopus 로고    scopus 로고
    • Hyperkyphotic posture predicts mortality in older community-dwelling men and women: A prospective study
    • Kado DM, Huang MH, Karlamangla AS, Barrett-Connor E, Greendale GA. Hyperkyphotic posture predicts mortality in older community-dwelling men and women: a prospective study. J Am Geriatr Soc. 2004;52:1662-1667.
    • (2004) J am Geriatr Soc , vol.52 , pp. 1662-1667
    • Kado, D.M.1    Huang, M.H.2    Karlamangla, A.S.3    Barrett-Connor, E.4    Greendale, G.A.5
  • 3
    • 0038067777 scopus 로고    scopus 로고
    • Overweight and obesity in women: Health risks and consequences
    • Hu FB. Overweight and obesity in women: health risks and consequences. J Women Health (Larchmt). 2003;12(2):163-172.
    • (2003) J Women Health (Larchmt) , vol.12 , Issue.2 , pp. 163-172
    • Hu, F.B.1
  • 4
    • 0034471041 scopus 로고    scopus 로고
    • Report of a WHO consultation. World Health Organ Tech Rep Ser
    • Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:1-253.
    • (2000) Obesity: Preventing and Managing the Global Epidemic , vol.894 , pp. 1-253
  • 6
    • 0036861322 scopus 로고    scopus 로고
    • Relationships among body mass, its components, and bone
    • Reid IR. Relationships among body mass, its components, and bone. Bone. 2002;31:547-555.
    • (2002) Bone , vol.31 , pp. 547-555
    • Reid, I.R.1
  • 7
    • 0000664911 scopus 로고    scopus 로고
    • Consensus development panel on osteoporosis
    • NIH. Consensus development panel on osteoporosis. JAMA. 2001;285: 785-795.
    • (2001) JAMA , vol.285 , pp. 785-795
  • 8
    • 36749026363 scopus 로고    scopus 로고
    • Menopause, estrogens, progestin, or their combination on body weight and anthropometric measurements
    • Cagnacci A, Zanin R, Cannoletta M, Generali M, Caretto S, Volpe A. Menopause, estrogens, progestin, or their combination on body weight and anthropometric measurements. Fertil Steril. 2007;88(6): 1603-1608.
    • (2007) Fertil Steril , vol.88 , Issue.6 , pp. 1603-1608
    • Cagnacci, A.1    Zanin, R.2    Cannoletta, M.3    Generali, M.4    Caretto, S.5    Volpe, A.6
  • 9
    • 0037990061 scopus 로고    scopus 로고
    • The relationship of obesity to the metabolic syndrome
    • Lebovitz HE. The relationship of obesity to the metabolic syndrome. Int J Clin Pract Suppl. 2003;134:18-27.
    • (2003) Int J Clin Pract Suppl , vol.134 , pp. 18-27
    • Lebovitz, H.E.1
  • 10
    • 0346849867 scopus 로고    scopus 로고
    • Obesity as a cardiovascular risk factor
    • Sowers JR. Obesity as a cardiovascular risk factor. Am J Med. 2003;8: 37S-41S.
    • (2003) Am J Med , vol.8 , pp. 37S-41S
    • Sowers, J.R.1
  • 11
    • 37548998960 scopus 로고    scopus 로고
    • Correlation of obesity and osteoporosis: Effect of fat mass on the determination of osteoporosis
    • Zhao LJ, Jiang H, Papasian CJ, et al. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res. 2008;23:17-29.
    • (2008) J Bone Miner Res , vol.23 , pp. 17-29
    • Zhao, L.J.1    Jiang, H.2    Papasian, C.J.3
  • 14
    • 0034781590 scopus 로고    scopus 로고
    • Bone mineral density and body composition in boys with distal forearm fractures: A dual-energy X-ray absorptiometry study
    • Goulding A, Jones IE, Taylor RW, Williams SM, Manning PJ. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy X-ray absorptiometry study. J Pediatr. 2001; 139:509-515.
    • (2001) J Pediatr , vol.139 , pp. 509-515
    • Goulding, A.1    Jones, I.E.2    Taylor, R.W.3    Williams, S.M.4    Manning, P.J.5
  • 15
    • 0033731670 scopus 로고    scopus 로고
    • Changes in the insulinlik growth factor-system may contribute to in vitro agerelate impaired osteoblast functions
    • Kveiborg M, Flyvbjerg A, Rattan SI, Kassem M. Changes in the insulinlik growth factor-system may contribute to in vitro agerelate impaired osteoblast functions. Exp Geronto. 2000;35:1061-1074.
    • (2000) Exp Geronto , vol.35 , pp. 1061-1074
    • Kveiborg, M.1    Flyvbjerg, A.2    Rattan, S.I.3    Kassem, M.4
  • 16
    • 0033105456 scopus 로고    scopus 로고
    • The association between low bone mass at the menopause and cardiovascular mortality
    • Von der Recke P, Hansen MA, Hassager C. The association between low bone mass at the menopause and cardiovascular mortality. Am J Med. 1999;106:273-278.
    • (1999) Am J Med , vol.106 , pp. 273-278
    • Von Der Recke, P.1    Hansen, M.A.2    Hassager, C.3
  • 17
    • 0026775342 scopus 로고
    • Fat mass is an important determinant of whole body bone density in premenopausal women but not in men
    • Reid IR, Plank LD, Evans MC. Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endoc Metab. 1992;75:779-782.
    • (1992) J Clin Endoc Metab , vol.75 , pp. 779-782
    • Reid, I.R.1    Plank, L.D.2    Evans, M.C.3
  • 18
    • 0023909432 scopus 로고
    • Evidence of estrogen receptors in normal human osteoblast-like cells
    • Eriksen EF, Colvard DS, Berg NJ, et al. Evidence of estrogen receptors in normal human osteoblast-like cells. Science. 1988 1;241(4861): 84-86.
    • (1988) Science , vol.1 , Issue.241 , pp. 84-86
    • Eriksen, E.F.1    Colvard, D.S.2    Berg, N.J.3
  • 19
    • 77956510065 scopus 로고    scopus 로고
    • New understanding of glucocorticoid action in bone cells
    • Kim HJ. New understanding of glucocorticoid action in bone cells. BMB Rep. 2010;43(8):524-529.
    • (2010) BMB Rep , vol.43 , Issue.8 , pp. 524-529
    • Kim, H.J.1
  • 20
    • 0023914660 scopus 로고
    • Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells
    • Komm BS, Terpening CM, Benz DJ, et al. Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science. 1988;241(4861):81-84.
    • (1988) Science , vol.241 , Issue.4861 , pp. 81-84
    • Komm, B.S.1    Terpening, C.M.2    Benz, D.J.3
  • 21
    • 0026631691 scopus 로고
    • Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor
    • Migliaccio S, Davis VL, Gibson MK, Gray TK, Korach KS. Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor. Endocrinology. 1992;130(5): 2617-2624.
    • (1992) Endocrinology , vol.130 , Issue.5 , pp. 2617-2624
    • Migliaccio, S.1    Davis, V.L.2    Gibson, M.K.3    Gray, T.K.4    Korach, K.S.5
  • 23
    • 47749139379 scopus 로고    scopus 로고
    • Effect of obesity on bone metabolism
    • Takeda S. Effect of obesity on bone metabolism. Clin Calcium. 2008;18: 632-637.
    • (2008) Clin Calcium , vol.18 , pp. 632-637
    • Takeda, S.1
  • 26
    • 0027529964 scopus 로고
    • Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group
    • Cummings SR, Black DM, Nevitt MC, et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993;341:72-75.
    • (1993) Lancet , vol.341 , pp. 72-75
    • Cummings, S.R.1    Black, D.M.2    Nevitt, M.C.3
  • 28
    • 0023188269 scopus 로고
    • Spine and femur density using dual-photon absorptiometry in US white women
    • Mazess RB, Barden HS, Ettinger M, et al. Spine and femur density using dual-photon absorptiometry in US white women. Bone Miner Res. 1987;2:211-219.
    • (1987) Bone Miner Res , vol.2 , pp. 211-219
    • Mazess, R.B.1    Barden, H.S.2    Ettinger, M.3
  • 29
    • 0027310187 scopus 로고
    • Effects of weight and body mass index on bone mineral density in men and women: The Framingham study
    • Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: The Framingham study. J Bone Miner Res. 1993;8:567-573.
    • (1993) J Bone Miner Res , vol.8 , pp. 567-573
    • Felson, D.T.1    Zhang, Y.2    Hannan, M.T.3    Erson, J.J.4
  • 30
    • 0028102263 scopus 로고
    • Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial
    • Marcus R, Greendale G, Blunt BA, et al. Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial. J Bone Miner Res. 1994;9:1467-1476.
    • (1994) J Bone Miner Res , vol.9 , pp. 1467-1476
    • Marcus, R.1    Greendale, G.2    Blunt, B.A.3
  • 31
    • 0026642505 scopus 로고
    • Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass
    • Reid IR, Ames R, Evans MC, et al. Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass. J Clin Endocrinol Metab. 1992;75:45-51.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 45-51
    • Reid, I.R.1    Ames, R.2    Evans, M.C.3
  • 32
    • 0032881714 scopus 로고    scopus 로고
    • Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group
    • Ravn P, Cizza G, Bjarnason NH, Thompson D et al. Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res. 1999;14:1622-1627.
    • (1999) J Bone Miner Res , vol.14 , pp. 1622-1627
    • Ravn, P.1    Cizza, G.2    Bjarnason, N.H.3    Thompson, D.4
  • 33
  • 34
  • 35
    • 33644852680 scopus 로고    scopus 로고
    • Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    • Hsu YH, Venners SA, Terwedow HA, et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006;83: 146-154.
    • (2006) Am J Clin Nutr , vol.83 , pp. 146-154
    • Hsu, Y.H.1    Venners, S.A.2    Terwedow, H.A.3
  • 36
    • 77950655856 scopus 로고    scopus 로고
    • Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index
    • Greco EA, Fornari R, Rossi F et al. Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract. 2010;64(6):817-820.
    • (2010) Int J Clin Pract , vol.64 , Issue.6 , pp. 817-820
    • Greco, E.A.1    Fornari, R.2    Rossi, F.3
  • 37
    • 0041386359 scopus 로고    scopus 로고
    • Leptin, body composition and bone mineral density in premenopausal women
    • Blum M, Harris SS, Must A, et al. Leptin, body composition and bone mineral density in premenopausal women. Calcif Tissue Int. 2003;73: 27-32.
    • (2003) Calcif Tissue Int , vol.73 , pp. 27-32
    • Blum, M.1    Harris, S.S.2    Must, A.3
  • 38
    • 77957941579 scopus 로고    scopus 로고
    • Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women
    • Kim KC, Shin DH, Lee SY, et al. Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women. Yonsei Med J. 2010;51(6):857-863.
    • (2010) Yonsei Med J , vol.51 , Issue.6 , pp. 857-863
    • Kim, K.C.1    Shin, D.H.2    Lee, S.Y.3
  • 39
    • 21744432492 scopus 로고    scopus 로고
    • Differential effect of obesity on bone mineral density in White, Hispanic and African American women: A cross sectional study
    • Castro JP, Joseph LA, Shin JJ, et al. Differential effect of obesity on bone mineral density in White, Hispanic and African American women: A cross sectional study. Nutr Metab (Lond). 2005;2:9.
    • (2005) Nutr Metab (Lond) , vol.2 , pp. 9
    • Castro, J.P.1    Joseph, L.A.2    Shin, J.J.3
  • 40
    • 33845884816 scopus 로고    scopus 로고
    • Racial differences in the association of subcutaneous and visceral fat on bone mineral content in prepubertal children
    • Afghani A, Goran MI. Racial differences in the association of subcutaneous and visceral fat on bone mineral content in prepubertal children. Calcif Tissue Int. 2006;79:383-388.
    • (2006) Calcif Tissue Int , vol.79 , pp. 383-388
    • Afghani, A.1    Goran, M.I.2
  • 42
    • 0029731765 scopus 로고    scopus 로고
    • Therapy of osteoporosis: Calcium, vitamin D, and exercise
    • Reid IR. Therapy of osteoporosis: Calcium, vitamin D, and exercise. Am J Med Sci. 1996;312:278-286.
    • (1996) Am J Med Sci , vol.312 , pp. 278-286
    • Reid, I.R.1
  • 43
    • 0035811739 scopus 로고    scopus 로고
    • Postmenopausal hormonereplacement therapy
    • Manson JE, Martin KA. Postmenopausal hormonereplacement therapy. N Engl J Med. 2001;345:34-40.
    • (2001) N Engl J Med , vol.345 , pp. 34-40
    • Manson, J.E.1    Martin, K.A.2
  • 44
    • 0039567273 scopus 로고    scopus 로고
    • Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy
    • Sorensen MB, Rosenfalck AM, Hojgaard L, Ottesen B. Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obes Res. 2001;9:622-626.
    • (2001) Obes Res , vol.9 , pp. 622-626
    • Sorensen, M.B.1    Rosenfalck, A.M.2    Hojgaard, L.3    Ottesen, B.4
  • 46
    • 2142643786 scopus 로고    scopus 로고
    • Oral glucocorticoid use is associated with an increased risk of fracture
    • Steinbuch M, Youket TE, Cohen S. Oral glucocorticoid use is associated with an increased risk of fracture. Osteoporos Int. 2004;15: 323-328.
    • (2004) Osteoporos Int , vol.15 , pp. 323-328
    • Steinbuch, M.1    Youket, T.E.2    Cohen, S.3
  • 47
    • 0025801880 scopus 로고
    • Control of terminal differentiation of adipose precursor cells by glucocorticoids
    • Gaillard D, Wabitsch M, Pipy B, Negrel R. Control of terminal differentiation of adipose precursor cells by glucocorticoids. J Lipid Res. 1991;32:569-579.
    • (1991) J Lipid Res , vol.32 , pp. 569-579
    • Gaillard, D.1    Wabitsch, M.2    Pipy, B.3    Negrel, R.4
  • 48
    • 0034463972 scopus 로고    scopus 로고
    • Understanding the role of glucocorticoids in obesity: Tissue-specific alterations of corticosterone metabolism in obese Zucker rats
    • Livingstone DE, Jones GC, Smith K, et al. Understanding the role of glucocorticoids in obesity: Tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000;141: 560-563.
    • (2000) Endocrinology , vol.141 , pp. 560-563
    • Livingstone, D.E.1    Jones, G.C.2    Smith, K.3
  • 49
    • 0036090467 scopus 로고    scopus 로고
    • Divergent effects of selective peroxisome proliferatoractivated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation
    • Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferatoractivated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002;143:2376-2384.
    • (2002) Endocrinology , vol.143 , pp. 2376-2384
    • Lecka-Czernik, B.1    Moerman, E.J.2    Grant, D.F.3    Lehmann, J.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 50
    • 84985973561 scopus 로고    scopus 로고
    • Bone loss and fractures risk associated with thiazolidinedione therapy
    • Riche DM, Travis King S. Bone loss and fractures risk associated with thiazolidinedione therapy. Endocrinology. 2007;148(6):2669-2680.
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2669-2680
    • Riche, D.M.1    Travis King, S.2
  • 51
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev. 2005;26:439-451.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 53
    • 4644226667 scopus 로고    scopus 로고
    • Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity
    • Vendrell J, Broch M, Vilarrasa N, et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity. Obes Res. 2004;12:962-971.
    • (2004) Obes Res , vol.12 , pp. 962-971
    • Vendrell, J.1    Broch, M.2    Vilarrasa, N.3
  • 54
    • 41649093318 scopus 로고    scopus 로고
    • Inflammatory mechanisms in the regulation of insulin resistance
    • Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14(3-4):222-231.
    • (2008) Mol Med , vol.14 , Issue.3 , pp. 222-231
    • Tilg, H.1    Moschen, A.R.2
  • 57
    • 0028143234 scopus 로고
    • Estrogen resistance caused by a mutation in the estrogen receptor gene in a man
    • Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen receptor gene in a man. N Engl J Med. 1994;331: 1056-1061.
    • (1994) N Engl J Med , vol.331 , pp. 1056-1061
    • Smith, E.P.1    Boyd, J.2    Frank, G.R.3
  • 58
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 1995;80:3689-3698.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 60
    • 0035912933 scopus 로고    scopus 로고
    • The role of estrogen and estrogen receptor-alpha in male adipose tissue
    • Cooke PS, Heine PA, Taylor JA, Lubahn DB. The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol. 2001;178:147-154.
    • (2001) Mol Cell Endocrinol , vol.178 , pp. 147-154
    • Cooke, P.S.1    Heine, P.A.2    Taylor, J.A.3    Lubahn, D.B.4
  • 61
    • 10744225853 scopus 로고    scopus 로고
    • Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: Effects of testosterone, alendronate, and estradiol treatment
    • Maffei L, Murata Y, Rochira V, et al. Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: Effects of testosterone, alendronate, and estradiol treatment. J Clin Endocrinol Metab. 2004;89: 61-70.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 61-70
    • Maffei, L.1    Murata, Y.2    Rochira, V.3
  • 62
    • 0031739555 scopus 로고    scopus 로고
    • Menopause, central body fatness, and insulin resistance: Effects of hormone-replacement therapy
    • Tchernof A, Calles-Escandon J, Sites CK, Poehlman ET. Menopause, central body fatness, and insulin resistance: Effects of hormone-replacement therapy. Coron Artery Dis. 1998;9: 503-511.
    • (1998) Coron Artery Dis , vol.9 , pp. 503-511
    • Tchernof, A.1    Calles-Escandon, J.2    Sites, C.K.3    Poehlman, E.T.4
  • 63
    • 0035949157 scopus 로고    scopus 로고
    • Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
    • Gambacciani M, Ciaponi M, Cappagli B, De Simone L, Orlandi R, Genazzani AR. Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy. Maturitas. 2001;39:125-132.
    • (2001) Maturitas , vol.39 , pp. 125-132
    • Gambacciani, M.1    Ciaponi, M.2    Cappagli, B.3    De Simone, L.4    Orlandi, R.5    Genazzani, A.R.6
  • 64
    • 0037302039 scopus 로고    scopus 로고
    • Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: A randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study
    • Jensen LB, Vestergaard P, Hermann AP, et al. Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: A randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study. J Bone Miner Res. 2003;18:333-342.
    • (2003) J Bone Miner Res , vol.18 , pp. 333-342
    • Jensen, L.B.1    Vestergaard, P.2    Hermann, A.P.3
  • 65
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women’s Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288:321-333.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Erson, G.L.2    Prentice, R.L.3
  • 68
    • 0033586747 scopus 로고    scopus 로고
    • The role of leptin in human obesity and disease: A review of current evidence
    • Mantzoros CS. The role of leptin in human obesity and disease: A review of current evidence. Ann Intern Med. 1999;130:671-680.
    • (1999) Ann Intern Med , vol.130 , pp. 671-680
    • Mantzoros, C.S.1
  • 69
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell. 2000;100:197-207.
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3
  • 70
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S, Elefteriou F, Levasseur R, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002;111:305-317.
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3
  • 71
    • 6344261900 scopus 로고    scopus 로고
    • Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women
    • Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res. 2004;19:546-551.
    • (2004) J Bone Miner Res , vol.19 , pp. 546-551
    • Kontogianni, M.D.1    Dafni, U.G.2    Routsias, J.G.3    Skopouli, F.N.4
  • 72
    • 0031773271 scopus 로고    scopus 로고
    • Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women
    • Goulding A, Taylor RW. Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women. Calcif Tissue Int. 1998;63: 456-458.
    • (1998) Calcif Tissue Int , vol.63 , pp. 456-458
    • Goulding, A.1    Taylor, R.W.2
  • 73
    • 0034838788 scopus 로고    scopus 로고
    • Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women
    • Yamauchi M, Sugimoto T, Yamaguchi T, et al. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin Endocrinol (Oxf). 2001;55:341-347.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 341-347
    • Yamauchi, M.1    Sugimoto, T.2    Yamaguchi, T.3
  • 74
    • 0035006326 scopus 로고    scopus 로고
    • Serum leptin levels are associated with bone mass in nonobese women
    • Pasco JA, Henry MJ, Kotowicz MA, et al. Serum leptin levels are associated with bone mass in nonobese women. J Clin Endocrinol Metab. 2001;86:1884-1887.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1884-1887
    • Pasco, J.A.1    Henry, M.J.2    Kotowicz, M.A.3
  • 75
    • 0036708144 scopus 로고    scopus 로고
    • Is leptin the link between fat and bone mass?
    • Thomas T, Burguera B. Is leptin the link between fat and bone mass? J Bone Miner Res. 2002;17:1563-1569.
    • (2002) J Bone Miner Res , vol.17 , pp. 1563-1569
    • Thomas, T.1    Burguera, B.2
  • 76
    • 0037300892 scopus 로고    scopus 로고
    • Leptin: A potential mediator for protective effects of fat mass on bone tissue
    • Thomas T. Leptin: A potential mediator for protective effects of fat mass on bone tissue. Joint Bone Spine. 2003;70:18-21.
    • (2003) Joint Bone Spine , vol.70 , pp. 18-21
    • Thomas, T.1
  • 77
    • 2342518168 scopus 로고    scopus 로고
    • The complex effects of leptin on bone metabolism through multiple pathways
    • Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol. 2004;4:295-300.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 295-300
    • Thomas, T.1
  • 78
    • 23044445737 scopus 로고    scopus 로고
    • Leptin modulate both resorption and formation while preventing disuse-induced bone loss in tailsuspended female rats
    • Martin A, de Vittoris R, David V, et al. Leptin modulate both resorption and formation while preventing disuse-induced bone loss in tailsuspended female rats. Endocrinology. 2005;146(8):3652-3659.
    • (2005) Endocrinology , vol.146 , Issue.8 , pp. 3652-3659
    • Martin, A.1    De Vittoris, R.2    David, V.3
  • 79
    • 18744376564 scopus 로고    scopus 로고
    • Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo
    • Cornish J, Callon KE, Bava U, et al. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2001; 175:405-415.
    • (2001) J Endocrinol , vol.175 , pp. 405-415
    • Cornish, J.1    Callon, K.E.2    Bava, U.3
  • 80
    • 0032982438 scopus 로고    scopus 로고
    • Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
    • Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999;140:1630-1638.
    • (1999) Endocrinology , vol.140 , pp. 1630-1638
    • Thomas, T.1    Gori, F.2    Khosla, S.3    Jensen, M.D.4    Burguera, B.5    Riggs, B.L.6
  • 81
    • 24144459585 scopus 로고    scopus 로고
    • The molecular clock mediates leptin-regulated bone formation
    • Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell. 2005;122:803-815.
    • (2005) Cell , vol.122 , pp. 803-815
    • Fu, L.1    Patel, M.S.2    Bradley, A.3    Wagner, E.F.4    Karsenty, G.5
  • 82
    • 15844384047 scopus 로고    scopus 로고
    • Leptin regulation of bone resorption by the sympathetic nervous system and CART
    • Elefteriou F, Ahn JD, Takeda S, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005;434: 514-520.
    • (2005) Nature , vol.434 , pp. 514-520
    • Elefteriou, F.1    Ahn, J.D.2    Takeda, S.3
  • 83
    • 33750453786 scopus 로고    scopus 로고
    • Convergence between bone and energy homeostases: Leptin regulation of bone mass
    • Karsenty G. Convergence between bone and energy homeostases: Leptin regulation of bone mass. Cell Metab. 2006;4:341-348.
    • (2006) Cell Metab , vol.4 , pp. 341-348
    • Karsenty, G.1
  • 84
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 85
    • 0035883810 scopus 로고    scopus 로고
    • Role of melanocortins in control of obesity
    • Wisse BE, Schwartz MW. Role of melanocortins in control of obesity. Lancet. 2001;358:857-859.
    • (2001) Lancet , vol.358 , pp. 857-859
    • Wisse, B.E.1    Schwartz, M.W.2
  • 86
    • 0242667851 scopus 로고    scopus 로고
    • Neuropeptide Y and energy homeostasis: Insights from Y receptor knockout models
    • Herzog H. Neuropeptide Y and energy homeostasis: Insights from Y receptor knockout models. Eur J Pharmacol. 2003;480:21-29.
    • (2003) Eur J Pharmacol , vol.480 , pp. 21-29
    • Herzog, H.1
  • 87
    • 0038781739 scopus 로고    scopus 로고
    • Molecular and genetic mechanisms of obesity: Implications for future management
    • Liu YJ, Araujo S, Recker RR, Deng HW. Molecular and genetic mechanisms of obesity: Implications for future management. Curr Mol Med. 2003;3:325-340.
    • (2003) Curr Mol Med , vol.3 , pp. 325-340
    • Liu, Y.J.1    Araujo, S.2    Recker, R.R.3    Deng, H.W.4
  • 88
    • 0037173035 scopus 로고    scopus 로고
    • Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice
    • Sainsbury A, Schwarzer C, Couzens M, et al. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci U S A. 2002;99:8938-8943.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8938-8943
    • Sainsbury, A.1    Schwarzer, C.2    Couzens, M.3
  • 89
    • 0036212496 scopus 로고    scopus 로고
    • Hypothalamic Y2 receptors regulate bone formation
    • Baldock PA, Sainsbury A, Couzens M, et al. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest. 2002;109:915-921.
    • (2002) J Clin Invest , vol.109 , pp. 915-921
    • Baldock, P.A.1    Sainsbury, A.2    Couzens, M.3
  • 90
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adiposederived protein Acrp30
    • Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adiposederived protein Acrp30. J Clin Invest. 2001;108:1875-1881.
    • (2001) J Clin Invest , vol.108 , pp. 1875-1881
    • Combs, T.P.1    Berg, A.H.2    Obici, S.3    Scherer, P.E.4    Rossetti, L.5
  • 91
    • 0034881391 scopus 로고    scopus 로고
    • The adipocytesecreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocytesecreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;7:947-953.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 92
    • 5344272498 scopus 로고    scopus 로고
    • Adiponectin and its receptors are expressed in bone-forming cells
    • Berner HS, Lyngstadaas SP, Spahr A, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004;35:842-849.
    • (2004) Bone , vol.35 , pp. 842-849
    • Berner, H.S.1    Lyngstadaas, S.P.2    Spahr, A.3
  • 93
    • 18044394024 scopus 로고    scopus 로고
    • Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
    • Oshima K, Nampei A, Matsuda M, et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun. 2005;331:520-526.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 520-526
    • Oshima, K.1    Nampei, A.2    Matsuda, M.3
  • 94
    • 23944517324 scopus 로고    scopus 로고
    • Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway
    • Luo XH, Guo LJ, Yuan LQ, et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res. 2005;309:99-109.
    • (2005) Exp Cell Res , vol.309 , pp. 99-109
    • Luo, X.H.1    Guo, L.J.2    Yuan, L.Q.3
  • 95
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930-1935.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 96
    • 0141638664 scopus 로고    scopus 로고
    • Adiponectin as a novel determinant of bone mineral density and visceral fat
    • Lenchik L, Register TC, Hsu FC et al. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003;33:646-651.
    • (2003) Bone , vol.33 , pp. 646-651
    • Lenchik, L.1    Register, T.C.2    Hsu, F.C.3
  • 97
    • 21244505055 scopus 로고    scopus 로고
    • Adiponectin is associated with bone mineral density in perimenopausal women
    • Jurimae J, Rembel K, Jurimae T, Rehand M. Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res. 2005;37:297-302.
    • (2005) Horm Metab Res , vol.37 , pp. 297-302
    • Jurimae, J.1    Rembel, K.2    Jurimae, T.3    Rehand, M.4
  • 98
    • 33749468246 scopus 로고    scopus 로고
    • Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism
    • Thommesen L, Stunes AK, Monjo M, et al. Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism. J Cell Biochem. 2006;99(3): 824-834.
    • (2006) J Cell Biochem , vol.99 , Issue.3 , pp. 824-834
    • Thommesen, L.1    Stunes, A.K.2    Monjo, M.3
  • 99
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004;145:2273-2282.
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 100
    • 0037631831 scopus 로고    scopus 로고
    • Insulin resistance and chronic cardiovascular inflammatory syndrome
    • Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev. 2003;24:278-301.
    • (2003) Endocr Rev , vol.24 , pp. 278-301
    • Fernandez-Real, J.M.1    Ricart, W.2
  • 101
    • 0035666553 scopus 로고    scopus 로고
    • Is obesity an inflammatory condition?
    • Das UN. Is obesity an inflammatory condition? Nutrition. 2001;17:953-966.
    • (2001) Nutrition , vol.17 , pp. 953-966
    • Das, U.N.1
  • 102
    • 0037278979 scopus 로고    scopus 로고
    • The interleukin 6-174G/C polymorphism is associated with indices of obesity in men
    • Berthier MT, Paradis AM, Tchernof A. The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. J Hum Genet. 2003;48:14-19.
    • (2003) J Hum Genet , vol.48 , pp. 14-19
    • Berthier, M.T.1    Paradis, A.M.2    Tchernof, A.3
  • 104
    • 0033923617 scopus 로고    scopus 로고
    • Shaughnessy SG. Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: Synergy with dexamethasone
    • Richards CD, Langdon C, Deschamps P, Pennica D, Shaughnessy SG. Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: Synergy with dexamethasone. Cytokine. 2000;12:613-621.
    • (2000) Cytokine , vol.12 , pp. 613-621
    • Richards, C.D.1    Langdon, C.2    Deschamps, P.3    Pennica, D.4
  • 105
    • 0026553473 scopus 로고
    • Introduction to bone biology
    • Rodan GA. Introduction to bone biology. Bone. 1992;13(Suppl 1): S3-S6.
    • (1992) Bone , vol.13 , pp. S3-S6
    • Rodan, G.A.1
  • 106
    • 0028175978 scopus 로고
    • Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage
    • Dodds RA, Merry K, Littlewood A, Gowen M. Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage. J Histochem Cytochem. 1994;42:733-744
    • (1994) J Histochem Cytochem , vol.42 , pp. 733-744
    • Dodds, R.A.1    Merry, K.2    Littlewood, A.3    Gowen, M.4
  • 107
    • 0031795161 scopus 로고    scopus 로고
    • Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage
    • Taguchi Y, Yamamoto M, Yamate T, et al. Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc Assoc Am Physicians. 1998;110:559-574.
    • (1998) Proc Assoc am Physicians , vol.110 , pp. 559-574
    • Taguchi, Y.1    Yamamoto, M.2    Yamate, T.3
  • 108
    • 26944456960 scopus 로고    scopus 로고
    • Interleukin-6: An osteotropic factor influencing bone formation?
    • Franchimont N, Wertz S, Malaise M 2005 Interleukin-6: An osteotropic factor influencing bone formation? Bone 37:601-606.
    • (2005) Bone , vol.37 , pp. 601-606
    • Franchimont, N.1    Wertz, S.2    Malaise, M.3
  • 110
    • 85047691524 scopus 로고    scopus 로고
    • Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways
    • Sims NA, Jenkins BJ, Quinn JM, et al. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. J Clin Invest. 2004;113:379-389.
    • (2004) J Clin Invest , vol.113 , pp. 379-389
    • Sims, N.A.1    Jenkins, B.J.2    Quinn, J.M.3
  • 111
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α.
    • Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α. Arterioscler Thromb Vasc Biol. 2005;25(10):2062-2068.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.10 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 112
    • 77249132284 scopus 로고    scopus 로고
    • Adipose tissue inflammation in obesity and metabolic syndrome
    • Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med. 2009 Aug;8(41):55-60.
    • (2009) Discov Med , vol.8 , Issue.41 , pp. 55-60
    • Nishimura, S.1    Manabe, I.2    Nagai, R.3
  • 113
    • 2142652189 scopus 로고    scopus 로고
    • PPAR
    • Akune T, Ohba S, Kamekura S, et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113:846-855.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3
  • 114
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble JM, Robinson CE, Wu X, et al. Peroxisome proliferatoractivated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol. 1996;50: 1087-1094.
    • (1996) Mol Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3
  • 115
    • 0033785920 scopus 로고    scopus 로고
    • Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation
    • Rodriguez JP, Montecinos L, Rios S, Reyes P, Martinez J. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem. 2000;79:557-565.
    • (2000) J Cell Biochem , vol.79 , pp. 557-565
    • Rodriguez, J.P.1    Montecinos, L.2    Rios, S.3    Reyes, P.4    Martinez, J.5
  • 116
    • 1642526587 scopus 로고    scopus 로고
    • Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs)
    • Sekiya I, Larson BL, Vuoristo JT, Cui JG, Prockop DJ. Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs). J Bone Miner Res. 2004;19:256-264.
    • (2004) J Bone Miner Res , vol.19 , pp. 256-264
    • Sekiya, I.1    Larson, B.L.2    Vuoristo, J.T.3    Cui, J.G.4    Prockop, D.J.5
  • 117
    • 0032416022 scopus 로고    scopus 로고
    • Bone stem cells
    • Aubin JE, Bone stem cells. J Cell Biochem.1998;Suppl 30-31:73-82.
    • (1998) J Cell Biochem , vol.30 , pp. 73-82
    • Aubin, J.E.1
  • 118
    • 0034954807 scopus 로고    scopus 로고
    • Aromatase, adiposity, aging and disease. The hypogonadalmetabolic-atherogenicdisease and aging connection
    • Cohen PG. Aromatase, adiposity, aging and disease. The hypogonadalmetabolic-atherogenicdisease and aging connection. Med Hypotheses. 2001;56:702-708.
    • (2001) Med Hypotheses , vol.56 , pp. 702-708
    • Cohen, P.G.1
  • 119
    • 0025854709 scopus 로고
    • Relationships between marrow fat and bone turnover in ovariectomized and intact rats
    • Martin RB, Zissimos SL. Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone. 1991;12: 123-131.
    • (1991) Bone , vol.12 , pp. 123-131
    • Martin, R.B.1    Zissimos, S.L.2
  • 120
    • 0025129055 scopus 로고
    • Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs
    • Martin RB, Chow BD, Lucas PA. Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs. Calcif Tissue Int. 1990;46:189-194.
    • (1990) Calcif Tissue Int , vol.46 , pp. 189-194
    • Martin, R.B.1    Chow, B.D.2    Lucas, P.A.3
  • 121
    • 0031732988 scopus 로고    scopus 로고
    • In vitro secretion of cytokines by human bone marrow: Effects of age and estrogen status
    • Cheleuitte D, Mizuno S, Glowacki J. In vitro secretion of cytokines by human bone marrow: Effects of age and estrogen status. J Clin Endocrinol Metab.1998;83:2043-2051.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2043-2051
    • Cheleuitte, D.1    Mizuno, S.2    Glowacki, J.3
  • 122
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways
    • Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004;3: 379-389.
    • (2004) Aging Cell , vol.3 , pp. 379-389
    • Moerman, E.J.1    Teng, K.2    Lipschitz, D.A.3    Lecka-Czernik, B.4
  • 123
    • 0030700448 scopus 로고    scopus 로고
    • Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6: A murine model of defective osteoblastogenesis and low turnover osteopenia
    • Kajkenova O, Lecka-Czernik B, Gubrij I, et al. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6: a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 1997;12:1772-1779.
    • (1997) J Bone Miner Res , vol.12 , pp. 1772-1779
    • Kajkenova, O.1    Lecka-Czernik, B.2    Gubrij, I.3
  • 124
    • 11244308010 scopus 로고    scopus 로고
    • Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity
    • Duque G, Macoritto M, Kremer R. Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity. Biogerontology. 2004;5:421-429.
    • (2004) Biogerontology , vol.5 , pp. 421-429
    • Duque, G.1    Macoritto, M.2    Kremer, R.3
  • 125
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004;20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 126
    • 0036318980 scopus 로고    scopus 로고
    • Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor {alpha} in adipocyte metabolism
    • Ross SE, Erickson RL, Gerin I. Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor {alpha} in adipocyte metabolism. Mol Cell Biol. 2002;22:5989-5999.
    • (2002) Mol Cell Biol , vol.22 , pp. 5989-5999
    • Ross, S.E.1    Erickson, R.L.2    Gerin, I.3
  • 127
    • 0037163113 scopus 로고    scopus 로고
    • Regulation of Wnt signaling during adipogenesis
    • Bennett CN, Ross SE, Longo KA. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002;277:30998-31004.
    • (2002) J Biol Chem , vol.277 , pp. 30998-31004
    • Bennett, C.N.1    Ross, S.E.2    Longo, K.A.3
  • 128
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fukai N. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001;107: 513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 129
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002;346: 1513-1521.
    • (2002) N Engl J Med , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 130
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • Kato M, Patel MS, Levasseur R. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002;157:303-314.
    • (2002) J Cell Biol , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.S.2    Levasseur, R.3
  • 131
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptorrelated protein 5 gene results in the autosomal dominant high-bonemass trait
    • Little RD, Carulli JP, Del Mastro RG. A mutation in the LDL receptorrelated protein 5 gene results in the autosomal dominant high-bonemass trait. Am J Hum Genet. 2002;70:11-19.
    • (2002) Am J Hum Genet , vol.70 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3
  • 132
    • 14744275847 scopus 로고    scopus 로고
    • Wright WS Regulation of osteoblastogenesis and bone mass by Wnt10b
    • Bennett CN, Longo KA, Wright WS Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A. 2005;102: 3324-3329.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3324-3329
    • Bennett, C.N.1    Longo, K.A.2
  • 133
    • 7244232742 scopus 로고    scopus 로고
    • Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylationdefective mutant of beta-catenin inhibits expression of a subset of adipogenic genes
    • Liu J, Farmer SR. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylationdefective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem. 2004;279:45020-45027.
    • (2004) J Biol Chem , vol.279 , pp. 45020-45027
    • Liu, J.1    Farmer, S.R.2
  • 134
    • 2542577369 scopus 로고    scopus 로고
    • Cooperation between TGFbeta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells
    • Zhou S, Eid K, Glowacki J. Cooperation between TGFbeta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res. 2004;19:463-470.
    • (2004) J Bone Miner Res , vol.19 , pp. 463-470
    • Zhou, S.1    Eid, K.2    Glowacki, J.3
  • 136
    • 18044388013 scopus 로고    scopus 로고
    • Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors
    • Kindblom JM, Gevers EF, Skrtic SM. Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors. Bone. 2005;36:607-616.
    • (2005) Bone , vol.36 , pp. 607-616
    • Kindblom, J.M.1    Gevers, E.F.2    Skrtic, S.M.3
  • 137
    • 0030700448 scopus 로고    scopus 로고
    • Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia
    • Kajkenova O, Lecka-Czernik B, Gubrij I. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 1997;12:1772-1779.
    • (1997) J Bone Miner Res , vol.12 , pp. 1772-1779
    • Kajkenova, O.1    Lecka-Czernik, B.2    Gubrij, I.3
  • 138
    • 15444366749 scopus 로고    scopus 로고
    • 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6)
    • Duque G, Macoritto M, Dion N, Ste-Marie LG, Kremer R. 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6). Am J Physiol Endocrinol Metab. 2005;288:E723-E730.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E723-E730
    • Duque, G.1    Macoritto, M.2    Dion, N.3    Ste-Marie, L.G.4    Kremer, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.