Is leptin the link between fat and bone mass?

Journal of Bone and Mineral Research

Volumn 17, Issue 9, 2002, Pages 1563-1569

  Thomas, Thierry ^a   Burguera, Bartolome ^b  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Bone; Fat; Leptin; Obesity; Osteoporosis

Indexed keywords

LEPTIN; OSTEOPROTEGERIN;

ANIMAL TISSUE; BLOOD BRAIN BARRIER; BONE DENSITY; BONE GROWTH; BONE MASS; BONE REMODELING; BONE TURNOVER; FAT CONTENT; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; SHORT SURVEY; STEM CELL; TRABECULAR BONE; ADIPOSE TISSUE; ANIMAL; BONE; BONE DEVELOPMENT; FEMALE; HISTOLOGY; HUMAN; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; REVIEW; SEXUAL DEVELOPMENT;

ADIPOSE TISSUE; ANIMAL; BONE AND BONES; BONE DENSITY; BONE REMODELING; FEMALE; HUMAN; LEPTIN; MALE; MICE; MICE, OBESE; OBESITY; OSTEOGENESIS; SEX CHARACTERISTICS; ANIMALS; HUMANS;

EID: 0036708144     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.9.1563     Document Type: Article

References (105)

1. Risk factors for spinal osteoporosis in men
2. Epidemiology of vertebral fractures in women
3. Muscle strength, physical fitness, and weight but not age predict femoral neck bone mass
4. Predictors of bone mass in perimenopausal women
5. Effects of weight, and body mass index on bone mineral density in men and women
6. Bone mass and body composition in normal women
7. Relationship between body size and bone mineral density in elderly and women
8. Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density
9. Relationship between body composition and bone mass in women
10. Fat mass is an important determinant of whole body bone density in premenopausal women but not in men
11. A multicenter study of the influence of fat and lean mass on bone mineral content: Evidence for difference in their relative influence at major fracture sites
12. Vertebral post-menopausal bone loss is reduced in overweight women: A longitudinal study in 155 early postmenopausal women
13. Influence of body mass index on the age-related slope of total and regional bone mineral content
14. Differences in body composition between female geriatric hip fracture patients and healthy controls: Body fat is more important as an explanatory factor for the fracture than body weight and lean body mass
15. How hip and whole-body bone mineral density predict hip fracture in elderly women: The EPIDOS Prospective Study
16. Conversion of androstenedione to estrone by human fat tissue
17. Source of estrogen production in postmenopausal women
18. Endogenous residual estrogen levels determine bone resorption even in late postmenopausal women
19. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
20. Determinants of total body and regional bone mineral density in normal postmenopausal women
21. Body composition and gonadal steroids in older white and black women
22. To what extent is bone mass determined by fat-free or fat mass?
23. The effect of body composition on bone density in pre- and postmenopausal women
24. Age-related changes in body composition of healthy and osteoporotic women
25. Circulating insulin levels are related to bone density in normal postmenopausal women
26. Insulin promotes growth of the cultured rat osteosarcoma cell line UMR-01: An osteoblast-like cell
27. Does hyperinsulinemia preserve bone?
28. Insulin and bone: A clinical and scientific review
29. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue
30. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
31. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
32. Relationship of serum leptin levels with body composition, sex steroid, and insulin levels in men and women
33. Obesity
34. Localization of the leptin receptor in the human brain
35. Role of leptin in hypothalamic-pituitary function
36. The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function
37. Expression of functional leptin receptors in rodent Leydig cells
38. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
39. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: Evidence for a dissociation of effects on appetite and neuroendocrine function
40. A role for leptin and its cognate receptor in hematopoiesis
41. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
42. Leptin can induce proliferation, differentiation, and functional activation of hemopoeitic cells
43. Leptin stimulates fetal and adult erythroid and myeloid development
44. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoeitic progenitor cells
45. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice
46. 12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
47. Expression of leptin receptor in lung: Leptin as a growth factor
48. Leptin action in intestinal cells
49. Biological action of leptin as an angiogenic factor
50. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
51. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
52. Leptin expression and action: New experimental paradigms
53. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta
54. Direct effects of leptin on brown and white adipose tissue
55. Lineage of osteogenic cells and their relationship to the stromal system
56. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
57. Human mesenchymal stem cells undergoing osteogenic differentiation express leptin and functional leptin receptor
58. The direct acions of leptin on bone cells increase bone strength in vivo-An explanation of low fracture rates in obesity
59. Leptin is a potent stimulator of bone growth in ob/ob mice
60. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization
61. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
62. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta
63. Potential role of leptin in endochondral ossification
64. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells
65. Leptin increases number of mineralized bone nodules in vitro
66. Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells
67. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
68. Leptin reduces ovariectomy-induced bone loss in rats
69. Leptin inhibits osteoclast generation
70. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes
71. Relationship between serum leptin and the insulin-like growth factor-I system in humans
72. Leptin, nutrition, and the thyroid: The why, the wherefore, and the wiring
73. Bone structure and calcium metabolism in obese Zucker rats
74. Central control of bone mass by leptin in rats
75. Obesity and the regulation of energy balance
76. Obesity is associated with a decreased of leptin transport across the blood brain barrier and up regulation of leptin receptor in the hypothalamus
77. Limited brain access for leptin in obesity
78. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
79. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
80. Cerebrospinal fluid and plasma concentrations of leptin, NPY, and alpha-MSH in obese women and their relationship to negative energy balance
81. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
82. Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice
83. Neuroendocrine regulation and actions of leptin
84. Hypothalamic Y2 receptors regulate bone formation
85. Leptin prevents disuse-induced bone loss in tail-suspended female rats
86. Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women
87. Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in post-menopausal women
88. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in post-menopausal women
89. Does leptin have an effect on bone in adult women?
90. Plasma leptin concentrations in postmenopausal women with osteoporosis
91. Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women
92. Serum leptin levels are associated with bone mass in nonobese women
93. Leptin is inversely related to age at menarche in human females
94. Nonadipose tissue production of leptin. Leptin as a novel placenta-derived hormone in humans
95. Serum leptin in short children born small for gestational age. Relationship with the growth response to growth hormone treatment
96. Relationship between concentration of serum leptin and fetal growth
97. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth
98. Cord blood leptin concentrations in relation to intrauterine growth
99. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea
100. Bone size and volumetric density in women with anorexia nervosa receiving estrogen replacement therapy and in women recovered from anorexia nervosa
101. Functional hypothalamic amenorrhea: Hypoleptinemia and disordered eating
102. Hyperleptinemia in female patients with ossification of spinal ligaments
103. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
104. Brief report: Effects of recombinant leptin therapy in a child with congenital leptin deficiency