Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Journal of Cell Biology

Volumn 157, Issue 2, 2002, Pages 303-314

  Kato, Masaki ^a   Patel, Millan S ^a   Levasseur, Regis ^a   Lobov, Ivan ^c   Chang, Benny H J ^a   Glass II, Donald A ^a   Hartmann, Christine ^d   Li, Lan ^a   Hwang, Tae Ho ^a   Brayton, Cory F ^b   Lang, Richard A ^c   Karsenty, Gerard ^a,b   Chan, Lawrence ^a,b  

^a Department of Molecular and Cellular Biology and Medicine ^*  (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Blindness; Low bone mass; Osteoblast function; Vascular regression; Wnt

Indexed keywords

CALCIUM; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; PHOSPHATE; RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MASS; CBFA 1 GENE; CELL PROLIFERATION; CONTROLLED STUDY; EYE; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; MALE; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOPENIA; PHENOTYPE; PRIORITY JOURNAL; VASCULARIZATION;

NON-PROGRAMMATIC;

ANIMALS; APOPTOSIS; BONE AND BONES; BONE DEVELOPMENT; BONE DISEASES, METABOLIC; CALCIUM; CELL DIVISION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EYE; EYE ABNORMALITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LDL-RECEPTOR RELATED PROTEINS; MACROPHAGES; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; ORGAN SIZE; OSTEOBLASTS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RECEPTORS, LDL; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WNT PROTEINS; ZEBRAFISH PROTEINS;

ANIMALIA;

EID: 0037092049     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201089     Document Type: Article

References (46)

1. Staining of the calcification front in human bone using contrasting fluorochromes in vitro
2. A new member of the frizzled family from Drosophila functions as a Wingless receptor
3. Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family
4. Macrophages induce apoptosis in normal cells in vivo
5. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity
6. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
7. Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes
8. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
9. Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13
10. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
11. Dual roles of Wnt signaling during chondrogenesis in the chicken limb
12. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton
13. Apolipoprotein E receptors: Linking brain development and Alzheimer's disease
14. LRP: A multifunctional scavenger and signaling receptor
15. Cloning of a novel member of the low-density lipoprotein receptor family
16. New aspects of Wnt signaling pathways in higher vertebrates
17. The mammalian low-density lipoprotein receptor family
18. cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13.2
19. Regression of the hyaloid vessels and pupillary membrane of the mouse
20. Determinants of peak bone mass
21. The genetic transformation of bone biology
22. A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognized apolipoprotein E
23. Limb development in mouse embryos. Analysis of teratogenic effects of retinoic acid
24. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
25. Apoprosis in mammalian eye development: Lens morphogenesis, vascular regression and immune privilege
26. Mactophages are required for cell death and tissue remodeling in the developing mouse eye
27. Apoptosis during macrophage-dependent tissue remodelling
28. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
29. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway
30. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse cell
31. A relationship between flow and apoptosis during programmed capillary regression is revealed by vital analysis
32. Tcf3 and Lefl regulate lineage differentiation of multipotent stem cells in skin
33. Bone histomorphometry: Standardization of nomenclature, symbols, and units, report of the ASBMR histomorphometry committee
34. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a
35. Negative feedback mechanisms and their roles during pattern formation
36. An LDL-receptor-related protein mediates Wnt signalling in mice
37. Cytoskeletal reorganization by soluble Wnt-3a protein signalling
38. Osteoporosis-pseudoglioma or osteogenesis imperfecta?
39. LDL-receptor-related proteins in Wnt signal transduction
40. A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart
41. Female development in mammals in regulated by Wnt-4 signalling
42. Dynamic histomorphometry of alveolar bone remodeling in the adult rat
43. The low-density lipoprotein receptor gene family: Multiple roles in lipid metabolism
44. The low-density lipoprotein receptor gene family: Multiple roles in lipid metabolism
45. Mechanisms of Wnt signaling in development
46. Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member