Targeted integration of a super-exon into the CFTR locus leads to functional correction of a cystic fibrosis cell line model

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Bednarski, Christien ^a   Tomczak, Katja ^b   Hövel, Beate Vom ^a   Weber, Wolf Michael ^b   Cathomen, Toni ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MESSENGER RNA; COMPLEMENTARY DNA; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ARTICLE; BRONCHUS MUCOSA; CFTR GENE; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; ION TRANSPORT; LUNG FIBROSIS; PROMOTER REGION; SEQUENCE ANALYSIS; CELL LINE; CHEMISTRY; CYSTIC FIBROSIS; EPITHELIUM CELL; GENE EDITING; GENETICS; GENOTYPE; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROCEDURES;

BASE SEQUENCE; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DEOXYRIBONUCLEASES; DNA, COMPLEMENTARY; EPITHELIAL CELLS; EXONS; GENE EDITING; GENETIC LOCI; GENOTYPE; HUMANS; MUTATION; RNA, MESSENGER; ZINC FINGERS;

EID: 84984917452     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0161072     Document Type: Article

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