Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 47, 2009, Pages 19934-19939

  Ott, Christopher J ^a   Blackledge, Neil P ^a,d   Kerschner, Jenny L ^a   Leir, Shih Hsing ^a   Crawford, Gregory E ^b   Cotton, Calvin U ^c   Harris, Ann ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b DUKE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cis acting elements; Cystic fibrosis transmembrane conductance regulator; Enhancer:promoter interactions; Regulation of expression

Indexed keywords

DEOXYRIBONUCLEASE I; SPACER DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CHROMATIN; CHROMATIN STRUCTURE; CONFORMATION; CONTROLLED STUDY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE; EPITHELIUM; FETUS; GENE; GENE CONSTRUCT; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENE SEQUENCE; GENE STRUCTURE; GENE THERAPY; HUMAN; HUMAN CELL; INTRON; MALE; NUCLEOTIDE SEQUENCE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENE;

CELLS, CULTURED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENHANCER ELEMENTS, GENETIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPATOCYTE NUCLEAR FACTOR 1; HUMANS; INTRONS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC;

EID: 73949111636     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900946106     Document Type: Article

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