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Volumn 590, Issue 18, 2016, Pages 3295-3306

Adenosine A2a receptors form distinct oligomers in protein detergent complexes

Author keywords

dimer; G protein coupled receptor; ligand chromatography; oligomer; protein detergent complex; size exclusion chromatography

Indexed keywords

ADENOSINE A2A RECEPTOR; DETERGENT; MICELLE;

EID: 84984860996     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1002/1873-3468.12367     Document Type: Article
Times cited : (9)

References (67)
  • 1
    • 0033118334 scopus 로고    scopus 로고
    • Molecular tinkering of G protein-coupled receptros: an evolutionary success
    • Bockaert J and Pin JP (1999) Molecular tinkering of G protein-coupled receptros: an evolutionary success. EMBO J 18, 1723–1729.
    • (1999) EMBO J , vol.18 , pp. 1723-1729
    • Bockaert, J.1    Pin, J.P.2
  • 2
    • 84870702282 scopus 로고    scopus 로고
    • Structure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics
    • McNeely PM, Naranjo AN and Robinson AS (2012) Structure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics. Biotechnol J 7, 1451–1461.
    • (2012) Biotechnol J , vol.7 , pp. 1451-1461
    • McNeely, P.M.1    Naranjo, A.N.2    Robinson, A.S.3
  • 3
    • 0036780743 scopus 로고    scopus 로고
    • G-protein-coupled receptor oligomerization and its potential for drug discovery
    • George SR, O'Dowd BF and Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1, 808–820.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 808-820
    • George, S.R.1    O'Dowd, B.F.2    Lee, S.P.3
  • 5
    • 2642550862 scopus 로고    scopus 로고
    • Challenges in the development of high protein concentration formulations
    • Shire SJ, Shahrokh Z and Liu J (2004) Challenges in the development of high protein concentration formulations. J Pharm Sci 93, 1390–1402.
    • (2004) J Pharm Sci , vol.93 , pp. 1390-1402
    • Shire, S.J.1    Shahrokh, Z.2    Liu, J.3
  • 6
    • 78349305715 scopus 로고    scopus 로고
    • Dynamics and flexibility of G-protein-coupled receptor conformations and their relevance to drug design
    • Vaidehi N (2010) Dynamics and flexibility of G-protein-coupled receptor conformations and their relevance to drug design. Drug Discov Today 15, 951–957.
    • (2010) Drug Discov Today , vol.15 , pp. 951-957
    • Vaidehi, N.1
  • 7
    • 51949088673 scopus 로고    scopus 로고
    • Lipid-rhodopsin hydrophobic mismatch alters rhodopsin helical content
    • Soubias O, Niu S, Mitchell DC and Gawrisch K (2008) Lipid-rhodopsin hydrophobic mismatch alters rhodopsin helical content. J Am Chem Soc 130, 12465–12471.
    • (2008) J Am Chem Soc , vol.130 , pp. 12465-12471
    • Soubias, O.1    Niu, S.2    Mitchell, D.C.3    Gawrisch, K.4
  • 8
    • 78751683949 scopus 로고    scopus 로고
    • The morphology and composition of cholesterol-rich micellar nanostructures determine transmembrane protein (GPCR) activity
    • O'Malley MA, Helgeson ME, Wagner NJ and Robinson AS (2011) The morphology and composition of cholesterol-rich micellar nanostructures determine transmembrane protein (GPCR) activity. Biophys J 100, L11–L13.
    • (2011) Biophys J , vol.100 , pp. L11-L13
    • O'Malley, M.A.1    Helgeson, M.E.2    Wagner, N.J.3    Robinson, A.S.4
  • 9
    • 84926623484 scopus 로고    scopus 로고
    • Large-scale production and protein engineering of G protein-coupled receptors for structural studies
    • Milic D and Veprintsev DB (2015) Large-scale production and protein engineering of G protein-coupled receptors for structural studies. Front Pharmacol 6, 66.
    • (2015) Front Pharmacol , vol.6 , pp. 66
    • Milic, D.1    Veprintsev, D.B.2
  • 10
    • 33645415883 scopus 로고    scopus 로고
    • Exceptional total and functional yields of the human adenosine (A2a) receptor expressed in the yeast Saccharomyces cerevisiae
    • Niebauer RT and Robinson AS (2006) Exceptional total and functional yields of the human adenosine (A2a) receptor expressed in the yeast Saccharomyces cerevisiae. Protein Expr Purif 46, 204–211.
    • (2006) Protein Expr Purif , vol.46 , pp. 204-211
    • Niebauer, R.T.1    Robinson, A.S.2
  • 11
    • 34250350252 scopus 로고    scopus 로고
    • High-level expression in Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional human adenosine A2a receptor
    • O'Malley MA, Lazarova T, Britton ZT and Robinson AS (2007) High-level expression in Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional human adenosine A2a receptor. J Struct Biol 159, 166–178.
    • (2007) J Struct Biol , vol.159 , pp. 166-178
    • O'Malley, M.A.1    Lazarova, T.2    Britton, Z.T.3    Robinson, A.S.4
  • 12
    • 33749987003 scopus 로고    scopus 로고
    • Optimization of the human adenosine A2a receptor yields in Saccharomyces cerevisiae
    • Wedekind A, O'Malley MA, Niebauer RT and Robinson AS (2006) Optimization of the human adenosine A2a receptor yields in Saccharomyces cerevisiae. Biotechnol Prog 22, 1249–1255.
    • (2006) Biotechnol Prog , vol.22 , pp. 1249-1255
    • Wedekind, A.1    O'Malley, M.A.2    Niebauer, R.T.3    Robinson, A.S.4
  • 17
    • 84935522404 scopus 로고    scopus 로고
    • Molecular determinants of CGS21680 binding to the human adenosine A2A receptor
    • Lebon G, Edwards PC, Leslie AG and Tate CG (2015) Molecular determinants of CGS21680 binding to the human adenosine A2A receptor. Mol Pharmacol 87, 907–915.
    • (2015) Mol Pharmacol , vol.87 , pp. 907-915
    • Lebon, G.1    Edwards, P.C.2    Leslie, A.G.3    Tate, C.G.4
  • 18
    • 79959564813 scopus 로고    scopus 로고
    • Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
    • Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG and Tate CG (2011) Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474, 521–525.
    • (2011) Nature , vol.474 , pp. 521-525
    • Lebon, G.1    Warne, T.2    Edwards, P.C.3    Bennett, K.4    Langmead, C.J.5    Leslie, A.G.6    Tate, C.G.7
  • 24
    • 13444271067 scopus 로고    scopus 로고
    • Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes
    • Torvinen M, Marcellino D, Canals M, Agnati LF, Lluis C, Franco R and Fuxe K (2005) Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Mol Pharmacol 67, 400–407.
    • (2005) Mol Pharmacol , vol.67 , pp. 400-407
    • Torvinen, M.1    Marcellino, D.2    Canals, M.3    Agnati, L.F.4    Lluis, C.5    Franco, R.6    Fuxe, K.7
  • 26
    • 56649106450 scopus 로고    scopus 로고
    • Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane
    • Vidi PA, Chen J, Irudayaraj JM and Watts VJ (2008) Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane. FEBS Lett 582, 3985–3990.
    • (2008) FEBS Lett , vol.582 , pp. 3985-3990
    • Vidi, P.A.1    Chen, J.2    Irudayaraj, J.M.3    Watts, V.J.4
  • 27
    • 84923854268 scopus 로고    scopus 로고
    • The GPCR heterotetramer: challenging classical pharmacology
    • Ferre S (2015) The GPCR heterotetramer: challenging classical pharmacology. Trends Pharmacol Sci 36, 145–152.
    • (2015) Trends Pharmacol Sci , vol.36 , pp. 145-152
    • Ferre, S.1
  • 32
    • 34250666273 scopus 로고    scopus 로고
    • A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
    • Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B and Sunahara RK (2007) A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci USA 104, 7682–7687.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7682-7687
    • Whorton, M.R.1    Bokoch, M.P.2    Rasmussen, S.G.3    Huang, B.4    Zare, R.N.5    Kobilka, B.6    Sunahara, R.K.7
  • 34
    • 34547434085 scopus 로고    scopus 로고
    • Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit
    • Ernst OP, Gramse V, Kolbe M, Hofmann KP and Heck M (2007) Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit. Proc Natl Acad Sci USA 104, 10859–10864.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10859-10864
    • Ernst, O.P.1    Gramse, V.2    Kolbe, M.3    Hofmann, K.P.4    Heck, M.5
  • 35
    • 79953194763 scopus 로고    scopus 로고
    • Dimerization and ligand binding affect the structure network of A(2A) adenosine receptor
    • Fanelli F and Felline A (2011) Dimerization and ligand binding affect the structure network of A(2A) adenosine receptor. Biochim Biophys Acta 1808, 1256–1266.
    • (2011) Biochim Biophys Acta , vol.1808 , pp. 1256-1266
    • Fanelli, F.1    Felline, A.2
  • 37
    • 4544278502 scopus 로고    scopus 로고
    • Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2a and dopamine D2 receptors
    • Ciruela F, Burgueno J, Casado V, Canals M, Marcellino D, Goldberg SR, Bader M, Fuxe K, Agnati LF, Lluis C et al. (2004) Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2a and dopamine D2 receptors. Anal Chem 76, 5354–5363.
    • (2004) Anal Chem , vol.76 , pp. 5354-5363
    • Ciruela, F.1    Burgueno, J.2    Casado, V.3    Canals, M.4    Marcellino, D.5    Goldberg, S.R.6    Bader, M.7    Fuxe, K.8    Agnati, L.F.9    Lluis, C.10
  • 38
    • 84858203893 scopus 로고    scopus 로고
    • Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling
    • Lohse MJ, Nuber S and Hoffmann C (2012) Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacol Rev 64, 299–336.
    • (2012) Pharmacol Rev , vol.64 , pp. 299-336
    • Lohse, M.J.1    Nuber, S.2    Hoffmann, C.3
  • 39
    • 84915747589 scopus 로고    scopus 로고
    • Kinetics of the early events of GPCR signalling
    • Adamson RJ and Watts A (2014) Kinetics of the early events of GPCR signalling. FEBS Lett 588, 4701–4707.
    • (2014) FEBS Lett , vol.588 , pp. 4701-4707
    • Adamson, R.J.1    Watts, A.2
  • 40
    • 84888364004 scopus 로고    scopus 로고
    • Surface plasmon resonance spectroscopy for characterisation of membrane protein-ligand interactions and its potential for drug discovery
    • Patching SG (2014) Surface plasmon resonance spectroscopy for characterisation of membrane protein-ligand interactions and its potential for drug discovery. Biochim Biophys Acta 1838, 43–55.
    • (2014) Biochim Biophys Acta , vol.1838 , pp. 43-55
    • Patching, S.G.1
  • 41
    • 44949236117 scopus 로고    scopus 로고
    • High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
    • Altenbach C, Kusnetzow AK, Ernst OP, Hofmann KP and Hubbell WL (2008) High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc Natl Acad Sci USA 105, 7439–7444.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7439-7444
    • Altenbach, C.1    Kusnetzow, A.K.2    Ernst, O.P.3    Hofmann, K.P.4    Hubbell, W.L.5
  • 44
    • 79953865760 scopus 로고    scopus 로고
    • Molecular dynamics of proteorhodopsin in lipid bilayers by solid-state NMR
    • Yang J, Aslimovska L and Glaubitz C (2011) Molecular dynamics of proteorhodopsin in lipid bilayers by solid-state NMR. J Am Chem Soc 133, 4874–4881.
    • (2011) J Am Chem Soc , vol.133 , pp. 4874-4881
    • Yang, J.1    Aslimovska, L.2    Glaubitz, C.3
  • 45
    • 0026052237 scopus 로고
    • Secretion of human epidermal growth factor from Saccharomyces cerevisiae using synthetic leader sequences
    • Clements JM, Catlin GH, Price MJ and Edwards RM (1991) Secretion of human epidermal growth factor from Saccharomyces cerevisiae using synthetic leader sequences. Gene 106, 267–272.
    • (1991) Gene , vol.106 , pp. 267-272
    • Clements, J.M.1    Catlin, G.H.2    Price, M.J.3    Edwards, R.M.4
  • 46
    • 0029347117 scopus 로고
    • Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae
    • Parekh R, Forrester K and Witttrup D (1995) Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae. Protein Expr Purif 6, 537–545.
    • (1995) Protein Expr Purif , vol.6 , pp. 537-545
    • Parekh, R.1    Forrester, K.2    Witttrup, D.3
  • 47
    • 77954129578 scopus 로고    scopus 로고
    • Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmids
    • Bryksin AV and Matsumura I (2010) Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmids. Biotechniques 48, 463–465.
    • (2010) Biotechniques , vol.48 , pp. 463-465
    • Bryksin, A.V.1    Matsumura, I.2
  • 48
    • 0036270543 scopus 로고    scopus 로고
    • Yeast transformation by the LiAc/SS carrier DNA/PEG method
    • Gietz RD and Woods RA (2002) Yeast transformation by the LiAc/SS carrier DNA/PEG method. Methods Enzymol 350, 87–96.
    • (2002) Methods Enzymol , vol.350 , pp. 87-96
    • Gietz, R.D.1    Woods, R.A.2
  • 49
    • 78049243585 scopus 로고    scopus 로고
    • Analysis of adenosine A(2)a receptor stability: effects of ligands and disulfide bonds
    • O'Malley MA, Naranjo AN, Lazarova T and Robinson AS (2010) Analysis of adenosine A(2)a receptor stability: effects of ligands and disulfide bonds. Biochemistry 49, 9181–9189.
    • (2010) Biochemistry , vol.49 , pp. 9181-9189
    • O'Malley, M.A.1    Naranjo, A.N.2    Lazarova, T.3    Robinson, A.S.4
  • 50
    • 12244292640 scopus 로고    scopus 로고
    • Purification and characterization of the human adenosine A2a receptor functionally expressed in Escherichia coli
    • Weiss HM and Grisshammer R (2002) Purification and characterization of the human adenosine A2a receptor functionally expressed in Escherichia coli. Eur J Biochem 269, 82–92.
    • (2002) Eur J Biochem , vol.269 , pp. 82-92
    • Weiss, H.M.1    Grisshammer, R.2
  • 51
    • 55649088213 scopus 로고    scopus 로고
    • Static light scattering to characterize membrane proteins in detergent solution
    • Slotboom DJ, Duurkens RH, Olieman K and Erkens GB (2008) Static light scattering to characterize membrane proteins in detergent solution. Methods 46, 73–82.
    • (2008) Methods , vol.46 , pp. 73-82
    • Slotboom, D.J.1    Duurkens, R.H.2    Olieman, K.3    Erkens, G.B.4
  • 53
    • 0030571043 scopus 로고    scopus 로고
    • Size-exclusion chromatography with on-line light-scatterring, absorbance, and refractive index detectors for studying proteins and their interactions
    • Wen J, Arakawa T and Philo JS (1996) Size-exclusion chromatography with on-line light-scatterring, absorbance, and refractive index detectors for studying proteins and their interactions. Anal Biochem 240, 155–166.
    • (1996) Anal Biochem , vol.240 , pp. 155-166
    • Wen, J.1    Arakawa, T.2    Philo, J.S.3
  • 54
    • 80054687050 scopus 로고    scopus 로고
    • Toward rational design of protein detergent complexes: determinants of mixed micelles that are critical for the in vitro stabilization of a G-protein coupled receptor
    • O'Malley MA, Helgeson ME, Wagner NJ and Robinson AS (2011) Toward rational design of protein detergent complexes: determinants of mixed micelles that are critical for the in vitro stabilization of a G-protein coupled receptor. Biophys J 101, 1938–1948.
    • (2011) Biophys J , vol.101 , pp. 1938-1948
    • O'Malley, M.A.1    Helgeson, M.E.2    Wagner, N.J.3    Robinson, A.S.4
  • 55
    • 60549094781 scopus 로고    scopus 로고
    • Detergent binding explains anomalous SDS-PAGE migration of membrane proteins
    • Rath A, Glibowicka M, Nadeau VG, Chen G and Deber CM (2009) Detergent binding explains anomalous SDS-PAGE migration of membrane proteins. Proc Natl Acad Sci USA 106, 1760–1765.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1760-1765
    • Rath, A.1    Glibowicka, M.2    Nadeau, V.G.3    Chen, G.4    Deber, C.M.5
  • 56
    • 35048820405 scopus 로고    scopus 로고
    • Fluorescence studies of homooligomerization of adenosine A2A and serotonin 5-HT1A receptors reveal the specificity of receptor interactions in the plasma membrane
    • Lukasieqicz S, Blasiak E, Gorecka-Faron A, Polit A, Tworzydlo M, Gorecki A, Wasylewski Z and Dziedzicka-Wasylewska M (2007) Fluorescence studies of homooligomerization of adenosine A2A and serotonin 5-HT1A receptors reveal the specificity of receptor interactions in the plasma membrane. Pharmacol Rep 59, 379–392.
    • (2007) Pharmacol Rep , vol.59 , pp. 379-392
    • Lukasieqicz, S.1    Blasiak, E.2    Gorecka-Faron, A.3    Polit, A.4    Tworzydlo, M.5    Gorecki, A.6    Wasylewski, Z.7    Dziedzicka-Wasylewska, M.8
  • 58
    • 84919935016 scopus 로고    scopus 로고
    • Conserved disulfide bond is not essential for the adenosine A2A receptor: extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition
    • Naranjo AN, Chevalier A, Cousins GD, Ayettey E, McCusker EC, Wenk C and Robinson AS (2015) Conserved disulfide bond is not essential for the adenosine A2A receptor: extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition. Biochim Biophys Acta 1848, 603–614.
    • (2015) Biochim Biophys Acta , vol.1848 , pp. 603-614
    • Naranjo, A.N.1    Chevalier, A.2    Cousins, G.D.3    Ayettey, E.4    McCusker, E.C.5    Wenk, C.6    Robinson, A.S.7
  • 59
    • 23644444909 scopus 로고    scopus 로고
    • Refractive index-based determination of detergent concentration and its application to the study of membrane proteins
    • Strop P and Brunger AT (2005) Refractive index-based determination of detergent concentration and its application to the study of membrane proteins. Protein Sci 14, 2207–2211.
    • (2005) Protein Sci , vol.14 , pp. 2207-2211
    • Strop, P.1    Brunger, A.T.2
  • 60
    • 84944929868 scopus 로고    scopus 로고
    • Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches
    • Byron O and Vestergaard B (2015) Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Curr Opin Struct Biol 35, 76–86.
    • (2015) Curr Opin Struct Biol , vol.35 , pp. 76-86
    • Byron, O.1    Vestergaard, B.2
  • 62
    • 38849171893 scopus 로고    scopus 로고
    • NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes
    • Maslennikov I, Kefala G, Johnson C, Riek R, Choe S and Kwiatkowski W (2007) NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes. BMC Struct Biol 7, 74.
    • (2007) BMC Struct Biol , vol.7 , pp. 74
    • Maslennikov, I.1    Kefala, G.2    Johnson, C.3    Riek, R.4    Choe, S.5    Kwiatkowski, W.6
  • 63
    • 46449094236 scopus 로고    scopus 로고
    • Stable interactions between the transmembrane domains of the adenosine A2A receptor
    • Thevenin D and Lazarova T (2008) Stable interactions between the transmembrane domains of the adenosine A2A receptor. Protein Sci 17, 1188–1199.
    • (2008) Protein Sci , vol.17 , pp. 1188-1199
    • Thevenin, D.1    Lazarova, T.2
  • 64
    • 23644460494 scopus 로고    scopus 로고
    • Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor
    • Thevenin D, Lazarova T, Roberts MF and Robinson CR (2005) Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Sci 14, 2177–2186.
    • (2005) Protein Sci , vol.14 , pp. 2177-2186
    • Thevenin, D.1    Lazarova, T.2    Roberts, M.F.3    Robinson, C.R.4
  • 66
    • 84866056455 scopus 로고    scopus 로고
    • Assessing the relative stability of dimer interfaces in G protein-coupled receptors
    • Johnston JM, Wang H, Provasi D and Filizola M (2012) Assessing the relative stability of dimer interfaces in G protein-coupled receptors. PLoS Comput Biol 8, e1002649.
    • (2012) PLoS Comput Biol , vol.8
    • Johnston, J.M.1    Wang, H.2    Provasi, D.3    Filizola, M.4
  • 67
    • 28444493656 scopus 로고    scopus 로고
    • Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation
    • Guo W, Shi L, Filizola M, Weinstein H and Javitch JA (2005) Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci USA 102, 17495–17500.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17495-17500
    • Guo, W.1    Shi, L.2    Filizola, M.3    Weinstein, H.4    Javitch, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.