The GPCR heterotetramer: Challenging classical pharmacology

Trends in Pharmacological Sciences

Volumn 36, Issue 3, 2015, Pages 145-152

  Ferré, Sergi ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

adenylyl cyclase; GPCR; oligomerization; signalosome

Indexed keywords

ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE DERIVATIVE; ADENYLATE CYCLASE; CAFFEINE; DIMER; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HOMODIMER; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISTRADEFYLLINE; MONOMER; SCH 442416; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TETRAMER; UNCLASSIFIED DRUG;

BINDING AFFINITY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVE SITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; CHEMISTRY; METABOLISM; PROTEIN MULTIMERIZATION;

PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84923854268     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.01.002     Document Type: Review

References (57)

1. A.G. Gilman G proteins: transducers of receptor-generated signals Annu. Rev. Biochem. 56 1987 615 649
2. T.M. Cabrera-Vera Insights into G protein structure, function and regulation Endocr. Rev. 23 2003 765 781
3. A. Levitzki, and S. Klein G-protein subunit dissociation is not an integral part of G-protein action Chembiochem 3 2002 815 818
4. R. Sadana, and C.W. Dessauer Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies Neurosignals 17 2009 5 22
5. C.W. Dessauer Identification of a Gialpha binding site on type V adenylyl cyclase J. Biol. Chem. 273 1998 25831 25839
6. R. Sadana N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer Mol. Pharmacol. 76 2009 1256 1264
7. R.R. Neubig Membrane organization in G-protein mechanisms FASEB J. 8 1994 939 946
8. A.M. Tolkovsky, and A. Levitzki Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes Biochemistry 17 1978 3795 3810
9. A.M. Tolkovsky, and A. Levitzki Coupling of a single adenylate cyclase to two receptors: adenosine and catecholamine Biochemistry 17 1979 3811 3817
10. S. Braun, and A. Levitzki Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase Biochemistry 18 1979 2134 2138
11. W. Gross, and M.J. Lohse Mechanism of activation of A2 adenosine receptors. II. A restricted collision-coupling model of receptor-effector interaction Mol. Pharmacol. 39 1991 524 530
12. C. Nanoff The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis Mol. Pharmacol. 39 1991 130 135
13. S.J. Singer, and G.L. Nicolson The fluid mosaic model of the structure of cell membranes Science 175 1972 720-731
14. L.J. Pike The challenge of lipid rafts J. Lipid Res. 50 Suppl. 2009 S323 S328
15. D.M. Cooper, and A.J. Crossthwaite Higher-order organization and regulation of adenylyl cyclases Trends Pharmacol. Sci. 27 2006 426 431
16. J.A. Allen Lipid raft microdomains and neurotransmitter signalling Nat. Rev. Neurosci. 8 2007 128 140
17. H.H. Patel G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains Handb. Exp. Pharmacol. 186 2008 167 184
18. V.Z. Slepak, and J.B. Hurley Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion IUBMB Life 60 2008 2 9
19. D.H. Rosenzweig Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins J. Neurosci. 27 2007 5484 5494
20. M. Nobles Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells Proc. Natl. Acad. Sci. U.S.A. 102 2005 18706 18711
21. C. Galés Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes Nat. Struct. Mol. Biol. 13 2006 778 786
22. P. Hein Gs activation is time-limiting in initiating receptor-mediated signaling J. Biol. Chem. 281 2006 33345 33351
23. S. Klein Signal transduction by a nondissociable heterotrimeric yeast G protein Proc. Natl. Acad. Sci. U.S.A. 97 2000 3219 3223
24. R.V. Rebois Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells J. Cell Sci. 119 2006 2807 2818
25. A. De Lean A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor J. Biol. Chem. 255 1980 7108 7117
26. S. Ferré G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives Pharmacol. Rev. 66 2014 413 434
27. M.R. Whorton A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein Proc. Natl. Acad. Sci. U.S.A. 104 2007 7682 7687
28. T.H. Bayburt Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins J. Biol. Chem. 282 2007 14875 14881
29. O.P. Ernst Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit Proc. Natl. Acad. Sci. U.S.A. 104 2007 10859 10864
30. A.J. Kuszak Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2 J. Biol. Chem. 284 2009 26732 26741
31. D.S. Redka Efficacy as an intrinsic property of the M(2) muscarinic receptor in its tetrameric state Biochemistry 52 2013 7405 7427
32. D.S. Redka Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor J. Biol. Chem. 289 2014 24347 24365
33. D. Calebiro Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization Proc. Natl. Acad. Sci. U.S.A. 110 2013 743 748
34. K. Herrick-Davis Fluorescence correlation spectroscopy analysis of serotonin, adrenergic, muscarinic, and dopamine receptor dimerization: the oligomer number puzzle Mol. Pharmacol. 84 2013 630 642
35. B. Jastrzebska GPCR: G protein complexes - the fundamental signaling assembly Amino Acids 45 2013 1303 1314
36. S. Patowary The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane Biochem. J. 452 2013 303 312
37. W.M. Oldham, and H.E. Hamm Heterotrimeric G protein activation by G-protein-coupled receptors Nat. Rev. Mol. Cell Biol. 9 2008 60 71
38. S.G. Rasmussen Crystal structure of the β2 adrenergic receptor-Gs protein complex Nature 477 2011 549 555
39. B. Jastrzebska Asymmetry of the rhodopsin dimer in complex with transducin FASEB J. 27 2013 1572 1584
40. J.R. Lane A new mechanism of allostery in a G protein-coupled receptor dimer Nat. Chem. Biol. 10 2014 745 752
41. G. Khelashvili CR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base Bioinformatics 26 2010 1804 1805
42. S. Ferré Building a new conceptual framework for receptor heteromers Nat. Chem. Biol. 5 2009 131 134
43. T. Kenakin, and L.J. Miller Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery Pharmacol. Rev. 62 2010 265 304
44. S. Ferré Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes Proc. Natl. Acad. Sci. U.S.A. 88 1991 7238 7241
45. K. Azdad Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization Neuropsychopharmacology 34 2009 972 986
46. P. Trifilieff Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2 receptor complexes in the striatum Biotechniques 51 2011 111 118
47. S. Ferré Adenosine A(2A) receptors and A(2A) receptor heteromers as key players in striatal function Front. Neuroanat. 5 2011 36
48. M.T. Armentero Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease Pharmacol. Ther. 132 2011 280 299
49. M. Jorg The dopamine D2 and adenosine A2A receptors: past, present and future trends for the treatment of Parkinson's disease Curr. Med. Chem. 21 2014 3188 3210
50. M. Orru Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists PLoS ONE 6 2011 e16088
51. Z. Justinová Differential effects of presynaptic versus postsynaptic adenosine A2A receptor blockade on Δ9-tetrahydrocannabinol (THC) self-administration in squirrel monkeys J. Neurosci. 34 2014 6480 6484
52. B. Kull Reciprocal interactions between adenosine A2A and dopamine D2 receptors in Chinese hamster ovary cells co-transfected with the two receptors Biochem. Pharmacol. 58 1999 1035 1045
53. J. Hillion Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors J. Biol. Chem. 277 2002 18091 18097
54. G. Navarro Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers Chem. Biol. 21 2014 1546 1556
55. X. Guitart Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer Mol. Pharmacol. 86 2014 417 429
56. M.J. Lohse Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling Pharmacol. Rev. 64 2012 299 336
57. E. Urizar CODA-RET reveals functional selectivity as a result of GPCR heteromerization Nat. Chem. Biol. 7 2011 624 630