Structure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics

Biotechnology Journal

Volumn 7, Issue 12, 2012, Pages 1451-1461

  Mcneely, Patrick M ^a   Naranjo, Andrea N ^a   Robinson, Anne S ^a,b  

^a UNIVERSITY OF DELAWARE   (United States)

^b Tulane University   (United States)

Author keywords

Biochemical engineering; GPCR; Membrane proteins; Membranes

Indexed keywords

DRUG DESIGN; DRUG DISCOVERY; DRUG MOLECULES; DRUG TARGETS; EXPERIMENTAL EVIDENCE; EXPERIMENTAL TECHNIQUES; G PROTEIN COUPLED RECEPTORS; GPCR; HEALTHY HUMANS; MEMBRANE PROTEINS; SIDE EFFECT; STRUCTURE-FUNCTION STUDIES;

BIOCHEMICAL ENGINEERING; DRUG INTERACTIONS; MEMBRANES; PROTEINS;

BIOLOGICAL MEMBRANES;

ADRENOMEDULLIN RECEPTOR; DELTA OPIATE RECEPTOR; G PROTEIN COUPLED RECEPTOR; KAPPA OPIATE RECEPTOR; MEMBRANE PROTEIN; MU OPIATE RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; NOCICEPTIN RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

CELL CULTURE; CELL INTERACTION; CRYSTALLIZATION; DROSOPHILA MELANOGASTER; DRUG DESIGN; DRUG MECHANISM; DRUG TARGETING; EMBRYO DEVELOPMENT; FLUORESCENCE CORRELATION SPECTROSCOPY; HETEROLOGOUS EXPRESSION; HUMAN; LIGAND BINDING; LIPID COMPOSITION; NONHUMAN; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; UNSPECIFIED SIDE EFFECT;

ANIMALS; BIOPHARMACEUTICS; DRUG DISCOVERY; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84870702282     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200076     Document Type: Review

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