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Volumn 20, Issue 8, 2014, Pages 703-709

G-Protein-Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System

Author keywords

Adenosine receptor; Cannabinoid receptor; Dopamine receptor; Glutamate receptor; GPCR heteromer; Heteromer

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

EID: 84904576722     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12277     Document Type: Review
Times cited : (24)

References (76)
  • 1
    • 0036780743 scopus 로고    scopus 로고
    • G-protein-coupled receptor oligomerization and its potential for drug discovery
    • George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 2002;1:808-820.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 808-820
    • George, S.R.1    O'Dowd, B.F.2    Lee, S.P.3
  • 2
    • 0031050888 scopus 로고    scopus 로고
    • Functional and structural complexity of signal transduction via G-protein-coupled receptors
    • Gudermann T, Schöneberg T, Schultz G. Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci 1997;20:399-427.
    • (1997) Annu Rev Neurosci , vol.20 , pp. 399-427
    • Gudermann, T.1    Schöneberg, T.2    Schultz, G.3
  • 3
    • 0035398487 scopus 로고    scopus 로고
    • G-protein-coupled receptors and signaling networks: Emerging paradigms
    • Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: Emerging paradigms. Trends Pharmacol Sci 2001;22:368-376.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 368-376
    • Marinissen, M.J.1    Gutkind, J.S.2
  • 4
    • 77957025793 scopus 로고    scopus 로고
    • On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers
    • Agnati LF, Guidolin D, Vilardaga JP, Ciruela F, Fuxe K. On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers. J Recept Signal Transduct Res 2010;30:287-303.
    • (2010) J Recept Signal Transduct Res , vol.30 , pp. 287-303
    • Agnati, L.F.1    Guidolin, D.2    Vilardaga, J.P.3    Ciruela, F.4    Fuxe, K.5
  • 5
    • 0042467972 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons
    • Agnati LF, Ferré S, Lluis C, Franco R, Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 2003;55:509-550.
    • (2003) Pharmacol Rev , vol.55 , pp. 509-550
    • Agnati, L.F.1    Ferré, S.2    Lluis, C.3    Franco, R.4    Fuxe, K.5
  • 6
    • 0035318509 scopus 로고    scopus 로고
    • Oligomerization of G-protein-coupled transmitter receptors
    • Bouvier M. Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2001;2:274-286.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 274-286
    • Bouvier, M.1
  • 7
    • 48449100036 scopus 로고    scopus 로고
    • Detection of heteromerization of more than two proteins by sequential BRET-FRET
    • Carriba P, Navarro G, Ciruela F, et al. Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nat Methods 2008;5:727-733.
    • (2008) Nat Methods , vol.5 , pp. 727-733
    • Carriba, P.1    Navarro, G.2    Ciruela, F.3
  • 8
    • 0035478438 scopus 로고    scopus 로고
    • Heterodimerization of G-protein-coupled receptors: Pharmacology, signaling and trafficking
    • Devi LA. Heterodimerization of G-protein-coupled receptors: Pharmacology, signaling and trafficking. Trends Pharmacol Sci 2001;22:532-537.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 532-537
    • Devi, L.A.1
  • 9
    • 72449211146 scopus 로고    scopus 로고
    • Oligomerization of G protein-coupled receptors: a reality
    • Ferré S, Franco R. Oligomerization of G protein-coupled receptors: a reality. Curr Opin Pharmacol 2010;10:1-5.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 1-5
    • Ferré, S.1    Franco, R.2
  • 10
    • 77957278232 scopus 로고    scopus 로고
    • G protein-coupled receptor heteromers as new targets for drug development
    • Ferré S, Navarro G, Casadó V, et al. G protein-coupled receptor heteromers as new targets for drug development. Prog Mol Biol Transl Sci 2010;91:41-52.
    • (2010) Prog Mol Biol Transl Sci , vol.91 , pp. 41-52
    • Ferré, S.1    Navarro, G.2    Casadó, V.3
  • 11
    • 60249098735 scopus 로고    scopus 로고
    • Building a new conceptual framework for receptor heteromers
    • Ferré S, Baler R, Bouvier M, et al. Building a new conceptual framework for receptor heteromers. Nat Chem Biol 2009;5:131-134.
    • (2009) Nat Chem Biol , vol.5 , pp. 131-134
    • Ferré, S.1    Baler, R.2    Bouvier, M.3
  • 12
    • 0037727707 scopus 로고    scopus 로고
    • Regulation of heptaspanning-membrane-receptor function by dimerization and clustering
    • Franco R, Canals M, Marcellino D, et al. Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. Trends Biochem Sci 2003;28:238-243.
    • (2003) Trends Biochem Sci , vol.28 , pp. 238-243
    • Franco, R.1    Canals, M.2    Marcellino, D.3
  • 13
    • 23944501304 scopus 로고    scopus 로고
    • Heterodimerization of g protein-coupled receptors: Specificity and functional significance
    • Prinster SC, Hague C, Hall RA. Heterodimerization of g protein-coupled receptors: Specificity and functional significance. Pharmacol Rev 2005;57:289-298.
    • (2005) Pharmacol Rev , vol.57 , pp. 289-298
    • Prinster, S.C.1    Hague, C.2    Hall, R.A.3
  • 14
    • 84860741916 scopus 로고    scopus 로고
    • History and biological significance of GPCR heteromerization in the neuroendocrine system
    • Tadagaki K, Jockers R, Kamal M. History and biological significance of GPCR heteromerization in the neuroendocrine system. Neuroendocrinology 2012;95:223-231.
    • (2012) Neuroendocrinology , vol.95 , pp. 223-231
    • Tadagaki, K.1    Jockers, R.2    Kamal, M.3
  • 15
    • 3142617997 scopus 로고    scopus 로고
    • Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties
    • Breit A, Lagacé M, Bouvier M. Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties. J Biol Chem 2004;279:28756-28765.
    • (2004) J Biol Chem , vol.279 , pp. 28756-28765
    • Breit, A.1    Lagacé, M.2    Bouvier, M.3
  • 16
    • 14644387575 scopus 로고    scopus 로고
    • Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
    • Bulenger S, Marullo S, Bouvier M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol Sci 2005;26:131-137.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 131-137
    • Bulenger, S.1    Marullo, S.2    Bouvier, M.3
  • 17
    • 15744401602 scopus 로고    scopus 로고
    • Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
    • Law P-Y, Erickson-Herbrandson LJ, Zha QQ, et al. Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. J Biol Chem 2005;280:11152-11164.
    • (2005) J Biol Chem , vol.280 , pp. 11152-11164
    • Law, P.-Y.1    Erickson-Herbrandson, L.J.2    Zha, Q.Q.3
  • 18
    • 34548530597 scopus 로고    scopus 로고
    • Functional relevance of neurotransmitter receptor heteromers in the central nervous system
    • Ferré S, Ciruela F, Woods AS, Lluis C, Franco R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends Neurosci 2007;30:440-446.
    • (2007) Trends Neurosci , vol.30 , pp. 440-446
    • Ferré, S.1    Ciruela, F.2    Woods, A.S.3    Lluis, C.4    Franco, R.5
  • 19
    • 49449095794 scopus 로고    scopus 로고
    • Novel pharmacological targets based on receptor heteromers
    • Franco R, Casadó V, Cortés A, et al. Novel pharmacological targets based on receptor heteromers. Brain Res Rev 2008;58:475-482.
    • (2008) Brain Res Rev , vol.58 , pp. 475-482
    • Franco, R.1    Casadó, V.2    Cortés, A.3
  • 20
    • 1242276192 scopus 로고    scopus 로고
    • Roles of G-protein-coupled receptor dimerization
    • Terrillon S, Bouvier M. Roles of G-protein-coupled receptor dimerization. EMBO Rep 2004;5:30-34.
    • (2004) EMBO Rep , vol.5 , pp. 30-34
    • Terrillon, S.1    Bouvier, M.2
  • 21
    • 3543080493 scopus 로고    scopus 로고
    • The State of GPCR Research in 2004
    • Ellis C. The State of GPCR Research in 2004. Nat Rev Drug Discov 2004;3:577-626.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 577-626
    • Ellis, C.1
  • 22
    • 8144222927 scopus 로고    scopus 로고
    • Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes
    • Terrillon S, Bouvier M. Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes. EMBO J 2004;23:3950-3961.
    • (2004) EMBO J , vol.23 , pp. 3950-3961
    • Terrillon, S.1    Bouvier, M.2
  • 23
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 2003;83:1017-1066.
    • (2003) Physiol Rev , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 24
    • 42349116262 scopus 로고    scopus 로고
    • Cannabinoid receptors: Where they are and what they do
    • Mackie K. Cannabinoid receptors: Where they are and what they do. J Neuroendocrinol 2008;20(Suppl 1):10-14.
    • (2008) J Neuroendocrinol , vol.20 , Issue.SUPPL. 1 , pp. 10-14
    • Mackie, K.1
  • 25
    • 84875230816 scopus 로고    scopus 로고
    • Endocannabinoid system and mood disorders: Priming a target for new therapies
    • Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F. Endocannabinoid system and mood disorders: Priming a target for new therapies. Pharmacol Ther 2013;138:18-37.
    • (2013) Pharmacol Ther , vol.138 , pp. 18-37
    • Micale, V.1    Di Marzo, V.2    Sulcova, A.3    Wotjak, C.T.4    Drago, F.5
  • 26
    • 56549089453 scopus 로고    scopus 로고
    • Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
    • Brusco A, Tagliaferro P, Saez T, Onaivi ES. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse 2008;62:944-949.
    • (2008) Synapse , vol.62 , pp. 944-949
    • Brusco, A.1    Tagliaferro, P.2    Saez, T.3    Onaivi, E.S.4
  • 27
    • 32844465920 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain
    • Gong J-P, Onaivi ES, Ishiguro H, et al. Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Res 2006;1071:10-23.
    • (2006) Brain Res , vol.1071 , pp. 10-23
    • Gong, J.-P.1    Onaivi, E.S.2    Ishiguro, H.3
  • 28
    • 77957293518 scopus 로고    scopus 로고
    • Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis
    • Lanciego JL, Barroso-Chinea P, Rico AJ, et al. Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. J Psychopharmacol 2011;25:97-104.
    • (2011) J Psychopharmacol , vol.25 , pp. 97-104
    • Lanciego, J.L.1    Barroso-Chinea, P.2    Rico, A.J.3
  • 29
    • 0032538908 scopus 로고    scopus 로고
    • Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system
    • Rosin DL, Robeva A, Woodard RL, Guyenet PG, Linden J. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J Comp Neurol 1998;401:163-186.
    • (1998) J Comp Neurol , vol.401 , pp. 163-186
    • Rosin, D.L.1    Robeva, A.2    Woodard, R.L.3    Guyenet, P.G.4    Linden, J.5
  • 30
    • 0035848459 scopus 로고    scopus 로고
    • Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum
    • Hettinger BD, Lee A, Linden J, Rosin DL. Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum. J Comp Neurol 2001;431:331-346.
    • (2001) J Comp Neurol , vol.431 , pp. 331-346
    • Hettinger, B.D.1    Lee, A.2    Linden, J.3    Rosin, D.L.4
  • 31
    • 67651017881 scopus 로고    scopus 로고
    • Physiology and pharmacology of striatal neurons
    • Kreitzer AC. Physiology and pharmacology of striatal neurons. Annu Rev Neurosci 2009;32:127-147.
    • (2009) Annu Rev Neurosci , vol.32 , pp. 127-147
    • Kreitzer, A.C.1
  • 32
    • 0025917767 scopus 로고
    • Does the absence of clinical expression of choreoathetosis, despite severe striatal atrophy, correlate with plasticity of neuropeptide synthesis?
    • Schiffmann SN, Vanderhaeghen JJ. Does the absence of clinical expression of choreoathetosis, despite severe striatal atrophy, correlate with plasticity of neuropeptide synthesis? J Neural Transm Suppl 1991;33:99-103.
    • (1991) J Neural Transm Suppl , vol.33 , pp. 99-103
    • Schiffmann, S.N.1    Vanderhaeghen, J.J.2
  • 34
    • 0345600938 scopus 로고    scopus 로고
    • A2A receptor and striatal cellular functions: Regulation of gene expression, currents, and synaptic transmission
    • Schiffmann SN, Dassesse D, d'Alcantara P, Ledent C, Swillens S, Zoli M. A2A receptor and striatal cellular functions: Regulation of gene expression, currents, and synaptic transmission. Neurology 2003;11(Suppl 6):S24-S29.
    • (2003) Neurology , vol.11 , Issue.SUPPL. 6
    • Schiffmann, S.N.1    Dassesse, D.2    d'Alcantara, P.3    Ledent, C.4    Swillens, S.5    Zoli, M.6
  • 35
    • 0032781426 scopus 로고    scopus 로고
    • Distribution, biochemistry and function of striatal adenosine A2A receptors
    • Svenningsson P, Le Moine C, Fisone G, Fredholm BB. Distribution, biochemistry and function of striatal adenosine A2A receptors. Prog Neurobiol 1999;59:355-396.
    • (1999) Prog Neurobiol , vol.59 , pp. 355-396
    • Svenningsson, P.1    Le Moine, C.2    Fisone, G.3    Fredholm, B.B.4
  • 36
    • 33745760564 scopus 로고    scopus 로고
    • The role of the basal ganglia in habit formation
    • Yin HH, Knowlton BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci 2006;7:464-476.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 464-476
    • Yin, H.H.1    Knowlton, B.J.2
  • 37
    • 0034081681 scopus 로고    scopus 로고
    • The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
    • Glass M, Dragunow M, Faull RL. The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience 2000;97:505-519.
    • (2000) Neuroscience , vol.97 , pp. 505-519
    • Glass, M.1    Dragunow, M.2    Faull, R.L.3
  • 38
    • 84862310662 scopus 로고    scopus 로고
    • Past, present, and future of the pathophysiological model of the Basal Ganglia
    • Obeso JA, Lanciego JL. Past, present, and future of the pathophysiological model of the Basal Ganglia. Front Neuroanat 2011;5:39.
    • (2011) Front Neuroanat , vol.5 , pp. 39
    • Obeso, J.A.1    Lanciego, J.L.2
  • 39
    • 84890068169 scopus 로고    scopus 로고
    • l-DOPA-treatment in primates disrupts the expression of A2A adenosine-CB1 cannabinoid-D2 dopamine receptor heteromers in the caudate nucleus
    • Bonaventura J, Rico AJ, Moreno E, et al. l-DOPA-treatment in primates disrupts the expression of A2A adenosine-CB1 cannabinoid-D2 dopamine receptor heteromers in the caudate nucleus. Neuropharmacology 2013;79C:90-100.
    • (2013) Neuropharmacology , vol.79 , pp. 90-100
    • Bonaventura, J.1    Rico, A.J.2    Moreno, E.3
  • 40
    • 84892840403 scopus 로고    scopus 로고
    • l-DOPA disrupts adenosine A2A-cannabinoid CB1-dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies
    • Pinna A, Bonaventura J, Farré D, et al. l-DOPA disrupts adenosine A2A-cannabinoid CB1-dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. Exp Neurol 2014;253:180-191.
    • (2014) Exp Neurol , vol.253 , pp. 180-191
    • Pinna, A.1    Bonaventura, J.2    Farré, D.3
  • 41
    • 0032217258 scopus 로고    scopus 로고
    • Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro
    • O'Kane EM, Stone TW. Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro. Eur J Pharmacol 1998;362:17-25.
    • (1998) Eur J Pharmacol , vol.362 , pp. 17-25
    • O'Kane, E.M.1    Stone, T.W.2
  • 42
    • 33644551294 scopus 로고    scopus 로고
    • Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
    • Ciruela F, Casadó V, Rodrigues RJ, et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J Neurosci 2006;26:2080-2087.
    • (2006) J Neurosci , vol.26 , pp. 2080-2087
    • Ciruela, F.1    Casadó, V.2    Rodrigues, R.J.3
  • 43
    • 84883465357 scopus 로고    scopus 로고
    • A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes
    • Cristóvão-Ferreira S, Navarro G, Brugarolas M, et al. A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes. Purinergic Signal 2013;9:433-449.
    • (2013) Purinergic Signal , vol.9 , pp. 433-449
    • Cristóvão-Ferreira, S.1    Navarro, G.2    Brugarolas, M.3
  • 44
    • 77952640781 scopus 로고    scopus 로고
    • Adenosine-cannabinoid receptor interactions. Implications for striatal function
    • Ferré S, Lluís C, Justinova Z, et al. Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br J Pharmacol 2010;160:443-453.
    • (2010) Br J Pharmacol , vol.160 , pp. 443-453
    • Ferré, S.1    Lluís, C.2    Justinova, Z.3
  • 45
    • 84866933069 scopus 로고    scopus 로고
    • Adenosine A(2A)-cannabinoid CB(1) receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission
    • Tebano MT, Martire A, Popoli P. Adenosine A(2A)-cannabinoid CB(1) receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission. Brain Res 2012;1476:108-118.
    • (2012) Brain Res , vol.1476 , pp. 108-118
    • Tebano, M.T.1    Martire, A.2    Popoli, P.3
  • 46
    • 78650714744 scopus 로고    scopus 로고
    • Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
    • Martire A, Tebano MT, Chiodi V, et al. Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission. J Neurochem 2011;116:273-280.
    • (2011) J Neurochem , vol.116 , pp. 273-280
    • Martire, A.1    Tebano, M.T.2    Chiodi, V.3
  • 47
    • 34548538764 scopus 로고    scopus 로고
    • Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids
    • Carriba P, Ortiz O, Patkar K, et al. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 2007;32:2249-2259.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2249-2259
    • Carriba, P.1    Ortiz, O.2    Patkar, K.3
  • 48
    • 34548384722 scopus 로고    scopus 로고
    • Neurotransmitter receptor heteromers and their integrative role in "local modules": The striatal spine module
    • Ferré S, Agnati LF, Ciruela F, et al. Neurotransmitter receptor heteromers and their integrative role in "local modules": The striatal spine module. Brain Res Rev 2007;55:55-67.
    • (2007) Brain Res Rev , vol.55 , pp. 55-67
    • Ferré, S.1    Agnati, L.F.2    Ciruela, F.3
  • 49
    • 33750882222 scopus 로고    scopus 로고
    • Heterodimeric adenosine receptors: A device to regulate neurotransmitter release
    • Ciruela F, Ferré S, Casadó V, et al. Heterodimeric adenosine receptors: A device to regulate neurotransmitter release. Cell Mol Life Sci 2006;63:2427-2431.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2427-2431
    • Ciruela, F.1    Ferré, S.2    Casadó, V.3
  • 50
    • 0037124032 scopus 로고    scopus 로고
    • Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    • Hillion J, Canals M, Torvinen M, et al. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 2002;277:18091-18097.
    • (2002) J Biol Chem , vol.277 , pp. 18091-18097
    • Hillion, J.1    Canals, M.2    Torvinen, M.3
  • 51
    • 65549160499 scopus 로고    scopus 로고
    • Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells
    • Cabello N, Gandía J, Bertarelli DCG, et al. Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 2009;109:1497-1507.
    • (2009) J Neurochem , vol.109 , pp. 1497-1507
    • Cabello, N.1    Gandía, J.2    Bertarelli, D.C.G.3
  • 52
    • 77956236975 scopus 로고    scopus 로고
    • Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers
    • Navarro G, Ferré S, Cordomi A, et al. Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers. J Biol Chem 2010;285:27346-27359.
    • (2010) J Biol Chem , vol.285 , pp. 27346-27359
    • Navarro, G.1    Ferré, S.2    Cordomi, A.3
  • 53
    • 55549147195 scopus 로고    scopus 로고
    • Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
    • Navarro G, Carriba P, Gandía J, et al. Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. ScientificWorldJournal 2008;8:1088-1097.
    • (2008) ScientificWorldJournal , vol.8 , pp. 1088-1097
    • Navarro, G.1    Carriba, P.2    Gandía, J.3
  • 54
    • 0016377247 scopus 로고
    • Dopaminergic involvement in hypothalamic function: Extrahypothalamic and hypothalamic control. A neuroanatomical analysis
    • Fuxe K, Goldstein M, Hökfelt T, Jonsson G, Lidbrink P. Dopaminergic involvement in hypothalamic function: Extrahypothalamic and hypothalamic control. A neuroanatomical analysis. Adv Neurol 1974;5:405-419.
    • (1974) Adv Neurol , vol.5 , pp. 405-419
    • Fuxe, K.1    Goldstein, M.2    Hökfelt, T.3    Jonsson, G.4    Lidbrink, P.5
  • 55
    • 0025768754 scopus 로고
    • Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes
    • Ferre S, von Euler G, Johansson B, Fredholm BB, Fuxe K. Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes. Proc Natl Acad Sci U S A 1991;88:7238-7241.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7238-7241
    • Ferre, S.1    von Euler, G.2    Johansson, B.3    Fredholm, B.B.4    Fuxe, K.5
  • 56
    • 79251549825 scopus 로고    scopus 로고
    • Striatal pre- and postsynaptic profile of adenosine A2A receptor antagonists
    • Orru M, Bakešová J, Brugarolas M, et al. Striatal pre- and postsynaptic profile of adenosine A2A receptor antagonists. PLoS ONE 2011;6:e16088.
    • (2011) PLoS ONE , vol.6
    • Orru, M.1    Bakešová, J.2    Brugarolas, M.3
  • 57
    • 84870874866 scopus 로고    scopus 로고
    • Istradefylline, an adenosine AA receptor antagonist, for patients with Parkinson's Disease: A meta-analysis
    • Chen W, Wang H, Wei H, Gu S, Wei H. Istradefylline, an adenosine AA receptor antagonist, for patients with Parkinson's Disease: A meta-analysis. J Neurol Sci 2013;324:21-28.
    • (2013) J Neurol Sci , vol.324 , pp. 21-28
    • Chen, W.1    Wang, H.2    Wei, H.3    Gu, S.4    Wei, H.5
  • 58
    • 83455244352 scopus 로고    scopus 로고
    • Istradefylline for the treatment of Parkinson's disease
    • Park A, Stacy M. Istradefylline for the treatment of Parkinson's disease. Expert Opin Pharmacother 2012;13:111-114.
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 111-114
    • Park, A.1    Stacy, M.2
  • 59
    • 0037015027 scopus 로고    scopus 로고
    • Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function
    • Ferré S, Karcz-Kubicha M, Hope BT, et al. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function. Proc Natl Acad Sci U S A 2002;99:11940-11945.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11940-11945
    • Ferré, S.1    Karcz-Kubicha, M.2    Hope, B.T.3
  • 60
    • 0034856088 scopus 로고    scopus 로고
    • The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: Interactions with adenosine A(2a) receptors
    • Popoli P, Pèzzola A, Torvinen M, et al. The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: Interactions with adenosine A(2a) receptors. Neuropsychopharmacology 2001;25:505-513.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 505-513
    • Popoli, P.1    Pèzzola, A.2    Torvinen, M.3
  • 61
    • 0034868541 scopus 로고    scopus 로고
    • Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats
    • Ossowska K, Konieczny J, Wolfarth S, Wierońska J, Pilc A. Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. Neuropharmacology 2001;41:413-420.
    • (2001) Neuropharmacology , vol.41 , pp. 413-420
    • Ossowska, K.1    Konieczny, J.2    Wolfarth, S.3    Wierońska, J.4    Pilc, A.5
  • 62
    • 27744450594 scopus 로고    scopus 로고
    • Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice
    • Kachroo A, Orlando LR, Grandy DK, Chen J-F, Young AB, Schwarzschild MA. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J Neurosci 2005;25:10414-10419.
    • (2005) J Neurosci , vol.25 , pp. 10414-10419
    • Kachroo, A.1    Orlando, L.R.2    Grandy, D.K.3    Chen, J.-F.4    Young, A.B.5    Schwarzschild, M.A.6
  • 63
    • 0030861647 scopus 로고    scopus 로고
    • Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia
    • Ferré S, Fredholm BB, Morelli M, Popoli P, Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci 1997;20:482-487.
    • (1997) Trends Neurosci , vol.20 , pp. 482-487
    • Ferré, S.1    Fredholm, B.B.2    Morelli, M.3    Popoli, P.4    Fuxe, K.5
  • 64
    • 21244440664 scopus 로고    scopus 로고
    • Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease
    • Jenner P. Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease. Expert Opin Investig Drugs 2005;14:729-738.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 729-738
    • Jenner, P.1
  • 65
    • 69949139695 scopus 로고    scopus 로고
    • Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum
    • Tebano MT, Martire A, Chiodi V, et al. Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. J Neurochem 2009;110:1921-1930.
    • (2009) J Neurochem , vol.110 , pp. 1921-1930
    • Tebano, M.T.1    Martire, A.2    Chiodi, V.3
  • 66
    • 4944240410 scopus 로고    scopus 로고
    • Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC
    • Soria G, Castañé A, Berrendero F, et al. Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC. Eur J Neurosci 2004;20:2203-2213.
    • (2004) Eur J Neurosci , vol.20 , pp. 2203-2213
    • Soria, G.1    Castañé, A.2    Berrendero, F.3
  • 67
    • 33646751913 scopus 로고    scopus 로고
    • Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats
    • Yao L, McFarland K, Fan P, Jiang Z, Ueda T, Diamond I. Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. Proc Natl Acad Sci U S A 2006;103:7877-7882.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7877-7882
    • Yao, L.1    McFarland, K.2    Fan, P.3    Jiang, Z.4    Ueda, T.5    Diamond, I.6
  • 68
    • 24944497593 scopus 로고    scopus 로고
    • Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons
    • Andersson M, Usiello A, Borgkvist A, et al. Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. J Neurosci 2005;25:8432-8438.
    • (2005) J Neurosci , vol.25 , pp. 8432-8438
    • Andersson, M.1    Usiello, A.2    Borgkvist, A.3
  • 69
    • 75849140535 scopus 로고    scopus 로고
    • Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
    • Hasbi A, Fan T, Alijaniaram M, et al. Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc Natl Acad Sci U S A 2009;106:21377-21382.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21377-21382
    • Hasbi, A.1    Fan, T.2    Alijaniaram, M.3
  • 70
    • 78751527600 scopus 로고    scopus 로고
    • Dopamine receptor homooligomers and heterooligomers in schizophrenia
    • Perreault ML, O'Dowd BF, George SR. Dopamine receptor homooligomers and heterooligomers in schizophrenia. CNS Neurosci Ther 2011;17:52-57.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 52-57
    • Perreault, M.L.1    O'Dowd, B.F.2    George, S.R.3
  • 71
    • 84890859688 scopus 로고    scopus 로고
    • Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
    • Borroto-Escuela DO, Romero-Fernandez W, Narvaez M, Oflijan J, Agnati LF, Fuxe K. Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes. Biochem Biophys Res Commun 2014;443:278-284.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 278-284
    • Borroto-Escuela, D.O.1    Romero-Fernandez, W.2    Narvaez, M.3    Oflijan, J.4    Agnati, L.F.5    Fuxe, K.6
  • 72
    • 79959993845 scopus 로고    scopus 로고
    • Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
    • Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology 2011;61:770-777.
    • (2011) Neuropharmacology , vol.61 , pp. 770-777
    • Albizu, L.1    Holloway, T.2    González-Maeso, J.3    Sealfon, S.C.4
  • 73
    • 79952898466 scopus 로고    scopus 로고
    • Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
    • Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 2011;493:76-79.
    • (2011) Neurosci Lett , vol.493 , pp. 76-79
    • Moreno, J.L.1    Holloway, T.2    Albizu, L.3    Sealfon, S.C.4    González-Maeso, J.5
  • 74
    • 84871760600 scopus 로고    scopus 로고
    • Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function
    • Moreno JL, Muguruza C, Umali A, et al. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 2012;287:44301-44319.
    • (2012) J Biol Chem , vol.287 , pp. 44301-44319
    • Moreno, J.L.1    Muguruza, C.2    Umali, A.3
  • 75
    • 40449139964 scopus 로고    scopus 로고
    • Identification of a serotonin/glutamate receptor complex implicated in psychosis
    • González-Maeso J, Ang RL, Yuen T, et al. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 2008;452:93-97.
    • (2008) Nature , vol.452 , pp. 93-97
    • González-Maeso, J.1    Ang, R.L.2    Yuen, T.3
  • 76
    • 81855189491 scopus 로고    scopus 로고
    • Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs
    • Fribourg M, Moreno JL, Holloway T, et al. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 2011;147:1011-1023.
    • (2011) Cell , vol.147 , pp. 1011-1023
    • Fribourg, M.1    Moreno, J.L.2    Holloway, T.3


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