The role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress

Current Molecular Medicine

Volumn 16, Issue 6, 2016, Pages 533-544

  Rozpedek W ^a   Pytel, D ^b   Mucha, B ^a,b   Leszczynska H ^a   Diehl, J A ^b   Majsterek, I ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; CHOP; eIF2 ; ER stress; PERK; Tumor; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; GLUCOSE TRANSPORTER 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN BCL 2; THAPSIGARGIN; TRANSFORMING GROWTH FACTOR ALPHA; TUNICAMYCIN; VASCULOTROPIN; ATF4 PROTEIN, HUMAN; DDIT3 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; INITIATION FACTOR 2; PROTEIN KINASE R;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CARCINOGENESIS; CELL PROTECTION; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HYPOXIA; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; ANIMAL; CELL HYPOXIA; CELL TRANSFORMATION; DISEASE COURSE; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84981507341     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524016666160523143937     Document Type: Review

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