Targeting unfolded protein response in cancer and diabetes

Endocrine-Related Cancer

Volumn 22, Issue 3, 2015, Pages c1-c4

  Mkrtchian, Souren ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Chemotherapy; Intracellular signaling; Islet cells; Oncology

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 94; INITIATION FACTOR 2; MEMBRANE PROTEIN; MESSENGER RNA; TUNICAMYCIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

APOPTOSIS; CARCINOGENESIS; CELL ACTIVITY; CELL CYCLE REGULATION; CELL DEATH; CELL DISRUPTION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS; DIABETOGENESIS; DOWN REGULATION; ENDOPLASMIC RETICULUM; GLUCOSE HOMEOSTASIS; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; RNA TRANSLATION; TRANSCRIPTION INITIATION; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL DIABETES MELLITUS; FEMALE; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; TRANSCRIPTION FACTOR CHOP;

EID: 84937042249     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-15-0106     Document Type: Review

References (15)

1. Back SH & Kaufman RJ 2012 Endoplasmic reticulum stress and type 2 diabetes. Annual Review of Biochemistry 81 767-793. (doi:10.1146/annurev-biochem-072909-095555)
2. Brewer JW 2014 Regulatory crosstalk within the mammalian unfolded protein response. Cellular and Molecular Life Sciences 71 1067-1079. (doi:10.1007/s00018-013-1490-2)
3. Dhanasekaran DN & Reddy EP 2008 JNK signaling in apoptosis. Oncogene 27 6245-6251. (doi:10.1038/onc.2008.301)
4. Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, KrokowskiD, Wang S, Hatzoglou M et al. 2013 ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biology 15 481-490. (doi:10.1038/ncb2738)
5. Lewin K 1951 In Field theory in social science: selected theoretical papers. Ed D Cartwright. 346pp. New York, NY, USA: Harper.
6. Ma Y, Brewer JW, Diehl JA & Hendershot LM 2002 Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. Journal of Molecular Biology 318 1351-1365. (doi:10.1016/S0022-2836(02)00234-6)
7. McCullough KD, Martindale JL, Klotz LO, Aw TY & Holbrook NJ 2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state. Molecular and Cellular Biology21 1249-1259. (doi:10.1128/MCB.21.4.1249-1259.2001)
8. Mihailidou C, Papazian I, Papavassiliou AG & Kiaris H 2010 CHOPdependent regulation of p21/waf1 during ER stress. Cellular Physiology and Biochemistry 25 761-766. (doi:10.1159/000315096)
9. Mihailidou C, Papavassiliou AG & Kiaris H 2014 A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes. Biochimie 99 19-27. (doi:10.1016/j.biochi.2013.11.003)
10. Mihailidou C, Chatzistamou I, Papavassiliou A & Kiaris H 2015a Improvement of chemotherapeutic drug efficacy by endoplasmic reticulum stress. Endocrine-Related Cancer 22 229-238. (doi:10.1530/ERC-15-0019)
11. Mihailidou C, Chatzistamou I, Papavassiliou A & Kiaris H 2015b Regulation of p21 during diabetes-associated stress of the endoplasmic reticulum. Endocrine-Related Cancer 22 217-228. (doi:10.1530/ERC-15-0018)
12. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E & Mori M 2002 Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. Journal of Clinical Investigation 109 525-532. (doi:10.1172/JCI0214550)
13. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR & Oakes SA 2008 Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Molecular and Cellular Biology 28 3943-3951. (doi:10.1128/MCB.00013-08)
14. Yoon MK, Mitrea DM, Ou L & Kriwacki RW 2012 Cell cycle regulation by the intrinsically disordered proteins p21 and p27. Biochemical Society Transactions 40 981-988. (doi:10.1042/BST20120092)
15. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH & Hung MC 2001 Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 3 245-252. (doi:10.1038/35060032)