Enzymatic characterization of ER stress-dependent kinase, PERK, and development of a high-throughput assay for identification of PERK inhibitors

Journal of Biomolecular Screening

Volumn 19, Issue 7, 2014, Pages 1024-1034

  Pytel, Dariusz ^a,b,c   Seyb, Kathleen ^a   Liu, Min ^a   Ray, Soumya S ^a   Concannon, John ^a   Huang, Mickey ^a   Cuny, Gregory D ^a   Diehl, J Alan ^a,b,c   Glicksman, Marcie A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

HTS; PERK; small molecule inhibitors

Indexed keywords

ADENOSINE TRIPHOSPHATE; IMATINIB; INITIATION FACTOR 2ALPHA; LDN 0020506; LDN 0070977; PERK KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; EIF2AK3 PROTEIN, HUMAN; ENZYME INHIBITOR; INITIATION FACTOR 2; PROTEIN KINASE R;

ANIMAL CELL; ARTICLE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; DRUG DEVELOPMENT; ENDOPLASMIC RETICULUM; HUMAN; METABOLISM; PHENOTYPE; PHOSPHORYLATION; PROCEDURES; SIGNAL TRANSDUCTION;

ANIMALS; COMPUTER SIMULATION; DRUG DESIGN; DRUG DISCOVERY; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; FIBROBLASTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84904639817     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114525853     Document Type: Article

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