The PERK/eIF2α/ATF4 module of the UPR in hypoxia resistance and tumor growth

Cancer Biology and Therapy

Volumn 5, Issue 7, 2006, Pages 723-728

  Fels, Diane R ^a   Koumenis, Constantinos ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

ATF4; eIF2 ; Hypoxia; Integrated stress response; PERK; Protein translation; Tumor microenvironment; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 12; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ETOPOSIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 1; INITIATION FACTOR 2; MEMBRANE PROTEIN; PROTEIN BCL X; TRANSCRIPTION FACTOR NRF2; PERK KINASE; PROTEIN KINASE R;

CANCER; DNA DAMAGE; DNA REPLICATION; HYPOXIA; MICROENVIRONMENT; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; RNA TRANSLATION; STRESS; TUMOR GROWTH; ANIMAL; CELL HYPOXIA; ENDOPLASMIC RETICULUM; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CELL HYPOXIA; EIF-2 KINASE; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; HUMANS; NEOPLASMS; PROTEIN FOLDING; SIGNAL TRANSDUCTION;

EID: 33751285479     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.7.2967     Document Type: Review

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