ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

Nature Cell Biology

Volumn 3, Issue 9, 2001, Pages 785-792

  Muthuswamy, Senthil K ^a   Li, Dongmei ^a,b   Lelievre, Sophie ^c,d   Bissell, Mina J ^d   Brugge, Joan S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c PURDUE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ACINAR CELL; ARTICLE; ASSAY; BASEMENT MEMBRANE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; BREAST TUMOR; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL INVASION; CELL POLARITY; CELL POPULATION; CONTROLLED STUDY; EPITHELIUM CELL; GEL; GENE EXPRESSION; GENETIC TRANSFORMATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MODEL; ONCOGENE C ERB; ONCOGENE NEU; PRIORITY JOURNAL; TIGHT JUNCTION;

ANIMALS; BREAST; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; CELL POLARITY; DIMERIZATION; DOGS; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; FEMALE; HUMANS; KIDNEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS;

EID: 0034854417     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb0901-785     Document Type: Article

References (47)

1. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
2. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
3. The ErbB signaling network: Receptor heterodimerization in development and cancer
4. Specificity within the EGF family/ErbB receptor family signaling network
5. The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
6. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
7. The biology of erbB-2/neu/HER-2 and its role in cancer
8. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
9. EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling
10. Transformation of NIH 3T3 cells by over-expression of the normal coding sequence of the rat neu gene
11. Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation
12. The type 1 growth factor receptor family: New ligands and receptors and their role in breast cancer
13. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers
14. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
15. A versatile synthetic dimerizer for the regulation of protein-protein interactions
16. ERBIN: A basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
17. Cytoplasmic juxtamembrane domain of the human EGF receptor is required for basolateral localization in MDCK cells
18. Transformation of human breast epithelial cells by c-Ha-ras oncogene
19. Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma
20. Adhesion-mediated signaling in the regulation of mammary epithelial cell survival
21. Tumor suppressors: Linking cell polarity and growth control
22. Transfer of functional EGF receptors to an IL3-dependent cell line
23. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion
24. The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions
25. Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras
26. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture
27. Influence of microenvironment of mammary epithelial cell survival in primary culture
28. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
29. Integrins and anoikis
30. Morphogenetic and proliferative responses to heregulin of mammary epithelial cells in vitro are dependent on HER2 and HER3 and differ from the responses to HER2 homodimerisation or hepatocyte growth factor
31. Molecular requirements for the effect of neuregulin on cell spreading, motility and colony organization
32. ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases
33. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
34. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
35. Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene
36. Transforming growth factor-α expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming complementary DNA leads to transformation
37. Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes
38. New model of ErbB-2 over-expression in human mammary luminal epithelial cells
39. Collagen-induced morphogenesis and expression of the α2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells
40. Oncogenic potential of erbB-2 in human mammary epithelial cells
41. The effects of the neuN and neuT genes on differentiation and transformation of mammary epithelial cells
42. Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells
43. Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis
44. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes
45. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc
46. Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor