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Volumn 365, Issue 3, 2016, Pages 607-619

Fibroblast activation in cancer: when seed fertilizes soil

Author keywords

Cancer; Carcinoma associated fibroblasts; Inflammation; Tumor microenvironment

Indexed keywords

CCL25 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON INDUCIBLE PROTEIN 10; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE;

EID: 84980030882     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-016-2467-x     Document Type: Review
Times cited : (232)

References (122)
  • 4
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • COI: 1:CAS:528:DC%2BD2cXlt1Oktrs%3D, PID: 15229479
    • Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4:540–550
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 5
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • COI: 1:CAS:528:DC%2BC3MXptV2isrk%3D, PID: 21772280
    • Ben-Neriah Y, Karin M (2011)Inflammation meets cancer, with NF-κB as the matchmaker.Nat Immunol 12:715–723
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 6
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • COI: 1:CAS:528:DC%2BD2cXpvVCjtLw%3D, PID: 15549095
    • Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432:332–337
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 10
    • 80053322515 scopus 로고    scopus 로고
    • Cell communication networks in cancer invasion
    • COI: 1:CAS:528:DC%2BC3MXht1Kmt7vE, PID: 21570276
    • Calvo F, Sahai E (2011) Cell communication networks in cancer invasion. Curr Opin Cell Biol 23:621–629
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 621-629
    • Calvo, F.1    Sahai, E.2
  • 12
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • COI: 1:CAS:528:DC%2BD2MXht1GqsrvF, PID: 16293724
    • Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS (2005) Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310:1504–1510
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 13
    • 84897504519 scopus 로고    scopus 로고
    • The role of reactive oxygen species and metabolism on cancer cells and their microenvironment
    • COI: 1:CAS:528:DC%2BC2cXht1KgsLs%3D, PID: 24406211
    • Costa A, Scholer-Dahirel A, Mechta-Grigoriou F (2014) The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Semin Cancer Biol 25:23–32
    • (2014) Semin Cancer Biol , vol.25 , pp. 23-32
    • Costa, A.1    Scholer-Dahirel, A.2    Mechta-Grigoriou, F.3
  • 14
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • COI: 1:CAS:528:DC%2BD1MXptVGqtQ%3D%3D, PID: 19111878
    • Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N (2009) PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15:21–34
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 15
    • 5444248307 scopus 로고    scopus 로고
    • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
    • PID: 15059978
    • De Wever O, Nguyen Q-D, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, Mareel M (2004) Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 18:1016–1018
    • (2004) FASEB J , vol.18 , pp. 1016-1018
    • De Wever, O.1    Nguyen, Q.-D.2    Van Hoorde, L.3    Bracke, M.4    Bruyneel, E.5    Gespach, C.6    Mareel, M.7
  • 17
    • 77954563614 scopus 로고    scopus 로고
    • Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
    • PID: 20405169
    • DeNardo DG, Andreu P, Coussens LM (2010) Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity. Cancer Metastasis Rev 29:309–316
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 309-316
    • DeNardo, D.G.1    Andreu, P.2    Coussens, L.M.3
  • 18
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • COI: 1:CAS:528:DC%2BD3sXnvV2hs7c%3D, PID: 14534577
    • Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425:577–584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 19
    • 0029149053 scopus 로고
    • Factors influencing myofibroblast differentiation during wound healing and fibrosis
    • PID: 7640660
    • Desmoulière A (1995) Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 19:471–476
    • (1995) Cell Biol Int , vol.19 , pp. 471-476
    • Desmoulière, A.1
  • 21
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal
    • COI: 1:STN:280:DyaL2s%2FmsV2mtw%3D%3D, PID: 3537791
    • Dvorak HF (1986) Tumors: wounds that do not heal. N Engl J Med 315:1650–1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 22
    • 84923184180 scopus 로고    scopus 로고
    • Focal adhesion signaling and therapy resistance in cancer
    • COI: 1:CAS:528:DC%2BC2cXhtlKmtLvE, PID: 25117005
    • Eke I, Cordes N (2015) Focal adhesion signaling and therapy resistance in cancer. Semin Cancer Biol 31:65–75
    • (2015) Semin Cancer Biol , vol.31 , pp. 65-75
    • Eke, I.1    Cordes, N.2
  • 23
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • COI: 1:CAS:528:DC%2BD3MXhsFOhur4%3D, PID: 11237532
    • Elenbaas B, Weinberg RA (2001) Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 264:169–184
    • (2001) Exp Cell Res , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 24
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • COI: 1:CAS:528:DC%2BC3cXlt1Kls7o%3D, PID: 20138012
    • Erez N, Truitt M, Olson P, Arron ST, Hanahan D (2010) Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 17:135–147
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 25
    • 79959560621 scopus 로고    scopus 로고
    • Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma
    • COI: 1:CAS:528:DC%2BC3MXotVegsro%3D, PID: 21635872
    • Fedorenko IV, Paraiso KHT, Smalley KSM (2011) Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma. Biochem Pharmacol 82:201–209
    • (2011) Biochem Pharmacol , vol.82 , pp. 201-209
    • Fedorenko, I.V.1    Paraiso, K.H.T.2    Smalley, K.S.M.3
  • 27
    • 0023831047 scopus 로고
    • A heparin-binding angiogenic protein—basic fibroblast growth factor—is stored within basement membrane
    • COI: 1:CAS:528:DyaL1cXht1GhtLs%3D, PID: 3277442
    • Folkman J, Klagsbrun M, Sasse J, Wadzinski M, Ingber D, Vlodavsky I (1988) A heparin-binding angiogenic protein—basic fibroblast growth factor—is stored within basement membrane. Am J Pathol 130:393–400
    • (1988) Am J Pathol , vol.130 , pp. 393-400
    • Folkman, J.1    Klagsbrun, M.2    Sasse, J.3    Wadzinski, M.4    Ingber, D.5    Vlodavsky, I.6
  • 28
    • 36749013537 scopus 로고    scopus 로고
    • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    • COI: 1:CAS:528:DC%2BD2sXhtlOns7bK, PID: 18037882
    • Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E (2007) Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 9:1392–1400
    • (2007) Nat Cell Biol , vol.9 , pp. 1392-1400
    • Gaggioli, C.1    Hooper, S.2    Hidalgo-Carcedo, C.3    Grosse, R.4    Marshall, J.F.5    Harrington, K.6    Sahai, E.7
  • 29
    • 40149088953 scopus 로고    scopus 로고
    • OSM, LIF, its receptors, and its relationship with the malignance in human breast carcinoma (in situ and in infiltrative)
    • García-Tuñón I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M (2008) OSM, LIF, its receptors, and its relationship with the malignance in human breast carcinoma (in situ and in infiltrative). Cancer Invest 26:222–229
    • (2008) Cancer Invest , vol.26 , pp. 222-229
    • García-Tuñón, I.1    Ricote, M.2    Ruiz, A.3    Fraile, B.4    Paniagua, R.5    Royuela, M.6
  • 30
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer
    • COI: 1:CAS:528:DyaK28XhsFGnsL0%3D, PID: 8640796
    • Gerweck LE, Seetharaman K (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 56:1194–1198
    • (1996) Cancer Res , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 31
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • COI: 1:CAS:528:DC%2BD38XhvF2jtL8%3D, PID: 11902585
    • Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2:48–58
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 32
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • COI: 1:CAS:528:DC%2BC3cXlsVSgu7g%3D, PID: 20303878
    • Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 33
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • COI: 1:CAS:528:DC%2BD3cXks1CktA%3D%3D, PID: 10647931
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 34
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 0024315697 scopus 로고
    • Structure and function of platelet-derived growth factor (PDGF) and related proteins
    • COI: 1:CAS:528:DyaL1MXkvFSms7Y%3D, PID: 2546599
    • Hannink M, Donoghue DJ (1989) Structure and function of platelet-derived growth factor (PDGF) and related proteins. Biochim Biophys Acta 989:1–10
    • (1989) Biochim Biophys Acta , vol.989 , pp. 1-10
    • Hannink, M.1    Donoghue, D.J.2
  • 36
    • 10644283057 scopus 로고    scopus 로고
    • Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
    • PID: 15591420
    • Harrison L, Blackwell K (2004) Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? Oncologist 9 (Suppl 5):31–40
    • (2004) Oncologist , vol.9 , pp. 31-40
    • Harrison, L.1    Blackwell, K.2
  • 38
    • 78649679778 scopus 로고    scopus 로고
    • Roles of fibroblast growth factor receptors in carcinogenesis
    • COI: 1:CAS:528:DC%2BC3cXhsVOktLnF, PID: 21047773
    • Haugsten EM, Wiedlocha A, Olsnes S, Wesche J (2010) Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res 8:1439–1452
    • (2010) Mol Cancer Res , vol.8 , pp. 1439-1452
    • Haugsten, E.M.1    Wiedlocha, A.2    Olsnes, S.3    Wesche, J.4
  • 39
    • 0035692411 scopus 로고    scopus 로고
    • Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies
    • COI: 1:CAS:528:DC%2BD38XhsVWlur4%3D, PID: 11831646
    • Hazlehurst LA, Dalton WS (2001) Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies. Cancer Metastasis Rev 20:43–50
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 43-50
    • Hazlehurst, L.A.1    Dalton, W.S.2
  • 40
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • COI: 1:CAS:528:DyaK1MXmvVymtLY%3D, PID: 10508235
    • Heldin C-H, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283–1316
    • (1999) Physiol Rev , vol.79 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 41
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure—an obstacle in cancer therapy
    • COI: 1:CAS:528:DC%2BD2cXos1ymu7s%3D, PID: 15510161
    • Heldin C-H, Rubin K, Pietras K, Ostman A (2004) High interstitial fluid pressure—an obstacle in cancer therapy. Nat Rev Cancer 4:806–813
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 42
    • 84928008693 scopus 로고    scopus 로고
    • Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling
    • COI: 1:CAS:528:DC%2BC2MXmsFegt7w%3D, PID: 25873177
    • Hirata E, Girotti MR, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E (2015) Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling. Cancer Cell 27:574–588
    • (2015) Cancer Cell , vol.27 , pp. 574-588
    • Hirata, E.1    Girotti, M.R.2    Viros, A.3    Hooper, S.4    Spencer-Dene, B.5    Matsuda, M.6    Larkin, J.7    Marais, R.8    Sahai, E.9
  • 44
    • 0023025366 scopus 로고
    • Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
    • COI: 1:CAS:528:DyaL28Xhs1amur4%3D, PID: 3456347
    • Ignotz RA, Massagué J (1986) Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261:4337–4345
    • (1986) J Biol Chem , vol.261 , pp. 4337-4345
    • Ignotz, R.A.1    Massagué, J.2
  • 45
    • 80053189244 scopus 로고    scopus 로고
    • Inflammatory alterations of the extracellular matrix in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3MXhtF2gurbJ, PID: 24212952
    • Iijima J, Konno K, Itano N (2011) Inflammatory alterations of the extracellular matrix in the tumor microenvironment. Cancers 3:3189–3205
    • (2011) Cancers , vol.3 , pp. 3189-3205
    • Iijima, J.1    Konno, K.2    Itano, N.3
  • 46
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: structure, assembly and role in tumour angiogenesis
    • COI: 1:CAS:528:DC%2BD3sXktFOnsbw%3D, PID: 12778132
    • Kalluri R (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3:422–433
    • (2003) Nat Rev Cancer , vol.3 , pp. 422-433
    • Kalluri, R.1
  • 48
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • COI: 1:CAS:528:DC%2BD2MXhtVGrurvL, PID: 16175180
    • Karin M, Greten FR (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression.Nat Rev Immunol 5:749–759
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 49
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD1cXlsFyrtro%3D, PID: 18463380
    • Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358:2039–2049
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 50
    • 84883143934 scopus 로고    scopus 로고
    • Metalloproteinases and their natural inhibitors in inflammation and immunity
    • COI: 1:CAS:528:DC%2BC3sXhtlWktLzE, PID: 23969736
    • Khokha R, Murthy A, Weiss A (2013) Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat Rev Immunol 13:649–665
    • (2013) Nat Rev Immunol , vol.13 , pp. 649-665
    • Khokha, R.1    Murthy, A.2    Weiss, A.3
  • 52
    • 84956878669 scopus 로고    scopus 로고
    • IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
    • COI: 1:CAS:528:DC%2BC28XjtlSgur8%3D, PID: 26621453
    • Koliaraki V, Pasparakis M, Kollias G (2015) IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. J Exp Med 212:2235–2251
    • (2015) J Exp Med , vol.212 , pp. 2235-2251
    • Koliaraki, V.1    Pasparakis, M.2    Kollias, G.3
  • 53
    • 0017814974 scopus 로고
    • Specificity of desmin to avian and mammalian muscle cells
    • COI: 1:STN:280:DyaE1c3ht12ntg%3D%3D, PID: 78766
    • Lazarides E, Balzer DR (1978) Specificity of desmin to avian and mammalian muscle cells. Cell 14:429–438
    • (1978) Cell , vol.14 , pp. 429-438
    • Lazarides, E.1    Balzer, D.R.2
  • 54
    • 2142646426 scopus 로고    scopus 로고
    • TGF-β signaling and the fibrotic response
    • COI: 1:CAS:528:DC%2BD2cXjvVOnt70%3D, PID: 15117886
    • Leask A, Abraham DJ (2004) TGF-β signaling and the fibrotic response. FASEB J 18:816–827
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 55
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour–host interface
    • COI: 1:CAS:528:DC%2BD3MXktVSjs78%3D, PID: 11357145
    • Liotta LA, Kohn EC (2001) The microenvironment of the tumour–host interface. Nature 411:375–379
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 58
    • 0033362351 scopus 로고    scopus 로고
    • Hepatocyte growth factor, a versatile signal for developing neurons
    • COI: 1:CAS:528:DyaK1MXhsl2gurY%3D, PID: 10195212
    • Maina F, Klein R (1999) Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci 2:213–217
    • (1999) Nat Neurosci , vol.2 , pp. 213-217
    • Maina, F.1    Klein, R.2
  • 60
    • 0028053831 scopus 로고
    • Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells
    • COI: 1:CAS:528:DyaK2cXmvFemtLk%3D, PID: 7527397
    • Matsumoto K, Matsumoto K, Nakamura T, Kramer RH (1994) Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 269:31807–31813
    • (1994) J Biol Chem , vol.269 , pp. 31807-31813
    • Matsumoto, K.1    Matsumoto, K.2    Nakamura, T.3    Kramer, R.H.4
  • 61
    • 80051802020 scopus 로고    scopus 로고
    • Raf kinases in cancer-roles and therapeutic opportunities
    • COI: 1:CAS:528:DC%2BC3MXmtV2hsrk%3D, PID: 21577205
    • Maurer G, Tarkowski B, Baccarini M (2011) Raf kinases in cancer-roles and therapeutic opportunities. Oncogene 30:3477–3488
    • (2011) Oncogene , vol.30 , pp. 3477-3488
    • Maurer, G.1    Tarkowski, B.2    Baccarini, M.3
  • 62
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: a major contributor to minimal residual disease
    • COI: 1:CAS:528:DC%2BD1MXhtVWhsb%2FP, PID: 19693095
    • Meads MB, Gatenby RA, Dalton WS (2009) Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 9:665–674
    • (2009) Nat Rev Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 64
    • 78649637459 scopus 로고    scopus 로고
    • Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
    • COI: 1:CAS:528:DC%2BC3MXhtV2rtLY%3D, PID: 20628066
    • Mishra P, Banerjee D, Ben-Baruch A (2011) Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy. J Leukoc Biol 89:31–39
    • (2011) J Leukoc Biol , vol.89 , pp. 31-39
    • Mishra, P.1    Banerjee, D.2    Ben-Baruch, A.3
  • 66
    • 0025365712 scopus 로고
    • Regulation of vimentin expression in cultured human mammary epithelial cells
    • Mørk C, Deurs B van, Petersen OW (1990) Regulation of vimentin expression in cultured human mammary epithelial cells. Differentiation 43:146–156
    • (1990) Differentiation , vol.43 , pp. 146-156
    • Mørk, C.1    van, D.B.2    Petersen, O.W.3
  • 67
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes—bipolar effects of the tumour stroma in cancer
    • COI: 1:CAS:528:DC%2BD2cXptFegt78%3D, PID: 15516957
    • Mueller MM, Fusenig NE (2004) Friends or foes—bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4:839–849
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 69
    • 0030877562 scopus 로고    scopus 로고
    • Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions
    • COI: 1:CAS:528:DyaK2sXkvFKqurg%3D, PID: 9242465
    • Nakamura T, Matsumoto K, Kiritoshi A, Tano Y, Nakamura T (1997) Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res 57:3305–3313
    • (1997) Cancer Res , vol.57 , pp. 3305-3313
    • Nakamura, T.1    Matsumoto, K.2    Kiritoshi, A.3    Tano, Y.4    Nakamura, T.5
  • 71
    • 34948905351 scopus 로고    scopus 로고
    • Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
    • COI: 1:CAS:528:DC%2BD2sXhtFCnt73N, PID: 17909625
    • Nissen LJ, Cao R, Hedlund E-M, Wang Z, Zhao X, Wetterskog D, Funa K, Bråkenhielm E, Cao Y (2007) Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 117:2766–2777
    • (2007) J Clin Invest , vol.117 , pp. 2766-2777
    • Nissen, L.J.1    Cao, R.2    Hedlund, E.-M.3    Wang, Z.4    Zhao, X.5    Wetterskog, D.6    Funa, K.7    Bråkenhielm, E.8    Cao, Y.9
  • 72
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • PID: 25071162
    • Öhlund D, Elyada E, Tuveson D (2014) Fibroblast heterogeneity in the cancer wound. J Exp Med 211:1503–1523
    • (2014) J Exp Med , vol.211 , pp. 1503-1523
    • Öhlund, D.1    Elyada, E.2    Tuveson, D.3
  • 74
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • COI: 1:CAS:528:DyaK1MXmslWktbc%3D, PID: 10519415
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.Cancer Res 59:5002–5011
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 75
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • COI: 1:CAS:528:DC%2BD2MXktlSiu7w%3D, PID: 15882617
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335–348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 76
    • 84868640245 scopus 로고    scopus 로고
    • The tumor microenvironment controls drug sensitivity
    • PID: 22961158
    • Ostman A (2012) The tumor microenvironment controls drug sensitivity. Nat Med 18:1332–1334
    • (2012) Nat Med , vol.18 , pp. 1332-1334
    • Ostman, A.1
  • 78
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 133:571–573
    • (1889) Lancet , vol.133 , pp. 571-573
    • Paget, S.1
  • 79
    • 84956913971 scopus 로고    scopus 로고
    • IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
    • COI: 1:CAS:528:DC%2BC28XksVemsLo%3D, PID: 26621452
    • Pallangyo CK, Ziegler PK, Greten FR (2015) IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med 212:2253–2266
    • (2015) J Exp Med , vol.212 , pp. 2253-2266
    • Pallangyo, C.K.1    Ziegler, P.K.2    Greten, F.R.3
  • 80
    • 84875217448 scopus 로고    scopus 로고
    • Fibroblast-mediated drug resistance in cancer
    • COI: 1:CAS:528:DC%2BC3sXisVygu78%3D, PID: 23376122
    • Paraiso KHT, Smalley KSM (2013) Fibroblast-mediated drug resistance in cancer. Biochem Pharmacol 85:1033–1041
    • (2013) Biochem Pharmacol , vol.85 , pp. 1033-1041
    • Paraiso, K.H.T.1    Smalley, K.S.M.2
  • 81
    • 0033579444 scopus 로고    scopus 로고
    • Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
    • COI: 1:CAS:528:DC%2BD3cXit1Wk, PID: 10593948
    • Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ, Rettig WJ (1999) Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem 274:36505–36512
    • (1999) J Biol Chem , vol.274 , pp. 36505-36512
    • Park, J.E.1    Lenter, M.C.2    Zimmermann, R.N.3    Garin-Chesa, P.4    Old, L.J.5    Rettig, W.J.6
  • 82
    • 0015023241 scopus 로고
    • Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroblasts
    • COI: 1:CAS:528:DyaE3MXht1eit7c%3D, PID: 5276775
    • Paul D, Lipton A, Klinger I (1971) Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroblasts. Proc Natl Acad Sci U S A 68:645–648
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 645-648
    • Paul, D.1    Lipton, A.2    Klinger, I.3
  • 87
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC38Xkt1ymtbc%3D, PID: 22439937
    • Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR (2012) Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21:418–429
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 88
    • 0027302568 scopus 로고
    • Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin
    • COI: 1:CAS:528:DyaK3sXlslymsb0%3D
    • Rettig WJ, Garin-Chesa P, Healey JH, Su SL, Ozer HL, Schwab M, Albino AP, Old LJ (1993) Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin. Cancer Res 53:3327–3335
    • (1993) Cancer Res , vol.53 , pp. 3327-3335
    • Rettig, W.J.1    Garin-Chesa, P.2    Healey, J.H.3    Su, S.L.4    Ozer, H.L.5    Schwab, M.6    Albino, A.P.7    Old, L.J.8
  • 90
    • 0026560454 scopus 로고
    • TGF-β: regulation of extracellular matrix
    • COI: 1:CAS:528:DyaK38Xkt1Smtbc%3D, PID: 1573828
    • Roberts AB, McCune BK, Sporn MB (1992) TGF-β: regulation of extracellular matrix. Kidney Int 41:557–559
    • (1992) Kidney Int , vol.41 , pp. 557-559
    • Roberts, A.B.1    McCune, B.K.2    Sporn, M.B.3
  • 93
    • 0034618408 scopus 로고    scopus 로고
    • Human breast carcinoma desmoplasia is PDGF initiated
    • COI: 1:CAS:528:DC%2BD3cXmvVyqs70%3D, PID: 10980609
    • Shao ZM, Nguyen M, Barsky SH (2000) Human breast carcinoma desmoplasia is PDGF initiated. Oncogene 19:4337–4345
    • (2000) Oncogene , vol.19 , pp. 4337-4345
    • Shao, Z.M.1    Nguyen, M.2    Barsky, S.H.3
  • 94
    • 70350376721 scopus 로고    scopus 로고
    • Wound repair at a glance
    • COI: 1:CAS:528:DC%2BD1MXhtlSitLzO, PID: 19726630
    • Shaw TJ, Martin P (2009) Wound repair at a glance. J Cell Sci 122:3209–3213
    • (2009) J Cell Sci , vol.122 , pp. 3209-3213
    • Shaw, T.J.1    Martin, P.2
  • 95
    • 75849159205 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
    • COI: 1:CAS:528:DC%2BC3cXhs1Knu7o%3D, PID: 19857592
    • Shimoda M, Mellody KT, Orimo A (2010) Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol 21:19–25
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 19-25
    • Shimoda, M.1    Mellody, K.T.2    Orimo, A.3
  • 97
    • 0022404365 scopus 로고
    • A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
    • COI: 1:CAS:528:DyaL28XhsFOrtg%3D%3D, PID: 2416458
    • Shimokado K, Raines EW, Madtes DK, Barrett TB, Benditt EP, Ross R (1985) A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43:277–286
    • (1985) Cell , vol.43 , pp. 277-286
    • Shimokado, K.1    Raines, E.W.2    Madtes, D.K.3    Barrett, T.B.4    Benditt, E.P.5    Ross, R.6
  • 98
    • 0034839704 scopus 로고    scopus 로고
    • The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells
    • COI: 1:CAS:528:DC%2BD3MXmslSrsrk%3D, PID: 11688561
    • Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ (2001) The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development 128:3117–3131
    • (2001) Development , vol.128 , pp. 3117-3131
    • Simian, M.1    Hirai, Y.2    Navre, M.3    Werb, Z.4    Lochter, A.5    Bissell, M.J.6
  • 102
    • 0034112481 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    • COI: 1:CAS:528:DC%2BD3cXjtVOrtLw%3D, PID: 10760088
    • Strutz F, Zeisberg M, Hemmerlein B, Sattler B, Hummel K, Becker V, Müller GA (2000) Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 57:1521–1538
    • (2000) Kidney Int , vol.57 , pp. 1521-1538
    • Strutz, F.1    Zeisberg, M.2    Hemmerlein, B.3    Sattler, B.4    Hummel, K.5    Becker, V.6    Müller, G.A.7
  • 103
    • 33846967113 scopus 로고    scopus 로고
    • Identification of fibroblast heterogeneity in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BD2sXksVyru7c%3D, PID: 17106243
    • Sugimoto H, Mundel TM, Kieran MW, Kalluri R (2006) Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther 5:1640–1646
    • (2006) Cancer Biol Ther , vol.5 , pp. 1640-1646
    • Sugimoto, H.1    Mundel, T.M.2    Kieran, M.W.3    Kalluri, R.4
  • 104
    • 84887188959 scopus 로고    scopus 로고
    • Microenvironment and tumor cell plasticity: an easy way out
    • COI: 1:CAS:528:DC%2BC3sXis1OntL0%3D, PID: 23376253
    • Taddei ML, Giannoni E, Comito G, Chiarugi P (2013) Microenvironment and tumor cell plasticity: an easy way out. Cancer Lett 341:80–96
    • (2013) Cancer Lett , vol.341 , pp. 80-96
    • Taddei, M.L.1    Giannoni, E.2    Comito, G.3    Chiarugi, P.4
  • 105
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • COI: 1:CAS:528:DC%2BD38Xksl2ltr8%3D, PID: 12189386
    • Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442–454
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 106
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery JP, Acloque H, Huang RYJ, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139:871–890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 107
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechano-regulation of connective tissue remodelling
    • COI: 1:CAS:528:DC%2BD38XjsFOgsbw%3D, PID: 11988769
    • Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349–363
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 349-363
    • Tomasek, J.J.1    Gabbiani, G.2    Hinz, B.3    Chaponnier, C.4    Brown, R.A.5
  • 110
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • Visser KE de, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24–37
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
  • 111
    • 0030942009 scopus 로고    scopus 로고
    • Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan
    • COI: 1:CAS:528:DyaK2sXjtVKhsr0%3D, PID: 9099966
    • Vukovic V, Tannock IF (1997) Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan. Br J Cancer 75:1167–1172
    • (1997) Br J Cancer , vol.75 , pp. 1167-1172
    • Vukovic, V.1    Tannock, I.F.2
  • 112
    • 70350721786 scopus 로고    scopus 로고
    • Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    • COI: 1:CAS:528:DC%2BD1MXhtlCjsrbL, PID: 19843665
    • Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S (2009) Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res 15:6630–6638
    • (2009) Clin Cancer Res , vol.15 , pp. 6630-6638
    • Wang, W.1    Li, Q.2    Yamada, T.3    Matsumoto, K.4    Matsumoto, I.5    Oda, M.6    Watanabe, G.7    Kayano, Y.8    Nishioka, Y.9    Sone, S.10    Yano, S.11
  • 113
    • 0037365537 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species
    • COI: 1:CAS:528:DC%2BD3sXitFaqurY%3D, PID: 12514119
    • Wartenberg M, Ling FC, Müschen M, Klein F, Acker H, Gassmann M, Petrat K, Pütz V, Hescheler J, Sauer H (2003) Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J 17:503–505
    • (2003) FASEB J , vol.17 , pp. 503-505
    • Wartenberg, M.1    Ling, F.C.2    Müschen, M.3    Klein, F.4    Acker, H.5    Gassmann, M.6    Petrat, K.7    Pütz, V.8    Hescheler, J.9    Sauer, H.10
  • 115
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • COI: 1:CAS:528:DC%2BC3MXmsVGmtbk%3D, PID: 21606941
    • Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393–410
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 117
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • COI: 1:CAS:528:DC%2BD38Xjslahtbs%3D, PID: 12004111
    • Wiseman BS, Werb Z (2002) Stromal effects on mammary gland development and breast cancer. Science 296:1046–1049
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 118
    • 34547569807 scopus 로고    scopus 로고
    • Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    • COI: 1:CAS:528:DC%2BD2sXosVSltLs%3D, PID: 17618273
    • Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P (2007) Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol 9:893–904
    • (2007) Nat Cell Biol , vol.9 , pp. 893-904
    • Wolf, K.1    Wu, Y.I.2    Liu, Y.3    Geiger, J.4    Tam, E.5    Overall, C.6    Stack, M.S.7    Friedl, P.8
  • 119
    • 84878455562 scopus 로고    scopus 로고
    • Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer
    • COI: 1:CAS:528:DC%2BC3sXjsFOqtro%3D, PID: 23402812
    • Wu X, Chen X, Zhou Q, Li P, Yu B, Li J, Qu Y, Yan J, Yu Y, Yan M, Zhu Z, Liu B, Su L (2013) Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer. Cancer Lett 335:128–135
    • (2013) Cancer Lett , vol.335 , pp. 128-135
    • Wu, X.1    Chen, X.2    Zhou, Q.3    Li, P.4    Yu, B.5    Li, J.6    Qu, Y.7    Yan, J.8    Yu, Y.9    Yan, M.10    Zhu, Z.11    Liu, B.12    Su, L.13
  • 122
    • 84961230948 scopus 로고    scopus 로고
    • The integrin–collagen connection—a glue for tissue repair?
    • COI: 1:CAS:528:DC%2BC28XhtlGqu7vK, PID: 27442113
    • Zeltz C, Gullberg D (2016) The integrin–collagen connection—a glue for tissue repair? J Cell Sci 129:1284–1284
    • (2016) J Cell Sci , vol.129 , pp. 1284
    • Zeltz, C.1    Gullberg, D.2


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