Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

Kidney International

Volumn 57, Issue 4, 2000, Pages 1521-1538

  Strutz, Frank ^a,b   Zeisberg, Michael ^a,b   Hemmerlein, Bernhard ^a,b   Sattler, Burkhard ^a,b   Hummel, Klaus ^a,b   Becker, Volker ^a,b   Müller, Gerhard A ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cell proliferation; FGF 2; Fibrosis; Interstitial fibroblast; Kidney

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR;

AUTOCRINE EFFECT; CELL CULTURE; CELL PROLIFERATION; CONFERENCE PAPER; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034112481     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00997.x     Document Type: Conference Paper

References (69)

1. 1. EDDY AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7:2495-2508, 1996
2. 2. ADZICK NS, LORENZ HP: Cells, matrix, growth factors and the surgeon: The biology of scarless fetal wound repair. Ann Surg 220:10-18, 1994
3. 3. WHITBY DJ, FERGUSON MWJ: The extracellular matrix of lip wounds in fetal, neonatal, and adult mice. Development 112:651-668, 1991
4. 4. WHITBY DJ, FERGUSON MWJ: Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 147:207-215, 1991
5. 5. EL NAHAS AM, MUCHANETA-KUBARA EC, ESSAWY M, SOYLEMEZOGLU O: Renal fibrosis: Insights into pathogenesis and treatment. Int J Biochem Cell Biol 29:55-62, 1997
6. 6. BOHLE A, MÜLLER GA, WEHRMANN M, MACKENSEN-HAFN S, XIAO JC: The pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies, and chronic interstitial nephritides. Kidney Int 49(Suppl 54):S2-S9, 1996
7. 7. KNECHT A, FINE LG, KLEINMAN KS, RODEMANN HP, MÜLLER GA, WOO DDL, NORMAN JT: Fibroblasts of rabbit kidney in culture. II. Paracrine stimulation of papillary fibroblasts by PDGF. Am J Physiol 261:F292-F299, 1991
8. 8. TANG WW, ULICH TR, LACEY DL, HILL DC, QI M, KAUFMAN SA, YEE J: Platelet derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol 148:1169-1180, 1996
9. 9. SPORN MB, ROBERTS AB: Transforming growth factor-β: Recent progress and new challenges. J Cell Biol 119:1017-1021, 1992
10. 10. BORDER WA, NOBLE NA: Mechanisms of disease: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
11. 11. FRIESEL RE, MACIAG T: Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction. FASEB J 9:919-925, 1995
12. 12. SHINOZAKI M, KAWARA S, HAYASHI N, KAKINUMA T, IGARASHI A, TAKEHARA K: Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor β: Simultaneous application with basic fibroblast growth factor causes persistent fibrosis. Biochem Biophys Res Commun 237:292-296, 1997
13. 13. BAIRD A, ESCH F, BÖHLEN P, LING N, GOSPODAROWICZ D: Isolation and partial characterization of an endothelial cell growth factor from the bovine kidney: Homology with basic fibroblast growth factor. Regul Pept 12:201-213, 1985
14. 14. FLOEGE J, ENG E, LINDNER V, YOUNG BA, REIDY MA, JOHNSON RJ: Rat glomerular mesangial cells synthesize basic fibroblast growth factor: Release, upregulated synthesis, and mitogenecity in mesangial proliferative glomerulonephritis. J Clin Invest 90:2362-2369, 1992
15. 15. TAKEUCHI A, YOSHIZAWA N, YAMAMOTO M, SAWASAKI Y, ODA T, SENOO A, NIWA H, FUSE Y: Basic fibroblast growth factor promotes proliferation of rat glomerular visceral epithelial cells in vitro. Am J Pathol 141:107-116, 1992
16. 16. HUGHES SE, HALL PA: Immunolocalization of fibroblast growth factor receptor 1 and its ligands in human tissues. Lab Invest 69:173-182, 1993
17. 17. CAUCHI J, ALCORN D, CANCILLA B, KEY B, BERKA JL, NURCUMBE V, RYYAN GB, BERTRAM JF: Light-microscopic immunolocalization of fibroblast growth factor-1 and -2 in adult rat kidney. Cell Tissue Res 285:179-187, 1996
18. 18. FLOEGE J, HUDKINS KL, EITNER F, CUI Y, MORRISON RS, SCHELLING MA, ALPERS CE: Localization of fibroblast growth factor-2 (basic FGF) and FGF receptor-1 in adult human kidney. Kidney Int 56:883-897, 1999
19. 19. SILVER BJ, JAFFER FE, ABBOUD HE: Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Proc Natl Acad Sci USA 86:1056-1060, 1988
20. 20. KANDA S, NOMATA K, SAHA PK, NISHIMURA N, YAMADA J, KANATAKE H, SAITO Y: Growth factor regulation of renal cortical tubular cells by epidermal growth factor, insulin-like growth factor-1, acidic and basic fibroblast growth factor, and transforming growth factor-β. Cell Biol Int Rep 13:687-699, 1989
21. 21. BALLERMANN BJ: Regulation of bovine glomerular endothelial cell growth in vitro. Am J Physiol 256:C182-C189, 1989
22. 22. FLOEGE J, ENG E, YOUNG BA, ALPERS CE, BARRETT TB, BOWEN-POPE DF, JOHNSON RJ: Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. J Clin Invest 92:2952-2962, 1993
23. 23. FLOEGE J, KRIZ W, SCHULZE M, SUSANI M, KERJASCHKI D, MOONEY A, COUSER WG, KOCH KM: Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy. J Clin Invest 96:2809-2819, 1995
24. 24. KRIZ W, HÄHNEL B, RÖSENER S, ELGER M: Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis. Kidney Int 48:1435-1450, 1995
25. 25. RAY PE, BRUGGEMAN LA, WEEKS BS, KOPP JB, BRYANT JL, OWENS JW, NOTKINS AL, KLOTMAN PE: bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. Kidney Int 46:759-772, 1994
26. 26. MÜLLER GA, FRANK J, RODEMANN HP, ENGLER-BLUM G: Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to investigate pathophysiologic mechanisms of renal interstitial fibrosis. Exp Nephrol 3:127-133, 1995
27. 27. STRUTZ F, OKADA H, LO CW, DANOFF T, CARONE B, TOMASZEWSKI J, NEILSON EG: Identification and characterization of fibroblast-specific protein 1 (FSP1). J Cell Biol 130:393-405, 1995
28. 32P-based hybridizations. Anal Biochem 210:235-244, 1993
29. 29. BOHLE A, GRUND KE, MACKENSEN S, TOLON M: Correlations between renal interstitium and level of serum creatinine: Morphometric investigations of biopsies in perimembranous glomerulonephritis. Virchows Arch A Pathol Anat Histol 373:15-22, 1977
30. 30. ALBERT SE, STRUTZ F, SHELTON K, HAVERTY T, SUN MJ, LI S, DENHAM A, MAKI RA, NEILSON EG: Characterization of a cis-acting regulatory element which silences expression of the class II-A β gene in epithelium. J Exp Med 180:233-240, 1994
31. 31. DIJKMAN HB, MENTZEL S, DE JONG AS, ASSMANN KJ: RNA in situ hybridization using digoxigenin labeled cRNA probes. Biochemica 2:21-25, 1995
32. 32. GRATZNER HG: Monoclonal antibody to 5-bromo-and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science 218:474-475, 1982
33. 33. JACOI TA, STRIKER GE, STETLER-STEVENSON M, STRIKER LJ: Mesangial cells from transgenic mice with progressive glomerulosclerosis exhibit stable, phenotypic changes including undetectable MMP-9 and increased type IV collagen. Lab Invest 75:791-799, 1996
34. 34. KRICKA LJ: Labels, labeling, analytical strategies, and applications, in Nonisotopic Probing, Blotting, and Sequencing, edited by KRICKA LJ, San Diego, New York, Boston, London, Sydney, Tokyo, Toronto, Academic Press, 1995, pp 3-40
35. 35. FLORKIEWICZ RZ, SOMMER A: Human basic fibroblast growth factor gene encodes four polypeptides: Three initiate translation from non-AUG codons. Proc Natl Acad Sci USA 86:3978-3981, 1989
36. 36. CLAYTON A, STEADMAN R, WILLIAMS JD: Cells isolated from the human cortical interstitium resemble myofibroblasts and bind neutrophils in an ICAM-1-dependent manner. J Am Soc Nephrol 8:604-615, 1997
37. 37. ALPERS CE, HUDKINS KL, FLOEGE J, JOHNSON RJ: Human renal cortical interstitial cells with some features of smooth muscle cells participate in tubulointerstitial and crescentic glomerular injury. J Am Soc Nephrol 5:201-210, 1994
38. 38. NATH KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20:1-17, 1992
39. 39. PALMER BF: The renal tubule in the progression of chronic renal failure. J Invest Med 45:346-361, 1997
40. 40. FOGO AB, KON V: Pathophysiology of progressive renal disease, in Immunologic Renal Diseases, edited by NEILSON EG, COUSER WG, Philadelphia, Lippincott-Raven, 1997, pp 683-704
41. 41. LONNEMANN G, SHAPIRO L, ENGLER-BLUM G, MÜLLER GA, KOCH KM, DINARELLO CA: Cytokines in human renal interstitial fibrosis. I. IL-1 is an autocrine growth factor for cultured fibrosis-derived kidney fibroblasts. Kidney Int 47:837-844, 1995
42. 42. PHILLIPS AO, TOPLEY N, MORRISEY K, WILLIAMS JD, STEADMAN R: Basic fibroblast growth factor stimulates the release of preformed transforming growth factor β1 from human proximal tubular cells in the absence of de novo gene transcription or mRNA translation. Lab Invest 76:591-600, 1997
43. 43. ANDERSON RJ, RAY CJ: Potential autocrine and paracrine mechanisms of recovery from mechanical injury of renal tubular epithelial cells. Am J Physiol 274:F463-F472, 1998
44. 44. MASON IJ: The ins and outs of fibroblast growth factors. Cell 78:547-552, 1994
45. 45. GONZALEZ A-M, BUSCAGLIA M, FOX R, ISACCHI A, SARMIENTOS P, FARRIS J, ONG M, MARTINEAU D, LAPPI DA, BAIRD A: Basic fibroblast growth factor in Dupuytren's contracture. Am J Pathol 141:661-671, 1992
46. 46. CHARLOTTE F, WIN KM, PRÉAUX AM, DHUMEAUX D, ZAFRANI ES, MAVIER P: Immunolocalization of heparin-binding growth factors (HBGF) types 1 and 2 in rat liver: Selective hyperexpression of HBGF-2 in carbon tetrachloride-induced fibrosis. J Pathol 169:471-476, 1993
47. 47. ORTEGA S, ITTMANN M, TSANG SH, EHRLICH M, BASILICO C: Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci USA 95:5672-5677, 1998
48. 48. MUTHUKRISHNAN L, WARDER E, MCNEIL, PL: Basic fibroblast growth factor is efficiently released from a cytosolic storage site through plasma membrane disruptions of endothelial cells. J Cell Physiol 148:1-16, 1991
49. 49. MIGNATTI P, MORIMOTO T, RIFKIN DB: Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner. Proc Natl Acad Sci USA 88:11007-11011, 1991
50. 50. NADASDY T, LASZIK Z, BLICK KE, JOHNSON DL, SILVA FG: Tubular atrophy in the end-stage kidney: A lectin and immunohistochemical study. Hum Pathol 25:22-28, 1994
51. 51. THOMAS GL, YANG B, WAGNER BE, SAVILL J, ELNAHAS AM: Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol Dial Transplant 13:2216-2226, 1998
52. 52. NG YY, HUANG TP, YANG WC, CHEN ZP, YANG AH, MU W, NIKOLIC-PATERSON DJ, ATKINS RC, LAN HY: Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54:864-876, 1998
53. 53. SCHWEIGERER L, NEUFELD G, FRIEDMAN J, ABRAHAM JA, FIDDES JC, GOSPODAROWICZ D: Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325:257-259, 1987
54. 54. DAVIS MG, ZHOU M, ALI S, COFFIN JD, DOETSCHMAN T, DORN GW: Intracrine and autocrine effects of basic fibroblast growth factor in vascular smooth muscle cells. J Mol Cell Cardiol 29:1061-1072, 1997
55. 55. YAYON A, KLAGSBRUN M, ESKO JD, LEDER P, ORNITZ DM: Cell surface heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptors. Cell 64:841-848, 1991
56. 56. FORD MD, CAUCHI J, GREFERATH U, BERTRAM JF: Expression of fibroblast growth factors and their receptors in rat glomeruli. Kidney Int 51:1729-1738, 1997
57. 57. KIN M, SATA M, UENO T, TORIMURA T, INUZUKA S, TSUJI R, SUJAKU K, SAKAMOTO M, SUGAWARA H, TAMAKI S, TANIKAWA K: Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism. J Hepatol 27:677-687, 1997
58. 58. RIECK P, OLIVER L, ENGELMANN K, FUHRMANN G, HARTMANN C, COURTOIS Y: The role of exogenous/endogenous basic fibroblast growth factor (FGF2) and transforming growth factor β (TGFβ-1) on human corneal endothelial cells proliferation in vitro. Exp Cell Res 220:36-46, 1995
59. 59. WANG Y, RAO U, MASCARI R, RICHARDS TJ, PANSON AJ, EDINGTON HD, SHIPE-SPOTLOE JM, DONNELLY SS, KIRKWOOD JM, BECKER D: Molecular analysis of melanoma precursor cells. Cell Growth Differ 7:1733-1740, 1996
60. 60. BARRACLOUGH R, FERNIG DG, RUDLAND PS, SMITH JA: Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture. J Cell Physiol 144:333-344, 1990
61. 61. ROSENBAUM J, BLAZEJEWSKI S, PREAUX A-M, MALLAT A, DHUMEAUX D, MAVIER P: Fibroblast growth factor 2 and transforming growth factor β1 interactions in human liver fibroblasts. Gastroenterology 109:1986-1996, 1995
62. 62. MÜLLER GA, STRUTZ F: Renal fibroblast heterogeneity. Kidney Int 48(Suppl 50):S33-S36, 1995
63. 63. STEIN-OAKLEY AN, MAGUIRE JA, DOWLING J, PERRY G, THOMSON NM: Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis. Kidney Int 51:195-204, 1997
64. 64. AVIEZER D, HECHT D, SAFRAN M, EISINGER M, DAVID G, YAYON A: Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis and angiogenesis. Cell 79:1005-1013, 1994
65. 65. MORITA H, SHINZATO T, DAVID G, MIZUTANI A, HABUCHI H, FUJITA Y, ITO M, ASAI J, MAEDA K, KIMATA K: Basic fibroblast growth factor-binding domain of heparan sulfate in the human glomerulosclerosis and renal tubulointerstitial fibrosis. Lab Invest 71:528-535, 1994
66. 66. TAN EML, ROUDA S, GREENBAUM SS, MOORE JH, FOX JW, SOLLBERG S: Acidic and basic fibroblast growth factors down-regulate collagen gene expression in keloid fibroblasts. Am J Pathol 142: 463-470, 1993
67. 67. DIAMOND JR, VANGOOR H, DING G, ENGELMYER E: Myofibroblasts in experimental hydronephrosis. Am J Pathol 146:121-129, 1995
68. 68. ZHANG K, REKTER MD, GORDON D, PHAN SH: Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. Am J Pathol 145:114-125, 1994
69. 69. STRUTZ F, MÜLLER GA: Interstitial pathomechanisms underlying progressive tubulointerstitial damage. Kidney Blood Press Res 22:67-75, 1999