Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

EMBO Reports

Volumn 16, Issue 10, 2015, Pages 1394-1408

  Madsen, Chris D ^a,b   Pedersen, Jesper T ^b   Venning, Freja A ^b   Singh, Lukram Babloo ^b   Moeendarbary, Emad ^c   Charras, Guillaume ^d   Cox, Thomas R ^b   Sahai, Erik ^a   Erler, Janine T ^b  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

cancer associated fibroblasts; hypoxia; PHD2; tumour invasion and metastasis; tumour stiffness

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYOSIN II; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; DICARBOXYLIC AMINO ACID; EGLN1 PROTEIN, HUMAN; EGLN1 PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; OXALYLGLYCINE; POSTN PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER ASSOCIATED FIBROBLAST; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; HYPOXIA; LIVER METASTASIS; LUNG METASTASIS; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TUMOR MICROENVIRONMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST; CELL HYPOXIA; CELL MOTION; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; GENETICS; METABOLISM; METASTASIS; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STROMA CELL; TUMOR CELL CULTURE; TUMOR INVASION;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; BREAST; CELL ADHESION MOLECULES; CELL HYPOXIA; CELL MOVEMENT; FEMALE; FIBROBLASTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MYOSIN TYPE II; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; ORGAN CULTURE TECHNIQUES; STROMAL CELLS; TUMOR CELLS, CULTURED;

EID: 84942825573     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201540107     Document Type: Article

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