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Volumn 7, Issue , 2016, Pages

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; WNT7A PROTEIN; WNT PROTEIN; WNT7A PROTEIN, MOUSE;

EID: 84954525154     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10305     Document Type: Article
Times cited : (126)

References (58)
  • 1
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De Wever, O., Demetter, P., Mareel, M. & Bracke, M. Stromal myofibroblasts are drivers of invasive cancer growth. Int. J. Cancer 123, 2229-2238 (2008).
    • (2008) Int. J. Cancer , vol.123 , pp. 2229-2238
    • De Wever, O.1    Demetter, P.2    Mareel, M.3    Bracke, M.4
  • 3
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumour stroma
    • Pietras, K. & Ostman, A. Hallmarks of cancer: interactions with the tumour stroma. Exp. Cell Res. 316, 1324-1331 (2010).
    • (2010) Exp. Cell Res. , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 4
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: An old hypothesis revisited
    • Schafer, M. & Werner, S. Cancer as an overhealing wound: an old hypothesis revisited. Nat. Rev. Mol. Cell Biol. 9, 628-638 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 5
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumour cells: A diabolic liaison driving cancer progression
    • Cirri, P. & Chiarugi, P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 31, 195-208 (2012).
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 6
    • 0031216358 scopus 로고    scopus 로고
    • Prognostic value of desmoplastic reaction and lymphocytic infiltration in the management of breast cancer
    • Cardone, A., Tolino, A., Zarcone, R., Borruto Caracciolo, G. & Tartaglia, E. Prognostic value of desmoplastic reaction and lymphocytic infiltration in the management of breast cancer. Panminerva Med. 39, 174-177 (1997).
    • (1997) Panminerva Med. , vol.39 , pp. 174-177
    • Cardone, A.1    Tolino, A.2    Zarcone, R.3    Borruto Caracciolo, G.4    Tartaglia, E.5
  • 7
    • 84875217448 scopus 로고    scopus 로고
    • Fibroblast-mediated drug resistance in cancer
    • Paraiso, K. H. & Smalley, K. S. Fibroblast-mediated drug resistance in cancer. Biochem. Pharmacol. 85, 1033-1041 (2013).
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1033-1041
    • Paraiso, K.H.1    Smalley, K.S.2
  • 8
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • Ohlund, D., Elyada, E. & Tuveson, D. Fibroblast heterogeneity in the cancer wound. J. Exp. Med. 211, 1503-1523 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1503-1523
    • Ohlund, D.1    Elyada, E.2    Tuveson, D.3
  • 9
    • 33846967113 scopus 로고    scopus 로고
    • Identification of fibroblast heterogeneity in the tumour microenvironment
    • Sugimoto, H., Mundel, T. M., Kieran, M. W. & Kalluri, R. Identification of fibroblast heterogeneity in the tumour microenvironment. Cancer Biol. Ther. 5, 1640-1646 (2006).
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 1640-1646
    • Sugimoto, H.1    Mundel, T.M.2    Kieran, M.W.3    Kalluri, R.4
  • 10
    • 67649975270 scopus 로고    scopus 로고
    • Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
    • Paulsson, J. et al. Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am. J. Pathol. 175, 334-341 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 334-341
    • Paulsson, J.1
  • 11
    • 84863724126 scopus 로고    scopus 로고
    • Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts
    • Simpkins, S. A., Hanby, A. M., Holliday, D. L. & Speirs, V. Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts. J. Pathol. 227, 490-498 (2012).
    • (2012) J. Pathol. , vol.227 , pp. 490-498
    • Simpkins, S.A.1    Hanby, A.M.2    Holliday, D.L.3    Speirs, V.4
  • 12
    • 84866703356 scopus 로고    scopus 로고
    • Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer
    • Busch, S., Ryden, L., Stal, O., Jirstrom, K. & Landberg, G. Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer. PLoS ONE 7, e45669 (2012).
    • (2012) PLoS ONE , vol.7
    • Busch, S.1    Ryden, L.2    Stal, O.3    Jirstrom, K.4    Landberg, G.5
  • 13
    • 0025758605 scopus 로고
    • Inhibition of lung colonization at two different steps in the metastatic sequence
    • Aslakson, C. J., McEachern, D., Conaway, D. H. & Miller, F. R. Inhibition of lung colonization at two different steps in the metastatic sequence. Clin. Exp. Metastasis 9, 139-150 (1991).
    • (1991) Clin. Exp. Metastasis , vol.9 , pp. 139-150
    • Aslakson, C.J.1    McEachern, D.2    Conaway, D.H.3    Miller, F.R.4
  • 14
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumour
    • Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumour. Cancer Res. 52, 1399-1405 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 15
    • 0020614390 scopus 로고
    • Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumour: Heterogeneity in phenotypic stability
    • Miller, F. R., Miller, B. E. & Heppner, G. H. Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumour: heterogeneity in phenotypic stability. Invasion Metastasis 3, 22-31 (1983).
    • (1983) Invasion Metastasis , vol.3 , pp. 22-31
    • Miller, F.R.1    Miller, B.E.2    Heppner, G.H.3
  • 16
    • 20944451492 scopus 로고    scopus 로고
    • Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium
    • MacFadyen, J. R. et al. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 579, 2569-2575 (2005).
    • (2005) FEBS Lett. , vol.579 , pp. 2569-2575
    • MacFadyen, J.R.1
  • 17
    • 39749092272 scopus 로고    scopus 로고
    • Endosialin (CD248) is a marker of tumour-associated pericytes in high-grade glioma
    • Simonavicius, N. et al. Endosialin (CD248) is a marker of tumour-associated pericytes in high-grade glioma. Mod. Pathol. 21, 308-315 (2008).
    • (2008) Mod. Pathol. , vol.21 , pp. 308-315
    • Simonavicius, N.1
  • 18
    • 10944232632 scopus 로고    scopus 로고
    • Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation
    • Untergasser, G. et al. Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation. Mech. Ageing Dev. 126, 59-69 (2005).
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 59-69
    • Untergasser, G.1
  • 19
    • 84891748444 scopus 로고    scopus 로고
    • Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts
    • Hawinkels, L. J. et al. Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts. Oncogene 33, 97-107 (2012).
    • (2012) Oncogene , vol.33 , pp. 97-107
    • Hawinkels, L.J.1
  • 20
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumour-promoting mammary stromal myofibroblasts
    • Kojima, Y. et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumour-promoting mammary stromal myofibroblasts. Proc. Natl Acad. Sci. USA 107, 20009-20014 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20009-20014
    • Kojima, Y.1
  • 21
    • 0024278715 scopus 로고
    • Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells
    • Van Obberghen-Schilling, E., Roche, N. S., Flanders, K. C., Sporn, M. B. & Roberts, A. B. Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J. Biol. Chem. 263, 7741-7746 (1988).
    • (1988) J. Biol. Chem. , vol.263 , pp. 7741-7746
    • Van Obberghen-Schilling, E.1    Roche, N.S.2    Flanders, K.C.3    Sporn, M.B.4    Roberts, A.B.5
  • 22
    • 84878615570 scopus 로고    scopus 로고
    • Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
    • Calvo, F. et al. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat. Cell Biol. 15, 637-646 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 637-646
    • Calvo, F.1
  • 23
    • 0031454063 scopus 로고    scopus 로고
    • Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants
    • Cygan, J. A., Johnson, R. L. & McMahon, A. P. Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124, 5021-5032 (1997).
    • (1997) Development , vol.124 , pp. 5021-5032
    • Cygan, J.A.1    Johnson, R.L.2    McMahon, A.P.3
  • 24
    • 0034598921 scopus 로고    scopus 로고
    • Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling
    • Hall, A. C., Lucas, F. R. & Salinas, P. C. Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100, 525-535 (2000).
    • (2000) Cell , vol.100 , pp. 525-535
    • Hall, A.C.1    Lucas, F.R.2    Salinas, P.C.3
  • 25
    • 0028951117 scopus 로고
    • Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb
    • Parr, B. A. & McMahon, A. P. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353 (1995).
    • (1995) Nature , vol.374 , pp. 350-353
    • Parr, B.A.1    McMahon, A.P.2
  • 26
    • 84867198093 scopus 로고    scopus 로고
    • Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury
    • Miyoshi, H., Ajima, R., Luo, C. T., Yamaguchi, T. P. & Stappenbeck, T. S. Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science 338, 108-113 (2012).
    • (2012) Science , vol.338 , pp. 108-113
    • Miyoshi, H.1    Ajima, R.2    Luo, C.T.3    Yamaguchi, T.P.4    Stappenbeck, T.S.5
  • 27
    • 84872009392 scopus 로고    scopus 로고
    • Fibronectin regulates wnt7a signaling and satellite cell expansion
    • Bentzinger, C. F. et al. Fibronectin regulates wnt7a signaling and satellite cell expansion. Cell Stem Cell 12, 75-87 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 75-87
    • Bentzinger, C.F.1
  • 28
    • 84870356419 scopus 로고    scopus 로고
    • Symmetric expansion of neural stem cells from the adult olfactory bulb is driven by astrocytes via WNT7A
    • Moreno-Estelles, M. et al. Symmetric expansion of neural stem cells from the adult olfactory bulb is driven by astrocytes via WNT7A. Stem Cells 30, 2796-2809 (2012).
    • (2012) Stem Cells , vol.30 , pp. 2796-2809
    • Moreno-Estelles, M.1
  • 29
    • 50349095325 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells
    • Carmon, K. S. & Loose, D. S. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol. Cancer Res. 6, 1017-1028 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1017-1028
    • Carmon, K.S.1    Loose, D.S.2
  • 30
    • 84858605181 scopus 로고    scopus 로고
    • WNT7A regulates tumour growth and progression in ovarian cancer through the WNT/beta-catenin pathway
    • Yoshioka, S. et al. WNT7A regulates tumour growth and progression in ovarian cancer through the WNT/beta-catenin pathway. Mol. Cancer Res. 10, 469-482 (2012).
    • (2012) Mol. Cancer Res. , vol.10 , pp. 469-482
    • Yoshioka, S.1
  • 31
    • 20444417412 scopus 로고    scopus 로고
    • Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing
    • Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280, 21653-21660 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 21653-21660
    • Lyu, J.1    Joo, C.K.2
  • 32
    • 66049092616 scopus 로고    scopus 로고
    • Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells
    • Le Grand, F., Jones, A. E., Seale, V., Scime, A. & Rudnicki, M. A. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4, 535-547 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 535-547
    • Le Grand, F.1    Jones, A.E.2    Seale, V.3    Scime, A.4    Rudnicki, M.A.5
  • 33
    • 79960614699 scopus 로고    scopus 로고
    • Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II
    • Ciani, L. et al. Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II. Proc. Natl Acad. Sci. USA 108, 10732-10737 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 10732-10737
    • Ciani, L.1
  • 35
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere, A., Geinoz, A., Gabbiani, F. & Gabbiani, G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122, 103-111 (1993).
    • (1993) J. Cell Biol. , vol.122 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 36
    • 1642334157 scopus 로고    scopus 로고
    • Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
    • Lewis, M. P. et al. Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br. J. Cancer 90, 822-832 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 822-832
    • Lewis, M.P.1
  • 37
    • 20144386127 scopus 로고    scopus 로고
    • Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    • Chang, H. Y. et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA 102, 3738-3743 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3738-3743
    • Chang, H.Y.1
  • 38
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
    • Calon, A. et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell 22, 571-584 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1
  • 39
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak, G. et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat. Med. 14, 518-527 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 518-527
    • Finak, G.1
  • 40
    • 19944432209 scopus 로고    scopus 로고
    • Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix
    • Eckhardt, B. L. et al. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol. Cancer Res. 3, 1-13 (2005).
    • (2005) Mol. Cancer Res. , vol.3 , pp. 1-13
    • Eckhardt, B.L.1
  • 41
    • 54549108997 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis
    • Lou, Y. et al. Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Dev. Dyn. 237, 2755-2768 (2008).
    • (2008) Dev. Dyn. , vol.237 , pp. 2755-2768
    • Lou, Y.1
  • 42
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumour metastasis
    • Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumour metastasis. Cell 117, 927-939 (2004).
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1
  • 43
    • 84880055491 scopus 로고    scopus 로고
    • Signal integration in TGF-beta, WNT, and Hippo pathways
    • Attisano, L. & Wrana, J. L. Signal integration in TGF-beta, WNT, and Hippo pathways. F1000prime Rep. 5, 17 (2013).
    • (2013) F1000prime Rep. , vol.5 , pp. 17
    • Attisano, L.1    Wrana, J.L.2
  • 44
    • 1242276498 scopus 로고    scopus 로고
    • TGFbeta and Wnt pathway cross-talk
    • Attisano, L. & Labbe, E. TGFbeta and Wnt pathway cross-talk. Cancer Metastasis Rev. 23, 53-61 (2004).
    • (2004) Cancer Metastasis Rev. , vol.23 , pp. 53-61
    • Attisano, L.1    Labbe, E.2
  • 45
    • 84875705913 scopus 로고    scopus 로고
    • Noncanonical WNT-5A signaling regulates TGF-beta-induced extracellular matrix production by airway smooth muscle cells
    • Kumawat, K. et al. Noncanonical WNT-5A signaling regulates TGF-beta-induced extracellular matrix production by airway smooth muscle cells. FASEB J. 27, 1631-1643 (2013).
    • (2013) FASEB J. , vol.27 , pp. 1631-1643
    • Kumawat, K.1
  • 46
    • 84859179083 scopus 로고    scopus 로고
    • Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis
    • Akhmetshina, A. et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat. Commun. 3, 735 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 735
    • Akhmetshina, A.1
  • 47
    • 84875501588 scopus 로고    scopus 로고
    • Counteracting stem cell expansion during wound repair: Distinct roles of non-canonical Wnt and TGF-beta
    • Miyoshi, H. & Stappenbeck, T. S. Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-beta. Cell Cycle 12, 387-388 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 387-388
    • Miyoshi, H.1    Stappenbeck, T.S.2
  • 48
    • 58249090579 scopus 로고    scopus 로고
    • Focus issue: An expanding world for TGF-beta signaling
    • Gough, N. R. Focus issue: an expanding world for TGF-beta signaling. Sci. Signal. 1, eg8 (2008).
    • (2008) Sci. Signal , vol.1 , pp. eg8
    • Gough, N.R.1
  • 49
    • 84872867267 scopus 로고    scopus 로고
    • LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
    • Ren, S. et al. LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc. Natl Acad. Sci. USA 110, 1440-1445 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1440-1445
    • Ren, S.1
  • 50
    • 0035861669 scopus 로고    scopus 로고
    • Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
    • Ishiguro, K. et al. Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. J. Biol. Chem. 276, 47483-47488 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 47483-47488
    • Ishiguro, K.1
  • 51
    • 33751502517 scopus 로고    scopus 로고
    • Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development
    • MacFadyen, J., Savage, K., Wienke, D. & Isacke, C. M. Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr. Patterns 7, 363-369 (2007).
    • (2007) Gene Expr. Patterns , vol.7 , pp. 363-369
    • MacFadyen, J.1    Savage, K.2    Wienke, D.3    Isacke, C.M.4
  • 52
    • 0035894949 scopus 로고    scopus 로고
    • Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo
    • Schaefer, B. C., Schaefer, M. L., Kappler, J. W., Marrack, P. & Kedl, R. M. Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol. 214, 110-122 (2001).
    • (2001) Cell Immunol. , vol.214 , pp. 110-122
    • Schaefer, B.C.1    Schaefer, M.L.2    Kappler, J.W.3    Marrack, P.4    Kedl, R.M.5
  • 53
    • 22344436842 scopus 로고    scopus 로고
    • Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
    • Curino, A. C. et al. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J. Cell Biol. 169, 977-985 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 977-985
    • Curino, A.C.1
  • 54
    • 0025284820 scopus 로고
    • P180, a novel recycling transmembrane glycoprotein with restricted cell type expression
    • Isacke, C. M., van der Geer, P., Hunter, T. & Trowbridge, I. S. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol. Cell Biol. 10, 2606-2618 (1990).
    • (1990) Mol. Cell Biol. , vol.10 , pp. 2606-2618
    • Isacke, C.M.1    Van Der Geer, P.2    Hunter, T.3    Trowbridge, I.S.4
  • 55
    • 41849125275 scopus 로고    scopus 로고
    • Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue
    • Robertson, D., Savage, K., Reis-Filho, J. & Isacke, C. Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. BMC Cell Biol. 9, 13 (2008).
    • (2008) BMC Cell Biol. , vol.9 , pp. 13
    • Robertson, D.1    Savage, K.2    Reis-Filho, J.3    Isacke, C.4
  • 56
    • 30944468766 scopus 로고    scopus 로고
    • Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue
    • Reis-Filho, J. S. et al. Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue. Mod. Pathol. 19, 307-319 (2006).
    • (2006) Mod. Pathol. , vol.19 , pp. 307-319
    • Reis-Filho, J.S.1
  • 57
    • 84860903681 scopus 로고    scopus 로고
    • Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients
    • Gyorffy, B., Lanczky, A. & Szallasi, Z. Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr. Relat. cancer 19, 197-208 (2012).
    • (2012) Endocr. Relat. Cancer , vol.19 , pp. 197-208
    • Gyorffy, B.1    Lanczky, A.2    Szallasi, Z.3
  • 58
    • 77953422867 scopus 로고    scopus 로고
    • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
    • Loi, S. et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc. Natl Acad. Sci. USA 107, 10208-10213 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10208-10213
    • Loi, S.1


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