메뉴 건너뛰기




Volumn 212, Issue 13, 2015, Pages 2253-2266

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SCATTER FACTOR; SMAD7 PROTEIN; SMURF1 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CRE RECOMBINASE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; I KAPPA B KINASE; INTEGRASE; SCATTER FACTOR RECEPTOR;

EID: 84956913971     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150576     Document Type: Article
Times cited : (120)

References (66)
  • 1
    • 78649997911 scopus 로고    scopus 로고
    • Jekyll and Hyde: the role of the microenvironment on the progression of cancer
    • Allen, M., and J. Louise Jones. 2011. Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J. Pathol. 223:162-176. http://dx.doi.org/10.1002/path.2803
    • (2011) J. Pathol. , vol.223 , pp. 162-176
    • Allen, M.1    Louise Jones, J.2
  • 2
    • 33947706133 scopus 로고    scopus 로고
    • Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut
    • Andoh, A., S. Bamba, M. Brittan, Y. Fujiyama, and N.A. Wright. 2007. Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacol. Ther. 114:94-106. http://dx.doi.org/10.1016/j.pharmthera.2006.12.004
    • (2007) Pharmacol. Ther. , vol.114 , pp. 94-106
    • Andoh, A.1    Bamba, S.2    Brittan, M.3    Fujiyama, Y.4    Wright, N.A.5
  • 3
    • 70350337085 scopus 로고    scopus 로고
    • Colon cancer metastasis: MACC1 and Met as metastatic pacemakers
    • Arlt, F., and U. Stein. 2009. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int. J. Biochem. Cell Biol. 41:2356-2359. http://dx.doi.org/10.1016/j.biocel.2009.08.001
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 2356-2359
    • Arlt, F.1    Stein, U.2
  • 4
    • 38149074076 scopus 로고    scopus 로고
    • Interleukin-1β up-regulation of Smad7 via NF-κB activation in human chondrocytes
    • Baugé, C., J. Attia, S. Leclercq, J.-P. Pujol, P. Galéra, and K. Boumédiene. 2008. Interleukin-1β up-regulation of Smad7 via NF-κB activation in human chondrocytes. Arthritis Rheum. 58:221-226. http://dx.doi.org/10.1002/art.23154
    • (2008) Arthritis Rheum. , vol.58 , pp. 221-226
    • Baugé, C.1    Attia, J.2    Leclercq, S.3    Pujol, J.-P.4    Galéra, P.5    Boumédiene, K.6
  • 9
    • 0034923219 scopus 로고    scopus 로고
    • Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
    • Buckley, C.D., D. Pilling, J.M. Lord, A.N. Akbar, D. Scheel-Toellner, and M. Salmon. 2001. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 22:199-204. http://dx.doi.org/10.1016/S1471-4906(01)01863-4
    • (2001) Trends Immunol. , vol.22 , pp. 199-204
    • Buckley, C.D.1    Pilling, D.2    Lord, J.M.3    Akbar, A.N.4    Scheel-Toellner, D.5    Salmon, M.6
  • 11
    • 84897556892 scopus 로고    scopus 로고
    • TGF-β in CAF-mediated tumor growth and metastasis
    • Calon, A., D.V.F. Tauriello, and E. Batlle. 2014. TGF-β in CAF-mediated tumor growth and metastasis. Semin. Cancer Biol. 25:15-22. http://dx.doi.org/10.1016/j.semcancer.2013.12.008
    • (2014) Semin. Cancer Biol. , vol.25 , pp. 15-22
    • Calon, A.1    Tauriello, D.V.F.2    Batlle, E.3
  • 14
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
    • Cirri, P., and P. Chiarugi. 2012. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 31:195-208. http://dx.doi.org/10.1007/s10555-011-9340-x
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 15
    • 33846005781 scopus 로고    scopus 로고
    • IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    • Clark, R.A., and T.S. Kupper. 2007. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 109:194-202. http://dx.doi.org/10.1182/blood-2006-02-002873
    • (2007) Blood. , vol.109 , pp. 194-202
    • Clark, R.A.1    Kupper, T.S.2
  • 16
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford, Y., I. Kasman, L. Yu, C. Zhong, X. Wu, Z. Modrusan, J. Kaminker, and N. Ferrara. 2009. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 15:21-34. http://dx.doi.org/10.1016/j.ccr.2008.12.004
    • (2009) Cancer Cell. , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 17
    • 84872685152 scopus 로고    scopus 로고
    • Differential secretome analysis of cancer-associated fibroblasts and bone marrow derived precursors to identify microenvironmental regulators of colon cancer progression
    • De Boeck, A., A. Hendrix, D. Maynard, M. Van Bockstal, A. Daniëls, P. Pauwels, C. Gespach, M. Bracke, and O. De Wever. 2013. Differential secretome analysis of cancer-associated fibroblasts and bone marrow derived precursors to identify microenvironmental regulators of colon cancer progression. Proteomics. 13:379-388. http://dx.doi.org/10.1002/pmic.201200179
    • (2013) Proteomics. , vol.13 , pp. 379-388
    • De Boeck, A.1    Hendrix, A.2    Maynard, D.3    Van Bockstal, M.4    Daniëls, A.5    Pauwels, P.6    Gespach, C.7    Bracke, M.8    De Wever, O.9
  • 18
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De Wever, O., P. Demetter, M. Mareel, and M. Bracke. 2008. Stromal myofibroblasts are drivers of invasive cancer growth. Int. J. Cancer. 123:2229-2238. http://dx.doi.org/10.1002/ijc.23925
    • (2008) Int. J. Cancer. , vol.123 , pp. 2229-2238
    • De Wever, O.1    Demetter, P.2    Mareel, M.3    Bracke, M.4
  • 20
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas, B., and R.A. Weinberg. 2001. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res. 264:169-184.
    • (2001) Exp. Cell Res. , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 22
    • 76349096670 scopus 로고    scopus 로고
    • Cancerassociated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner
    • Erez, N., M. Truitt, P. Olson, S.T. Arron, and D. Hanahan. 2010. Cancerassociated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner. Cancer Cell. 17:135-147.
    • (2010) Cancer Cell. , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 23
    • 84884211557 scopus 로고    scopus 로고
    • TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers
    • Freudlsperger, C., Y. Bian, S. Contag Wise, J. Burnett, J. Coupar, X. Yang, Z. Chen, C. Van Waes, J. Burnett, J. Coupar, et al. 2013. TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene. 32:1549-1559. http://dx.doi.org/10.1038/onc.2012.171
    • (2013) Oncogene. , vol.32 , pp. 1549-1559
    • Freudlsperger, C.1    Bian, Y.2    Contag Wise, S.3    Burnett, J.4    Coupar, J.5    Yang, X.6    Chen, Z.7    Van Waes, C.8    Burnett, J.9    Coupar, J.10
  • 24
    • 0034629581 scopus 로고    scopus 로고
    • TGFβ1 and TNFα secreted by mast cells stimulated via the FcεRI activate fibroblasts for high-level production of monocyte chemoattractant protein-1 (MCP-1)
    • Gordon, J.R. 2000. TGFβ1 and TNFα secreted by mast cells stimulated via the FcεRI activate fibroblasts for high-level production of monocyte chemoattractant protein-1 (MCP-1). Cell. Immunol. 201:42-49. http://dx.doi.org/10.1006/cimm.2000.1631
    • (2000) Cell. Immunol. , vol.201 , pp. 42-49
    • Gordon, J.R.1
  • 25
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R., L. Eckmann, T.F. Greten, J.M. Park, Z.-W. Li, L.J. Egan, M.F. Kagnoff, and M. Karin. 2004. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118:285-296. http://dx.doi.org/10.1016/j.cell.2004.07.013
    • (2004) Cell. , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.-W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 26
    • 34548225362 scopus 로고    scopus 로고
    • NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ
    • Greten, F.R., M.C. Arkan, J. Bollrath, L.-C. Hsu, J. Goode, C. Miething, S.I. Göktuna, M. Neuenhahn, J. Fierer, S. Paxian, et al. 2007. NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ. Cell. 130:918-931. http://dx.doi.org/10.1016/j.cell.2007.07.009
    • (2007) Cell. , vol.130 , pp. 918-931
    • Greten, F.R.1    Arkan, M.C.2    Bollrath, J.3    Hsu, L.-C.4    Goode, J.5    Miething, C.6    Göktuna, S.I.7    Neuenhahn, M.8    Fierer, J.9    Paxian, S.10
  • 27
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan, D., and L.M. Coussens. 2012. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309-322. http://dx.doi.org/10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell. , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 28
    • 35148866130 scopus 로고    scopus 로고
    • Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-κB pathway
    • Hong, S., C. Lee, and S.-J. Kim. 2007. Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-κB pathway. Cancer Res. 67:9577-9583. http://dx.doi.org/10.1158/0008-5472.CAN-07-1179
    • (2007) Cancer Res. , vol.67 , pp. 9577-9583
    • Hong, S.1    Lee, C.2    Kim, S.-J.3
  • 29
    • 77957855880 scopus 로고    scopus 로고
    • HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
    • Hoot, K.E., M. Oka, G. Han, E. Bottinger, Q. Zhang, and X.J. Wang. 2010. HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion. J. Clin. Invest. 120:3606-3616. http://dx.doi.org/10.1172/JCI43304
    • (2010) J. Clin. Invest. , vol.120 , pp. 3606-3616
    • Hoot, K.E.1    Oka, M.2    Han, G.3    Bottinger, E.4    Zhang, Q.5    Wang, X.J.6
  • 30
    • 77953725777 scopus 로고    scopus 로고
    • Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma:a pivotal role of CCL7
    • Jung, D.W., Z.M. Che, J. Kim, K. Kim, K.Y. Kim, D. Williams, and J. Kim. 2010. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma:a pivotal role of CCL7. Int. J. Cancer. 127:332-344.
    • (2010) Int. J. Cancer. , vol.127 , pp. 332-344
    • Jung, D.W.1    Che, Z.M.2    Kim, J.3    Kim, K.4    Kim, K.Y.5    Williams, D.6    Kim, J.7
  • 31
    • 77953859606 scopus 로고    scopus 로고
    • NF-κB as a critical link between inflammation and cancer
    • Karin, M. 2009. NF-κB as a critical link between inflammation and cancer. Cold Spring Harb. Perspect. Biol. 1:a000141. http://dx.doi.org/10.1101/cshperspect.a000141
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1 , pp. a000141
    • Karin, M.1
  • 32
    • 84868628410 scopus 로고    scopus 로고
    • Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
    • Koliaraki, V., M. Roulis, and G. Kollias. 2012. Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J. Clin. Invest. 122:4231-4242. http://dx.doi.org/10.1172/JCI63917
    • (2012) J. Clin. Invest. , vol.122 , pp. 4231-4242
    • Koliaraki, V.1    Roulis, M.2    Kollias, G.3
  • 33
    • 84956878669 scopus 로고    scopus 로고
    • IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
    • Koliaraki, V., M. Pasparakis, and G. Kollias. 2015. IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. J. Exp. Med. http://dx.doi.org/10.1084/jem.20150576
    • (2015) J. Exp. Med
    • Koliaraki, V.1    Pasparakis, M.2    Kollias, G.3
  • 34
    • 1642334157 scopus 로고    scopus 로고
    • Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
    • Lewis, M.P., K.A. Lygoe, M.L. Nystrom, W.P. Anderson, P.M. Speight, J.F. Marshall, and G.J. Thomas. 2004. Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br. J. Cancer. 90:822-832. http://dx.doi.org/10.1038/sj.bjc.6601611
    • (2004) Br. J. Cancer. , vol.90 , pp. 822-832
    • Lewis, M.P.1    Lygoe, K.A.2    Nystrom, M.L.3    Anderson, W.P.4    Speight, P.M.5    Marshall, J.F.6    Thomas, G.J.7
  • 35
    • 81255138189 scopus 로고    scopus 로고
    • A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3
    • Liu, X., Q. Wang, G. Yang, C. Marando, H.K. Koblish, L.M. Hall, J.S. Fridman, E. Behshad, R. Wynn, Y. Li, et al. 2011. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin. Cancer Res. 17:7127-7138. http://dx.doi.org/10.1158/1078-0432.CCR-11-1157
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7127-7138
    • Liu, X.1    Wang, Q.2    Yang, G.3    Marando, C.4    Koblish, H.K.5    Hall, L.M.6    Fridman, J.S.7    Behshad, E.8    Wynn, R.9    Li, Y.10
  • 36
    • 84863204524 scopus 로고    scopus 로고
    • Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival
    • Liu, Y., Q. Li, and L. Zhu. 2012. Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival. Tumori. 98:105-112.
    • (2012) Tumori. , vol.98 , pp. 105-112
    • Liu, Y.1    Li, Q.2    Zhu, L.3
  • 37
    • 78650770246 scopus 로고    scopus 로고
    • Hepatocyte growth factor twenty years on: Much more than a growth factor
    • Nakamura, T., K. Sakai, T. Nakamura, and K. Matsumoto. 2011. Hepatocyte growth factor twenty years on: Much more than a growth factor. J. Gastroenterol. Hepatol. 26(Suppl 1):188-202. http://dx.doi.org/10.1111/j.1440-1746.2010.06549.x
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 188-202
    • Nakamura, T.1    Sakai, K.2    Nakamura, T.3    Matsumoto, K.4
  • 38
    • 7944229122 scopus 로고    scopus 로고
    • Interleukin-1β increases RAN TES gene expression and production in synovial fibroblasts from human temporomandibular joint
    • Ogura, N., M. Tobe, H. Sakamaki, H. Nagura, H. Hosaka, M. Akiba, Y. Abiko, and T. Kondoh. 2004. Interleukin-1β increases RAN TES gene expression and production in synovial fibroblasts from human temporomandibular joint. J. Oral Pathol. Med. 33:629-633. http://dx.doi.org/10.1111/j.1600-0714.2004.00260.x
    • (2004) J. Oral Pathol. Med. , vol.33 , pp. 629-633
    • Ogura, N.1    Tobe, M.2    Sakamaki, H.3    Nagura, H.4    Hosaka, H.5    Akiba, M.6    Abiko, Y.7    Kondoh, T.8
  • 39
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • Öhlund, D., E. Elyada, and D. Tuveson. 2014. Fibroblast heterogeneity in the cancer wound. J. Exp. Med. 211:1503-1523.
    • (2014) J. Exp. Med. , vol.211 , pp. 1503-1523
    • Öhlund, D.1    Elyada, E.2    Tuveson, D.3
  • 41
    • 84997941720 scopus 로고    scopus 로고
    • An overview of the c-MET signaling pathway
    • Organ, S.L., and M.-S. Tsao. 2011. An overview of the c-MET signaling pathway. Ther. Adv. Med. Oncol. S7-S19. http://dx.doi.org/10.1177/1758834011422556
    • (2011) Ther. Adv. Med. Oncol. , pp. S7-S19
    • Organ, S.L.1    Tsao, M.-S.2
  • 42
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A., P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, R. Naeem, V.J. Carey, A.L. Richardson, and R.A. Weinberg. 2005. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335-348. http://dx.doi.org/10.1016/j.cell.2005.02.034
    • (2005) Cell. , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 43
    • 60949101225 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and tumor growth--bystanders turning into key players
    • Östman, A., and M. Augsten. 2009. Cancer-associated fibroblasts and tumor growth--bystanders turning into key players. Curr. Opin. Genet. Dev. 19:67-73.
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 67-73
    • Östman, A.1    Augsten, M.2
  • 44
  • 45
    • 0028175988 scopus 로고
    • GM-CSF, IL-1α, IL-1β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1 alpha and TNF-α
    • Pang, G., L. Couch, R. Batey, R. Clancy, and A. Cripps. 1994. GM-CSF, IL-1α, IL-1β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1 alpha and TNF-α. Clin. Exp. Immunol. 96:437-443.
    • (1994) Clin. Exp. Immunol. , vol.96 , pp. 437-443
    • Pang, G.1    Couch, L.2    Batey, R.3    Clancy, R.4    Cripps, A.5
  • 47
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto, C., A. Bardelli, Z. Zhen, F. Maina, P. dalla Zonca, S. Giordano, A. Graziani, G. Panayotou, and P.M. Comoglio. 1994. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 77:261-271.
    • (1994) Cell. , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3    Maina, F.4    Dalla Zonca, P.5    Giordano, S.6    Graziani, A.7    Panayotou, G.8    Comoglio, P.M.9
  • 49
    • 79751501829 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    • Quante, M., S.P. Tu, H. Tomita, T. Gonda, S.S.W. Wang, S. Takashi, G.H. Baik, W. Shibata, B. Diprete, K.S. Betz, et al. 2011. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 19:257-272. http://dx.doi.org/10.1016/j.ccr.2011.01.020
    • (2011) Cancer Cell. , vol.19 , pp. 257-272
    • Quante, M.1    Tu, S.P.2    Tomita, H.3    Gonda, T.4    Wang, S.S.W.5    Takashi, S.6    Baik, G.H.7    Shibata, W.8    Diprete, B.9    Betz, K.S.10
  • 50
    • 77956883321 scopus 로고    scopus 로고
    • Activation of fibroblasts in cancer stroma
    • Räsänen, K., and A. Vaheri. 2010. Activation of fibroblasts in cancer stroma. Exp. Cell Res. 316:2713-2722. http://dx.doi.org/10.1016/j.yexcr.2010.04.032
    • (2010) Exp. Cell Res. , vol.316 , pp. 2713-2722
    • Räsänen, K.1    Vaheri, A.2
  • 53
    • 84872370561 scopus 로고    scopus 로고
    • Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    • Schwitalla, S., P.K. Ziegler, D. Horst, V. Becker, I. Kerle, Y. Begus-Nahrmann, A. Lechel, K.L. Rudolph, R. Langer, J. Slotta-Huspenina, et al. 2013b. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell. 23:93-106. http://dx.doi.org/10.1016/j.ccr.2012.11.014
    • (2013) Cancer Cell. , vol.23 , pp. 93-106
    • Schwitalla, S.1    Ziegler, P.K.2    Horst, D.3    Becker, V.4    Kerle, I.5    Begus-Nahrmann, Y.6    Lechel, A.7    Rudolph, K.L.8    Langer, R.9    Slotta-Huspenina, J.10
  • 54
    • 84871080983 scopus 로고    scopus 로고
    • From sentinel cells to inflammatory culprits:cancer-associated fibroblasts in tumour-related inflammation
    • Servais, C., and N. Erez. 2013. From sentinel cells to inflammatory culprits:cancer-associated fibroblasts in tumour-related inflammation. J. Pathol. 229:198-207.
    • (2013) J. Pathol. , vol.229 , pp. 198-207
    • Servais, C.1    Erez, N.2
  • 55
    • 58149352266 scopus 로고    scopus 로고
    • MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
    • Stein, U., W. Walther, F. Arlt, H. Schwabe, J. Smith, I. Fichtner, W. Birchmeier, and P.M. Schlag. 2009. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat. Med. 15:59-67. http://dx.doi.org/10.1038/nm.1889
    • (2009) Nat. Med. , vol.15 , pp. 59-67
    • Stein, U.1    Walther, W.2    Arlt, F.3    Schwabe, H.4    Smith, J.5    Fichtner, I.6    Birchmeier, W.7    Schlag, P.M.8
  • 57
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino, L., A. Bertotti, and P.M. Comoglio. 2010. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 11:834-848.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 60
    • 79952738601 scopus 로고    scopus 로고
    • Tpl2 kinase signal transduction in inflammation and cancer
    • Vougioukalaki, M., D.C. Kanellis, K. Gkouskou, and A.G. Eliopoulos. 2011. Tpl2 kinase signal transduction in inflammation and cancer. Cancer Lett. 304:80-89. http://dx.doi.org/10.1016/j.canlet.2011.02.004
    • (2011) Cancer Lett. , vol.304 , pp. 80-89
    • Vougioukalaki, M.1    Kanellis, D.C.2    Gkouskou, K.3    Eliopoulos, A.G.4
  • 61
    • 66549096021 scopus 로고    scopus 로고
    • Regulation of TGF-βsignaling by Smad7
    • Yan, X., Z. Liu, and Y. Chen. 2009. Regulation of TGF-βsignaling by Smad7. Acta Biochim. Biophys. Sin. (Shanghai). 41:263-272. http://dx.doi.org/10.1093/abbs/gmp018
    • (2009) Acta Biochim. Biophys. Sin. (Shanghai). , vol.41 , pp. 263-272
    • Yan, X.1    Liu, Z.2    Chen, Y.3
  • 62
    • 77953023274 scopus 로고    scopus 로고
    • TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
    • Yang, L., Y. Pang, and H.L. Moses. 2010. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol. 31:220-227. http://dx.doi.org/10.1016/j.it.2010.04.002
    • (2010) Trends Immunol. , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 63
    • 84900530792 scopus 로고    scopus 로고
    • Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue
    • Yin, J., J.H. Lee, J. Zhang, Z. Gao, V.Y. Polotsky, and J. Ye. 2014. Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue. Am. J. Physiol. Endocrinol. Metab. 306:E929-E936. http://dx.doi.org/10.1152/ajpendo.00687.2013
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E929-E936
    • Yin, J.1    Lee, J.H.2    Zhang, J.3    Gao, Z.4    Polotsky, V.Y.5    Ye, J.6
  • 64
    • 33748533173 scopus 로고    scopus 로고
    • Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1β
    • Yucel-Lindberg, T., and G. Brunius. 2006. Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1β. Arch. Oral Biol. 51:892-898. http://dx.doi.org/10.1016/j.archoralbio.2006.03.004
    • (2006) Arch. Oral Biol. , vol.51 , pp. 892-898
    • Yucel-Lindberg, T.1    Brunius, G.2
  • 65
    • 79251498620 scopus 로고    scopus 로고
    • + fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation
    • + fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am. J. Pathol. 178:382-390. http://dx.doi.org/10.1016/j.ajpath.2010.11.017
    • (2011) Am. J. Pathol. , vol.178 , pp. 382-390
    • Zhang, J.1    Chen, L.2    Xiao, M.3    Wang, C.4    Qin, Z.5
  • 66
    • 0036097913 scopus 로고    scopus 로고
    • Ligand-dependent genetic recombination in fibroblasts: a potentially powerful technique for investigating gene function in fibrosis
    • Zheng, B., Z. Zhang, C.M. Black, B. de Crombrugghe, and C.P. Denton. 2002. Ligand-dependent genetic recombination in fibroblasts: a potentially powerful technique for investigating gene function in fibrosis. Am. J. Pathol. 160:1609-1617. http://dx.doi.org/10.1016/S0002-9440(10)61108-X
    • (2002) Am. J. Pathol. , vol.160 , pp. 1609-1617
    • Zheng, B.1    Zhang, Z.2    Black, C.M.3    De Crombrugghe, B.4    Denton, C.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.