-
2
-
-
77957286169
-
Causes and risk factors for death in systemic sclerosis: A study from the EULAR Scleroderma Trials and Research (EUSTAR) database
-
Tyndall AJ, Bannert B, Vonk M, Airo P, Cozzi F, Carreira PE, et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 2010; 69: 1809-15.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1809-1815
-
-
Tyndall, A.J.1
Bannert, B.2
Vonk, M.3
Airo, P.4
Cozzi, F.5
Carreira, P.E.6
-
3
-
-
33847348491
-
Systemic sclerosis: A prototypic multisystem fibrotic disorder
-
Varga J, Abraham D,. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007; 117: 557-67.
-
(2007)
J Clin Invest
, vol.117
, pp. 557-567
-
-
Varga, J.1
Abraham, D.2
-
4
-
-
19944427133
-
The Janus kinases (Jaks)
-
Yamaoka K, Saharinen P, Pesu M, Holt VE III, Silvennoinen O, O'Shea JJ,. The Janus kinases (Jaks). Genome Biol 2004; 5: 253.
-
(2004)
Genome Biol
, vol.5
, pp. 253
-
-
Yamaoka, K.1
Saharinen, P.2
Pesu, M.3
Holt Iii, V.E.4
Silvennoinen, O.5
O'Shea, J.J.6
-
5
-
-
35348850734
-
Hematopoietic cytokine receptor signaling
-
Baker SJ, Rane SG, Reddy EP,. Hematopoietic cytokine receptor signaling. Oncogene 2007; 26: 6724-37.
-
(2007)
Oncogene
, vol.26
, pp. 6724-6737
-
-
Baker, S.J.1
Rane, S.G.2
Reddy, E.P.3
-
6
-
-
32144453842
-
JAK/STAT signal transduction: Regulators and implication in hematological malignancies
-
Valentino L, Pierre J,. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 2006; 71: 713-21.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 713-721
-
-
Valentino, L.1
Pierre, J.2
-
8
-
-
49449087811
-
Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
-
Akhmetshina A, Dees C, Pileckyte M, Szucs G, Spriewald BM, Zwerina J, et al. Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts. Arthritis Rheum 2008; 58: 2553-64.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2553-2564
-
-
Akhmetshina, A.1
Dees, C.2
Pileckyte, M.3
Szucs, G.4
Spriewald, B.M.5
Zwerina, J.6
-
9
-
-
0034937852
-
Criteria for the classification of early systemic sclerosis
-
LeRoy EC, Medsger TA Jr,. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001; 28: 1573-6.
-
(2001)
J Rheumatol
, vol.28
, pp. 1573-1576
-
-
Leroy, E.C.1
Medsger Jr., T.A.2
-
10
-
-
34447627350
-
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
-
Pardanani A, Hood J, Lasho T, Levine RL, Martin MB, Noronha G, et al. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia 2007; 21: 1658-68.
-
(2007)
Leukemia
, vol.21
, pp. 1658-1668
-
-
Pardanani, A.1
Hood, J.2
Lasho, T.3
Levine, R.L.4
Martin, M.B.5
Noronha, G.6
-
11
-
-
37149006718
-
Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
-
Distler JH, Jungel A, Pileckyte M, Zwerina J, Michel BA, Gay RE, et al. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheum 2007; 56: 4203-15.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 4203-4215
-
-
Distler, J.H.1
Jungel, A.2
Pileckyte, M.3
Zwerina, J.4
Michel, B.A.5
Gay, R.E.6
-
12
-
-
79957637197
-
Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
-
Dees C, Tomcik M, Zerr P, Akhmetshina A, Horn A, Palumbo K, et al. Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann Rheum Dis 2011; 70: 1304-10.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1304-1310
-
-
Dees, C.1
Tomcik, M.2
Zerr, P.3
Akhmetshina, A.4
Horn, A.5
Palumbo, K.6
-
13
-
-
79957634934
-
The transcription factor JunD mediates transforming growth factor β-induced fibroblast activation and fibrosis in systemic sclerosis
-
Palumbo K, Zerr P, Tomcik M, Vollath S, Dees C, Akhmetshina A, et al. The transcription factor JunD mediates transforming growth factor β-induced fibroblast activation and fibrosis in systemic sclerosis. Ann Rheum Dis 2011; 70: 1320-6.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1320-1326
-
-
Palumbo, K.1
Zerr, P.2
Tomcik, M.3
Vollath, S.4
Dees, C.5
Akhmetshina, A.6
-
14
-
-
79955567838
-
Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
-
Dees C, Zerr P, Tomcik M, Beyer C, Horn A, Akhmetshina A, et al. Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum 2011; 63: 1396-404.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1396-1404
-
-
Dees, C.1
Zerr, P.2
Tomcik, M.3
Beyer, C.4
Horn, A.5
Akhmetshina, A.6
-
15
-
-
33745996622
-
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
-
Woessner JF Jr,. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961; 93: 440-7.
-
(1961)
Arch Biochem Biophys
, vol.93
, pp. 440-447
-
-
Woessner Jr., J.F.1
-
16
-
-
79956122627
-
Platelet-derived serotonin links vascular disease and tissue fibrosis
-
Dees C, Akhmetshina A, Zerr P, Reich N, Palumbo K, Horn A, et al. Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med 2011; 208: 961-72.
-
(2011)
J Exp Med
, vol.208
, pp. 961-972
-
-
Dees, C.1
Akhmetshina, A.2
Zerr, P.3
Reich, N.4
Palumbo, K.5
Horn, A.6
-
17
-
-
33846209989
-
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
-
Distler JH, Jungel A, Huber LC, Schulze-Horsel U, Zwerina J, Gay RE, et al. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 2007; 56: 311-22.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 311-322
-
-
Distler, J.H.1
Jungel, A.2
Huber, L.C.3
Schulze-Horsel, U.4
Zwerina, J.5
Gay, R.E.6
-
18
-
-
78249233276
-
Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
-
Marquart S, Zerr P, Akhmetshina A, Palumbo K, Reich N, Tomcik M, et al. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum 2010; 62: 3467-76.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3467-3476
-
-
Marquart, S.1
Zerr, P.2
Akhmetshina, A.3
Palumbo, K.4
Reich, N.5
Tomcik, M.6
-
19
-
-
79960146286
-
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia
-
Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med 2011; 17: 845-53.
-
(2011)
Nat Med
, vol.17
, pp. 845-853
-
-
Russell, R.C.1
Sufan, R.I.2
Zhou, B.3
Heir, P.4
Bunda, S.5
Sybingco, S.S.6
-
20
-
-
58249120518
-
Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
-
Akhmetshina A, Venalis P, Dees C, Busch N, Zwerina J, Schett G, et al. Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis. Arthritis Rheum 2009; 60: 219-24.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 219-224
-
-
Akhmetshina, A.1
Venalis, P.2
Dees, C.3
Busch, N.4
Zwerina, J.5
Schett, G.6
-
21
-
-
77954659778
-
Inhibition of JAK-STAT signaling by TG101348: A novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells
-
Lasho T, Tefferi A, Pardanani A,. Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells. Leukemia 2010; 24: 1378-80.
-
(2010)
Leukemia
, vol.24
, pp. 1378-1380
-
-
Lasho, T.1
Tefferi, A.2
Pardanani, A.3
-
22
-
-
73949136283
-
Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
-
Wang Y, Fiskus W, Chong DG, Buckley KM, Natarajan K, Rao R, et al. Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood 2009; 114: 5024-33.
-
(2009)
Blood
, vol.114
, pp. 5024-5033
-
-
Wang, Y.1
Fiskus, W.2
Chong, D.G.3
Buckley, K.M.4
Natarajan, K.5
Rao, R.6
-
23
-
-
77957668307
-
Animal models of systemic sclerosis: Prospects and limitations
-
[review]
-
Beyer C, Schett G, Distler O, Distler JH,. Animal models of systemic sclerosis: prospects and limitations [review]. Arthritis Rheum 2010; 62: 2831-44.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2831-2844
-
-
Beyer, C.1
Schett, G.2
Distler, O.3
Distler, J.H.4
-
24
-
-
0031886413
-
Increased expression of TGF-β receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
-
Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M,. Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype. J Invest Dermatol 1998; 110: 47-51.
-
(1998)
J Invest Dermatol
, vol.110
, pp. 47-51
-
-
Kawakami, T.1
Ihn, H.2
Xu, W.3
Smith, E.4
Leroy, C.5
Trojanowska, M.6
-
25
-
-
77954730368
-
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
-
Pang M, Ma L, Gong R, Tolbert E, Mao H, Ponnusamy M, et al. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int 2010; 78: 257-68.
-
(2010)
Kidney Int
, vol.78
, pp. 257-268
-
-
Pang, M.1
Ma, L.2
Gong, R.3
Tolbert, E.4
Mao, H.5
Ponnusamy, M.6
-
26
-
-
53049110853
-
Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells
-
Shi Y, Zhang Y, Wang C, Du C, Zhao S, Qi Z, et al. Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells. FEBS Lett 2008; 582: 3484-8.
-
(2008)
FEBS Lett
, vol.582
, pp. 3484-3488
-
-
Shi, Y.1
Zhang, Y.2
Wang, C.3
Du, C.4
Zhao, S.5
Qi, Z.6
-
27
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med 2010; 363: 1117-27.
-
(2010)
N Engl J Med
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
Pardanani, A.D.4
Cortes-Franco, J.5
Thomas, D.A.6
-
28
-
-
79751532774
-
JAK inhibitor therapy for myelofibrosis: Critical assessment of value and limitations
-
Pardanani A, Vannucchi AM, Passamonti F, Cervantes F, Barbui T, Tefferi A,. JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia 2011; 25: 218-25.
-
(2011)
Leukemia
, vol.25
, pp. 218-225
-
-
Pardanani, A.1
Vannucchi, A.M.2
Passamonti, F.3
Cervantes, F.4
Barbui, T.5
Tefferi, A.6
-
29
-
-
79951510594
-
JAK2 inhibitors: What's the true therapeutic potential?
-
Santos FP, Verstovsek S,. JAK2 inhibitors: what's the true therapeutic potential? Blood Rev 2011; 25: 53-63.
-
(2011)
Blood Rev
, vol.25
, pp. 53-63
-
-
Santos, F.P.1
Verstovsek, S.2
-
30
-
-
0032907817
-
Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma
-
Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, et al. Animal model of sclerotic skin. I: local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 1999; 112: 456-62.
-
(1999)
J Invest Dermatol
, vol.112
, pp. 456-462
-
-
Yamamoto, T.1
Takagawa, S.2
Katayama, I.3
Yamazaki, K.4
Hamazaki, Y.5
Shinkai, H.6
-
31
-
-
33646572542
-
Systemic sclerosis: Hypothesis-driven treatment strategies
-
Charles C, Clements P, Furst DE,. Systemic sclerosis: hypothesis-driven treatment strategies. Lancet 2006; 367: 1683-91.
-
(2006)
Lancet
, vol.367
, pp. 1683-1691
-
-
Charles, C.1
Clements, P.2
Furst, D.E.3
-
32
-
-
68749094404
-
Therapies for interstitial lung disease: Past, present and future
-
Kim R, Meyer KC,. Therapies for interstitial lung disease: past, present and future. Ther Adv Respir Dis 2008; 2: 319-38.
-
(2008)
Ther Adv Respir Dis
, vol.2
, pp. 319-338
-
-
Kim, R.1
Meyer, K.C.2
-
33
-
-
55949123306
-
Pulmonary rehabilitation in idiopathic pulmonary fibrosis: A call for continued investigation
-
Swigris JJ, Brown KK, Make BJ, Wamboldt FS,. Pulmonary rehabilitation in idiopathic pulmonary fibrosis: a call for continued investigation. Respir Med 2008; 102: 1675-80.
-
(2008)
Respir Med
, vol.102
, pp. 1675-1680
-
-
Swigris, J.J.1
Brown, K.K.2
Make, B.J.3
Wamboldt, F.S.4
|