Hepatocyte growth factor, a versatile signal for developing neurons

Nature Neuroscience

Volumn 2, Issue 3, 1999, Pages 213-217

  Maina, Flavio ^a   Klein, Rüdiger ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; NEUROTROPHIC FACTOR; SCATTER FACTOR;

CELL DIFFERENTIATION; CELL SURVIVAL; MOTONEURON; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ANIMALS; CELL AGING; EMBRYO; HEPATOCYTE GROWTH FACTOR; NEURONS; SIGNAL TRANSDUCTION;

EID: 0033362351     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/6310     Document Type: Review

References (50)

1. Birchmeier, C. & Gherardi, E. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol. 8, 404-410 (1998).
2. Birchmeier, W. et al. Role of HGF/SF and c-met in morphogenesis and metastasis of epithelial cells. Ciba Found. Symp. 212, 230-240 (1997).
3. Jeffers, M., Rong, S. & Vande Woude, G. F. Hepatocyte growth factor/scatter factor - Met signaling in tumorigenesis and invasion/metastasis. J. Mol. Med. 74, 505-513 (1996).
4. Streit, A. et al. A role for HGF/SF in neuronal induction and its expression in Hensen's node during gastrulation. Development 121, 813-824 (1995).
5. Streit, A. et al. Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. Development 124, 1191-1202 (1997).
6. Schmidt, C. et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373, 699-702 (1995).
7. Uehara, Y. et al Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373, 702-705 (1995).
8. Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. & Birchmeier, C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376, 768-771 (1995).
9. Maina, F. et al. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87, 531-542 (1996).
10. Sonnenberg, E., Meyer, D., Weidner, K. M. & Birchmeier, C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J. Cell Biol 123, 223-235 (1993).
11. Jung, W. et al. Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain. J. Cell Biol. 126, 485-494 (1994).
12. Achim, C. L. et al. Expression of HGF and c-Met in the developing and adult brain. Dev. Brain Res. 102, 299-303 (1997).
13. Thewke, D. P. & Seeds, N. W. Expression of hepatocyte growth factor/scatter factor, its receptor, c-Met, and tissue-type plasminogen activator during development of the murine olfactory system. J. Neurosci. 16, 6933-6944 (1996).
14. Hamanoue, M. et al. Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro. J. Neurosci. Res. 43, 554-564 (1996).
15. Di Renzo, M. F. et al. Selective expression of the Met/HGF receptor in human central nervous system microglia. Oncogene 8, 219-222 (1993).
16. Krasnoselsky, A. et al. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. J. Neurosci. 14, 7284-7290 (1994).
17. Ebens, A. et al. Hepatocyte growth factor/Scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron 17, 1157-1172 (1996).
18. Maina, F., Hilton, M. C., Ponzetto, C., Davies, A. M. & Klein, R. Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons. Genes Devel. 11, 3341-3350 (1997).
19. Wong, V. et al. Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor. J. Biol. Chem. 272, 5187-5191 (1997).
20. Yamamoto, Y. et al. Hepatocyte growth factor (HGF/SF) is an essential muscle-derived survival factor for a subpopulation of embryonic motoneurons. Development 124, 2903-2913 (1997).
21. Oppenheim, R. W. Neurotrophic survival molecules for motoneurons: an embarrassment of riches. Neuron 17, 195-197 (1996).
22. Fagan, A. M. et al. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J. Neurosci. 16, 6208-6218 (1996).
23. Wyatt, S., Pinon, L. G. P., Ernfors, P. & Davies, A. M. Sympathetic neuron survival and TrkA expression in NT-3-deficient mouse embryos. EMBO J. 16, 3115-3123 (1997).
24. Maina, F. et al. Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron 20, 835-846 (1998).
25. Yang, X.-M. et al. Autocrine hepatocyte growth factor provides a local mechanism for promoting axonal growth. J. Neurosci. 18, 8369-8381 (1998).
26. Ponzetto, C. et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77, 261-271 (1994).
27. Boccaccio, C. et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391, 285-288 (1998).
28. Weidner, K. M. et al. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176 (1996).
29. Rodrigues, G. A., Park, M. & Schlessinger, J. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16, 2634-2645 (1997).
30. Nguyen, L. et al. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356. J. Biol. Chem. 272, 20811-20819 (1997).
31. Kochhar, K. S. & Iyer, A. P. Hepatocyte growth factor induces activation of Nck and phospholipase C-gamma in lung carcinoma cells. Cancer Lett. 12, 163-169 (1996).
32. Chen, H. C, Chan, P. C., Tang, M. J., Cheng, C. H. & Chang, T. J. Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation. J. Biol. Chem. 273, 25777-25782 (1998).
33. Monard, D. Cell-derived proteases and protease inhibitors are regulators of neurite outgrowth. Trends Neurosci. 11, 541-544 (1988).
34. Pittman, R. N. & Buettner, H. M. Degradation of extracellular matrix by neuronal proteases. Dev. Neurosci. 11, 361-375 (1989).
35. Rong, S. et al. Tumorigenesis induced by co-expression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor. Cell Growth Differ. 4, 563-569 (1993).
36. Ponzetto, C. et al. Specific uncoupling of GRB2 from the Met receptor: differential effect on transformation and motility. J. Biol. Chem. 271, 14119-14123 (1996).
37. Royal, I. & Park, M. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase. J. Biol. Chem. 270, 27780-27787 (1995).
38. Ridley, A. J., Comoglio, P. M. & Hall, A. Regulation of scatter factor/hepatocyte growth factor responces by Ras, Rac, and Rho in MDCK cells. Mol. Cell. Biol. 15, 1110-1122 (1995).
39. Hartmann, G., Weidner, K. M., Schwarz, H. & Birchmeier, W. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras. J. Cell. Biol. 269, 21936-21939 (1994).
40. Barinaga, M. Neurotrophic factors enter the clinic. Science 264, 772-774 (1994).
41. Lindvall, O. & Odin, P. Clinical application of cell transplantation and neurotrophic factors in CNS disorders. Curr. Opin. Neurobiol. 4, 752-757 (1994).
42. Schatzl, H. M. Neurotrophic factor: ready to go? Trends Neurosci. 18, 463-464 (1995).
43. Nishi, R. Neurotrophic factors: two are better than one. Science 265, 1052-1053 (1994).
44. Tuszynski, M. H., Roberts, J., Senut, M. C. & Gage, F. H. Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 3, 305-314 (1996).
45. Martinez-Serrano, A., Fischer, W. & Bjorklund, A. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain. Neuron 15, 473-484 (1995).
46. Apfel, S. C., Lipson, L., Arezzo, J. C. & Kessler, J. A. Nerve growth factor prevents neuropathy in mice. Ann. Neurol. 29, 87-90 (1991).
47. Apfel, S. C., Arezzo, J. C., Brownlee, M., Federoff, H. & Kessler, J. A. Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res. 634, 7-12 (1994).
48. Shiota, G., Wang, T.C., Nakamura, T. & Schmidt, E. V. Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 19, 962-972 (1994).
49. Allen, R. E., Sheenan, S. M., Taylor, R. G., Kendall, T. L. & Rice, G. M. Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro. J. Cell Physiol. 165, 307-312 (1995).
50. Ueki, T., et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat. Med. 5, 226-230 (1999).