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Volumn 212, Issue 13, 2015, Pages 2235-2251

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; STAT3 PROTEIN; AUTACOID; COLLAGEN TYPE 6; CYTOKINE; I KAPPA B KINASE;

EID: 84956878669     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150542     Document Type: Article
Times cited : (106)

References (40)
  • 1
    • 39549089300 scopus 로고    scopus 로고
    • Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    • Armaka, M., M. Apostolaki, P. Jacques, D.L. Kontoyiannis, D. Elewaut, and G. Kollias. 2008. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J. Exp. Med. 205:331-337. http://dx.doi.org/10.1084/jem.20070906
    • (2008) J. Exp. Med. , vol.205 , pp. 331-337
    • Armaka, M.1    Apostolaki, M.2    Jacques, P.3    Kontoyiannis, D.L.4    Elewaut, D.5    Kollias, G.6
  • 3
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • Ben-Neriah, Y., and M. Karin. 2011. Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol. 12:715-723. http://dx.doi.org/10.1038/ni.2060
    • (2011) Nat. Immunol. , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 6
    • 4544243747 scopus 로고    scopus 로고
    • At the crossroads of inflammation and cancer
    • Clevers, H. 2004. At the crossroads of inflammation and cancer. Cell. 118:671-674. http://dx.doi.org/10.1016/j.cell.2004.09.005
    • (2004) Cell. , vol.118 , pp. 671-674
    • Clevers, H.1
  • 7
    • 0035206705 scopus 로고    scopus 로고
    • The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis
    • Cooper, H.S., L. Everley, W.C. Chang, G. Pfeiffer, B. Lee, S. Murthy, and M.L. Clapper. 2001. The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis. Gastroenterology. 121:1407-1416. http://dx.doi.org/10.1053/gast.2001.29609
    • (2001) Gastroenterology. , vol.121 , pp. 1407-1416
    • Cooper, H.S.1    Everley, L.2    Chang, W.C.3    Pfeiffer, G.4    Lee, B.5    Murthy, S.6    Clapper, M.L.7
  • 8
    • 84858718448 scopus 로고    scopus 로고
    • NF-κB and the link between inflammation and cancer
    • DiDonato, J.A., F. Mercurio, and M. Karin. 2012. NF-κB and the link between inflammation and cancer. Immunol. Rev. 246:379-400. http://dx.doi.org/10.1111/j.1600-065X.2012.01099.x
    • (2012) Immunol. Rev. , vol.246 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 10
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner
    • Erez, N., M. Truitt, P. Olson, S.T. Arron, and D. Hanahan. 2010. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell. 17:135-147. http://dx.doi.org/10.1016/j.ccr.2009.12.041
    • (2010) Cancer Cell. , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 13
    • 69449102284 scopus 로고    scopus 로고
    • Innate immune signaling by Tolllike receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
    • Fukata, M., Y. Hernandez, D. Conduah, J. Cohen, A. Chen, K. Breglio, T. Goo, D. Hsu, R. Xu, and M.T. Abreu. 2009. Innate immune signaling by Tolllike receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm. Bowel Dis. 15:997-1006. http://dx.doi.org/10.1002/ibd.20880
    • (2009) Inflamm. Bowel Dis. , vol.15 , pp. 997-1006
    • Fukata, M.1    Hernandez, Y.2    Conduah, D.3    Cohen, J.4    Chen, A.5    Breglio, K.6    Goo, T.7    Hsu, D.8    Xu, R.9    Abreu, M.T.10
  • 14
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • Fukata, M., L. Shang, R. Santaolalla, J. Sotolongo, C. Pastorini, C. España, R. Ungaro, N. Harpaz, H.S. Cooper, G. Elson, et al. 2011. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm. Bowel Dis. 17:1464-1473. http://dx.doi.org/10.1002/ibd.21527
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1464-1473
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5    España, C.6    Ungaro, R.7    Harpaz, N.8    Cooper, H.S.9    Elson, G.10
  • 15
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R., L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, L.J. Egan, M.F. Kagnoff, and M. Karin. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118:285-296. http://dx.doi.org/10.1016/j.cell.2004.07.013
    • (2004) Cell. , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 17
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I., F.R. Greten, and M. Karin. 2010. Immunity, inflammation, and cancer. Cell. 140:883-899. http://dx.doi.org/10.1016/j.cell.2010.01.025
    • (2010) Cell. , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 18
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan, D., and L.M. Coussens. 2012. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309-322. http://dx.doi.org/10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell. , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 19
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and R.A. Weinberg. 2011. Hallmarks of cancer: the next generation. Cell. 144:646-674. http://dx.doi.org/10.1016/j.cell.2011.02.013
    • (2011) Cell. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 21
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri, R., and M. Zeisberg. 2006. Fibroblasts in cancer. Nat. Rev. Cancer. 6:392-401. http://dx.doi.org/10.1038/nrc1877
    • (2006) Nat. Rev. Cancer. , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 22
    • 84868628410 scopus 로고    scopus 로고
    • Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
    • Koliaraki, V., M. Roulis, and G. Kollias. 2012. Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J. Clin. Invest. 122:4231-4242. http://dx.doi.org/10.1172/JCI63917
    • (2012) J. Clin. Invest. , vol.122 , pp. 4231-4242
    • Koliaraki, V.1    Roulis, M.2    Kollias, G.3
  • 23
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • Li, Q., D. Van Antwerp, F. Mercurio, K.F. Lee, and I.M. Verma. 1999. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science. 284:321-325. http://dx.doi.org/10.1126/science.284.5412.321
    • (1999) Science. , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.F.4    Verma, I.M.5
  • 24
  • 25
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani, A., P. Allavena, A. Sica, and F. Balkwill. 2008. Cancer-related inflammation. Nature. 454:436-444. http://dx.doi.org/10.1038/nature07205
    • (2008) Nature. , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 27
    • 35548932872 scopus 로고    scopus 로고
    • A global double-fluorescent Cre reporter mouse
    • Muzumdar, M.D., B. Tasic, K. Miyamichi, L. Li, and L. Luo. 2007. A global double-fluorescent Cre reporter mouse. Genesis. 45:593-605. http://dx.doi.org/10.1002/dvg.20335
    • (2007) Genesis. , vol.45 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 28
    • 34548162712 scopus 로고    scopus 로고
    • An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammationdriven tumor progression
    • Neufert, C., C. Becker, and M.F. Neurath. 2007. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammationdriven tumor progression. Nat. Protoc. 2:1998-2004. http://dx.doi.org/10.1038/nprot.2007.279
    • (2007) Nat. Protoc. , vol.2 , pp. 1998-2004
    • Neufert, C.1    Becker, C.2    Neurath, M.F.3
  • 30
    • 84956913971 scopus 로고    scopus 로고
    • IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
    • Pallangyo, C.K., P.K. Ziegler, and F.R. Greten. 2015. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J. Exp. Med. 212:. http://dx.doi.org/10.1084/jem.20150576
    • (2015) J. Exp. Med. , vol.212
    • Pallangyo, C.K.1    Ziegler, P.K.2    Greten, F.R.3
  • 34
    • 84871080983 scopus 로고    scopus 로고
    • From sentinel cells to inflammatory culprits:cancer-associated fibroblasts in tumour-related inflammation
    • Servais, C., and N. Erez. 2013. From sentinel cells to inflammatory culprits:cancer-associated fibroblasts in tumour-related inflammation. J. Pathol. 229:198-207.
    • (2013) J. Pathol. , vol.229 , pp. 198-207
    • Servais, C.1    Erez, N.2
  • 35
    • 84902539173 scopus 로고    scopus 로고
    • Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling
    • Shaker, A., M. Gargus, J. Fink, J. Binkley, I. Darwech, E. Swietlicki, M.S. Levin, and D.C. Rubin. 2014. Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling. Transl. Res. 164:70-83. http://dx.doi.org/10.1016/j.trsl.2014.03.007
    • (2014) Transl. Res. , vol.164 , pp. 70-83
    • Shaker, A.1    Gargus, M.2    Fink, J.3    Binkley, J.4    Darwech, I.5    Swietlicki, E.6    Levin, M.S.7    Rubin, D.C.8
  • 39
    • 34347262689 scopus 로고    scopus 로고
    • Chemically induced mouse models of intestinal inflammation
    • Wirtz, S., C. Neufert, B. Weigmann, and M.F. Neurath. 2007. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2:541-546. http://dx.doi.org/10.1038/nprot.2007.41
    • (2007) Nat. Protoc. , vol.2 , pp. 541-546
    • Wirtz, S.1    Neufert, C.2    Weigmann, B.3    Neurath, M.F.4
  • 40
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu, H., D. Pardoll, and R. Jove. 2009. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer. 9:798-809. http://dx.doi.org/10.1038/nrc2734
    • (2009) Nat. Rev. Cancer. , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3


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