Recent Insights Into Health Benefits of Carotenoids

Handbook on Natural Pigments in Food and Beverages: Industrial Applications for Improving Food Color

Volumn , Issue , 2016, Pages 474-497

  Cooperstone, J L ^a   Schwartz, S J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Age related macular degeneration; Antioxidants; Cancer; Cardiovascular disease; Carotenoids; Chronic disease; Health; Photosensitivity; Provitamin A

Indexed keywords

EID: 84979879903     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-08-100371-8.00020-8     Document Type: Chapter

References (154)

1. Age-Related Eye Disease Study 2 Group Lutein+zeaxanthin and omega-3 fatty acids for age-related macular degeneration. Journal of the American Medical Association 2013, 309:2005-2015. 10.1001/jama.2013.4997.
2. Age-Related Eye Disease Study Group A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Archives of Ophthalmology 2001, 119:1417-1436.
3. Ahmed S.S., Lott M.N., Marcus D.M. The macular xanthophylls. Survey of Ophthalmology 2005, 50:183-193. 10.1016/j.survophthal.2004.12.009.
4. Anstey A. Systemic photoprotection with alpha-tocopherol (vitamin E) and beta-carotene. Clinical and Experimental Dermatology 2002, 27:170-176.
5. Arden G.B., Barker F.M. Canthaxanthin and the eye: a critical ocular toxicological assessment. Journal of Toxicology Cutaneous and Ocular Toxicology 1991, 10:115-155. 10.3109/15569529109057908.
6. Aronow M.E., Chew E.Y. Age-related eye disease study 2: perspectives, recommendations, and unanswered questions. Current Opinion in Ophthalmology 2014, 25:186-190. 10.1097/ICU.0000000000000046.
7. Astley S.B., Elliott R.M., Archer D.B., Southon S. Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage:repair balance in human lymphocytes. British Journal of Nutrition 2004, 91:63-72. 10.1079/BJN20031001.
8. Aust O., Stahl W., Sies H., Tronnier H., Heinrich U. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. International Journal for Vitamin and Nutrition Research 2005, 75:54-60. 10.1024/0300-9831.74.1.
9. Barber N.J., Zhang X., Zhu G., Pramanik R., Barber J.A., Martin F.L., Morris J.D.H., Muir G.H. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases 2006, 9:407-413. 10.1038/sj.pcan.4500895.
10. Bauernfeind J. Carotenoid vitamin A precursors and analogs in food and feeds. Journal of Agricultural and Food Chemistry 1972, 20:455-473.
11. Beatty S., Murray I.J., Henson D.B., Carden D., Koh H., Boulton M.E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Investigative Ophthalmology & Visual Science 2001, 42:439-446.
12. Ben-Dor A., Steiner M., Gheber L., Danilenko M., Dubi N., Linnewiel K., Zick A., Sharoni Y., Levy J. Carotenoids activate the antioxidant response element transcription system. Molecular Cancer Therapeutics 2005, 4:177-186.
13. Bertram J.S. Carotenoids and gene regulation. Nutrition Reviews 1999, 57:182-191.
14. Bohn T., Blackwell M., Francis D.M., Tian Q., Schwartz S.J., Clinton S.K., Blackwood M., Francis D.M., Tian Q., Schwartz S.J., Clinton S.K., Blackwell M., Francis D.M., Tian Q., Schwartz S.J., Clinton S.K., Blackwood M. Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials. Nutrition and Cancer 2013, 65:919-929. 10.1080/01635581.2011.630156.
15. Bone R.A., Landrum J.T., Friedes L.M., Gomez C.M., Kilburn M.D., Menendez E., Vidal I., Wang W. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Experimental Eye Research 1997, 64:211-218. 10.1006/exer.1996.0210.
16. Bone R.A., Landrum J.T., Mayne S.T., Gomez C.M., Tibor S.E., Twaroska E.E. Macular pigment in donor eyes with and without AMD: a case-control study. Investigative Ophthalmology & Visual Science 2001, 42:235-240.
17. Bowen P.E., Stacewicz-Sapuntzakis M., Diwadkar-Navsariwala V. Pigments in fruits and vegetables. Pigments in Fruits and Vegetables 2015, 31-67. Springer Science+Business Media, New York. 10.1007/978-1-4939-2356-4. C. Chen (Ed.).
18. Britton G. Vitamin A and vitamin A deficiency. Carotenoids Volume 5: Nutrition and Health 2009, 173-190. Birkauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
19. Britton G. Functions of carotenoid metabolites and breakdown products. Carotenoids Volume 4: Natural Functions 2008, 309-324. Birkauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
20. Britton G. Overview of carotenoid biosynthesis. Carotenoids Volume 3: Biosynthesis 1998, 13-147. Birkauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
21. Carotenoids Handbook 2004, Birkhauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
22. Brown M.J., Ferruzzi M.G., Nguyen M.L., Cooper D.A., Eldridge A.L., Schwartz S.J., White W.S. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. American Journal of Clinical Nutrition 2004, 80:396-403.
23. Bub A., Watzl B., Abrahamse L., Delincée H., Adam S., Wever J., Müller H., Rechkemmer G. Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. Journal of Nutrition 2000, 130:2200-2206.
24. Bunker C.H., McDonald A.C., Evans R.W., de la Rosa N., Boumosleh J.M., Patrick A.L. A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. Nutrition and Cancer 2007, 57:130-137. 10.1080/01635580701274046.
25. Burton G., Ingold K. Beta-carotene: an unusual type of lipid antioxidant. Science 1984, 224:569-573.
26. Burton-Freeman B., Talbot J., Park E., Krishnankutty S., Edirisinghe I. Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women. Molecular Nutrition & Food Research 2012, 56:622-631. 10.1002/mnfr.201100649.
27. Castenmiller J.J.M., West C.E. Bioavailability and bioconversion of carotenoids. Annual Review of Nutrition 1998, 18:19-38.
28. Césarini J.P., Michel L., Maurette J.M., Adhoute H., Béjot M. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatology Photoimmunology and Photomedicine 2003, 19:182-189. 10.1034/j.1600-0781.2003.00044.x.
29. Chen L., Stacewicz-Sapuntzakis M., Duncan C., Sharifi R., Ghosh L., van Breemen R., Ashton D., Bowen P.E. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. Journal of the National Cancer Institute 2001, 93:1872-1879.
30. Clark P.E., Hall M.C., Borden L.S., Miller A.A., Hu J.J., Lee W.R., Stindt D., D'Agostino R., Lovato J., Harmon M., Torti F.M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology 2006, 67:1257-1261. 10.1016/j.urology.2005.12.035.
31. Clevidence B.A., Bieri J.G. Association of carotenoids with human plasma lipoproteins. Methods in Enzymology 1993, 214:33-46.
32. Cooper D., Eldridge A., Peters J. Dietary carotenoids and certain cancers, heart disease, and age-related macular degeneration: a review of recent research. Nutrition Reviews 1999, 57:201-214. 10.1111/j.1753-4887.1999.tb06944.x.
33. Cooperstone J.L., Ralston R.A., Riedl K.M., Haufe T.C., Schweiggert R.M., King S.A., Timmers C.D., Francis D.M., Lesinski G.B., Clinton S.K., Schwartz S.J. Enhanced bioavailability of lycopene in humans when consumed as cis-isomers from tangerine tomatoes compared to red tomato juicees, a randomized, cross-over clinical trial. Molecular Nutrition & Food Research 2015, 59:658-669. 10.1002/mnfr.201400013.
34. Dauchet L., Amouyel P., Hercberg S., Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. Journal of Nutrition 2006, 136:2588-2593.
35. De Gruijl F.R. Skin cancer and solar UV radiation. European Journal of Cancer 1999, 35:2003-2009. 10.1016/S0959-8049(99)00283-X.
36. Di Mascio P., Kaiser S., Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Archives of Biochemistry and Biophysics 1989, 274:532. 10.1016/0003-9861(89)90467-0.
37. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 1981, 66:1191-1308.
38. Eliassen A.H., Hendrickson S.J., Brinton L.A., Buring J.E., Campos H., Dai Q., Dorgan J.F., Franke A.A., Gao Y., Goodman M.T., Hallmans G., Helzlsouer K.J., Hoffman-Bolton J., Hulten K., Sesso H.D., Sowell A.L., Tamimi R.M., Toniolo P., Wilkens L.R., Winkvist A., Zeleniuch-Jacquotte A., Zheng W., Hankinson S.E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. Journal of the National Cancer Institute 2012, 104:1905-1916. 10.1093/jnci/djs461.
39. Eliassen A.H., Liao X., Rosner B., Tamimi R.M., Tworoger S.S., Hankinson S.E. Plasma carotenoids and risk of breast cancer over 20 y of follow-up. American Journal of Clinical Nutrition 2015, 101:1197-1205. 10.3945/ajcn.114.105080.
40. English D.R., Armstrong B.K., Kricker A., Fleming C. Sunlight and cancer. Cancer Causes & Control 1997, 8:271-283.
41. Epstein J.H. Effects of beta-carotene on ultraviolet induced cancer formation in the hairless mouse skin. Photochemistry and Photobiology 1977, 25:211-213.
42. Esmaillzadeh A., Kimiagar M., Mehrabi Y., Azadbakht L., Hu F.B., Willett W.C. Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. American Journal of Clinical Nutrition 2006, 84:1489-1497.
43. Garmyn M., Ribaya-Mercado J.D., Russel R.M., Bhawan J., Gilchrest B.A. Effect of beta-carotene supplementation on the human sunburn reaction. Experimental Dermatology 1995, 4:104-111. 10.1111/j.1600-0625.1995.tb00231.x.
44. Gartner C., Stahl W., Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. American Journal of Clinical Nutrition 1997, 66:116-122.
45. Gaziano J.M., Manson J.E., Branch L.G., Colditz G.A., Willett W.C., Buring J.E. A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. Annals of Epidemiology 1995, 5:255-260. 10.1016/1047-2797(94)00090-G.
46. Ghavipour M., Saedisomeolia A., Djalali M., Sotoudeh G., Eshraghyan M.R., Malekshahi Moghadam A., Wood L.G., Moghadam A.M., Wood L.G., Malekshahi Moghadam A., Wood L.G., Moghadam A.M., Wood L.G., Malekshahi Moghadam A., Wood L.G., Moghadam A.M., Wood L.G. Tomato juice consumption reduces systemic inflammation in overweight and obese females. British Journal of Nutrition 2012, 109:2031-2035. 10.1017/S0007114512004278.
47. Giovannucci E. Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature. Journal of Nutrition 2005, 135:2030S-2031S.
48. Giovannucci E., Ascherio A., Rimm E.B., Stampfer M.J., Colditz G.A., Willett W.C. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995, 87:1767-1776.
49. Gollnick H.P., Hopfenmuller W., Hemmes C., Chun S.C., Schmid C., Sundermeier K., Biesalski H.K. Systemic beta carotene plus topic UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the Berlin-Eilath study. European Journal of Dermatology 2011, 6:200-205. 10.1556/AAlim.2015.0002.
50. Grainger E.M., Schwartz S.J., Wang S., Unlu N.Z., Boileau T.W.-M., Ferketich A.K., Monk J.P., Gong M.C., Bahnson R.R., DeGroff V.L., Clinton S.K. A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutrition and Cancer 2008, 60:145-154. 10.1080/01635580701621338.
51. Hadley C.W., Clinton S.K., Schwartz S.J. The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. Journal of Nutrition 2003, 133:727-732.
52. Harrison E.H. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochimica et Biophysica Acta 2012, 1821:70-77. 10.1016/j.bbalip.2011.06.002.
53. He F., Nowson C., Lucas M., MacGregor G. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. Journal of Human Hypertension 2007, 21:717-728. 10.1038/sj.jhh.1002212.
54. Heinonen O., Huttunen J., Albanes D. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The New England Journal of Medicine 1994, 330:1029-1035.
55. Heinrich U., Gärtner C., Wiebusch M., Eichler O., Sies H., Tronnier H., Stahl W., Gartner C., Wiebusch M., Eichler O., Sies H., Tronnier H., Stahl W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. Journal of Nutrition 2003, 133:98-101.
56. Hininger I.A., Meyer-Wenger A., Moser U., Wright A., Southon S., Thurnham D., Chopra M., Van Den Berg H., Olmedilla B., Favier A.E., Roussel A.-M. No significant effects of lutein, lycopene or ?-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. Journal of the American College of Nutrition 2001, 20:232-238. 10.1080/07315724.2001.10719037.
57. Hozawa A., Jacobs D.R., Steffes M.W., Gross M.D., Lyn M., Lee D.-H., Jacobs D.R., Steffes M.W., Gross M.D., Steffen L.M., Lee D.-H. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development In young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clinical Chemistry 2007, 53:447-455. 10.1373/clinchem.2006.074930.
58. Huang D., Ou B., Prior R.L. The chemistry behind antioxidant capacity assays. Journal of Agricultural and Food Chemistry 2005, 53:1841-1856. 10.1021/jf030723c.
59. Institutes of Medicine Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc 2002, National Academy Press, Washington, DC.
60. Institutes of Medicine Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids 2000, National Academy Press, Washington, DC.
61. Jacob K., Periago M.J., Böhm V., Berruezo G.R., Bohm V., Berruezo G.R. Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation. British Journal of Nutrition 2008, 99:137-146. 10.1017/S0007114507791894.
62. Jatoi A., Burch P., Hillman D., Vanyo J.M., Dakhil S., Nikcevich D., Rowland K., Morton R., Flynn P.J., Young C., Tan W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology 2007, 69:289-294. 10.1016/j.urology.2006.10.019.
63. Johnson E.J., Krinsky N.I. Carotenoids and coronary heart disease. Carotenoids Volume 5: Nutrition and Health 2009, 288-300. Birkhauser Verkag, Basek. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
64. Johnson E.J., Neuringer M., Russell R.M., Schalch W., Snodderly D.M. Nutritional manipulation of primate retinas, III: effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys. Investigative Ophthalmology & Visual Science 2005, 46:692-702. 10.1167/iovs.02-1192.
65. Jung S., Wu K., Giovannucci E., Spiegelman D., Willett W.C., Smith-Warner S.A. Carotenoid intake and risk of colorectal adenomas in a cohort of male health professionals. Cancer Causes & Control 2013, 24:705-717. 10.1007/s10552-013-0151-y.
66. Khachik F., Beecher G.R., Goli M.B., Lusby W.R., Smith J.C. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Analytical Chemistry 1992, 64:2111-2122.
67. Khachik F., Spangler C., Smith J., Canfield L., Steck A., Pfander H. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Analytical Chemistry 1997, 69:1873-1881.
68. Kim Y.C., Masutani H., Yamaguchi Y., Itoh K., Yamamoto M., Yodoi J. Hemin-induced activation of the thioredoxin gene by Nrf2: a differential regulation of the antioxidant responsive element by a switch of its binding factors. Journal of Biological Chemistry 2001, 276:18399-18406. 10.1074/jbc.M100103200.
69. Knekt P., Reunanen A., Jarvinen R., Seppanen R., Heliovaara M., Aromaa A. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. American Journal of Epidemiology 1994, 139:1180-1189.
70. Köpcke W., Krutmann J. Protection from sunburn with ?-carotene - a meta-analysis. Photochemistry and Photobiology 2008, 84:284-288. 10.1111/j.1751-1097.2007.00253.x.
71. Kopec R.E., Cooperstone J.L., Schweiggert R.M., Young G.S., Harrison E.H., Francis D.M., Clinton S.K., Schwartz S.J. Avocado consumption enhances human postprandial provitamin A absorption and conversion from a novel high-beta-carotene tomato sauce and from carrots. Journal of Nutrition 2014, 144:1158-1166. 10.3945/jn.113.187674.
72. Krinsky N.I. Effects of carotenoids in cellular and animal systems. American Journal of Clinical Nutrition 1991, 53:238S-246S.
73. Krinsky N.I. Antioxidant functions of carotenoids. Free Radical Biology and Medicine 1989, 7:617-635.
74. Krinsky N.I., Cronwell D.G., Oncley J.L. The transport of vitamin A and carotenoids in human plasma. Archives of Biochemistry Biophysics 1958, 73:233-246.
75. Krinsky N.I., Landrum J.T., Bone R.A. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annual Review of Nutrition 2003, 23:171-201. 10.1146/annurev.nutr.23.011702.073307.
76. Krinsky N.I., Yeum K.-J. Carotenoid-radical interactions. Biochemical and Biophysical Research Communications 2003, 305:754-760. 10.1016/S0006-291X(03)00816-7.
77. Krutovskikh V., Asamoto M., Takasuka N., Murakoshi M., Nishino H., Tsuda H. Differential dose-dependent effects of alpha, beta-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo. Japanese Journal of Cancer Research 1997, 88:1121-1124.
78. Kushi L.H., Folsom A.R., Prineas R.J., Mink P.J., Wu Y., Bostick R.M. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. The New England Journal of Medicine 1996, 334:1156-1162.
79. Lee J., Jiang S., Levine N., Watson R.R. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proceedings of the Society for Experimental Biology and Medicine 2000, 223:170-174.
80. Li Y.-F., Chang Y.-Y., Hunag H.-C., Wu Y.-C., Yang M.-D., Chao P.-M. Tomato juice supplementation in young women reduces inflammatory adipokine levels independently of body fat reduction. Nutrition 2015, 31:691-696. 10.1016/j.nut.2014.11.008.
81. Lian F., Wang X.-D. Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells. International Journal of Cancer 2008, 123:1262-1268.
82. Livny O., Kaplan I., Reifen R., Polak-Charcon S., Madar Z., Schwartz B. Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells. Journal of Nutrition 2002, 132:3754-3759.
83. Lu M.-S., Fang Y.-J., Chen Y.-M., Luo W.-P., Pan Z.-Z., Zhong X., Zhang C.-X. Higher intake of carotenoid is associated with a lower risk of colorectal cancer in Chinese adults: a case-control study. European Journal of Nutrition 2015, 54:619-628. 10.1007/s00394-014-0743-7.
84. Lu Q.-Y., Hung J.-C., Heber D., Go V.L.W., Reuter V.E., Cordon-Cardo C., Scher H.I., Marshall J.R., Zhang Z.-F. Inverse associations between plasma lycopene and other carotenoids and prostate Cancer. Cancer Epidemiology Biomarkers & Prevention 2001, 10:749-756.
85. Luvizotto R.D.A.M., Nascimento A.F., Imaizumi E., Pierine D.T., Conde S.J., Correa C.R., Yeum K.-J., Ferreira A.L.A. Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats. British Journal of Nutrition 2013, 110:1803-1809. 10.1017/S0007114513001256.
86. Ma L., Dou H.-L., Wu Y.-Q., Huang Y.-M., Huang Y.-B., Xu X.-R., Zou Z.-Y., Lin X.-M. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. British Journal of Nutrition 2012, 107:350-359. 10.1017/S0007114511004260.
87. Mares-Perlman J.A., Fisher A.I., Klein R., Palta M., Block G., Millen A.E., Wright J.D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. American Journal of Epidemiology 2001, 153:424-432. 10.1093/aje/153.5.424.
88. Mathews-Roth M., Pathak M., Parrish J., Fitzpatrick T., Kass E., Toda K., Clemens W. A clinical trial of the effects of oral beta-carotene on the responses of human skin to solar radiation. Journal of Investigative Dermatology 1972, 59:349-353.
89. Mathews-Roth M.M. Carotenoids in erythropoetic protoporphyria and other photosensitivity diseases. Annals of the New York Academy of Sciences 1993, 691:127-138.
90. Mathews-Roth M.M. Carotenoid pigment administration and delay in development of UV-B induced tumors. Photochemistry and Photobiology 1983, 37:509-511.
91. Mathews-Roth M.M., Krinsky N.I. Carotenoids affect development of UV-B induced skin cancer. Photochemistry and Photobiology 1987, 46:507-509.
92. Mathews-Roth M.M., Krinsky N.I. Carotenoid dose level and protection against UV-B induced skin tumors. Photochemistry and Photobiology 1985, 42:35-38.
93. Mathews-Roth M.M., Pathak M.A. Phytoene as a photoprotective agent against sunburn (>280nm) radiation in guinea pigs. Photochemistry and Photobiology 1975, 21:261-263.
94. Mathews-Roth M.M., Pathak M.A., Fitzpatrick T.B., Harber L.C., Kass E.H. Beta-carotene as an oral photoprotective agent in erythropoetic protoporphyria. Journal of the American Medical Association 1974, 228:1004-1008.
95. Mathews-Roth M.M., Pathak M.A., Fitzpatrick T.B., Harber L.C., Kass E.H. Beta-carotene as a photoprotective agent in erythropoetic protoporphyria. The New England Journal of Medicine 1970, 282:1231-1234.
96. Mathews-Roth M.M., Pathak M.A., Fitzpatrick T.B., Harber L.H., Kass E.H. Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases. Archives of Dermatology 1977, 113:1229-1232. 10.1001/archderm.1977.01640090077011.
97. Michaud D.S., Deskanich D., Rimm E.B., Colditz G.A., Speizer F.E., Willett W.C., Giovannucci E. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. American Journal of Clinical Nutrition 2000, 72:990-997.
98. Moon J.-K.K., Shibamoto T. Antioxidant assays for plant and food components. Journal of Agricultural and Food Chemistry 2009, 57:1655-1666. 10.1021/jf803537k.
99. Moran N.A., Jarvik T. Lateral transfer of genes from fungi underlies carotenoid production in aphids. Science 2010, 328:624-627. 10.1126/science.1187113.
100. Mucci L.A., Tamimi R., Lagiou P., Trichopoulou A., Benetou V., Spanos E., Trichopoulos D. Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system?. BJU International 2001, 87:814-820. 10.1046/j.1464-410X.2001.02191.x.
101. Nolan J.M., Meagher K., Kashani S., Beatty S. Response to Bernstein et al. Eye 2014, 28:242-244. 10.1038/eye.2013.258.
102. Nolan J.M., Meagher K., Kashani S., Beatty S., Bernstein P., Johnson E., Neuringer M., Schalch W., Scierle J. What is meso-zeaxanthin, and where does it come from?. Eye 2013, 27:899-905. 10.1038/eye.2013.98.
103. Noy N. Vitamin A. Biochemical, Physiological, Molecular Aspects of Human Nutrition 2006, 835-862. Saunders Elsevier, St. Louis, MO. M.H. Stipanuk (Ed.).
104. Obarzanek E., Sacks F.M., Vollmer W.M., Bray G.A., Miller E.R., Lin P.H., Karanja N.M., Most-Windhauser M.M., Moore T.J., Swain J.F., Bales C.W., Proschan M.A. Effects on blood lipids of a blood pressure-lowering diet: the dietary approaches to stop hypertension (DASH) trial. American Journal of Clinical Nutrition 2001, 74:80-89.
105. Omenn G.S., Goodman G., Thornquist M., Grizzle J., Rosenstock L., Barnhart S., Balmes J., Cherniack M.G., Cullen M.R., Glass A., Keogh J., Meyskens F., Valanis B., Williams J. The ?-carotene and retinol efficacy trial (CARET) for chemoprevention of lung cancer in high risk populations: smokers and asbestos-exposed workers. Cancer Research 1994, 54:2038S-2043S. 10.1016/0169-5002(94)92177-6.
106. Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P., Meyskens F.L., Valanis B., Williams J.H., Barnhart S., Hammar S. Effects of a combination of beta carotene and vitamin A on lung Cancer and cardiovascular disease. The New England Journal of Medicine 1996, 334:1150-1155. 10.1056/NEJM199605023341802.
107. Oyebode O., Gordon-Dseagu V., Walker A., Mindell J.S. Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of health survey for England data. Journal of Epidemiology & Community Health 2014, 68:856-862. 10.1136/jech-2013-203500.
108. Palozza P., Serini S., Di Nicuolo F., Piccioni E., Calviello G. Prooxidant effects of beta-carotene in cultured cells. Molecular Aspects of Medicine 2003, 24:353-362. 10.1016/S0098-2997(03)00031-1.
109. Palozza P., Simone R., Catalano A., Russo M., Bohm V. Lycopene modulation of molecular targets affected by smoking exposure. Current Cancer Drug Targets 2012, 12:640-657.
110. Peto R., Doll R., Buckley J., Sporn M. Can dietary beta-carotene materially reduce human cancer rates?. Nature 1981, 290:201-208.
111. Prior R.L., Wu X., Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agricultural and Food Chemistry 2005, 53:4290-4302. 10.1021/jf0502698.
112. Ramos-Gomez M., Kwak M.K., Dolan P.M., Itoh K., Yamamoto M., Talalay P., Kensler T.W. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:3410-3415. 10.1073/pnas.051618798.
113. Rao A.V., Rao L.G. Carotenoids and human health. Pharmacological Research 2007, 55:207-216. 10.1016/j.phrs.2007.01.012.
114. Rautalahti M., Albanes D., Virtamo J., Taylor P., Huttunen J., Heinonen O. Beta-carotene did not work: aftermath of the ATBC study. Cancer Letters 1997, 114:235-236.
115. Riedl J., Linseisen J., Hoffmann J., Wolfram G. Some dietary fibers reduce the absorption of carotenoids in women. Journal of Nutrition 1999, 129:2170-2176.
116. Rimm E.B., Stampfer M.J., Ascherio A., Giovannucci E., Colditz G.A., Willett W.C. Vitamin E consumption and the risk of coronary heart disease in men. The New England Journal of Medicine 1993, 328:1450-1456.
117. Rizwan M., Rodriguez-Blanco I., Harbottle A., Birch-Machin M.A., Watson R.E.B., Rhodes L.E. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. British Journal of Dermatology 2011, 164:154-162. 10.1111/j.1365-2133.2010.10057.x.
118. Rock C.L. Carotenoids and cancer. Carotenoids in Health and Disease 2004, 269-286. Marcel Dekker, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
119. Rock C.L. Carotenoids and cancer. Carotenoids Volume 5: Nutrition and Health 2009, 269-286. Birkhauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
120. Rock C.L., Lovalvo J.L., Emenhiser C., Ruffin M.T., Flatt S.W., Schwartz S.J. Bioavailability of beta-carotene is lower in raw than in processed carrots and spinach in women. Journal of Nutrition 1998, 128:913-916.
121. Rock C.L., Swendseid M.E. Plasma beta-carotene response in humans after meals supplemented with dietary pectin. American Journal of Clinical Nutrition 1992, 55:96-99.
122. Ross A.C., Harrison E.H. Vitamin A: nutrition aspects of retinoids and carotenoids. Handbook of Vitamins 2014, 1-50. CRC Press, Boca Raton, FL. 10.1016/0891-5849(91)90176-4. J. Zempleni, J.W. Suttie, J.F. Gregory, P.J. Stover (Eds.).
123. Sacks F.M., Svetkey L.P., Vollmer W.M., Appel L.J., Bray G.A., Harsha D., Obarzanek E., Conlin P.R., Miller E.R., Simons-Morton D.G., Karanja N., Lin P.-H. Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. The New England Journal of Medicine 2001, 344:3-10.
124. Sahyoun N.R., Jacques P.F., Russell R.M. Carotenoids, vitamins C and E, and mortality in an elderly population. American Journal of Epidemiology 1996, 144:501-511.
125. Schalch W., Landrum J.T., Bone R.A. The eye. Carotenoids Volume 5: Nutrition and Health 2009, 301-334. Birkauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
126. Schwarz S., Obermüller-Jevic U.C., Hellmis E., Koch W., Jacobi G., Biesalski H.-K. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. Journal of Nutrition 2008, 138:49-53.
127. Schweiggert R.M., Carle R. Carotenoid deposition in plant and animal foods and its impact on bioavailability. Critical Reviews In Food Science and Nutrition 2016, (Epub ahead of print). 10.1080/10408398.2015.1012756.
128. Schweiggert R.M., Kopec R.E., Villalobos-Gutierrez M.G., Högel J., Quesada S., Esquivel P., Schwartz S.J., Carle R. Carotenoids are more bioavailable from papaya than from tomato and carrot in humans: a randomised cross-over study. British Journal of Nutrition 2014, 111:490-498. 10.1017/S0007114513002596.
129. Seddon J.M., Ajani U.A., Sperduto R.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., Yannuzzi L.A., Willet W. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Journal of the American Medical Association 1994, 272:1413-1420.
130. Sesso H.D., Gaziano J.M. Heart and vascular diseases. Carotenoids in Health and Disease 2004, 473-490. Marcel Dekker, New York. N.I. Krinsky, S.T. Mayne, H. Sies (Eds.).
131. Sharoni Y., Danilenko M., Dubi N., Ben-Dor A., Levy J. Carotenoids and transcription. Archives of Biochemistry and Biophysics 2004, 430:89-96. 10.1016/j.abb.2004.03.009.
132. Sharoni Y., Linnewiel-Hermoni K., Zango G., Khanin M., Salman H., Veprik A., Danilenko M., Levy J. The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention. American Journal of Clinical Nutrition 2012, 96S:1173S-1178S. 10.3945/ajcn.112.034645.
133. Sies H., Stahl W. Nutritional protection against skin damage from sunlight. Annual Review of Nutrition 2004, 24:173-200. 10.1146/annurev.nutr.24.012003.132320.
134. Stahl W., Heinrich U., Aust O., Tronnier H., Sies H. Lycopene-rich products and dietary photoprotection. Photochemical & Photobiological Sciences 2005, 5:238-242. 10.1039/b505312a.
135. Stahl W., Heinrich U., Jungmann H., Sies H., Tronnier H. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. American Journal of Clinical Nutrition 2000, 71:795-798.
136. Stahl W., Heinrich U., Wiseman S., Eichler O., Sies H., Tronnier H. Dietary tomato paste protects against ultraviolet light-induced erythema in humans. Journal of Nutrition 2001, 131:1449-1451.
137. Stahl W., Nicolai S., Briviba K., Hanusch M., Broszeit G., Peters M., Martin H.D., Sies H. Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis 1997, 18:89-92. 10.1093/carcin/18.1.89.
138. Stahl W., Sies H. Beta-carotene and other carotenoids in protection from sunlight. American Journal of Clinical Nutrition 2012, 96:1179-1184. 10.3945/ajcn.112.034819.
139. Steinmetz K.A., Potter J.D. Vegetables, fruit, and cancer prevention: a review. Journal of the American Dietetic Association 1996, 96:1027-1039. 10.1016/S0002-8223(96)00273-8.
140. Story E.N., Kopec R.E., Schwartz S.J., Harris G.K. An update on the health effects of tomato lycopene. Annual Review of Food Science and Technology 2010, 1:189-210. 10.1146/annurev.food.102308.124120.
141. Unlu N.Z., Bohn T., Francis D., Clinton S.K., Schwartz S.J. Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes. Journal of Agricultural and Food Chemistry 2007, 55:1597-1603. 10.1021/jf062337b.
142. Vaishampayan U., Hussain M., Banerjee M., Seren S., Sarkar F.H., Fontana J., Forman J.D., Cher M.L., Powell I., Pontes J.D., Kucuk O. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutrition and Cancer 2007, 59:1-7.
143. Wan L., Tan H.-L., Thomas-Ahner J.M., Pearl D.K., Erdman J.W., Moran N.E., Clinton S.K. Dietary tomato and lycopene impact androgen signaling- and carcinosgenesis-related gene expression during early TRAMP prostate carcinogenesis. Cancer Prevention Research 2014, 7:1228-1240. 10.1158/1940-6207.CAPR-14-0182.
144. Wang X.-D. Carotenoids. Modern Nutrition in Health and Disease 2014, 427-439. Lippincott Williams & Wilkins, Baltimore, MD. A.C. Ross, B. Caballero, R.J. Cousins, K.L. Tucker, T.R. Ziegler (Eds.).
145. Wang X.-D. Lycopene metabolism and its biological significance. American Journal of Clinical Nutrition 2012, 96S:1214S-1222S. 10.3945/ajcn.111.032359.1.
146. Watzl B., Kulling S.E., Moseneder J., Barth S.W., Bub A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. American Journal of Clinical Nutrition 2005, 82:1052-1058.
147. Wolf C., Steiner A., Hönigsmann H. Do oral carotenoids protect human skin against ultraviolet erythema, psoralen phototoxicity, and ultraviolet-induced DNA damage?. Journal of Investigative Dermatology 1988, 90:55-57.
148. Yeum K.-J., Aldini G., Russell R.M., Krinsky N.I. Antioxidants/pro-oxidant actions of carotenoids. Carotenoids Volume 5: Nutrition and Health 2009, 235-268. Birkauser Verlag, Basel, Switzerland. G. Britton, S. Liaaen-Jensen, H. Pfander (Eds.).
149. Yochum L.A., Folsom A.R., Kushi L.H. Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women. American Journal of Clinical Nutrition 2000, 72:476-483.
150. Zhang L., Cooney R.V., Bertram J.S. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 1991, 12:2109-2114.
151. Zhang L.X., Cooney R.V., Bertram J.S. Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Research 1992, 52:5707-5712.
152. Zhang X., Spiegelman D., Baglietto L., Bernstein L., Boggs D.A., van den Brandt P.A., Buring J.E., Gapstur S.M., Giles G.G., Giovannucci E., Goodman G., Hankinson S.E., Helzlsouer K.J., Horn-Ross P.L., Inoue M., Jung S., Khudyakov P., Larsson S.C., Lof M., McCullough M.L., Miller A.B., Neuhouser M.L., Palmer J.R., Park Y., Robien K., Rohan T.E., Ross J.A., Schouten L.J., Shikany J.M., Tsugane S., Visvanathan K., Weiderpass E., Wolk A., Willett W.C., Zhang S.M., Ziegler R.G., Smith-Warner S.A. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. American Journal of Clinical Nutrition 2012, 95:713-725. 10.3945/ajcn.111.014415.
153. Ziegler R.G., Mayne S.T., Swanson C.A. Nutrition and lung cancer. Cancer Causes & Control 1996, 7:157-177.
154. Zu K., Mucci L., Rosner B.A., Clinton S.K., Loda M., Stampfer M.J., Giovannucci E. Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era. Journal of the National Cancer Institute 2014, 35:2154-2155. 10.1093/jnci/djt430.