Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching

Carcinogenesis

Volumn 18, Issue 1, 1997, Pages 89-92

  Stahl, Wilhelm ^a   Nicolai, Swantje ^a   Briviba, Karlis ^a   Hanusch, Michael ^a   Broszeit, Guido ^a   Peters, Manfred ^a   Martin, Hans Dieter ^a   Sies, Helmut ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; CANTHAXANTHIN; CAROTENOID; CRYPTOXANTHIN; SINGLET OXYGEN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER PREVENTION; CELL COMMUNICATION; CONTROLLED STUDY; COVALENT BOND; EMBRYO; GAP JUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANTIOXIDANTS; CAROTENOIDS; CELL COMMUNICATION; CELL LINE; FIBROBLASTS; GAP JUNCTIONS; OXYGEN;

EID: 0031418651     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.1.89     Document Type: Article

References (20)

1. Gerster,H. (1993) Anticarcinogenic effects of common carotenoids. Int. J. Vit. Nutr. Res., 63, 93-121.
2. van Poppel,G. and Goldbohm,R.A. (1995) Epidemiological evidence for β-carotene and cancer prevention. Am. J. Clin. Nutr., 62, 1393S-1402S.
3. ATBC-Study Group (1994) The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl .J. Med, 330, 1029-1035.
4. Zhang,L.-X., Cooney,R.V. and Bertram,J.S. (1992) Carotenoids up-regulate connexin43 gene expression independent of their pro-vitamin A or antioxidant properties. Cancer Res., 52, 5707-5712,
5. Zhang,L.-X., Cooney,R.V. and Bertram,J.S. (1991) Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis, 12, 2109-2114.
6. Krinsky,N.I. (1993) Actions of carotenoids in biological systems. Ann. Rev. Nutr., 13, 561-587.
7. Olson,J.A. and Krinsky,N.I. (1995) Introduction: the colorful, fascinating world of the carotenoids: important physiological modulators. FASEB J., 9, 1547-1550.
8. Sies,H. and Stahl,W. (1995) Vitamins E and C, β-carotene and other carotenoids as antioxidants. Am. J. Clin. Nutr., 62, 1315S-1321S.
9. Di Mascio,P., Kaiser,S. and Sies,H. (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys., 274, 532-538.
10. Devasagayam,T.P.A., Ippendorf,H., Werner,T., Martin,H.-D. and Sies,H. (1992) Carotenoids, novel polyene polyketones and new capsorubin isomers as efficient quenchers of singlet molecular oxygen. In Ong,A.S.H. and Packer,L. (eds), Lipid-soluble Antioxidants: Biochemistry and Clinical Applications, Birkhäser Verlag Basel, Switzerland, pp. 255-264.
11. Burton,G.W. and Ingold,K.U. (1984) β-Carotene: an unusual type of lipid antioxidant. Science, 224, 569-573.
12. Hossain,M.Z., Zhang,L.-X. and Bertram.J.S. (1993) Retinoids and carotenoids upregulate gap-junctional communication: correlation with enhanced growth control and cancer prevention. Progr. Cell Res., 3, 301-309.
13. Hanusch,M., Stahl,W., Schulz,W.A. and Sies,H. (1995) Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin. Arch., Biochem. Biophys., 317, 423-428.
14. Martin,H.-D. and Werner,T. (1992) Modified carotenoids: spectroscopy and conformation of capsorubin and related end group isomers. J. Mol. Struct., 266, 91-96.
15. Steward,W.W. (1978) Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. Cell, 14, 741-759.
16. Di Mascio,P. and Sies,H. (1989) Quantification of singlet oxygen generated by thermolysis of 3,3′-(1,4-naphthylidene) dipropionate. Monomol and dimol photoemission and the effects of 1,4-diazobicyclo (2.2.2) octane. J. Am. Chem. Soc., 111, 2909-2914.
17. Di Mascio,R, Sundquist,A.R., Devasagayam,T.P.A. and Sies,H. (1992) Assay of lycopene and other carotenoids as singlet oxygen quenchers. Meth. Enzymol., 213, 429-438.
18. Krinsky,N.I. (1994) Carotenoids and cancer: basic research studies. In Frei,B. (ed.), Natural Antioxidants in Human Health and Disease, Academic Press, San Diego, pp. 239-261.
19. Foote,C.S., Chang,Y.C. and Denny,R.W. (1970) Chemistry of singlet oxygen. X. Carotenoid quenching parallels biological protection. J. Am. Chem. Soc., 92, 5216-5219.
20. Miller,N.J., Sampson,J., Candeias,L.P., Bramley,P.M. and Rice-Evans,C.A. (1996) Antioxidant activities of carotenes and xanthophylls. FEBS Lett., 384, 240-242.