The macular xanthophylls

Survey of Ophthalmology

Volumn 50, Issue 2, 2005, Pages 183-193

  Ahmed, Shazia S ^a   Lott, McGregor N ^a   Marcus, Dennis M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Age related macular degeneration; Carotenoids; Lutein; Macular pigment; Xanthophylls; Zeaxanthin

Indexed keywords

AGENTS ACTING ON THE EYE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BILBERRY EXTRACT; CAROTENOID; CENTRUM SILVER; COPPER; GINKGO BILOBA EXTRACT; HERBACEOUS AGENT; I SENSE OCUSHIELD; ICAPS L AND Z ICAPS AREDS; LYCOPENE; MACULA RX; MESO ZEAXANTHIN; OCUGUARD; OCUVITE EXTRA; OCUVITE LUTEIN; OCUVITE PRESERVISION; RETINOL; SELENIUM; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN; ZINC;

BILBERRY; CORRELATION ANALYSIS; DENSITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG LABELING; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FILTER; HUMAN; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; REVIEW;

EID: 14844282072     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.survophthal.2004.12.009     Document Type: Article

References (111)

1. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 Arch Ophthalmol 119 2001 1417 1436
2. Antioxidant status and neovascular age-related macular degeneration Eye Disease Case-Control Study Group Arch Ophthalmol 111 1993 104 109
3. Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Macular Photocoagulation Study Group Arch Ophthalmol 111 1993 1189 1199
4. Risk factors for neovascular age-related macular degeneration. The Eye Disease Case-Control Study Group Arch Ophthalmol 110 1992 1701 1708
5. D. Armstrong, and T. Hiramitsu Studies of experimentally induced retinal degeneration: 2. Early morphological changes produced by lipid peroxides in the albino rabbit Jpn J Ophthalmol 34 1990 158 173
6. S. Beatty, I.J. Murray, and D.B. Henson Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population Invest Ophthalmol Vis Sci 42 2001 439 446
7. T.T. Berendschot, R.A. Goldbohm, and W.A. Klöpping Influence of lutein supplementation on macular pigment, assessed with two objective techniques Invest Ophthalmol Vis Sci 41 2000 3322 3326
8. P.S. Bernstein, N.A. Balashov, and E.D. Tsong Retinal tubulin binds macular carotenoids Invest Ophthalmol Vis Sci 38 1997 167 175
9. P.S. Bernstein, F. Khachik, and L.S. Carvalho Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye Exp Eye Res 72 2001 215 223
10. P.S. Bernstein, M.D. Yoshida, and N.B. Katz Raman detection of macular carotenoid pigments in intact human retina Invest Ophthalmol Vis Sci 39 1998 2003 2011
11. P.S. Bernstein, D.Y. Zhao, and S.W. Wintch Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients Ophthalmology 109 2002 1780 1787
12. M.S. Blumenkranz, S.R. Russell, and M.G. Robey Risk factors in age-related maculopathy complicated by choroidal neovascularization Ophthalmology 93 1986 552 558
13. R.A. Bone, J.T. Landrum, and Z. Dixon Lutein and zeaxanthin in the eyes, serum and diet of human subjects Exp Eye Res 71 2000 239 245
14. R.A. Bone, J.T. Landrum, and L. Fernandez Analysis of the macular pigment by HPLC: retinal distribution and age study Invest Ophthalmol Vis Sci 29 1988 843 849
15. R.A. Bone, J.T. Landrum, and L.M. Friedes Distribution of lutein and zeaxanthin stereoisomers in the human retina Exp Eye Res 64 1997 211 218
16. R.A. Bone, J.T. Landrum, and G.W. Hime Stereochemistry of the human macular carotenoids Invest Ophthalmol Vis Sci 34 1993 2033 2040
17. R.A. Bone, J.T. Landrum, and S.T. Mayne Macular pigment in donor eyes with and without AMD: a case-control study Invest Ophthalmol Vis Sci 42 2001 235 240
18. R.A. Bone, J.T. Landrum, and S.L. Tarsis Preliminary identification of the human macular pigment Vision Res 25 1985 1531 1535
19. R.A. Bone, J.T. Landrum, and S.L. Tarsis Preliminary identification of the human macular pigment Vision Res 25 1985 1531 1535
20. P.E. Bowen, S.M. Herbst-Espinosa, and E.A. Hussain Esterification does not impair lutein bioavailability in humans J Nutr 132 2002 3668 3673
21. G. Chaine, A. Hullo, and J. Sahel Case-control study of the risk factors for age related macular degeneration. France-DMLA Study Group Br J Ophthalmol 82 1998 996 1002
22. B.A. Clevidence, and J.G. Bieri Association of carotenoids with human plasma lipoproteins Methods Enzymol 214 1993 33 46
23. R.J. Cogdell, T.G. Monger, and W.W. Parson Carotenoid triplet states in reaction centers from Rhodopseudomonas sphaeroides and Rhodospirillum rubrum Biochim Biophys Acta 408 1975 189 199
24. K.J. Cruickshanks, R. Klein, and B.E. Klein Sunlight and age-related macular degeneration. The Beaver Dam Eye Study Arch Ophthalmol 111 1993 514 518
25. P. Darzins, P. Mitchell, and R.F. Heller Sun exposure and age-related macular degeneration. An Australian case-control study Ophthalmology 104 1997 770 776
26. S. de Pee, C.E. West, and D. Permaesih Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and beta-carotene in schoolchildren in Indonesia Am J Clin Nutr 68 1998 1058 1067
27. P. Di Mascio, S. Kaiser, and H. Sies Lycopene as the most efficient biological carotenoid singlet oxygen quencher Arch Biochem Biophys 274 1989 532 538
28. N. Drasdo, and C.W. Fowler Non-linear projection of the retinal image in a wide-angle schematic eye Br J Ophthalmol 58 1974 709 714
29. C.S. Foote Photosensitized oxidation and singlet oxygen: consequences in biological systems W.A. Pryor Free Radicals in Biology ed 2 1976 Academic Press New York 85 133
30. C. Gärtner, W. Stahl, and H. Sies Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human Int J Vitam Nutr Res 66 1996 119 125
31. J.D.M. Gass Stereoscopic atlas of macular diseases ed 4 1997 Mosby St Louis
32. Z. Gregor, A.C. Bird, and I.H. Chisholm Senile disciform macular degeneration in the second eye Br J Ophthalmol 61 1977 141 147
33. W.T. Ham, H.A. Mueller, and J.J. Ruffolo Action spectrum for retinal injury from near-ultraviolet radiation in the aphakic monkey Am J Ophthalmol 93 1982 299 306
34. W.T. Ham, H.A. Mueller, and D.H. Sliney Retinal sensitivity to damage from short wavelength light Nature 260 1976 153 155
35. B.R. Hammond, T.A. Ciulla, and D.M. Snodderly Macular pigment density is reduced in obese subjects Invest Ophthalmol Vis Sci 43 2002 47 50
36. B.R. Hammond, J. Curran-Celentano, and S. Judd Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns Vision Res 36 1996 2001 2012
37. B.R. Hammond, and K. Fuld Interocular differences in macular pigment density Invest Ophthalmol Vis Sci 33 1992 350 355
38. B.R. Hammond, K. Fuld, and D.M. Snodderly Iris color and macular pigment optical density Exp Eye Res 62 1996 293 297
39. B.R. Hammond, E.J. Johnson, and R.M. Russell Dietary modification of human macular pigment density Invest Ophthalmol Vis Sci 38 1997 1795 1801
40. G.J. Handelman, E.A. Dratz, and C.C. Reay Carotenoids in the human macula and whole retina Invest Ophthalmol Vis Sci 29 1988 850 855
41. G.J. Handelman, Z.D. Nightingale, and A.H. Lichtenstein Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk Am J Clin Nutr 70 1999 247 251
42. G.J. Handelman, D.M. Snodderly, and N.I. Krinsky Biological control of primate macular pigment. Biochemical and densitometric studies Invest Ophthalmol Vis Sci 32 1991 257 267
43. J. Herz, and U. Beffert Apolipoprotein E receptors: linking brain development and Alzheimer's disease Nat Rev Neurosci 1 2000 51 58
44. M.J. Hogan, J.A. Alvarado, and J.E. Weddell Histology of the human eye: an atlas and textbook 1971 WB Saunders Philadelphia pp 508-19
45. J.M. Holden, A.L. Eldridge, and G.R. Beecher Carotenoid content of U.S. foods: an update of the database J Food Comp Anal 12 1999 169 196
46. F.G. Holz, B. Piguet, and D.C. Minassian Decreasing stromal iris pigmentation as a risk factor for age-related macular degeneration Am J Ophthalmol 117 1994 19 23
47. L.G. Hyman, A.M. Lilienfeld, and F.L. Ferris Senile macular degeneration: a case-control study Am J Epidemiol 118 1983 213 227
48. E.J. Johnson, B.R. Hammond, and K.J. Yeum Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density Am J Clin Nutr 71 2000 1555 1562
49. K. Jørgensen, and L.H. Skibsted Carotenoid scavenging of radicals. Effect of carotenoid structure and oxygen partial pressure on antioxidative activity Z Lebensm Unters Forsch 196 1993 423 429
50. A. Junghans, H. Sies, and W. Stahl Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes Arch Biochem Biophys 391 2001 160 164
51. H.A. Kahn, H.M. Leibowitz, and J.P. Ganley The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study Am J Epidemiol 106 1977 33 41
52. L.A. Kaplan, J.M. Lau, and E.A. Stein Carotenoid composition, concentrations, and relationships in various human organs Clin Physiol Biochem 8 1990 1 10
53. F. Khachik, F.B. Askin, and K. Lai Distribution, bioavailability, and metabolism of carotenoids in humans W.R. Bidlack S.T. Omaye M.S. Meskin D. Jahner Phytochemicals, A New Paradigm 1998 Technomic Lancaster 77 96
54. F. Khachik, G.R. Beecher, and M.B. Goli Separation and identification of carotenoids and their oxidation products in the extracts of human plasma Anal Chem 64 1992 2111 2122
55. F. Khachik, P.S. Bernstein, and D.L. Garland Identification of lutein and zeaxanthin oxidation products in human and monkey retinas Invest Ophthalmol Vis Sci 38 1997 1802 1811
56. F. Khachik, F.F. de Moura, and D.Y. Zhao Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models Invest Ophthalmol Vis Sci 43 2002 3383 3392
57. F. Khachik, C.J. Spangler, and J.C. Smith Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum Anal Chem 69 1997 1873 1881
58. K. Kirschfeld Carotenoid pigments: their possible role in protecting against photooxidation in eyes and photoreceptor cells Proc R Soc Lond B Biol Sci 216 1982 71 85
59. B.E. Klein, and R. Klein Cataracts and macular degeneration in older Americans Arch Ophthalmol 100 1982 571 573
60. M.L. Klein, W.M. Mauldin, and V.D. Stoumbos Heredity and age-related macular degeneration. Observations in monozygotic twins Arch Ophthalmol 112 1994 932 937
61. R. Klein, B.E. Klein, and K.L. Linton Prevalence of age-related maculopathy. The Beaver Dam Eye Study Ophthalmology 99 1992 933 943
62. R. Klein, B.E. Klein, and K.L. Linton The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking Am J Epidemiol 137 1993 190 200
63. R. Klein, M.L. Rowland, and M.I. Harris Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey Ophthalmology 102 1995 371 381
64. N.I. Krinski Carotenoid protection against oxidation Pure Appl Chem 51 1979 649 660
65. N.I. Krinsky, J.T. Landrum, and R.A. Bone Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye Annu Rev Nutr 23 2003 171 201
66. J.T. Landrum, R.A. Bone, and H. Joa A one year study of the macular pigment: the effect of 140 days of a lutein supplement Exp Eye Res 65 1997 57 62
67. H.M. Leibowitz, D.E. Krueger, and L.R. Maunder The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975 Surv Ophthalmol 24 1980 335 610
68. I. Leung, M. Tso, and W. Li Absorption and tissue distribution of zeaxanthin and lutein in rhesus monkeys after taking Fructus lycii (Gou Qi Zi) extract Invest Ophthalmol Vis Sci 42 2001 466 471
69. B.P. Lim, A. Nagao, and J. Terao Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation Biochim Biophys Acta 1126 1992 178 184
70. M.R. Malinow, L. Feeney-Burns, and L.H. Peterson Diet-related macular anomalies in monkeys Invest Ophthalmol Vis Sci 19 1980 857 863
71. J.A. Mares-Perlman, W.E. Brady, and R. Klein Serum antioxidants and age-related macular degeneration in a population-based case-control study Arch Ophthalmol 113 1995 1518 1523
72. J.A. Mares-Perlman, A.I. Fisher, and R. Klein Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey Am J Epidemiol 153 2001 424 432
73. J.A. Mares-Perlman, R. Klein, and B.E. Klein Association of zinc and antioxidant nutrients with age-related maculopathy Arch Ophthalmol 114 1996 991 997
74. S.M. Meyers, and A.A. Zachary Monozygotic twins with age-related macular degeneration Arch Ophthalmol 106 1988 651 653
75. M. Michels, H. Lewis, and G.W. Abrams Macular phototoxicity caused by fiberoptic endoillumination during pars plana vitrectomy Am J Ophthalmol 114 1992 287 296
76. P. Mitchell, W. Smith, and K. Attebo Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study Ophthalmology 102 1995 1450 1460
77. National Advisory Eye Council Vision research - a national plan:1994-98 1998 National Institutes of Health Bethesda, MD Publication Number NIH 93-3186
78. S.E. Nilsson, S.P. Sundelin, and U. Wihlmark Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage Doc Ophthalmol 106 2003 13 16
79. J.J. Nussbaum, R.C. Pruett, and F.C. Delori Historic perspectives. Macular yellow pigment. The first 200 years Retina 1 1981 296 310
80. F. Ojima, H. Sakamoto, and Y. Ishiguro Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low-density lipoprotein Free Radic Biol Med 15 1993 377 384
81. R.S. Parker Carotenoids in human blood and tissues J Nutr 119 1989 101 104
82. L.M. Rapp, S.S. Maple, and J.H. Choi Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina Invest Ophthalmol Vis Sci 41 2000 1200 1209
83. S. Richer Part II: ARMD - Pilot (case series) environment intervention data J Am Optom Assoc 70 1990 24 36
84. A.G. Robson, J.D. Moreland, and D. Pauleikhoff Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry Vision Res 43 2003 1765 1775
85. M.A. Sandberg, A.R. Gaudio, and S. Miller Iris pigmentation and extent of disease in patients with neovascular age-related macular degeneration Invest Ophthalmol Vis Sci 35 1994 2734 2740
86. W. Schalch Carotenoids in the retina - a review of their possible role in preventing or limiting damage caused by light and oxygen EXS 62 1992 280 298
87. H. Schatz, and H.R. McDonald Atrophic macular degeneration. Rate of spread of geographic atrophy and visual loss Ophthalmology 96 1989 1541 1551
88. J.M. Seddon, U.A. Ajani, and B.D. Mitchell Familial aggregation of age-related maculopathy Am J Ophthalmol 123 1997 750 754
89. J.M. Seddon, U.A. Ajani, and R.D. Sperduto Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group JAMA 272 1994 1413 1420
90. J. Shanmugaratnam, E. Berg, and L. Kimerer Retinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles Brain Res Mol Brain Res 50 1997 113 120
91. W.G. Siems, O. Sommerburg, and F.J. van Kuijk Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro Biofactors 10 1999 105 113
92. D.M. Snodderly Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins Am J Clin Nutr 62 1995 1448S 1461S
93. D.M. Snodderly, G.J. Handelman, and A.J. Adler Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys Invest Ophthalmol Vis Sci 32 1991 268 279
94. O. Sommerburg, J.E. Keunen, and A.C. Bird Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes Br J Ophthalmol 82 1998 907 910
95. O.G. Sommerburg, W.G. Siems, and J.S. Hurst Lutein and zeaxanthin are associated with photoreceptors in the human retina Curr Eye Res 19 1999 491 495
96. J.E. Stewart, E.R. Skinner, and P.V. Best Receptor binding of an apolipoprotein E-rich subfraction of high density lipoprotein to rat and human brain membranes Int J Biochem Cell Biol 30 1998 407 415
97. E.R. Strahlman, S.L. Fine, and A. Hillis The second eye of patients with senile macular degeneration Arch Ophthalmol 101 1983 1191 1193
98. A. Sujak, J. Gabrielska, and W. Grudziński Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects Arch Biochem Biophys 371 1999 301 307
99. J.S. Sunness, N.M. Bressler, and Y. Tian Measuring geographic atrophy in advanced age-related macular degeneration Invest Ophthalmol Vis Sci 40 1999 1761 1769
100. H.R. Taylor, S. West, and B. Muñoz The long-term effects of visible light on the eye Arch Ophthalmol 110 1992 99 104
101. L.R. Thomson, Y. Toyoda, and A. Langner Elevated retinal zeaxanthin and prevention of light-induced photoreceptor cell death in quail Invest Ophthalmol Vis Sci 43 2002 3538 3549
102. Y. Toyoda, L.R. Thomson, and A. Langner Effect of dietary zeaxanthin on tissue distribution of zeaxanthin and lutein in quail Invest Ophthalmol Vis Sci 43 2002 1210 1221
103. M. Trieschmann, G. Spital, and A. Lommatzsch Macular pigment: quantitative analysis on autofluorescence images Graefes Arch Clin Exp Ophthalmol 241 2003 1006 1012
104. G. Wald Human vision and the spectrum Science 101 1945 653
105. J.J. Weiter, F. Delori, and C.K. Dorey Central sparing in annular macular degeneration Am J Ophthalmol 106 1988 286 292
106. J.J. Weiter, F.C. Delori, and G.L. Wing Relationship of senile macular degeneration to ocular pigmentation Am J Ophthalmol 99 1985 185 187
107. J.S. Werner, S.K. Donnelly, and R. Kliegl Aging and human macular pigment density. Appended with translations from the work of Max Schultze and Ewald Hering Vision Res 27 1987 257 268
108. J.S. Werner, and B.R. Wooten Opponent chromatic mechanisms: relation to photopigments and hue naming J Opt Soc Am 69 1979 422 434
109. S.K. West, F.S. Rosenthal, and N.M. Bressler Exposure to sunlight and other risk factors for age-related macular degeneration Arch Ophthalmol 107 1989 875 879
110. B.R. Wooten, B.R. Hammond, and R.I. Land A practical method for measuring macular pigment optical density Invest Ophthalmol Vis Sci 40 1999 2481 2489
111. A.Y. Yemelyanov, N.B. Katz, and P.S. Bernstein Ligand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina Exp Eye Res 72 2001 381 392