Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema

International Journal for Vitamin and Nutrition Research

Volumn 75, Issue 1, 2005, Pages 54-60

  Aust, Olivier ^a   Stahl, Wilhelm ^a   Sies, Helmut ^a   Tronnier, Hagen ^b   Heinrich, Ulrike ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Carotenoids; Erythema; Skin; Sun protection; UV light

Indexed keywords

CAROTENOID; LYCOPENE; PHYTOENE; PHYTOFLUENE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; LIGHT EXPOSURE; MALE; NORMAL HUMAN; SKIN PROTECTION; TOMATO; ULTRAVIOLET RADIATION;

ADULT; ANTIOXIDANTS; CAROTENOIDS; DIETARY SUPPLEMENTS; ERYTHEMA; HUMANS; LYCOPERSICON ESCULENTUM; PLANT PREPARATIONS; REFERENCE VALUES; SKIN; STATISTICS, NONPARAMETRIC; TIME FACTORS; ULTRAVIOLET RAYS;

CAESALPINIA CILIATA; LYCOPERSICON ESCULENTUM;

EID: 15244350242     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.75.1.54     Document Type: Article

References (26)

1. Wenk, J., Brenneisen, P., Meewes, C., Wlaschek, M., Peters, T., Blaudschun, R., Ma, W., Kuhr, L., Schneider, L. and Scharffetter-Kochanek, K. (2001) UV-induced oxidative stress and photoaging. Curr. Probl. Dermatol. 29, 83-94.
2. Klotz, L. O., Holbrook, N. J. and Sies, H. (2001) UVA and singlet oxygen as inducers of cutaneous signaling events. Curr. Probl. Dermatol. 29, 95-113.
3. Berneburg, M. and Krutmann, J. (2000) Photoimmunology, DNA repair and photocarcinogenesis. J. Photochem. Photobiol. B 54, 87-93.
4. Armstrong, B. K. and Kricker, A. (2001) The epidemiology of UV induced skin cancer. J. Photochem. Photobiol. B 63, 8-18.
5. Stahl, W. and Sies, H. (2002) Carotenoids and protection against solar UV radiation. Skin Pharmacol. Appl. Skin Physiol. 15, 291-296.
6. Sies, H. and Stahl, W. (2004) Nutritional protection against skin damage from sunlight. Ann. Rev. Nutr 24, 173-200.
7. Mathews-Roth, M.M., Pathak, M. A., Parrish, J. A., Fitzpatrick, T. B., Kass, E. H., Toda, K. and Clemens, W. (1972) A clinical trial of the effects of oral beta-carotene on the responses of human skin to solar radiation. J. Invest. Dermatol. 59, 349-353.
8. Gollnick, H. P. M., Hopfenmüller, W., Hemmes, C., Chun, S. C., Schmid, C., Sundermeier, K. and Biesalski, H. K. (1996) Systemic beta carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the Berlin-Eilath study. Eur. J. Dermatol. 6, 200-205.
9. Lee, J., Jiang, S., Levine, N. and Watson, R. R. (2000) Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc. Soc. Exp. Biol. Med. 223, 170-174.
10. Stahl, W., Heinrich, U., Jungmann, H., Sies, H. and Tronnier, H. (2000) Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am. J. Clin. Nutr. 71, 795-798.
11. Di Mascio, P., Kaiser, S. and Sies, H. (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 274, 532-538.
12. Mortensen, A., Skibsted, L. H. and Truscott, T. G. (2001) The interaction of dietary carotenoids with radical species. Arch. Biochem. Biophys. 385, 13-19.
13. Heinrich, U., Gärtner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H. and Stahl, W. (2003) Supplementation with β-carotene or a similar amount of mixed carotenoids protects humans against UV-inducederythema. J. Nutr. 133, 98-101.
14. Mangels, A. R., Holden, J. M., Beecher, G. R., Forman, M. R. and Lanza, E. ( 1993) Carotenoid content of fruits and vegetables: an evaluation of analytical data. J. Am. Diet. Assoc. 93, 284-296.
15. Stahl, W., Heinrich, U., Wiseman, S., Eichler, O., Sies, H. and Tronnier, H. (2001) Dietary tomato paste protects against ultraviolet light-induced erythema in humans. J. Nutr. 131, 1449-1451.
16. Sandmann, G. (1994) Carotenoid biosynthesis in microorganisms and plants. Eur. J. Biochem. 223, 7-24.
17. Bramley, P.M. (2002) Regulation of carotenoid formation during tomato fruit ripening and development. J. Exp. Bot. 53, 2107-2113.
18. Paetau, I., Khachik, F., Brown, E. D., Beecher, G. R., Kramer, T. R., Chittams, J. and Clevidence, B. A. (1998) Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans. Am. J. Clin. Nutr. 68, 1187-1195.
19. Pathak, M. A. (1982) Sunscreens: topical and systemic approaches for protection of human skin against harmful effects of solar radiation. J. Am. Acad. Dermatol. 7, 285-312.
20. Stahl, W., Sundquist, A. R., Hanusch, M., Schwarz, W. and Sies, H. (1993) Separation of beta-carotene and lycopene geometrical isomers in biological samples. Clin. Chem. 39, 810-814.
21. Stahl, W., Heinrich, U., Jungmann, H., von Laar, J., Schietzel, M., Sies, H. and Tronnier, H. (1998) Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J. Nutr. 128, 903-907.
22. Khachik, F., Spangler, C. J., Smith, J. C., Canfield, L. M., Steck, A. and Pfander, H. (1997) Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem. 69, 1873-1881.
23. Olmedilla, B., Granado, F., Southon, S., Wright, A. J., Blanco, I., Gil-Martinez, E., Berg, H., Corridan, B., Roussel, A. M., Chopra, M. and Thurnham, D. I. (2001) Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. Br. J. Nutr. 85, 227-238.
24. Paetau, I., Rao, D., Wiley, E. R., Brown, E. D. and Clevidence, B. A. (1999) Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Am. J. Clin. Nutr. 70, 490-494.
25. Richelle, M., Bortlik, K., Liardet, S., Hager, C., Lambelet, P., Baur, M., Applegate, L. A. and Offord, E. A. (2002) A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J. Nutr. 132, 404-408.
26. Yeum, K. J. and Russell, R. M. (2002) Carotenoid bioavailability and bioconversion. Annu. Rev. Nutr. 22, 483-504.