Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

Molecular Neurodegeneration

Volumn 11, Issue 1, 2016, Pages

  Sohn, Peter Dongmin ^a   Tracy, Tara E ^a,b   Son, Hye In ^c   Zhou, Yungui ^a   Leite, Renata E P ^d   Miller, Bruce L ^b   Seeley, William W ^b   Grinberg, Lea T ^b   Gan, Li ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alzheimer's disease; Axon initial segment; Neuronal cytoskeleton; Neuronal polarity; Tau acetylation

Indexed keywords

ANKYRIN G; BETAIV SPECTRIN; CYTOSKELETON PROTEIN; EPOTHILONE D; GLUTAMINE; LYSINE; MUTANT PROTEIN; SPECTRIN; TAU PROTEIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXON; AXON INITIAL SEGMENT CYTOSKELETON; CONTROLLED STUDY; CYTOSKELETON; DENDRITE; DOWN REGULATION; FEMALE; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROTUBULE; MOUSE; NERVE CELL; NONHUMAN; PROTEIN ACETYLATION; PROTEIN LOCALIZATION; PROTEIN STABILITY; TRANSGENIC MOUSE; ACETYLATION; ANIMAL; AXON INITIAL SEGMENT; C57BL MOUSE; CELL POLARITY; CONFOCAL MICROSCOPY; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT; VERY ELDERLY; WESTERN BLOTTING;

ACETYLATION; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; AXON INITIAL SEGMENT; BLOTTING, WESTERN; CELL POLARITY; CYTOSKELETON; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEURONS; RATS; TAU PROTEINS;

EID: 84978399481     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-016-0109-0     Document Type: Article

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