The biological activities of natural lignans from olives and virgin olive oils: A review

Journal of Functional Foods

Volumn 26, Issue , 2016, Pages 36-47

  López Biedma, Alicia ^a   Sánchez Quesada, Cristina ^a   Delgado Rodríguez, Miguel ^a,b   Gaforio, José J ^a  

^a UNIVERSITY OF JAÉN   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

(+) pinoresinol; 1 acetoxypinoresinol; Anti inflammatory; Antioxidant; Bioavailability; Metabolism

Indexed keywords

EID: 84978371457     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2016.07.005     Document Type: Review

References (83)

1. Adlercreutz H. Lignans and human health. Critical Reviews in Clinical Laboratory Sciences 2007, 44(5-6):483-525.
2. Antonini E., Farina A., Leone A., Mazzara E., Urbani S., Selvaggini R., Servili M., Ninfali P. Phenolic compounds and quality parameters of family farming versus protected designation of origin (PDO) extra-virgin olive oils. Journal of Food Composition and Analysis 2015, 43:75-81. 10.1016/j.jfca.2015.04.015.
3. Arslan D., Karabekir Y., Schreiner M. Variations of phenolic compounds, fatty acids and some qualitative characteristics of Sariulak olive oil as induced by growing area. Food Research International 2013, 54(2):1897-1906. 10.1016/j.foodres.2013.06.016.
4. Bonoli M., Bendini A., Cerretani L., Lercker G., Toschi T.G. Qualitative and semiquantitative analysis of phenolic compounds in extra virgin olive oils as a function of the ripening degree of olive fruits by different analytical techniques. Journal of Agricultural and Food Chemistry 2004, 52(23):7026-7032. 10.1021/jf048868m.
5. Brenes M., García A., Rios J.J., García P., Garrido A. Use of 1-acetoxypinoresinol to authenticate Picual olive oils. International Journal of Food Science & Technology 2002, 37(6):615-625. 10.1046/j.1365-2621.2002.00591.x.
6. Brenes M., Garcia A., Dobarganes M.C., Velasco J., Romero C. Influence of thermal treatments simulating cooking processes on the polyphenol content in virgin olive oil. Journal of Agricultural and Food Chemistry 2002, 50(21):5962-5967.
7. Brenes M., Garcia A., Garcia P., Garrido A. Acid hydrolysis of secoiridoid aglycons during storage of virgin olive oil. Journal of Agricultural and Food Chemistry 2001, 49(11):5609-5614.
8. Brenes M., Hidalgo F., Garcia A., Rios J., Garcia P., Zamora R., Garrido A. Pinoresinol and 1-acetoxypinoresinol, two new phenolic compounds identified in olive oil. Journal of the American Oil Chemists' Society 2000, 77(7):715-720.
9. Carpinella M.C., Giorda L.M., Ferrayoli C.G., Palacios S.M. Antifungal effects of different organic extracts from Melia azedarach L. on phytopathogenic fungi and their isolated active components. Journal of Agricultural and Food Chemistry 2003, 51(9):2506-2511. 10.1021/jf026083f.
10. Carrasco-Pancorbo A., Cerretani L., Bendini A., Segura-Carretero A., Del Carlo M., Gallina-Toschi T., Lercker G., Compagnone D., Fernandez-Gutierrez A. Evaluation of the antioxidant capacity of individual phenolic compounds in virgin olive oil. Journal of Agricultural and Food Chemistry 2005, 53(23):8918-8925. 10.1021/jf0515680.
11. Chin Y.W., Chai H.B., Keller W.J., Kinghorn A.D. Lignans and other constituents of the fruits of Euterpe oleracea (acai) with antioxidant and cytoprotective activities. Journal of Agricultural and Food Chemistry 2008, 56(17):7759-7764. 10.1021/jf801792n.
12. Chin Y.W., Jones W.P., Rachman I., Riswan S., Kardono L.B., Chai H.B., Farnsworth N.R., Cordell G.A., Swanson S.M., Cassady J.M., Kinghorn A.D. Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia. Phytotherapy Research : PTR 2006, 20(1):62-65. 10.1002/ptr.1806.
13. Chiung Y.M., Hayashi H., Matsumoto H., Otani T., Yoshida K., Huang M.Y., Chen R.X., Liu J.R., Nakayama M. New metabolites, tetrahydrofuran lignans, produced by streptomyces sp. IT-44. Journal of Antibiotics 1994, 47(4):487-491.
14. Chtourou M., Gargouri B., Jaber H., Abdelhedi R., Bouaziz M. Comparative study of olive oil quality from Chemlali Afax versus Arbequina cultivated in Tunisia. European Journal of Lipid Science and Technology : EJLST 2013, 115(6):631-640. 10.1002/ejlt.201200234.
15. Cotterchio M., Boucher B.A., Kreiger N., Mills C.A., Thompson L.U. Dietary phytoestrogen intake - lignans and isoflavones - and breast cancer risk (Canada). Cancer Causes & Control : CCC 2008, 19(3):259-272. 10.1007/s10552-007-9089-2.
16. Dar A.A., Arumugam N. Lignans of sesame: Purification methods, biological activities and biosynthesis - A review. Bioorganic Chemistry 2013, 50:1-10. 10.1016/j.bioorg.2013.06.009.
17. D'Archivio M., Filesi C., Vari R., Scazzocchio B., Masella R. Bioavailability of the polyphenols: Status and controversies. International Journal of Molecular Sciences 2010, 11(4):1321-1342. 10.3390/ijms11041321.
18. During A., Debouche C., Raas T., Larondelle Y. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal caco-2 cells. The Journal of Nutrition 2012, 142(10):1798-1805.
19. Fini L., Hotchkiss E., Fogliano V., Graziani G., Romano M., De Vol E.B., Qin H., Selgrad M., Boland C.R., Ricciardiello L. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis 2008, 29(1):139-146.
20. Gambacorta G., Faccia M., Previtali M.A., Pati S., La Notte E., Baiano A. Effects of olive maturation and stoning on quality indices and antioxidant content of extra virgin oils (cv. Coratina) during storage. Journal of Food Science 2010, 75(3):C229-C235. 10.1111/j.1750-3841.2010.01516.x.
21. García A., Brenes M., Martínez F., Alba J., García P., Garrido A. High-performance liquid chromatography evaluation of phenols in virgin olive oil during extraction at laboratory and industrial scale. Journal of the American Oil Chemists' Society 2001, 78(6):625-629.
22. Garcia-Villalba R., Carrasco-Pancorbo A., Oliveras-Ferraros C., Menendez J.A., Segura-Carretero A., Fernandez-Gutierrez A. Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization-time of flight-mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2012, 898:69-77. 10.1016/j.jchromb.2012.04.021.
23. Gómez Caravaca A.M., Carrasco Pancorbo A., Canabate Diaz B., Segura Carretero A., Fernandez Gutierrez A. Electrophoretic identification and quantitation of compounds in the polyphenolic fraction of extra-virgin olive oil. Electrophoresis 2005, 26(18):3538-3551. 10.1002/elps.200500202.
24. Harborne J.B., Baxter H., Moss G.P. Phytochemical dictionary: A handbook of bioactive compounds from plants 1999, Taylor & Francis, Wallington.
25. Hashim Y.Z., Rowland I.R., McGlynn H., Servili M., Selvaggini R., Taticchi A., Esposto S., Montedoro G., Kaisalo L., Wähälä K., Gill C.I. Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro. International Journal of Cancer. Journal International du Cancer 2008, 122(3):495-500. 10.1002/ijc.23148.
26. Heinonen S., Nurmi T., Liukkonen K., Poutanen K., Wahala K., Deyama T., Nishibe S., Adlercreutz H. In vitro metabolism of plant lignans: New precursors of mammalian lignans enterolactone and enterodiol. Journal of Agricultural and Food Chemistry 2001, 49(7):3178-3186.
27. Hirano T., Fukuoka K., Oka K., Naito T., Hosaka K., Mitsuhashi H., Matsumoto Y. Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1. Cancer Investigation 1990, 8(6):595-602.
28. Hwang B., Lee J., Liu Q.H., Woo E.R., Lee D.G. Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii. Molecules (Basel, Switzerland) 2010, 15(5):3507-3516. 10.3390/molecules15053507.
29. In S.J., Seo K.H., Song N.Y., Lee D.S., Kim Y.C., Baek N.I. Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity. Archives of Pharmacal Research 2015, 38(1):26-34. 10.1007/s12272-014-0358-9.
30. Jung H.W., Mahesh R., Lee J.G., Lee S.H., Kim Y.S., Park Y.K. Pinoresinol from the fruits of forsythia koreana inhibits inflammatory responses in LPS-activated microglia. Neuroscience Letters 2010, 480(3):215-220. 10.1016/j.neulet.2010.06.043.
31. Kajla P., Sharma A., Sood D.R. Flaxseed-a potential functional food source. Journal of Food Science and Technology 2015, 52(4):1857-1871. 10.1007/s13197-014-1293-y.
32. Kalua C.M., Bedgood D.R., Bishop A.G., Prenzler P.D. Changes in virgin olive oil quality during low-temperature fruit storage. Journal of Agricultural and Food Chemistry 2008, 56(7):2415-2422. 10.1021/jf073027b.
33. Kang M.H., Naito M., Sakai K., Uchida K., Osawa T. Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro. Life Sciences 2000, 66(2):161-171.
34. Kang W., Wang J. In vitro antioxidant properties and in vivo lowering blood lipid of forsythia suspense leaves. Medicinal Chemistry Research 2010, 19:617-628.
35. Kardono L.B., Tsauri S., Padmawinata K., Pezzuto J.M., Kinghorn A.D. Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia. Journal of Natural Products 1990, 53(6):1447-1455.
36. Kim H.J., Ono E., Morimoto K., Yamagaki T., Okazawa A., Kobayashi A., Satake H. Metabolic engineering of lignan biosynthesis in forsythia cell culture. Plant & Cell Physiology 2009, 50(12):2200-2209. 10.1093/pcp/pcp156.
37. Kim H.Y., Kim J.K., Choi J.H., Jung J.Y., Oh W.Y., Kim D.C., Lee H.S., Kim Y.S., Kang S.S., Lee S.H., Lee S.M. Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. Journal of Pharmacological Sciences 2010, 112(1):105-112.
38. Koch K., Buchter C., Havermann S., Watjen W. The lignan pinoresinol induces nuclear translocation of DAF-16 in Caenorhabditis elegans but has no effect on life span. Phytotherapy Research : PTR 2015, 29(6):894-901. 10.1002/ptr.5330.
39. Kulik T., Busko M., Pszczolkowska A., Perkowski J., Okorski A. Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum. Letters in Applied Microbiology 2014, 59(1):99-107. 10.1111/lam.12250.
40. Kuo P.C., Lin M.C., Chen G.F., Yiu T.J., Tzen J.T. Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans. Journal of Agricultural and Food Chemistry 2011, 59(7):3214-3219. 10.1021/jf104311g.
41. Kwak J.H., Kang M.W., Roh J.H., Choi S.U., Zee O.P. Cytotoxic phenolic compounds from Chionanthus retusus. Archives of Pharmacal Research 2009, 32(12):1681-1687. 10.1007/s12272-009-2203-0.
42. Lapi D., Di Maro M., Mastantuono T., Battiloro L., Sabatino L., Muscariello E., Colantuoni A. Effects of oleuropein and pinoresinol on microvascular damage induced by hypoperfusion and reperfusion in rat pial circulation. Microcirculation (New York, N.Y.: 1994) 2015, 22(1):79-90. 10.1111/micc.12175.
43. Lee J.W., Lee J.H., Lee C., Jin Q., Lee D., Kim Y., Hong J.T., Lee M.K., Hwang B.Y. Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2015, 25(4):960-962. 10.1016/j.bmcl.2014.12.012.
44. Li C.Y., Zhai H.Y., Tang S.A., Duan H.Q. Studies on the chemical constituents of Pachysandra terminalis and their antioxidant activity. Journal of Chinese Medicinal Materials 2010, 33(5):729-732.
45. Lin Y., Yngve A., Lagergren J., Lu Y. Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes & Control : CCC 2012, 23(6):837-844. 10.1007/s10552-012-9952-7.
46. Liu J., Nakamura S., Xu B., Matsumoto T., Ohta T., Fujimoto K., Ogawa K., Fukaya M., Miyake S., Matsuda H. Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus. Journal of Natural Medicines 2015, 69(1):135-141. 10.1007/s11418-014-0869-1.
47. Manach C., Scalbert A., Morand C., Remesy C., Jimenez L. Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition 2004, 79(5):727-747.
48. Menendez J.A., Vazquez-Martin A., Garcia-Villalba R., Carrasco-Pancorbo A., Oliveras-Ferraros C., Fernandez-Gutierrez A., Segura-Carretero A. tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial extra-virgin olive oil (EVOO). BMC Cancer 2008, 8:377. 10.1186/1471-2407-8-377.
49. Menendez J.A., Vazquez-Martin A., Oliveras-Ferraros C., Garcia-Villalba R., Carrasco-Pancorbo A., Fernandez-Gutierrez A., Segura-Carretero A. Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. International Journal of Molecular Medicine 2008, 22(4):433-439.
50. Menendez J.A., Vazquez-Martin A., Oliveras-Ferraros C., Garcia-Villalba R., Carrasco-Pancorbo A., Fernandez-Gutierrez A., Segura-Carretero A. Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: Relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2. International Journal of Oncology 2009, 34(1):43-51.
51. Milder I.E., Feskens E.J., Arts I.C., Bueno de Mesquita H.B., Hollman P.C., Kromhout D. Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and women. The Journal of Nutrition 2005, 135(5):1202-1207.
52. Mimaki Y., Kuroda M., Asano T., Sashida Y. Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. Journal of Natural Products 1999, 62(9):1279-1283.
53. Minh C.V., Nhiem N.X., Yen H.T., Kiem P.V., Tai B.H., Le Tuan Anh H., Hien T.T., Park S., Kim N., Kim S.H. Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Archives of Pharmacal Research 2015, 38(8):1443-1448. 10.1007/s12272-014-0490-6.
54. Nurmi T., Mursu J., Peñalvo J.L., Poulsen H.E., Voutilainen S. Dietary intake and urinary excretion of lignans in Finnish men. The British Journal of Nutrition 2010, 103(05):677-685. 10.1017/S0007114509992261.
55. Oliveras López M.J., Innocenti M., Ieri F., Giaccherini C., Romani A., Mulinacci N. HPLC/DAD/ESI/MS detection of lignans from Spanish and Italian Olea europaea L. fruits. Journal of Food Composition and Analysis 2008, 21(1):62-70. 10.1016/j.jfca.2007.04.012.
56. Owen R.W., Giacosa A., Hull W.E., Haubner R., Spiegelhalder B., Bartsch H. The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. European Journal of Cancer (Oxford, England: 1990) 2000, 36(10):1235-1247.
57. Owen R.W., Giacosa A., Hull W.E., Haubner R., Wurtele G., Spiegelhalder B., Bartsch H. Olive-oil consumption and health: The possible role of antioxidants. The Lancet Oncology 2000, 1:107-112.
58. Owen R.W., Mier W., Giacosa A., Hull W.E., Spiegelhalder B., Bartsch H. Identification of lignans as major components in the phenolic fraction of olive oil. Clinical Chemistry 2000, 46(7):976-988.
59. Pan J.Y., Chen S.L., Yang M.H., Wu J., Sinkkonen J., Zou K. An update on lignans: Natural products and synthesis. Natural Product Reports 2009, 26(10):1251-1292. 10.1039/b910940d.
60. Penalvo J.L., Nurmi T., Haajanen K., Al-Maharik N., Botting N., Adlercreutz H. Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection. Analytical Biochemistry 2004, 332(2):384-393. 10.1016/j.ab.2004.05.046.
61. Peterson J., Dwyer J., Adlercreutz H., Scalbert A., Jacques P., McCullough M.L. Dietary lignans: Physiology and potential for cardiovascular disease risk reduction. Nutrition Reviews 2010, 68(10):571-603. 10.1111/j.1753-4887.2010.00319.x.
62. Rafieian-Kopaei M., Setorki M., Doudi M., Baradaran A., Nasri H. Atherosclerosis: Process, indicators, risk factors and new hopes. International Journal of Preventive Medicine 2014, 5(8):927-946.
63. Saarinen N.M., Power K.A., Chen J., Thompson L.U. Lignans are accessible to human breast cancer xenografts in athymic mice. Nutrition and Cancer 2008, 60(2):245-250. 10.1080/01635580701649669.
64. Saleem M., Kim H.J., Ali M.S., Lee Y.S. An update on bioactive plant lignans. Natural Product Reports 2005, 22(6):696-716. 10.1039/b514045p.
65. Selvaggini R., Servili M., Urbani S., Esposto S., Taticchi A., Montedoro G. Evaluation of phenolic compounds in virgin olive oil by direct injection in high-performance liquid chromatography with fluorometric detection. Journal of Agricultural and Food Chemistry 2006, 54(8):2832-2838. 10.1021/jf0527596.
66. Sepporta M.V., Mazza T., Morozzi G., Fabiani R. Pinoresinol inhibits proliferation and induces differentiation on human HL60 leukemia cells. Nutrition and Cancer 2013, 65(8):1208-1218. 10.1080/01635581.2013.828089.
67. Servili M., Taticchi A., Esposito S., Urbani S., Selvaggini R., Montedoro G. Effect of olive stoning on the volatile and phenolic composition of virgin olive oil. Journal of Agricultural and Food Chemistry 2007, 55(17):7028-7035. 10.1021/jf070600i.
68. Shi Y.N., Shi Y.M., Yang L., Li X.C., Zhao J.H., Qu Y., Zhu H.T., Wang D., Cheng R.R., Yang C.R., Xu M., Zhang Y.J. Lignans and aromatic glycosides from Piper wallichii and their antithrombotic activities. Journal of Ethnopharmacology 2015, 162:87-96. 10.1016/j.jep.2014.12.038.
69. Sok D.E., Cui H.S., Kim M.R. Isolation and bioactivities of furfuran type lignan compounds from edible plants. Recent Patents on Food, Nutrition & Agriculture 2009, 1(1):87-95.
70. Soler A., Romero M.P., Macià A., Saha S., Furniss C.S.M., Kroon P.A., Motilva M.J. Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial caco-2/TC7 cell line. Food Chemistry 2010, 119:703-714.
71. Suarez M., Romero M.P., Macia A., Valls R.M., Fernandez S., Sola R., Motilva M.J. Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2009, 877(32):4097-4106. 10.1016/j.jchromb.2009.10.025.
72. Thompson L.U., Chen J.M., Li T., Strasser-Weippl K., Goss P.E. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 2005, 11(10):3828-3835.
73. Toledo E., Salas-Salvado J., Donat-Vargas C., Buil-Cosiales P., Estruch R., Ros E., Corella D., Fitó M., Hu F.B., Arós F., Gómez-Gracia E., Romaguera D., Ortega-Calvo M., Serra-Majem L., Pintó X., Schröder H., Basora J., Sorlí J.V., Bulló M., Serra-Mir M., Martinez-Gonzalez M.A. Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: A randomized clinical trial. JAMA Internal Medicine 2015, 175(11):1752-1760. 10.1001/jamainternmed.2015.4838.
74. Torres-Sanchez L., Galvan-Portillo M., Wolff M.S., Lopez-Carrillo L. Dietary consumption of phytochemicals and breast cancer risk in Mexican women. Public Health Nutrition 2009, 12(6):825-831. 10.1017/S136898000800325X.
75. Touillaud M.S., Thiebaut A.C., Fournier A., Niravong M., Boutron-Ruault M.C., Clavel-Chapelon F. Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. Journal of the National Cancer Institute 2007, 99(6):475-486.
76. Tsukamoto H., Hisada S., Nishibe S. Lignans from bark of the Olea plants. I. Chemical & Pharmaceutical Bulletin 1984, 32(7):2730-2735.
77. Umezawa T. Diversity in lignan biosynthesis. Phytochemistry Reviews 2003, 2(3):371-390.
78. Vissers M.N., Zock P.L., Roodenburg A.J., Leenen R., Katan M.B. Olive oil phenols are absorbed in humans. The Journal of Nutrition 2002, 132(3):409-417.
79. Vuorela S., Kreander K., Karonen M., Nieminen R., Hamalainen M., Galkin A., Laitinen L., Salminen J.P., Moilanen E., Pihlaja K., Vuorela H., Vuorela P., Heinonen M. Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. Journal of Agricultural and Food Chemistry 2005, 53(15):5922-5931. 10.1021/jf050554r.
80. Wikul A., Damsud T., Kataoka K., Phuwapraisirisan P. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting alpha-glucosidase. Bioorganic & Medicinal Chemistry Letters 2012, 22(16):5215-5217. 10.1016/j.bmcl.2012.06.068.
81. Yang C.P., Huang G.J., Huang H.C., Chen Y.C., Chang C.I., Wang S.Y., Chang H.S., Tseng Y.H., Chien S.C., Kuo Y.H. The effect of the aerial part of Lindera akoensis on lipopolysaccharides (LPS)-induced nitric oxide production in RAW264.7 cells. International Journal of Molecular Sciences 2013, 14(5):9168-9181. 10.3390/ijms14059168.
82. Yeo H., Chin Y.W., Park S.Y., Kim J. Lignans of Rosa multiflora roots. Archives of Pharmacal Research 2004, 27(3):287-290.
83. Yi B., Hu L., Mei W., Zhou K., Wang H., Luo Y., Wei X., Dai H. Antioxidant phenolic compounds of cassava (Manihot esculenta) from Hainan. Molecules (Basel, Switzerland) 2011, 16(12):10157-10167. 10.3390/molecules161210157.