Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: Relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2

International Journal of Oncology

Volumn 34, Issue 1, 2009, Pages 43-51

  Menendez, Javier A ^a   Vazquez Martin, Alejandro ^a   Oliveras Ferraros, Cristina ^a   Garcia Villalba, Rocio ^a,b   Carrasco Pancorbo, Alegria ^b   Fernandez Gutierrez, Alberto ^b   Segura Carretero, Antonio ^b  

^a HOSPITAL JOSEP TRUETA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Breast cancer; HER2; Mediterranean diet; Olive oil; Phenolics; Tyrosine kinase

Indexed keywords

ACETOXYPINORESINOL; DEACETOXY OLEUROPEIN AGLYCONE; ELENOLIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYDROXYTYROSOL; LIGNAN DERIVATIVE; LIGSTROSIDE AGLYCONE; OLEUROPEIN AGLYCONE; OLIVE OIL; PINORESINOL; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; SECOIRIDOID; TYROSINE; TYROSOL; UNCLASSIFIED DRUG; FLAVONOID; IRIDOID; LIGNAN; PHENOL DERIVATIVE; POLYPHENOLS; PROTEIN TYROSINE KINASE; VEGETABLE OIL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; BREAST EPITHELIUM; CANCER INHIBITION; COLONY FORMATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALIGNANT TRANSFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; WILD TYPE; BREAST; CELL CULTURE; CELL TRANSFORMATION; CHEMISTRY; CLONOGENIC ASSAY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; RETROVIRUS;

APOPTOSIS; BREAST; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; HUMANS; IRIDOIDS; LIGNANS; PHENOLS; PLANT OILS; PROTEIN-TYROSINE KINASES; RECEPTOR, ERBB-2; RETROVIRIDAE;

EID: 60749117034     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000127     Document Type: Article

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