Dietary lignans: Physiology and potential for cardiovascular disease risk reduction

Nutrition Reviews

Volumn 68, Issue 10, 2010, Pages 571-603

  Peterson, Julia ^a   Dwyer, Johanna ^b   Adlercreutz, Herman ^c   Scalbert, Augustin ^d   Jacques, Paul ^a   McCullough, Marjorie L ^e  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

^d INRA and University of Auvergne   (France)

^e AMERICAN CANCER SOCIETY   (United States)

Author keywords

Cardiovascular disease; Lignans; Review

Indexed keywords

C REACTIVE PROTEIN; ENTERODIOL; ENTEROLACTONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIGNAN; LIGNIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MATAIRESINOL; PINORESINOL; SECOISOLARICIRESINOL; SESAMIN; SYRINGARESINOL;

BACTERIAL METABOLISM; BIOSYNTHESIS; BIOTRANSFORMATION; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFECT; DRUG STRUCTURE; EDITORIAL; FOOD COMPOSITION; FRUIT; GASTROINTESTINAL ABSORPTION; GLYCEMIC CONTROL; HUMAN; MORTALITY; NUT; NUTRITIONAL ASSESSMENT; PLANT SEED; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; CARDIOVASCULAR DISEASE; CHEMISTRY; EVIDENCE BASED MEDICINE; FLAX; REVIEW; RISK ASSESSMENT; RISK FACTOR;

CARDIOVASCULAR DISEASES; EVIDENCE-BASED MEDICINE; FLAX; HUMANS; LIGNANS; RISK ASSESSMENT; RISK FACTORS;

EID: 78149490248     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2010.00319.x     Document Type: Editorial

References (203)

1. Penttinen P, Jaehrling J, Damdimopoulos AE, et al. Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. Endocrinology. 2007;148:4875-4886.
2. Adlercreutz H. Lignans and human health. Crit Rev Clin Lab Sci. 2007;44:483-525.
3. Adlercreutz H, Mousavi Y, Clark J, et al. Dietary phytoestrogens and cancer: in vitro and in vivo studies. J Steroid Biochem Mol Biol. 1992;41:331-337.
4. Setchell KDR, Lawson AM, Mitchell FL, Adlercreutz H, Kirk DN, Axelson M. Lignans in man and animal species. Nature. 1980;287:740-742.
5. Davin LB, Lewis NG. Dirigent proteins and dirigent sites explain the mystery of specificity of radical precursor coupling in lignan and lignin biosynthesis. Plant Physiol. 2000;123:453-462.
6. Raffaelli B, Hoikkala A, Leppala E, Wahala K. Enterolignans. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;777:29-43.
7. Saleem M, Kim HJ, Ali MS, Lee YS. An update on bioactive plant lignans. Nat Prod Rep. 2005;22:696-716.
8. Umezawa T. Diversity in lignan biosynthesis. Phytochem Rev. 2003;2:371-390.
9. Heinonen S, Nurmi T, Liukkonen K, et al. In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J Agric Food Chem. 2001;49:3178-3186.
10. Mazur WM, Duke JA, Wahala K, Rasku S, Adlercreutz H. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. J Nutr Biochem. 1998;9:193-200.
11. Milder IEJ, Arts ICW, Venema DP, Lasaroms JJP, Wahala K, Hollman PCH. Optimization of a liquid chromatography-tandem mass spectrometry method for quantification of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in foods. J Agric Food Chem. 2004;52:4643-4651.
12. Smeds AI, Eklund PC, Sjoholm RE, et al. Quantification of a broad spectrum of lignans in cereals, oilseeds, and nuts. J Agric Food Chem. 2007;55:1337-1346.
13. Katsuzaki H, Kawakishi S, Osawa T. Sesaminol glucosides in sesame seeds. Phytochemistry. 1994;35:773-776.
14. Kim KS, Park SH, Choung MG. Nondestructive determination of lignans and lignan glycosides in sesame seeds by near infrared reflectance spectroscopy. J Agric Food Chem. 2006;54:4544-4550.
15. Ryu SN, Ho CT, Osawa T. High performance liquid chromatographic determination of antioxidant lignan glycosides in some varieties of sesame. J Food Lipids. 1998;5:17-28.
16. Li X, Yuan JP, Xu SP, Wang JH, Liu X. Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography. J Chromatogr A. 2008;1185:223-232.
17. Muir AD. Flax lignans - analytical methods and how they influence our understanding of biological activity. J AOAC Int. 2006;89:1147-1157.
18. Strandas C, Kamal-Eldin A, Andersson R, Aman P. Composition and properties of flaxseed phenolic oligomers. Food Chem. 2008;110:106-112.
19. Struijs K, Vincken JP, Verhoef R, Van Oostveen-van Casteren WHM, Voragen AGJ, Gruppen H. The flavonoid herbacetin diglucoside as a constituent of the lignan macromolecule from flaxseed hulls. Phytochemistry. 2007;68:1227-1235.
20. Struijs K, Vincken JP, Verhoef R, Voragen AGJ, Gruppen H. Hydroxycinnamic acids are ester-linked directly to glucosyl moieties within the lignan macromolecule from flaxseed hulls. Phytochemistry. 2008;69:1250-1260.
21. Struijs K, Vincken JP, Doeswijk TG, Voragen AGJ, Gruppen H. The chain length of lignan macromolecule from flaxseed hulls is determined by the incorporation of coumaric acid glucosides and ferulic acid glucosides. Phytochemistry. 2009;70:262-269.
22. Penalvo JL, Heinonen SM, Aura AM, Adlercreutz H. Dietary sesamin is converted to enterolactone in humans. J Nutr. 2005;135:1056-1062.
23. Davin LB, Jourdes M, Patten AM, Kim K-W, Vassao DG, Lewis NG. Dissection of lignin macromolecular configuration and assembly: Comparison to related biochemical processes in allyl/propenyl phenol and lignan biosynthesis. Nat Prod Rep. 2008;25:1015-1090.
24. Hatfield R, Vermerris W. Lignin formation in plants. The dilemma of linkage specificity. Plant Physiol. 2001;126:1351-1357.
25. Begum A, Nicolle C, Mila I, et al. Dietary lignins are precursors of mammalian lignans in rats. J Nutr. 2004;134:120-127.
26. DeVries J. On defining dietary fibre. Proc Nutr Soc. 2003;62:37-43.
27. Muir AD, Westcott ND. Flax, The Genus Linum. London: Taylor & Francis; 2003.
28. Penalvo JL, Haajanen KM, Botting N, Adlercreutz H. Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry. J Agric Food Chem. 2005;53:9342-9347.
29. Kuhnle GGC, Dell'Aquila C, Aspinall SM, Runswick SA, Mulligan AA, Bingham SA. Phytoestrogen content of cereals and cereal-based foods consumed in the UK. Nutr Cancer. 2009;61:302-309.
30. Milder IE, Arts IC, Van De Putte B, Venema DP, Hollman PC. Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol. Br J Nutr. 2005;93:393-402.
31. Penalvo JL, Adlercreutz H, Uehara M, Ristimaki A, Watanabe S. Lignan content of selected foods from Japan. J Agric Food Chem. 2008;56:401-409.
32. Thompson LU, Boucher BA, Zhen L, Cotterchio M, Kreiger N. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer. 2006;54:184-201.
33. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95-120.
34. Mazur W, Fotsis T, Wahala K, Ojala S, Salakka A, Adlercreutz H. Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Anal Biochem. 1996;233:169-180.
35. Mazur W. Phytoestrogen content in foods. Baillieres Clin Endocrinol Metab. 1996;12:729-742.
36. Antignac JP, Cariou R, Le Bizec B, Andre F. New data regarding phytoestrogens content in bovine milk. Food Chem. 2004;87:275-281.
37. Kuhnle GGC, Dell'Aquila C, Aspinall SM, Runswick SA, Mulligan AA, Bingham SA. Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafood. J Agric Food Chem. 2008;56:10099-10104.
38. Gagnon N, Cortes C, Da Silva D, et al. Ruminal metabolism of flaxseed (Linum usitatissimum) lignans to the mammalian lignan enterolactone and its concentration in ruminal fluid, plasma, urine and milk of dairy cows. Br J Nutr. 2009;102:1015-1023.
39. Smeds AI, Willfor SM, Pietarinen SP, Peltonen-Sainio P, Reunanen MH. Occurrence of "mammalian" lignans in plant and water sources. Planta. 2007;226:639-646.
40. Brenes M, Garcia A, Dobarganes MC, Velasco J, Romero C. Influence of thermal treatments simulating cooking processes on the polyphenol content in virgin olive oil. J Agric Food Chem. 2002;50:5962-5967.
41. Kikuzaki H, Kayano S, Fukutsuka N, et al. Abscisic acid related compounds and lignans in prunes (Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC). J Agric Food Chem. 2004;52:344-349.
42. Liukkonen KH, Katina K, Wilhelmsson A, et al. Process-induced changes on bioactive compounds in whole grain rye. Proc Nutr Soc. 2003;62:117-122.
43. Nilsson M, Aman P, Harkonen H, et al. Nutrient and lignan content, dough properties and baking performance of rye samples used in Scandinavia. Acta Agric Scand B, Soil Plant Sci. 1997;47:26-34.
44. Penalvo JL, Heinonen SM, Nurmi T, Deyama T, Nishibe S, Adlercreutz H. Plant lignans in soy-based health supplements. J Agric Food Chem. 2004;52:4133-4138.
45. Romero C, Brenes M, Yousfi K, Garcia P, Garcia A, Garrido A. Effect of cultivar and processing method on the contents of polyphenols in table olives. J Agric Food Chem. 2004;52:479-484.
46. Hall CA III, Manthey FA, Lee RE, Niehaus M. Stability of alpha-linolenic acid and secoisolariciresinol diglucoside in flaxseed fortified macaroni. J Food Sci. 2005;70:C483-C489.
47. Hyvarinen HK, Pihlava JM, Hiidenhovi JA, Hietaniemi V, Korhonen HJT, Ryhanen EL. Effect of processing and storage on the stability of flaxseed lignan added to bakery products. J Agric Food Chem. 2006;54:48-53.
48. Hyvarinen HK, Pihlava JM, Hiidenhovi JA, Hietaniemi V, Korhonen HJT, Ryhanen EL. Effect of processing and storage on the stability of flaxseed lignan added to dairy products. J Agric Food Chem. 2006;54:8788-8792.
49. Muir AD, Westcott ND. Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. J Agric Food Chem. 2000;48:4048-4052.
50. Strandas C, Kamal-Eldin A, Andersson R, Aman P. Phenolic glucosides in bread containing flaxseed. Food Chem. 2008;110:997-999.
51. Choi SD, Cho MJ. Changes in fractionation pattern of the sesame seed lipid and minor components during storage. J Korean Agric Chem Soci. 1983;26:255-260.
52. Kim IH, Choe EN. Effects of bleaching on the properties of roasted sesame oil. J Food Sci. 2005;70:C48-C52.
53. Kumar CM, Rao AGA, Singh SA. Effect of infrared heating on the formation of sesamol and quality of defatted flours from Sesamum indicum L. J Food Sci. 2009;74:H105-H111.
54. Lee SW, Jeung MK, Park MH, Lee SY, Lee JH. Effects of roasting conditions of sesame seeds on the oxidative stability of pressed oil during thermal oxidation. Food Chem. 2010;118:681-685.
55. Moazzami AA, Haese SL, Kamal-Eldin A. Lignan contents in sesame seeds and products. Eur J Lipid Sci Technol. 2007;109:1022-1027.
56. Shahidi F, Amarowicz R, Abou-Gharbia HA, Shehata AAY. Endogenous antioxidants and stability of sesame oil as affected by processing and storage. J Am Oil Chem Soc. 1997;74:143-148.
57. WH W. The contents of lignans in commercial sesame oils of Taiwan and their changes during heating. Food Chem. 2007;104:341-344.
58. Yen GC. Influence of seed roasting process on the changes in composition and quality of sesame (Sesame indicum) oil. J Sci Food Agric. 1990;50:563-570.
59. Yoshida H, Abe S, Hirakawa Y, Takagi S. Roasting effects on fatty acid distributions of triacylglycerols and phospholipids in sesame (Sesamum indicum) seeds. J Sci Food Agric. 2001;81:620-626.
60. Webb AL, McCullough ML. Dietary lignans: potential role in cancer prevention. Nutr Cancer. 2005;51:117-131.
61. Horn-Ross PL, Hoggatt KJ, Lee MM. Phytoestrogens and thyroid cancer risk: the San Francisco Bay Area Thyroid Cancer study. Cancer Epidemiol Biomarkers Prev. 2002;11:43-49.
62. Horn-Ross PL, Barnes S, Lee VS, et al. Reliability and validation of an assessment of usual phytoestrogen consumption (United States). Cancer Causes Control. 2006;17:85-93.
63. Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. BMC Cancer. 2006;6:148. doi:10.1186/1471-2407-6-148.
64. Bhakta D, Dos Santos Silva I, Higgins C, et al. A semiquantitative food frequency questionnaire is a valid indicator of the usual intake of phytoestrogens by south Asian women in the UK relative to multiple 24-h dietary recalls and multiple plasma samples. J Nutr. 2005;135:116-123.
65. Hedelin M, Lof M, Olsson M, Adlercreutz H, Sandin S, Weiderpass E. Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. J Nutr. 2008;138:938-945.
66. Van Der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005;111:465-471.
67. Galvan-Portillo MV, Wolff MS, Torres-Sanchez LE, Lopez-Cervantes M, Lopez-Carrillo L. Assessing phytochemical intake in a group of Mexican women. Salud Publica Mex. 2007;49:126-131.
68. Cotterchio M, Boucher BA, Kreiger N, Mills CA, Thompson LU. Dietary phytoestrogen intake - lignans and isoflavones - and breast cancer risk (Canada). Cancer Causes Control. 2008;19:259-272.
69. Touillaud MS, Thiebaut AC, Fournier A, Niravong M, Boutron-Ruault MC, Clavel-Chapelon F. Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. J Natl Cancer Inst. 2007;99:475-486.
70. Valsta L, Kilkkinen A, Mazur W, et al. Phyto-oestrogen database of foods and average intake in Finland. Br J Nutr. 2003;89(Suppl):S31-S38.
71. Milder IEJ, Feskens EJM, Arts ICW, Mesquita HBB, Hollman PCH, Kromhout D. Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and women. J Nutr. 2005;135:1202-1207.
72. De Kleijn MJ, Van Der Schouw YT, Wilson PW, Grobbee DE, Jacques PF. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: the Framingham study. J Nutr. 2002;132:276-282.
73. Linseisen J, Piller R, Hermann S, Chang-Claude J. German case-control study. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Int J Cancer. 2004;110:284-290.
74. Nagel G, Mack U, Von Fournier D, Linseisen J. Dietary phytoestrogen intake and mammographic density - results of a pilot study. Eur J Med Res. 2005;10:389-394.
75. Pellegrini N, Valtueña S, Ardigò D, et al. Intake of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol in relation to vascular inflammation and endothelial dysfunction in middle age-elderly men and post-menopausal women living in northern Italy. Nutr Metab Cardiovasc Dis. 2010;20:64-71.
76. Milder IE, Feskens EJ, Arts IC, Bueno-de-Mesquita HB, Hollman PC, Kromhout D. Intakes of four dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study. Am J Clin Nutr. 2006;84:400-405.
77. Clavel T, Dore J, Blaut M. Bioavailability of lignans in human subjects. Nutr Res Rev. 2006;19:187-196.
78. Kuijsten A, Arts IC, Vree TB, Hollman PC. Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. J Nutr. 2005;135:795-801.
79. Kuijsten A, Arts IC, Van't Veer P, Hollman PC. The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed. J Nutr. 2005;135:2812-2816.
80. Jan KC, Hwang LS, Ho CT. Biotransformation of sesaminol triglucoside to mammalian lignans by intestinal microbiota. J Agric Food Chem. 2009;57:6101-6106.
81. Clavel T, Henderson G, Alpert CA, et al. Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans. Appl Environ Microbiol. 2005;71:6077-6085.
82. Clavel T, Henderson G, Engst W, Dore J, Blaut M. Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. FEMS Microbiol Ecol. 2006;55:471-478.
83. Yuan JP, Li X, Xu SP, Wang JH, Liu X. Hydrolysis kinetics of secoisolariciresinol diglucoside oligomers from flaxseed. J Agric Food Chem. 2008;56:10041-10047.
84. Clavel T, Borrmann D, Braune A, Dore J, Blaut M. Occurrence and activity of human intestinal bacteria involved in the conversion of dietary lignans. Anaerobe. 2006;12:140-147.
85. Lampe JW, Atkinson C, Hullar MA. Assessing exposure to lignans and their metabolites in humans. J AOAC Int. 2006;89:1174-1181.
86. Liu Z, Saarinen NM, Thompson LU. Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats. J Nutr. 2006;136:906-912.
87. Fuchs D, Piller R, Linseisen J, Daniel H, Wenzel U. The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis. Proteomics. 2007;7:3278-3288.
88. Low YL, Taylor JI, Grace PB, et al. Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. Cancer Epidemiol Biomarkers Prev. 2005;14:213-220.
89. Low YL, Taylor JI, Grace PB, et al. Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men. J Nutr. 2005;135:2680-2686.
90. Low YL, Dunning AM, Dowsett M, et al. Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants. Cancer Epidemiol Biomarkers Prev. 2007;16:1009-1016.
91. Smeds AI, Hakala K, Hurmerinta TT, Kortela L, Saarinen NM, Makela SI. Determination of plant and enterolignans in human serum by high-performance liquid chromatography with tandem mass spectrometric detection. J Pharm Biomed Anal. 2006;41:898-905.
92. Penalvo JL, Nurmi T, Haajanen K, Al-Maharik N, Botting N, Adlercreutz H. Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection. Anal Biochem. 2004;332:384-393.
93. Nurmi T, Voutilainen S, Nyyssonen K, Adlercreutz H, Salonen JT. Liquid chromatography method for plant and mammalian lignans in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;798:101-110.
94. Holloway WD, Tasman-Jones C, Lee SP. Digestion of certain fractions of dietary fiber in humans. Am J Clin Nutr. 1978;31:927-930.
95. Joshi S, Agte V. Digestibility of dietary fiber components in vegetarian men. Plant Foods Hum Nutr. 1995;48:39-44.
96. Kelsay JL, Goering HK, Behall KM, Prather ES. Effect of fiber from fruits and vegetables on metabolic responses of human subjects: fiber intakes, fecal excretions, and apparent digestibilities. Am J Clin Nutr. 1981;34:1849-1852.
97. Van Dokkum W, Pikaar NA, Thissen JT. Physiological effects of fibre-rich types of bread. 2. Dietary fibre from bread: digestibility by the intestinal microflora and water-holding capacity in the colon of human subjects. Br J Nutr. 1983;50:61-74.
98. Horner NK, Kristal AR, Prunty J, Skor HE, Potter JD, Lampe JW. Dietary determinants of plasma enterolactone. Cancer Epidemiol Biomarkers Prev. 2002;11:121-126.
99. Kilkkinen A, Stumpf K, Pietinen P, Valsta LM, Tapanainen H, Adlercreutz H. Determinants of serum enterolactone concentration. Am J Clin Nutr. 2001;73:1094-1100.
100. Jansen GH, Arts IC, Nielen MW, Muller M, Hollman PC, Keijer J. Uptake and metabolism of enterolactone and enterodiol by human colon epithelial cells. Arch Biochem Biophys. 2005;435:74-82.
101. Adlercreutz H, Vanderwildt J, Kinzel J, et al. Lignan and isoflavonoid conjugates in human urine. J Steroid Biochem Mol Biol. 1995;52:97-103.
102. Knust U, Hull WE, Spiegelhalder B, Bartsch H, Strowitzki T, Owen RW. Analysis of enterolignan glucuronides in serum and urine by HPLC-ESI-MS. Food Chem Toxicol. 2006;44:1038-1049.
103. Jacobs E, Metzler M. Oxidative metabolism of the mammalian lignans enterolactone and enterodiol by rat, pig, and human liver microsomes. J Agric Food Chem. 1999;47:1071-1077.
104. Niemeyer HB, Honig DM, Kulling SE, Metzler M. Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol. J Agric Food Chem. 2003;51:6317-6325.
105. Dean B, Chang S, Doss GA, King C, Thomas PE. Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys. Arch Biochem Biophys. 2004;429:244-251.
106. Jan KC, Ho CT, Hwang LS. Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats. Mol Nutr Food Res. 2009;53(Suppl):S36-S43.
107. Jan KC, Hwang LS, Ho CT. Tissue distribution and elimination of sesaminol triglucoside and its metabolites in rat. Mol Nutr Food Res. 2009;53:815-825.
108. Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A. Bioavailability of phyto-oestrogens. Br J Nutr. 2003;89(Suppl):S45-S58.
109. Ide T, Ashakumary L, Takahashi Y, Kushiro M, Fukuda N, Sugano M. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. 2001;1534:1-13.
110. Kong X, Yang JR, Guo LQ, et al. Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet. Eur J Pharmacol. 2009;620:84-89.
111. Matsumura Y, Kita S, Ohgushi R, Okui T. Effects of sesamin on altered vascular reactivity in aortic rings of deoxycorticosterone acetate-salt-induced hypertensive rat. Biol Pharm Bull. 2000;23:1041-1045.
112. Nakano D, Kurumazuka D, Nagai Y, Nishiyama A, Kiso Y, Matsumura Y. Dietary sesamin suppresses aortic NADPH oxidase in DOCA salt hypertensive rats. Clin Exp Pharmacol Physiol. 2008;35:324-326.
113. Penalvo JL, Hopia A, Adlercreutz H. Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice. Eur J Nutr. 2006;45:439-444.
114. Penumathsa SV, Koneru S, Zhan L, et al. Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hypercholesterolemic myocardium. J Mol Cell Cardiol. 2008;44:170-179.
115. Prasad K. Flaxseed and cardiovascular health. J Cardiovasc Pharmacol. 2009;54:369-377.
116. Prasad K. Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis. 2005;179:269-275.
117. Prasad K. Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Atherosclerosis. 2008;197:34-42.
118. Sano T, Oda E, Yamashita T, et al. Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice. Blood Coagul Fibrinolysis. 2003;14:707-712.
119. Yamashita K, Ikeda S, Obayashi M. Comparative effects of flaxseed and sesame seed on vitamin E and cholesterol levels in rats. Lipids. 2003;38:1249-1255.
120. Cho SH, Lee HR, Kim TH, Choi SW, Lee WJ, Choi Y. Effects of defatted safflower seed extract and phenolic compounds in diet on plasma and liver lipid in ovariectomized rats fed high-cholesterol diets. J Nutr Sci Vitaminol. 2004;50:32-37.
121. Penumathsa SV, Koneru S, Thirunavukkarasu M, Zhan L, Prasad K, Maulik N. Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury. J Pharmacol Exp Ther. 2007;320:951-959.
122. Wu JH, Hodgson JM, Clarke MW, et al. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. Hypertension. 2009;54:1151-1158.
123. Chiu PY, Leung HY, Siu AH, Poon MK, Ko KM. Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts. Acta Pharmacol Sin. 2007;28:1559-1565.
124. Cho SH, Rhee SJ, Choi SW, Choi Y. Effects of forsythia fruit extracts and lignan on lipid metabolism. Biofactors. 2004;22:161-163.
125. Hu H, Zhang XX, Wang YY, Chen SZ. Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin. Acta Pharmacol Sin. 2005;26:1063-1068.
126. Tsai SK, Huang CH, Huang SS, Hung LM, Hong CY. Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin. Pharmacology. 1999;59:227-233.
127. Chen YH, Lin SJ, Chen JW, Ku HH, Chen YL. Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br J Pharmacol. 2002;135:37-47.
128. Chen HY, Hung YC, Lee EJ, Chen TY, Chuang IC, Wu TS. The protective efficacy of magnolol in hind limb ischemia-reperfusion injury. Phytomedicine. 2009;16:976-981.
129. Jin YC, Kim KJ, Kim YM, et al. Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Exp Biol Med. 2008;233:1280-1288.
130. Lee YM, Hsiao G, Chen HR, Chen YC, Sheu JR, Yen MH. Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats. Eur J Pharmacol. 2001;422:159-167.
131. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90:288-297.
132. Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab. 2009;34:89-98.
133. Pan A, Sun J, Chen Y, et al. Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. Plos ONE. 2007;2:e1148.
134. Miyawaki T, Aono H, Toyoda-Ono Y, Maeda H, Kiso Y, Moriyama K. Antihypertensive effects of sesamin in humans. J Nutr Sci Vitaminol. 2009;55:87-91.
135. Hallund J, Ravn-Haren G, Bugel S, Tholstrup T, Tetens I. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women. J Nutr. 2006;136:112-116.
136. Zhang W, Wang X, Liu Y, et al. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr. 2008;99:1301-1309.
137. Marblestone B. The Effects of Flaxseed SDG on Perimenopausal Women with Mild Hyperlipidemia. San Diego, CA: University of San Diego; 2008. (dissertation abstract).
138. Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, Nakamura H. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis. 1996;122:135-136.
139. Wu JH, Hodgson JM, Puddey IB, Belski R, Burke V, Croft KD. Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutr Metab Cardiovasc Dis. 2009;19:774-780.
140. Hallund J, Tetens I, Bugel S, Tholstrup T, Bruun JM. The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutr Metab Cardiovasc Dis. 2008;18:497-502.
141. Pan A, Demark-Wahnefried W, Ye X, et al. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Br J Nutr. 2009;101:1145-1149.
142. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Van Der Schouw YT. Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study. J Hypertens. 2004;22:1381-1388.
143. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Van Der Schouw YT. Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study. Atherosclerosis. 2005;178:95-100.
144. Van Der Schouw YT, Sampson L, Willett WC, Rimm EB. The usual intake of lignans but not that of isoflavones may be related to cardiovascular risk factors in U.S. men. J Nutr. 2005;135:260-266.
145. Van Der Schouw YT, Pijpe A, Lebrun CE, et al. Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women. Arterioscler Thromb Vasc Biol. 2002;22:1316-1322.
146. De Moura FF. Whole Grain Intake and Cardiovascular Disease and Whole Grain Intake and Diabetes Review. Bethesda, MD: Life Sciences Research Office Inc; 2008:79.
147. Pietinen P, Strumpf K, Mannisto S, Kataja V, Uusitupa M, Adlercreutz H. Serum enterolactone and risk of breast cancer: a case-control study in Eastern Finland. Cancer Epidemiol Biomarkers Prev. 2001;10:339-344.
148. Strumpf K, Pietinen P, Puska P, Adlercreutz H. Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland. Cancer Epidemiol Biomarkers Prev. 2000;9:1369-1372.
149. Vanharanta M, Voutilainen S, Rissanen TH, Adlercreutz H, Salonen JT. Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med. 2003;163:1099-1104.
150. Vanharanta M, Voutilainen S, Lakka TA, Van Der Lee M, Adlercreutz H, Salonen JT. Risk of acute cardiovascular events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet. 1999;354:2112-2115.
151. Kilkkinen A, Erlund I, Virtanen MJ, Alfthan G, Ariniemi K, Virtamo J. Serum enterolactone concentration and the risk of coronary heart disease in a case-cohort study of Finnish male smokers. Am J Epidemiol. 2006;163:687-693.
152. Kuijsten A, Bueno-de-Mesquita HB, Boer JM, et al. Plasma enterolignans are not associated with nonfatal myocardial infarction risk. Atherosclerosis. 2009;203:145-152.
153. Vanharanta M, Voutilainen S, Nurmi T, et al. Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis. 2002;160:465-469.
154. Hillman LC, Peters SG, Fisher CA, Pomare EW. The effects of the fiber components pectin, cellulose and lignin on serum cholesterol levels. Am J Clin Nutr. 1985;42:207-213.
155. Truswell AS. Dietary fibre and blood lipids. Curr Opin Lipidol. 1995;6:14-19.
156. Levi F, Pasche C, Lucchini F, La Vecchia C. Dietary fibre and the risk of colorectal cancer. Eur J Cancer. 2001;37:2091-2096.
157. Negri E, Franceschi S, Parpinel M, La Vecchia C. Fiber intake and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1998;7:667-671.
158. Soler M, Bosetti C, Franceschi S, et al. Fiber intake and the risk of oral, pharyngeal and esophageal cancer. Int J Cancer. 2001;91:283-287.
159. La Vecchia C, Ferraroni M, Franceschi S, Mezzetti M, Decarli A, Negri E. Fibers and breast cancer risk. Nutr Cancer. 1997;28:264-269.
160. Pelucchi C, La Vecchia C, Chatenoud L, et al. Dietary fibres and ovarian cancer risk. Eur J Cancer. 2001;37:2235-2239.
161. Galeone C, Pelucchi C, Talamini R, et al. Fibre intake and renal cell carcinoma: a case-control study from Italy. Int J Cancer. 2007;121:1869-1872.
162. Gimeno SG, Hirai AT, Harima HA, et al. Japanese-Brazilian Diabetes Study Group. Fat and fiber consumption are associated with peripheral arterial disease in a cross-sectional study of a Japanese-Brazilian population. Circ J. 2008;72:44-50.
163. Lupton JR, Turner ND. Dietary fiber and coronary disease: does the evidence support an association? Curr Atheroscler Rep. 2003;5:500-505.
164. Negri E, La Vecchia C, Pelucchi C, Bertuzzi M, Tavani A. Fiber intake and risk of nonfatal acute myocardial infarction. Eur J Clin Nutr. 2003;57:464-470.
165. Pereira MA, O'Reilly E, Augustsson K, et al. Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med. 2004;164:370-376.
166. Streppel MT, Ocke MC, Boshuizen HC, Kok FJ, Kromhout D. Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutphen Study. Am J Clin Nutr. 2008;88:1119-1125.
167. Bazzano LA, He J, Ogden LG, Loria CM, Whelton PK. National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Dietary fiber intake and reduced risk of coronary heart disease in US men and women: the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med. 2003;163:1897-1904.
168. Liu S, Buring JE, Sesso HD, Rimm EB, Willett WC, Manson JE. A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol. 2002;39:49-56.
169. Wu H, Dwyer KM, Fan Z, Shircore A, Fan J, Dwyer JH. Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr. 2003;78:1085-1091.
170. He J, Whelton PK. Effect of dietary fiber and protein intake on blood pressure: a review of epidemiologic evidence. Clin Exp Hypertens. 1999;21:785-796.
171. Lairon D, Bertrais S, Vincent S, et al. French Supplementation en Vitamines et Mineraux AntioXydants (SU.VI.MAX) Adult Cohort. Dietary fibre intake and clinical indices in the French Supplementation en Vitamines et Mineraux AntioXydants (SU.VI.MAX) adult cohort. Proc Nutr Soc. 2003;62:11-15.
172. Bo S, Durazzo M, Guidi S, et al. Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr. 2006;84:1062-1069.
173. King DE, Egan BM, Geesey ME. Relation of dietary fat and fiber to elevation of C-reactive protein. Am J Cardiol. 2003;92:1335-1339.
174. King DE. Dietary fiber, inflammation, and cardiovascular disease. Mol Nutr Food Res. 2005;49:594-600.
175. King DE, Egan BM, Woolson RF, Mainous AG 3rd, Al-Solaiman Y, Jesri A. Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. Arch Intern Med. 2007;167:502-506.
176. Ma Y, Griffith JA, Chasan-Taber L, et al. Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr. 2006;83:760-766.
177. Carnethon MR, Loria CM, Hill JO, Sidney S, Savage PJ, Coronary LK. Artery Risk Development in Young Adults study. Risk factors for the metabolic syndrome: the Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985-2001. Diabetes Care. 2004;27:2707-2715.
178. Delzenne NM, Cani PD. A place for dietary fibre in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2005;8:636-640.
179. Galisteo M, Duarte J, Zarzuelo A. Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J Nutr Biochem. 2008;19:71-84.
180. Ylonen K, Saloranta C, Kronberg-Kippila C, Groop L, Aro A, Botnia VSM. Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes: the Botnia Dietary Study. Diabetes Care. 2003;26:1979-1985.
181. De Castro TG, Gimeno SG, Ferreira SR, Cardoso MA. Japanese-Brazilian Diabetes Study Group. Association of dietary fiber with temporal changes in serum cholesterol in Japanese-Brazilians. J Nutr Sci Vitaminol. 2006;52:205-210.
182. Wu K, Bowman R, Welch AA, et al. Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study. Eur Heart J. 2007;28:2930-2936.
183. Aller R, De Luis DA, Izaola O, et al. Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial. Diabetes Res Clin Pract. 2004;65:7-11.
184. Bazzano LA. Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk. Curr Atheroscler Rep. 2008;10:473-477.
185. Castro IA, Barroso LP, Sinnecker P. Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach. Am J Clin Nutr. 2005;82:32-40.
186. Fernandez ML. Soluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk. Curr Opin Lipidol. 2001;12:35-40.
187. Flight I, Clifton P. Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature. Eur J Clin Nutr. 2006;60:1145-1159.
188. Rideout TC, Harding SV, Jones PJ, Fan MZ. Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: current understandings and future research priorities. Vasc Health Risk Manag. 2008;4:1023-1033.
189. Lee YP, Puddey IB, Hodgson JM. Protein, fibre and blood pressure: potential benefit of legumes. Clin Exp Pharmacol Physiol. 2008;35:473-476.
190. Steemburgo T, Dall'Alba V, Almeida JC, Zelmanovitz T, Gross JL, De Azevedo MJ. Intake of soluble fibers has a protective role for the presence of metabolic syndrome in patients with type 2 diabetes. Eur J Clin Nutr. 2009;63:127-133.
191. Ventura EE, Davis JN, Alexander KE, et al. Dietary intake and the metabolic syndrome in overweight Latino children. J Am Diet Assoc. 2008;108:1355-1359.
192. McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PW, Jacques PF. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care. 2004;27:538-546.
193. Newby PK, Maras J, Bakun P, Muller D, Ferrucci L, Tucker KL. Intake of whole grains, refined grains, and cereal fiber measured with 7-d diet records and associations with risk factors for chronic disease. Am J Clin Nutr. 2007;86:1745-1753.
194. Alonso A, Beunza JJ, Bes-Rastrollo M, Pajares RM, Martinez-Gonzalez MA. Vegetable protein and fiber from cereal are inversely associated with the risk of hypertension in a Spanish cohort. Arch Med Res. 2006;37:778-786.
195. Lairon D, Arnault N, Bertrais S, et al. Dietary fiber intake and risk factors for cardiovascular disease in French adults. Am J Clin Nutr. 2005;82:1185-1194.
196. Erkkila AT, Herrington DM, Mozaffarian D, Lichtenstein AH. Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease. Am Heart J. 2005;150:94-101.
197. Jensen MK, Koh-Banerjee P, Hu FB, et al. Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men. Am J Clin Nutr. 2004;80:1492-1499.
198. Wolk A, Manson JE, Stampfer MJ, et al. Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. JAMA. 1999;281:1998-2004.
199. Mozaffarian D, Kumanyika SK, Lemaitre RN, Olson JL, Burke GL, Siscovick DS. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA. 2003;289:1659-1666.
200. Oh K, Hu FB, Cho E, et al. Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women. Am J Epidemiol. 2005;161:161-169.
201. Truswell AS. Cereal grains and coronary heart disease. Eur J Clin Nutr. 2002;56:1-14.
202. Burr ML. Secondary prevention of CHD in UK men: the Diet and Reinfarction Trial and its sequel. Proc Nutr Soc. 2007;66:9-15.
203. Ness AR, Hughes J, Elwood PC, Whitley E, Smith GD, Burr ML. The long-term effect of dietary advice in men with coronary disease: follow-up of the Diet and Reinfarction Trial (DART). Eur J Clin Nutr. 2002;56:512-518.