Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells

Environmental Toxicology

Volumn 31, Issue 8, 2016, Pages 957-969

  Lin, Chin Chung ^a,b   Lee, Ming Huei ^a,b   Lin, Ju Hwa ^c   Lin, Meng Liang ^c   Chueh, Fu Shin ^d   Yu, Chien Chih ^c   Lin, Jing Pin ^c   Chou, Yu Cheng ^e,f   Hsu, Shu Chun ^c   Chung, Jing Gung ^c,d  

^a FENG YUAN HOSPITAL   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d ASIA UNIVERSITY   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f TZU CHI UNIVERSITY   (Taiwan)

Author keywords

apoptosis; cell cycle arrest; crude extract of Rheum palmatum L. (CERP); human osteosarcoma cells U 2 OS

Indexed keywords

CELL DEATH; CYTOLOGY; DISEASES; MITOCHONDRIA; RECONNAISSANCE AIRCRAFT;

ANTICANCER EFFECTS; CELL-CYCLE ARREST; CRUDE EXTRACT; HUMAN COLON CANCER CELLS; HUMAN OSTEOSARCOMA CELLS; MITOCHONDRIAL-DEPENDENT PATHWAYS; PANCREATIC CANCERS; RHEUMATOID ARTHRITIS;

CELLS;

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CALCIUM ION; CALPAIN 2; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; ENDONUCLEASE G; FAS ANTIGEN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN CDC25A; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE; RHEUM PALMATUM EXTRACT; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ADOLESCENCE; APOPTOSIS; CANCER; CAUSE OF DEATH; CELLS AND CELL COMPONENTS; DISEASE TREATMENT; DNA; ENZYME ACTIVITY; GENOTOXICITY; HERB; LIFE CYCLE ANALYSIS; MITOCHONDRION; ORNAMENTAL SPECIES; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RHUBARB; S PHASE CELL CYCLE CHECKPOINT; WESTERN BLOTTING;

CHINA;

ANIMALIA; COXSACKIEVIRUS; RHEUM PALMATUM;

EID: 84977493841     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.22105     Document Type: Article

References (46)

1. Adams J. 2004. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 4:349–360.
2. Campbell MJ, Hamilton B, Shoemaker M, Tagliaferri M, Cohen I, Tripathy D. 2002. Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Res 22:3843–3852.
3. Chang YM, Velmurugan BK, Kuo WW, Chen YS, Ho TJ, Tsai CT, Ye CX, Tsai CH, Tsai FJ, Huang CY. 2013. Inhibitory effect of alpinate Oxyphyllae fructus extracts on Ang II-induced cardiac pathological remodeling-related pathways in H9c2 cardiomyoblast cells. Biomedicine 3:148–152.
4. Chen JJ, Mikelis CM, Zhang Y, Gutkind JS, Zhang B. 2013. TRAIL induces apoptosis in oral squamous carcinoma cells—a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget 4:206–217.
5. Chiu YJ, Hour MJ, Lu CC, Chung JG, Kuo SC, Huang WW, Chen HJ, Jin YA, Yang JS. 2011. Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway. J Orthop Res 29:1448–1456.
6. Cui Z, Song E, Hu DN, Chen M, Rosen R, McCormick SA. 2012. Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway. Curr Eye Res 37:730–739.
7. Das S, Das J, Samadder A, Boujedaini N, Khuda-Bukhsh AR. 2012. Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria. Exp Biol Med (Maywood) 237:1433–1448.
8. Huang WW, Chiu YJ, Fan MJ, Lu HF, Yeh HF, Li KH, Chen PY, Chung JG, Yang JS. 2010. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res 54:1585–1595.
9. Hung FM, Chen YL, Huang AC, Hsiao YP, Yang JS, Chung MT, Chueh FS, Lu HF, Chung JG. 2013. Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells. Oncol Rep 29:1053–1060.
10. Ji BC, Yu CC, Yang ST, Hsia TC, Yang JS, Lai KC, Ko YC, Lin JJ, Lai TY, Chung JG. 2012. Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells. Oncol Rep 27:959–964.
11. Kang SC, Lee CM, Choung ES, Bak JP, Bae JJ, Yoo HS, Kwak JH, Zee OP. 2008. Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum. Arch Pharm Res 31:722–726.
12. Kapoor R, Rizvi F, Kakkar P. 2013. Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases. Apoptosis 18:9–27.
13. Kar S, Palit S, Ball WB, Das PK. 2012. Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis 17:735–747.
14. Kim WH, Song HO, Choi HJ, Bang HI, Choi DY, Park H. 2012. Ethyl gallate induces apoptosis of HL-60 cells by promoting the expression of caspases-8, -9, -3, apoptosis-inducing factor and endonuclease G. Int J Mol Sci 13:11912–11922.
15. Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. 2011. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. Eur J Pharmacol 670:96–104.
16. Lee HH, Park C, Jeong JW, Kim MJ, Seo MJ, Kang BW, Park JU, Kim GY, Choi BT, Choi YH, et al. 2013. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen speciesmediated mitochondrial death pathway. Int J Oncol 42:1036–1044.
17. Li Z, Huang Y, Dong F, Li W, Ding L, Yu G, Xu D, Yang Y, Xu X, Tong D. 2012. Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. J Biosci 37:1005–1016.
18. Li Y, Li D, Yuan S, Wang Z, Tang F, Nie R, Weng J, Ma L, Tang B. 2013. Embelin-induced MCF-7 breast cancer cell apoptosis and blockade of MCF-7 cells in the G2/M phase via the mitochondrial pathway. Oncol Lett 5:1005–1009.
19. Liao CL, Hsu SC, Yu CC, Yang JS, Tang NY, Wood WG, Lin JG, Chung JG. 2014. The crude extract of Corni Fructus induces apoptotic cell death through reactive oxygen speciesmodulated pathways in U-2 OS human osteosarcoma cells. Environ Toxicol 29:1020–1031.
20. Lin YL, Wu CF, Huang YT. 2008. Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells. Plant Med 74:1246–1252.
21. Lin ML, Lu YC, Chung JG, Li YC, Wang SG, N GS, Wu CY, Su HL, Chen SS. 2010. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett 291:46–58.
22. Liu JF, Huang YL, Yang WH, Chang CS, Tang CH. 2012. 1-Benzyl-2-phenylbenzimidazole (BPB), a benzimidazole derivative, induces cell apoptosis in human chondrosarcoma through intrinsic and extrinsic pathways. Int J Mol Sci 13:16472–16488.
23. Luo W, Su X, Gong S, Qin Y, Liu W, Li J, Yu H, Xu Q. 2009. Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts. Biosci Trends 3:124–126.
24. Ma YS, Hsu SC, Weng SW, Yu CC, Yang JS, Lai KC, Lin JP, Lin JG, Chung JG. 2014. Crude extract of Rheum palmatum L. induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways. Environ Toxicol 29:969–980.
25. Marina N, Gebhardt M, Teot L, Gorlick R. 2004. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9:422–441.
26. Ou Yang F, Wang G, Guo W, Zhang Y, Xiang W, Zhao M. 2013. AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells. Food Chem 138:2130–2139.
27. Papachristou DJ, Batistatou A, Sykiotis GP, Varakis I, Papavassiliou AG. 2003. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone 32:364–371.
28. Rajkumar V, Guha G, Kumar RA. 2011. Apoptosis induction in MDA-MB-435S, Hep3B and PC-3 cell lines by Rheum emodi rhizome extracts. Asian Pac J Cancer Prev 12:1197–1200.
29. Ren J, Cheng H, Xin WQ, Chen X, Hu K. 2012. Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells. Oncol Rep 28:1719–1726.
30. Sun ZH, Bu P. 2012. Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line. Exp Ther Med 3:1077–1081.
31. Sun C, Guo XX, Zhu D, Xiao C, Bai X, Li Y, Zhan Z, Li XL, Song ZG, Jin YH. 2013. Apoptosis is Induced in cancer cells via the mitochondrial pathway by the novel xylocydine-derived compound JRS-15. Int J Mol Sci 14:850–870.
32. Tang JC, Zhang JN, Wu YT, Li ZX. 2006. Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity. Phytother Res 20:1046–1051.
33. Tang N, Song WX, Luo J, Haydon RC, He TC. 2008. Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res 466:2114–2130.
34. Unni KK. 1998. Osteosarcoma of bone. J Orthop Sci 3:287–294.
35. Wang JB, Kong WJ, Wang HJ, Zhao HP, Xiao HY, Dai CM, Xiao XH, Zhao YL, Jin C, Zhang L, et al. 2011a. Toxic effects caused by rhubarb (Rheum palmatum L.) are reversed on immature and aged rats. J Ethnopharmacol 134:216–220.
36. Wang JB, Zhao HP, Zhao YL, Jin C, Liu DJ, Kong WJ, Fang F, Zhang L, Wang HJ, Xiao XH. 2011b. Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. PLoS One 6:e24498.
37. Ward WG, Mikaelian K, Dorey F, Mirra JM, Sassoon A, Holmes EC, Eilber FR, Eckardt JJ. 1994. Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases. J Clin Oncol 12:1849–1858.
38. Weckbach S, Hohmann C, Denk S, Kellermann P, Huber-Lang MS, Baumann B, Wirth T, Gebhard F, Bachem M, Perl M. 2013. Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury. J Trauma Acute Care Surg 74:792–800.
39. Wu CL, Huang AC, Yang JS, Liao CL, Lu HF, Chou ST, Ma CY, Hsia TC, Ko YC, Chung JG. 2011a. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells. J Orthop Res 29:1199–1209.
40. Wu PP, Liu KC, Huang WW, Ma CY, Lin H, Yang JS, Chung JG. 2011b. Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. Oncol Rep 25:551–557.
41. Xing XY, Zhao YL, Kong WJ, Wang JB, Jia L, Zhang P, Yan D, Zhong YW, Li RS, Xiao XH. 2011. Investigation of the “dose–time–response” relationships of rhubarb on carbon tetrachloride-induced liver injury in rats. J Ethnopharmacol 135:575–581.
42. Xiong HR, Shen YY, Lu L, Hou W, Luo F, Xiao H, Yang ZQ. 2012. The inhibitory effect of Rheum palmatum against coxsackievirus B3 in vitro and in vivo. Am J Chin Med 40:801–812.
43. Xu Y, Zhang J, Shi W, Liu Y. 2013. Anticancer effects of 3,3'-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells. Oncol Lett 5:655–662.
44. Yu CS, Huang AC, Lai KC, Huang YP, Lin MW, Yang JS, Chung JG. 2012. Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells. Oncol Rep 28:949–954.
45. Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Munch G, Wu MJ. 2011. Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds. J Agric Food Chem 59:12361–12367.
46. Zhang H, Qian Y, Liu Y, Li G, Cui P, Zhu Y, Ma H, Ji X, Guo S, Tadashi H. 2012. Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells. J Trad Chin Med 32:621–626.