Toxic effects caused by rhubarb (Rheum palmatum L.) are reversed on immature and aged rats

Journal of Ethnopharmacology

Volumn 134, Issue 2, 2011, Pages 216-220

  Wang, Jia Bo ^a   Kong, Wei Jun ^a,c   Wang, Hong Juan ^b   Zhao, Hai Ping ^a,d   Xiao, He Yin ^b   Dai, Chun Mei ^a,c   Xiao, Xiao He ^a   Zhao, Yan Ling ^a   Jin, Cheng ^a   Zhang, Lin ^a,c   Fang, Fang ^a,c   Li, Rui Sheng ^a  

^a 302 MILITARY HOSPITAL   (China)

^b WANGJING HOSPITAL   (China)

^c CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Age; Hepatotoxicity; Interleukin; Nephrotoxicity; Rhubarb; Safety evaluation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILE ACID; CALCIUM; CHOLESTEROL; CREATININE; INTERLEUKIN 6; INTERLEUKIN 8; NITROGEN; PHOSPHATE; PROTEIN; RHUBARB EXTRACT;

AGED; AGING; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT DISEASE; CALCIUM BLOOD LEVEL; CHOLESTEROL BILE LEVEL; CHOLESTEROL BLOOD LEVEL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; FEMALE; HISTOPATHOLOGY; IMMATURITY; KUPFFER CELL; LIVER NECROSIS; LIVER TOXICITY; LYMPHOCYTIC INFILTRATION; MALE; NEPHROTOXICITY; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHYTOCHEMISTRY; RAT; REVERSAL REACTION; RHUBARB; TOXICITY TESTING;

AGE FACTORS; ANIMALS; BILIARY TRACT DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FEMALE; INTERLEUKIN-6; KIDNEY DISEASES; KIDNEY TUBULES; LIVER; LYMPHOCYTES; MALE; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RHEUM; RHIZOME;

RATTUS; RHEUM PALMATUM; RHEUM X HYBRIDUM;

EID: 79952706482     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.12.008     Document Type: Article

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