Apoptosis is induced in cancer cells via the mitochondrial pathway by the novel xylocydine-derived compound JRS-15

International Journal of Molecular Sciences

Volumn 14, Issue 1, 2013, Pages 850-870

  Sun, Chao ^a   Guo, Xiao Xi ^a   Zhu, Dan ^a   Xiao, Chuan ^a   Bai, Xiao ^b   Li, Yang ^a   Zhan, Zhuo ^a   Li, Xiang Long ^a   Song, Zhi Guang ^a   Jin, Ying Hua ^a  

^a JILIN UNIVERSITY   (China)

^b Basic Medical College   (China)

Author keywords

Apoptosis; Bak; Bax; Bcl xL; Cell cycle; Cytochrome c; JRS 15; Smac; XIAP

Indexed keywords

4 AMINO 6 [3 (3 BROMOPHENYL)PHENYL] 7 (BETA LEVO XYLOFURANOSYL)PYROLOL[2,3 D]PYRIMIDINE 5 CYANO; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; ENZYME INHIBITOR; JRS 15; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; XYLOCYDINE; 4-AMINO-6-(3-(3-BROMOPHENYL)PHENYL)-7-(XYLOFURANOSYL)PYROLO(2,3-D)PYRIMIDINE-5-NITRILE; 4-AMINO-6-BROMO-7-(XYLOFURANOSYL)PYRROLO(2,3-D)PYRIMIDINE-5-CARBOXAMIDE; CASPASE; CYCLIN DEPENDENT KINASE; NUCLEOSIDE; PROTEIN BCL X; XIAP PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE REGULATION; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; HEPG2 CELL LINE; IMMUNOBLOTTING; METABOLISM; MITOCHONDRION; NEOPLASM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BCL-X PROTEIN; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HELA CELLS; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR STRUCTURE; NEOPLASMS; NUCLEOSIDES; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84872195917     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14010850     Document Type: Article

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