AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells

Food Chemistry

Volumn 138, Issue 4, 2013, Pages 2130-2139

  Ouyang, Fengju ^a   Wang, Guibin ^a   Guo, Wei ^b   Zhang, Yuanyuan ^a   Xiang, Wenhua ^b   Zhao, Min ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Apoptosis; Cell cycle; Human hepatoma cells; Medicinal mushrooms

Indexed keywords

AKT PHOSPHORYLATION; BCL-2 FAMILY PROTEINS; CELL CYCLE; HUMAN HEPATOMA CELLS; MEDICINAL MUSHROOM; MITOCHONDRIA-MEDIATED APOPTOSIS PATHWAYS; MITOCHONDRIAL PATHWAYS; MOLECULAR MECHANISM;

CELL PROLIFERATION; FUNGI; MITOCHONDRIA; POLYSACCHARIDES; PROTEINS; TUMORS;

CELL DEATH;

CASPASE 3; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYSACCHARIDE; PROTEIN KINASE B; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HEPG2; HEPATOMA CELL; HUMAN; HUMAN CELL; MUSHROOM; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

AGARICALES; APOPTOSIS; BIOLOGICAL FACTORS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOCHONDRIA; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; S PHASE CELL CYCLE CHECKPOINTS; SIGNAL TRANSDUCTION;

BASIDIOMYCOTA;

EID: 84874007734     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.10.047     Document Type: Article

References (31)

1. C.E. Caldon, R.J. Daly, R.L. Sutherland, and E.A. Musgrove Cell cycle control in breast cancer cells Journal of Cellular Biochemistry 97 2 2006 261 274
2. K.C. Cheng, H.C. Huang, J.H. Chen, J.W. Hsu, H.C. Cheng, and C.H. Ou Ganoderma lucidum polysaccharides in human monocytic leukemia cells: From gene expression to network construction BMC Genomics 8 2007 411
3. J. Fang, M. Ding, L. Yang, L.Z. Liu, and B.H. Jiang PI3K/PTEN/AKT signalling regulates prostate tumour angiogenesis Cellular Signalling 19 12 2007 2487 2497
4. A.I. Gomaa, S.A. Khan, M.B. Toledano, I. Waked, and S.D. Taylor-Robinson Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis World Journal of Gastroenterology 14 27 2008 4300 4308
5. X. Grana, and E.P. Reddy Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs) Oncogene 11 2 1995 211 219
6. J. Guo, T. Zhu, L. Collins, Z.X. Xiao, S.H. Kim, and C.Y. Chen Modulation of lung cancer growth arrest and apoptosis by Phellinus linteus Molecular Carcinogenesis 46 2 2007 144 154
7. C.A. Hobbs, and S.K. Gilmour High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation Journal of Cellular Biochemistry 77 3 2000 345 360
8. B.H. Jiang, and L.Z. Liu PI3K/PTEN signalling in tumourigenesis and angiogenesis Biochimica et Biophysica Acta 1784 1 2008 150 158
9. J.F. Kerr, C.M. Winterford, and B.V. Harmon Apoptosis. Its significance in cancer and cancer therapy Cancer 73 8 1994 2013 2026
10. G.Y. Kim, M.G. Han, Y.S. Song, B.C. Shin, Y.I. Shin, and H.J. Lee Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-kappaB Biological and Pharmaceutical Bulletin 27 10 2004 1656 1662
11. Y.O. Kim, H.W. Park, J.H. Kim, J.Y. Lee, S.H. Moon, and C.S. Shin Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus Life Sciences 79 2006 72 80
12. J. Lee, and K.T. Lim Phytoglycoprotein (38 kDa) induces cell cycle (G/G) arrest and apoptosis in HepG2 cells Journal of Cellular Biochemistry 112 11 2011 3129 3139
13. C.L. Li, T. Tian, K.J. Nan, N. Zhao, Y.H. Guo, and J. Cui Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro Oncology Reports 20 6 2008 1465 1471
14. G. Li, D.H. Kim, T.D. Kim, B.J. Park, H.D. Park, and J.I. Park Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells Cancer Letters 216 2 2004 175 181
15. T. Miyazaki, and M. Nishijima Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumour polysaccharide of Ganoderma lucidum Chemical Pharmaceutical Bulletin (Tokyo) 29 12 1981 3611 3616
16. N. Mohamad, A. Gutierrez, M. Nunez, C. Cocca, G. Martin, and G. Cricco Mitochondrial apoptotic pathways Biocell 29 2 2005 149 161
17. S. Ortega, M. Malumbres, and M. Barbacid Cyclin D-dependent kinases, INK4 inhibitors and cancer Biochimica et Biophysica Acta 1602 1 2002 73 87
18. V.E. Ooi, and F. Liu Immunomodulation and anticancer activity of polysaccharide-protein complexes Current Medicinal Chemistry 7 2000 715 729
19. C. Park, C.Y. Jin, G.Y. Kim, I.W. Choi, T.K. Kwon, and B.T. Choi Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK Toxicology and Applied Pharmacology 227 2 2008 219 228
20. C. Park, C.Y. Jin, H.J. Kwon, H.J. Hwang, G.Y. Kim, and I.W. Choi Induction of apoptosis by esculetin in human leukemia U937 cells: Roles of Bcl-2 and extracellular-regulated kinase signalling Toxicology In Vitro 24 2 2010 486 494
21. C.J. Sherr G1 phase progression: Cycling on cue Cell 79 4 1994 551 555
22. D. Sliva, A. Jedinak, J. Kawasaki, K. Harvey, and V. Slivova Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling British Journal of Cancer 98 8 2008 1348 1356
23. K.S. Song, S.M. Cho, J.H. Lee, H.M. Kim, S.B. Han, and K.S. Ko B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus Chemical and Pharmaceutical Bulletin 43 12 1995 2105 2108
24. S. Syam, A.B. Abdul, M.A. Sukari, S. Mohan, S.I. Abdelwahab, and T.S. Wah The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest Molecules 16 8 2011 7155 7170
25. C.B. Thompson Apoptosis in the pathogenesis and treatment of disease Science 267 5203 1995 1456 1462
26. S. Ukai, T. Kiho, C. Hara, M. Morita, A. Goto, and N. Imaizumi Polysaccharides in fungi. XIII. Antitumour activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae, and Auricularia species Chemical Pharmaceutical Bulletin (Tokyo) 31 2 1983 741 744
27. G.B. Wang, L.L. Dong, Y.Y. Ji, W.H. Xang, and M. Zhao Inhibitory effects of Phellinus baumii polysaccharide on the proliferation and invasion of HepG2 cell Mycosystema (Chinese) 30 2 2011 361 365
28. S.P. Wasser Medicinal mushrooms as a source of antitumour and immunomodulating polysaccharides Applied Microbiology and Biotechnology 60 3 2002 258 274
29. L. Weng, J. Brown, and C. Eng PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways Human Molecular Genetics 10 3 2001 237 242
30. Z. Yao, X.C. Che, R. Lu, M.N. Zheng, Z.F. Zhu, and J.P. Li Inhibition by tyroserleutide (YSL) on the invasion and adhesion of the mouse melanoma cell Molecular Medicine 13 1-2 2007 14 21
31. B.Z. Zaidman, M. Yassin, J. Mahajna, and S.P. Wasser Medicinal mushroom modulators of molecular targets as cancer therapeutics Applied Microbiology and Biotechnology 67 4 2005 453 468