Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 959-964

  Ji, Bin Chuan ^a   Yu, Chien Chih ^b   Yang, S U Tso ^b,c   Hsia, T E Chun ^c   Yang, Jai Sing ^b   Lai, Kuang Chi ^d,e   Ko, Yang Ching ^f   Lin, Jen Jyh ^b,c   Lai, Tung Yuan ^g,h   Chung, Jing Gung ^b,i  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f ST MARTIN DE PORRES HOSPITAL   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^h TAIPEI MEDICAL UNIVERSITY   (Taiwan)

ⁱ ASIA UNIVERSITY   (Taiwan)

Author keywords

Comet assay; Deguelin; DNA damage; DNA repair; Human lung cancer NCI H460 cells

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DEGUELIN; DNA DEPENDENT PROTEIN KINASE; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL LEVEL; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; DRUG EFFICACY; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; ONCOGENE; ONCOGENE ATM; ONCOGENE ATR; ONCOGENE DNA PK; ONCOGENE MGMT; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BRCA1 PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COMET ASSAY; DNA DAMAGE; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; DNA TOPOISOMERASES, TYPE I; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORESIS, AGAR GEL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROTENONE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84863016361     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1622     Document Type: Article

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