Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts

BioScience Trends

Volumn 3, Issue 4, 2009, Pages 124-126

  Luo, Weisheng ^a   Su, Xiaojian ^b   Gong, Shouji ^a   Qin, Yongjun ^b   Liu, Weibing ^b   Li, Jia ^c   Yu, Haiping ^c   Xu, Qing ^a  

^a GUILIN MEDICAL UNIVERSITY   (China)

^b GUANGXI NORMAL UNIVERSITY   (China)

^c National Center for Drug Screening   (China)

Author keywords

Rheum palmatum L.; SARS 3CL protease

Indexed keywords

3C LIKE PROTEASE, SARS CORONAVIRUS; 3C-LIKE PROTEASE, SARS CORONAVIRUS; CYSTEINE PROTEINASE; PLANT EXTRACT; VIRUS PROTEIN;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IC 50; POLYMERASE CHAIN REACTION; RHUBARB; SARS CORONAVIRUS;

CYSTEINE ENDOPEPTIDASES; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; POLYMERASE CHAIN REACTION; RHEUM; SARS VIRUS; VIRAL PROTEINS;

EID: 77952580567     PISSN: 18817815     EISSN: 18817823     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Wang P, Xie YY, Wang YS, Xu SL, Wang GT, Song YY, Xu HZ, Yao P, Wang ZY. Study on antiviral action of Rheum officinale Baill. Acta Academiae Medicinae Shandong. 1996; 34:166-169. (in Chinese)
2. Xu X, Li L, Cong J. An overview of antiviral research of Chinese medicine Rhubarb. China Pharmacist. 2005; 8:70-72. (in Chinese)
3. Ho TY, Wu SL, Chen JC, Li CC, Hsiang CY. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007; 74:92-101.
4. Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY, Hsieh CC, Chao PD. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res. 2005; 68:36-42.
5. Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003; 300:1763-1767.
6. Wu YS, Lin WH, Hsu JT, Hsieh HP. Antiviral drug discovery against SARS-CoV. Curr Med Chem. 2006; 13:2003-2020.
7. Wang Z, Wang G, Xu H, Wang P. Anti-herpes virus action of alcohol extract of Rhubarb. China Journal of Chinese Materia Medica. 1996; 21:364-366. (in Chinese)