1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole derivative, induces cell apoptosis in human chondrosarcoma through intrinsic and extrinsic pathways

International Journal of Molecular Sciences

Volumn 13, Issue 12, 2012, Pages 16472-16488

  Liu, Ju Fang ^a,b   Huang, Yuan Li ^c   Yang, Wei Hung ^b,d,e   Chang, Chih Shiang ^b   Tang, Chih Hsin ^b,f  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d Taichung Hospital   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Benzimidazole; Chinese herb; Chondrosarcoma; Extrinsic pathway; Intrinsic pathway

Indexed keywords

1 BENZYL 2 PHENYLBENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; CASPASE 8; DEATH RECEPTOR; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; UNCLASSIFIED DRUG; 1-BENZYL-2-PHENYLBENZIMIDAZOLE; 2-PHENYLBENZIMIDAZOLE; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARTILAGE CELL; CELL SURVIVAL; CELL VIABILITY; CHONDROSARCOMA; COLONY FORMATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN SECRETION; SARCOMA CELL; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BONE TUMOR; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; NUDE MOUSE; PATHOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION;

ANIMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; BONE NEOPLASMS; CELLS, CULTURED; CHONDROSARCOMA; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, SCID; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871708931     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131216472     Document Type: Article

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