A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits

PLoS ONE

Volumn 11, Issue 6, 2016, Pages

  Volkov, Petr ^a   Olsson, Anders H ^a,b   Gillberg, Linn ^b   Jørgensen, Sine W ^b   Brøns, Charlotte ^b   Eriksson, Karl Fredrik ^c   Groop, Leif ^a   Jansson, Per Anders ^d   Nilsson, Emma ^a,b   Rönn, Tina ^a   Vaag, Allan ^b   Ling, Charlotte ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c LUND UNIVERSITY   (Sweden)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 2; ADENYLATE CYCLASE; ADENYLATE CYCLASE 3; APOLIPOPROTEIN A5; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLINERGIC RECEPTOR NICOTINIC ALPHA 5; ENZYME; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATASE CATALYTIC SUBUNIT 2; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 7; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN RECEPTOR; MESSENGER RNA; NICOTINIC RECEPTOR; PROOPIOMELANOCORTIN; RIBOSOME PROTEIN; RIBOSOME PROTEIN L27A; SORTILIN; SYNTHETASE; THREONINE SYNTHASE LIKE 2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 57; GLYCOSYLATED HEMOGLOBIN;

ADCY3 GENE; ADIPOSE TISSUE; ADULT; APOA5 GENE; ARTICLE; BODY MASS; CETP GENE; CHOLESTEROL BLOOD LEVEL; CHRNA5 GENE; DIABETES MELLITUS; DNA METHYLATION; DNA STRUCTURE; FADS2 GENE; G6PC2 GENE; GCKR GENE; GENE; GENE EXPRESSION; GENE INTERACTION; GENE REPLICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOME ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLUCOSE BLOOD LEVEL; GPX7 GENE; HEMOGLOBIN BLOOD LEVEL; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INSULIN BLOOD LEVEL; LEPR GENE; MALE; METABOLIC PARAMETERS; OBESITY; OVERLAPPING GENE; PHENOTYPE; POMC GENE; QUANTITATIVE TRAIT LOCUS; RPL27A GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SORT1 GENE; THNSL2 GENE; ZFP57 GENE; COHORT ANALYSIS; CPG ISLAND; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDY; GENETIC VARIATION; GENETICS; HUMAN GENOME; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; QUANTITATIVE TRAIT; REPRODUCIBILITY; SCANDINAVIA;

ADIPOSE TISSUE; ADULT; BODY MASS INDEX; COHORT STUDIES; CPG ISLANDS; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOME, HUMAN; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SCANDINAVIAN AND NORDIC COUNTRIES;

EID: 84976869314     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0157776     Document Type: Article

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