Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

Diabetologia

Volumn 55, Issue 12, 2012, Pages 3341-3349

  Jacobsen, S C ^a,b   Brons C ^a,b   Bork Jensen, J ^a,b   Ribel Madsen, R ^a   Yang, B ^c   Lara, E ^d   Hall, E ^c   Calvanese, V ^d   Nilsson, E ^a   Jorgensen S W ^a,b   Mandrup, S ^e   Ling, C ^c   Fernandez, A F ^d   Fraga, M F ^d   Poulsen, P ^a   Vaag, A ^a,b  

^a STENO DIABETES CENTER   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c LUND UNIVERSITY   (Sweden)

^d Department of Diagnostic Radiology   (Spain)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

DNA methylation; Epigenetic; Gene expression; Genome wide; High fat overfeeding; Human; Illumina Infinium 27k Bead Array; Reversibility; Skeletal muscle; Type 2 diabetes

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN RESISTANCE; LIPID DIET; MALE; MUSCLE BIOPSY; NORMAL HUMAN; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PYROSEQUENCING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRANSCRIPTION INITIATION SITE;

CATION TRANSPORT PROTEINS; CPG ISLANDS; CROSS-OVER STUDIES; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIET, HIGH-FAT; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OVERNUTRITION; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84868211134     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2717-8     Document Type: Article

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