DNA methylation and body-mass index: A genome-wide analysis

The Lancet

Volumn 383, Issue 9933, 2014, Pages 1990-1998

  Dick, Katherine J ^a,c   Nelson, Christopher P ^a,c   Tsaprouni, Loukia ^d,e   Sandling, Johanna K ^d,f   Aïssi, Dylan ^g,h,i   Wahl, Simone ^j,k   Meduri, Eshwar ^d   Morange, Pierre Emmanuel ^l   Gagnon, France ^m   Grallert, Harald ^j,k   Waldenberger, Melanie ^k   Peters, Annette ^k,n   Erdmann, Jeanette ^n,o   Hengstenberg, Christian ^n,p   Cambien, Francois ^g,h,i   Goodall, Alison H ^a,c   Ouwehand, Willem H ^d,q,r   Schunkert, Heribert ^n,p   Thompson, John R ^b   Spector, Tim D ^s   Gieger, Christian ^k   Trégouët, David Alexandre ^g,h,i   Deloukas, Panos ^d,t,u   Samani, Nilesh J ^a,c   more..

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c GLENFIELD HOSPITAL   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF BEDFORDSHIRE   (United Kingdom)

^f UPPSALA UNIVERSITY   (Sweden)

^g SORBONNE UNIVERSITÉ   (France)

^h Institute OfCardiometabolism and Nutrition   (France)

ⁱ ICAN Institute for Cardiometabolism and Nutrition   (France)

^j GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^k INSTITUTE OF EPIDEMIOLOGY   (Germany)

^l AIX MARSEILLE UNIVERSITY   (France)

^m UNIVERSITY OF TORONTO   (Canada)

ⁿ DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^o UNIVERSITY OF LÜBECK   (Germany)

^p TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^q UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^r NHS BLOOD AND TRANSPLANT   (United Kingdom)

^s KING'S COLLEGE LONDON   (United Kingdom)

^t QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^u KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 3ALPHA;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD CELL; BODY MASS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; GENE REPLICATION; GENOME ANALYSIS; OBESITY;

EID: 84921316380     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(13)62674-4     Document Type: Article

References (45)

1. BA Swinburn, G Sacks, KD Hall et al. The global obesity pandemic: shaped by global drivers and local environments Lancet 378 2011 804 814
2. JR Speakman, S O'Rahilly Fat: an evolving issue Dis Model Mech 5 2012 569 573
3. EK Speliotes, CJ Willer, SI Berndt et al. Association analyses of 249796 individuals reveal 18 new loci associated with body mass index Nat Genet 42 2010 937 948
4. PA Jones Functions of DNA methylation: islands, start sites, gene bodies and beyond Nat Rev Genet 13 2012 484 492
5. P Lopez-Serra, M Esteller DNA methylation-Associated silencing of tumor-suppressor microRNAs in cancer Oncogene 31 2012 1609 1622
6. L Laurent, E Wong, G Li et al. Dynamic changes in the human methylome during differentiation Genome Res 20 2010 320 331
7. AK Maunakea, RP Nagarajan, M Bilenky et al. Conserved role of intragenic DNA methylation in regulating alternative promoters Nature 466 2010 253 257
8. F Lienert, C Wirbelauer, I Som, A Dean, F Mohn, D Schübeler Identification of genetic elements that autonomously determine DNA methylation states Nat Genet 43 2011 1091 1097
9. R Feil, MF Fraga Epigenetics and the environment: emerging patterns and implications Nat Rev Genet 13 2011 97 109
10. EE Schadt Molecular networks as sensors and drivers of common human diseases Nature 461 2009 218 223
11. J Sandoval, H Heyn, S Moran et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome Epigenetics 6 2011 692 702
12. S Garnier, V Tuong, J Brocheton et al. Genome-wide haplotype analysis of cis expression quantitative trati loci in monocytes PLoS Genet 9 2013 e1003240
13. M Heinig, E Petretto, C Wallace et al. A trans-Acting locus regulates an anti-viral expression network and type 1 diabetes risk Nature 467 2010 460 464
14. DA Trégouët, S Heath, N Saut et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach Blood 113 2009 5298 5303
15. HE Wichmann, C Gieger, T Illig for the MONICA/KORA Study Group KORA-gen - resource for population genetics, controls and a broad spectrum of disease phenotypes Gesundheitswesen 67 suppl 1 2005 S26 S30
16. AC Nica, L Parts, D Glass the MuTHER Consortium The architecture of gene regulatory variation across multiple human tissues: the MuTHER study PLoS Genet 7 2011 e1002003
17. E Grundberg, KS Small, AK Hedman the Multiple Tissue Human Expression Resource (MuTHER) Consortium Mapping cis- and trans-regulatory effects across multiple tissues in twins Nat Genet 44 2012 1084 1089
18. J Maksimovic, L Gordon, A Oshlack SWAN: Subset-quantile within array normalization for Illumina Infinium HumanMethylation450 BeadChips Genome Biol 13 2012 R44
19. BM Bolstad, RA Irizarry, M Astrand, TP Speed A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 2003 185 193
20. Y Benjamini, Y Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Statist Soc B 57 1995 289 300
21. S Dedeurwaerder, M Defrance, E Calonne, H Denis, C Sotiriou, F Fuks Evaluation of the Infinium Methylation 450K technology Epigenomics 3 2011 771 784
22. LP Breitling, R Yang, B Korn, B Burwinkel, H Brenner Tobacco-smoking-related differential DNA methylation: 27K discovery and replication Am J Hum Genet 88 2011 450 457
23. YA Chen, M Lemire, S Choufani et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray Epigenetics 8 2013 203 209
24. CL Relton, A Groom, B St Pourcain et al. DNA methylation patterns in cord blood DNA and body size in childhood PLoS One 7 2012 e31821
25. X Wang, H Zhu, H Snieder et al. Obesity related methylation changes in DNA of peripheral blood leukocytes BMC Med 8 2010 87
26. MS Almén, JA Jacobsson, G Moschonis et al. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes Genomics 99 2012 132 137
27. AP Feinberg, RA Irizarry, D Fradin et al. Personalized epigenomic signatures that are stable over time and covary with body mass index Sci Transl Med 2 2010 49ra67
28. A Moleres, J Campión, FI Milagro the EVASYON Study Group Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study FASEB J 27 2013 2504 2512
29. T Rönn, P Volkov, C Davegårdh et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue PLoS Genet 9 2013 e1003572
30. SN Greer, JL Metcalf, Y Wang, M Ohh The updated biology of hypoxia-inducible factor EMBO J 31 2012 2448 2460
31. M Heikkilå, A Pasanen, KI Kivirikko, J Myllyharju Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response Cell Mol Life Sci 68 2011 3885 3901
32. Y Makino, R Cao, K Svensson et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression Nature 414 2001 550 554
33. Y Makino, A Kanopka, WJ Wilson, H Tanaka, L Poellinger Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus J Biol Chem 277 2002 32405 32408
34. C Jiang, A Qu, T Matsubara et al. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice Diabetes 60 2011 2484 2495
35. MK Shin, LF Drager, Q Yao et al. Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α PLoS One 7 2012 e46562
36. H Zhang, G Zhang, FJ Gonzalez, SM Park, D Cai Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation PLoS Biol 9 2011 e1001112
37. YS Park, AE David, Y Huang et al. In vivo delivery of cell-permeable antisense hypoxia-inducible factor 1α oligonucleotide to adipose tissue reduces adiposity in obese mice J Control Release 161 2012 1 9
38. M Heidbreder, F Qadri, O Jöhren et al. Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin Biochem Biophys Res Commun 352 2007 437 443
39. M Hatanaka, S Shimba, M Sakaue et al. Hypoxia-inducible factor-3α functions as an accelerator of 3T3-L1 adipose differentiation Biol Pharm Bull 32 2009 1166 1172
40. MR Robciuc, J Naukkarinen, A Ortega-Alonso et al. Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins J Lipid Res 52 2011 1575 1582
41. JT Bell, AA Pai, JK Pickrell et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines Genome Biol 12 2011 R10
42. JR Gibbs, MP van der Brug, DG Hernandez et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain PLoS Genet 6 2010 e1000952
43. MR Bonsignore, WT McNicholas, JM Montserrat, J Eckel Adipose tissue in obesity and obstructive sleep apnoea Eur Respir J 39 2012 746 767
44. PN Cockerill Structure and function of active chromatin and DNase I hypersensitive sites FEBS J 278 2011 2182 2210
45. P Kraft Curses - winner's and otherwise - in genetic epidemiology Epidemiology 19 2008 649 651