-
2
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
10.1056/NEJMoa012512, 1370926, 11832527
-
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346:393-403. 10.1056/NEJMoa012512, 1370926, 11832527.
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
Walker, E.A.6
Nathan, D.M.7
-
3
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
10.1056/NEJM200105033441801, 11333990, Finnish Diabetes Prevention Study Group
-
Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Aunola S, Cepaitis Z, Moltchanov V, Hakumaki M, Mannelin M, Martikkala V, Sundvall J, Uusitupa M, . Finnish Diabetes Prevention Study Group Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001, 344:1343-1350. 10.1056/NEJM200105033441801, 11333990, Finnish Diabetes Prevention Study Group.
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindstrom, J.2
Eriksson, J.G.3
Valle, T.T.4
Hamalainen, H.5
Ilanne-Parikka, P.6
Keinanen-Kiukaanniemi, S.7
Laakso, M.8
Louheranta, A.9
Rastas, M.10
Salminen, V.11
Aunola, S.12
Cepaitis, Z.13
Moltchanov, V.14
Hakumaki, M.15
Mannelin, M.16
Martikkala, V.17
Sundvall, J.18
Uusitupa, M.19
-
4
-
-
33645523067
-
Prevalence of overweight and obesity in the United States, 1999-2004
-
10.1001/jama.295.13.1549, 16595758
-
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555. 10.1001/jama.295.13.1549, 16595758.
-
(2006)
JAMA
, vol.295
, pp. 1549-1555
-
-
Ogden, C.L.1
Carroll, M.D.2
Curtin, L.R.3
McDowell, M.A.4
Tabak, C.J.5
Flegal, K.M.6
-
5
-
-
38449098674
-
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
-
10.2337/db07-0910, 17942823
-
Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jorgensen T, Pedersen O, Hansen T. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008, 57:95-101. 10.2337/db07-0910, 17942823.
-
(2008)
Diabetes
, vol.57
, pp. 95-101
-
-
Andreasen, C.H.1
Stender-Petersen, K.L.2
Mogensen, M.S.3
Torekov, S.S.4
Wegner, L.5
Andersen, G.6
Nielsen, A.L.7
Albrechtsen, A.8
Borch-Johnsen, K.9
Rasmussen, S.S.10
Clausen, J.O.11
Sandbaek, A.12
Lauritzen, T.13
Hansen, L.14
Jorgensen, T.15
Pedersen, O.16
Hansen, T.17
-
6
-
-
33749833173
-
PGC-1alpha gene and physical activity in type 2 diabetes mellitus
-
10.1249/01.jes.0000240021.92254.23, 17031255
-
Franks PW, Loos RJ. PGC-1alpha gene and physical activity in type 2 diabetes mellitus. Exerc Sport Sci Rev 2006, 34:171-175. 10.1249/01.jes.0000240021.92254.23, 17031255.
-
(2006)
Exerc Sport Sci Rev
, vol.34
, pp. 171-175
-
-
Franks, P.W.1
Loos, R.J.2
-
7
-
-
34249337761
-
Perceptions of epigenetics
-
10.1038/nature05913, 17522671
-
Bird A. Perceptions of epigenetics. Nature 2007, 447:396-398. 10.1038/nature05913, 17522671.
-
(2007)
Nature
, vol.447
, pp. 396-398
-
-
Bird, A.1
-
8
-
-
2342599054
-
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle
-
10.2337/diabetes.53.5.1208, 15111488
-
McGee SL, Hargreaves M. Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes 2004, 53:1208-1214. 10.2337/diabetes.53.5.1208, 15111488.
-
(2004)
Diabetes
, vol.53
, pp. 1208-1214
-
-
McGee, S.L.1
Hargreaves, M.2
-
9
-
-
33645028038
-
Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms
-
10.1111/j.1440-1681.2006.04362.x, 16620308
-
McGee SL, Hargreaves M. Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pharmacol Physiol 2006, 33:395-399. 10.1111/j.1440-1681.2006.04362.x, 16620308.
-
(2006)
Clin Exp Pharmacol Physiol
, vol.33
, pp. 395-399
-
-
McGee, S.L.1
Hargreaves, M.2
-
10
-
-
0037381848
-
Exercise increases nuclear AMPK α2 in human skeletal muscle
-
10.2337/diabetes.52.4.926, 12663462
-
McGee SL, Howlett KF, Starkie RL, Cameron-Smith D, Kemp BE, Hargreaves M. Exercise increases nuclear AMPK α2 in human skeletal muscle. Diabetes 2003, 52:926-928. 10.2337/diabetes.52.4.926, 12663462.
-
(2003)
Diabetes
, vol.52
, pp. 926-928
-
-
McGee, S.L.1
Howlett, K.F.2
Starkie, R.L.3
Cameron-Smith, D.4
Kemp, B.E.5
Hargreaves, M.6
-
11
-
-
33644910891
-
Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle
-
McGee SL, Sparling D, Olson AL, Hargreaves M. Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle. FASEB J 2006, 20:348-349.
-
(2006)
FASEB J
, vol.20
, pp. 348-349
-
-
McGee, S.L.1
Sparling, D.2
Olson, A.L.3
Hargreaves, M.4
-
12
-
-
42449161465
-
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
-
10.2337/db07-0843, 18184930
-
McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M. AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 2008, 57:860-867. 10.2337/db07-0843, 18184930.
-
(2008)
Diabetes
, vol.57
, pp. 860-867
-
-
McGee, S.L.1
van Denderen, B.J.2
Howlett, K.F.3
Mollica, J.4
Schertzer, J.D.5
Kemp, B.E.6
Hargreaves, M.7
-
13
-
-
77954523386
-
Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner
-
Brøns C, Jacobsen S, Nilsson E, Rönn T, Jensen CB, Storgaard H, Poulsen P, Groop L, Ling C, Astrup A, Vaag A. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab 2010, 95:3048-3056.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 3048-3056
-
-
Brøns, C.1
Jacobsen, S.2
Nilsson, E.3
Rönn, T.4
Jensen, C.B.5
Storgaard, H.6
Poulsen, P.7
Groop, L.8
Ling, C.9
Astrup, A.10
Vaag, A.11
-
14
-
-
20444411948
-
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
-
Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005, 135:1382-1386.
-
(2005)
J Nutr
, vol.135
, pp. 1382-1386
-
-
Lillycrop, K.A.1
Phillips, E.S.2
Jackson, A.A.3
Hanson, M.A.4
Burdge, G.C.5
-
15
-
-
50049108528
-
Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
-
10.1017/S0007114507894438, 2564112, 18186951
-
Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, Burdge GC. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr 2008, 100:278-282. 10.1017/S0007114507894438, 2564112, 18186951.
-
(2008)
Br J Nutr
, vol.100
, pp. 278-282
-
-
Lillycrop, K.A.1
Phillips, E.S.2
Torrens, C.3
Hanson, M.A.4
Jackson, A.A.5
Burdge, G.C.6
-
16
-
-
34247514180
-
Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
-
10.1017/S000711450769196X, 2211425, 17433129
-
Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 2007, 97:1064-1073. 10.1017/S000711450769196X, 2211425, 17433129.
-
(2007)
Br J Nutr
, vol.97
, pp. 1064-1073
-
-
Lillycrop, K.A.1
Slater-Jefferies, J.L.2
Hanson, M.A.3
Godfrey, K.M.4
Jackson, A.A.5
Burdge, G.C.6
-
17
-
-
75649087405
-
Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction
-
10.3945/ajcn.2009.28085, 19939982
-
Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie ME, Mill J, Pérusse L, Vohl MC. Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. Am J Clin Nutr 2010, 91:309-320. 10.3945/ajcn.2009.28085, 19939982.
-
(2010)
Am J Clin Nutr
, vol.91
, pp. 309-320
-
-
Bouchard, L.1
Rabasa-Lhoret, R.2
Faraj, M.3
Lavoie, M.E.4
Mill, J.5
Pérusse, L.6
Vohl, M.C.7
-
18
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
10.1073/pnas.0500398102, 1174919, 16009939
-
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005, 102:10604-10609. 10.1073/pnas.0500398102, 1174919, 16009939.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
Ballestar, E.2
Paz, M.F.3
Ropero, S.4
Setien, F.5
Ballestar, M.L.6
Heine-Suner, D.7
Cigudosa, J.C.8
Urioste, M.9
Benitez, J.10
Boix-Chornet, M.11
Sanchez-Aguilera, A.12
Ling, C.13
Carlsson, E.14
Poulsen, P.15
Vaag, A.16
Stephan, Z.17
Spector, T.D.18
Wu, Y.Z.19
Plass, C.20
Esteller, M.21
more..
-
19
-
-
73249133400
-
Epigenetics: a molecular link between environmental factors and type 2 diabetes
-
10.2337/db09-1003, 2780862, 19940235
-
Ling C, Groop L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 2009, 58:2718-2725. 10.2337/db09-1003, 2780862, 19940235.
-
(2009)
Diabetes
, vol.58
, pp. 2718-2725
-
-
Ling, C.1
Groop, L.2
-
20
-
-
41149172495
-
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
-
10.1007/s00125-007-0916-5, 2270364, 18270681
-
Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008, 51(4):615-22. 10.1007/s00125-007-0916-5, 2270364, 18270681.
-
(2008)
Diabetologia
, vol.51
, Issue.4
, pp. 615-622
-
-
Ling, C.1
Del Guerra, S.2
Lupi, R.3
Rönn, T.4
Granhall, C.5
Luthman, H.6
Masiello, P.7
Marchetti, P.8
Groop, L.9
Del Prato, S.10
-
21
-
-
44749089106
-
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
-
10.1007/s00125-008-1018-8, 18488190
-
Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, Tuomi T, Isomaa B, Groop L, Vaag A, Ling C. Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 2008, 51:1159-1168. 10.1007/s00125-008-1018-8, 18488190.
-
(2008)
Diabetologia
, vol.51
, pp. 1159-1168
-
-
Ronn, T.1
Poulsen, P.2
Hansson, O.3
Holmkvist, J.4
Almgren, P.5
Nilsson, P.6
Tuomi, T.7
Isomaa, B.8
Groop, L.9
Vaag, A.10
Ling, C.11
-
22
-
-
36049002392
-
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
-
10.1172/JCI30938, 2030455, 17948130
-
Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, Hagert P, Nilsson E, Mabey AG, Nilsson P, Vaag A, Groop L. Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest 2007, 117:3427-3435. 10.1172/JCI30938, 2030455, 17948130.
-
(2007)
J Clin Invest
, vol.117
, pp. 3427-3435
-
-
Ling, C.1
Poulsen, P.2
Simonsson, S.3
Ronn, T.4
Holmkvist, J.5
Almgren, P.6
Hagert, P.7
Nilsson, E.8
Mabey, A.G.9
Nilsson, P.10
Vaag, A.11
Groop, L.12
-
23
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
10.1038/nature08514, 2857523, 19829295
-
Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009, 462:315-322. 10.1038/nature08514, 2857523, 19829295.
-
(2009)
Nature
, vol.462
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
Hawkins, R.D.4
Hon, G.5
Tonti-Filippini, J.6
Nery, J.R.7
Lee, L.8
Ye, Z.9
Ngo, Q.M.10
Edsall, L.11
Antosiewicz-Bourget, J.12
Stewart, R.13
Ruotti, V.14
Millar, A.H.15
Thomson, J.A.16
Ren, B.17
Ecker, J.R.18
-
24
-
-
70349999407
-
DNA Methylation differences after exposure to prenatal famine are common and timing- and sex-specific
-
10.1093/hmg/ddp353, 2758137, 19656776
-
Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE, Heijmans BT. DNA Methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009, 18:4046-4053. 10.1093/hmg/ddp353, 2758137, 19656776.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4046-4053
-
-
Tobi, E.W.1
Lumey, L.H.2
Talens, R.P.3
Kremer, D.4
Putter, H.5
Stein, A.D.6
Slagboom, P.E.7
Heijmans, B.T.8
-
25
-
-
55949137722
-
Persistent epigenetic differences associated with prenatal exposure to famine in humans
-
10.1073/pnas.0806560105, 2579375, 18955703
-
Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE, Lumey LH. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA 2008, 105:17046-17049. 10.1073/pnas.0806560105, 2579375, 18955703.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17046-17049
-
-
Heijmans, B.T.1
Tobi, E.W.2
Stein, A.D.3
Putter, H.4
Blauw, G.J.5
Susser, E.S.6
Slagboom, P.E.7
Lumey, L.H.8
-
26
-
-
78650291801
-
Obesity related methylation changes in DNA of peripheral blood leukocytes
-
10.1186/1741-7015-8-14, 21176133
-
Wang X, Zhu H, Sneider H, Su S, Munn D, Harshfiels G, Maria BL, Dong Y, Treiber F, Gutin B, Shi H. Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med 2010, 8:87. 10.1186/1741-7015-8-14, 21176133.
-
(2010)
BMC Med
, vol.8
, pp. 87
-
-
Wang, X.1
Zhu, H.2
Sneider, H.3
Su, S.4
Munn, D.5
Harshfiels, G.6
Maria, B.L.7
Dong, Y.8
Treiber, F.9
Gutin, B.10
Shi, H.11
-
27
-
-
1642456674
-
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2
-
10.1016/S1074-7613(03)00351-0, 14738763
-
Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger TL, Doherty P, Ihle JN. Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity 2004, 20:37-46. 10.1016/S1074-7613(03)00351-0, 14738763.
-
(2004)
Immunity
, vol.20
, pp. 37-46
-
-
Carpino, N.1
Turner, S.2
Mekala, D.3
Takahashi, Y.4
Zang, H.5
Geiger, T.L.6
Doherty, P.7
Ihle, J.N.8
-
28
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
10.1038/ng.381, 2889014, 19430480
-
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009, 41:703-707. 10.1038/ng.381, 2889014, 19430480.
-
(2009)
Nat Genet
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
Akolkar, B.4
Cooper, J.D.5
Erlich, H.A.6
Julier, C.7
Morahan, G.8
Nerup, J.9
Nierras, C.10
Plagnol, V.11
Pociot, F.12
Schuilenburg, H.13
Smyth, D.J.14
Stevens, H.15
Todd, J.A.16
Walker, N.M.17
Rich, S.S.18
-
29
-
-
54949126675
-
TRIM family proteins and their emerging roles in innate immunity
-
10.1038/nri2413, 18836477
-
Ozato K, Shin DM, Chang TH, Morse HC. TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol 2008, 8:849-860. 10.1038/nri2413, 18836477.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 849-860
-
-
Ozato, K.1
Shin, D.M.2
Chang, T.H.3
Morse, H.C.4
-
30
-
-
70350674919
-
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
-
10.1113/jphysiol.2009.176156, 2770159, 19723777
-
Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 2009, 587:4963-4976. 10.1113/jphysiol.2009.176156, 2770159, 19723777.
-
(2009)
J Physiol
, vol.587
, pp. 4963-4976
-
-
Plagemann, A.1
Harder, T.2
Brunn, M.3
Harder, A.4
Roepke, K.5
Wittrock-Staar, M.6
Ziska, T.7
Schellong, K.8
Rodekamp, E.9
Melchior, K.10
Dudenhausen, J.W.11
|