The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?

Annual Review of Biochemistry

Volumn 85, Issue , 2016, Pages 631-657

  Levine, Zebulon G ^a   Walker, Suzanne ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Glycosyltransferase mechanism; HCF 1; Host cell factor 1; Nutrient sensing; O GlcNAcylation; O linked N acetylglucosamine transferase; OGT structure; Tetratricopeptide repeat; TPR

Indexed keywords

CELL PROTEIN; HEXOSAMINE; HOST CELL FACTOR 1; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE TRANSFERASE; SCAFFOLD PROTEIN; TRANSCRIPTION FACTOR; TRANSFERASE; UNCLASSIFIED DRUG; HCFC1 PROTEIN, HUMAN; HOST CELL FACTOR C1; N ACETYLGLUCOSAMINYLTRANSFERASE; O-GLCNAC TRANSFERASE;

ARTICLE; BIOCHEMISTRY; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL MATURATION; CELL SURVIVAL; CELL VIABILITY; DROSOPHILA; DROSOPHILA MELANOGASTER; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME STRUCTURE; GOLGI COMPLEX; HUMAN; MAMMAL CELL; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; ACYLATION; ANIMAL; CELL DIVISION; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; EUKARYOTIC CELL; GENETICS; GLYCOSYLATION; MAMMAL; METABOLISM; MOLECULAR MODEL; MOUSE; PROTEIN PROCESSING; SPECIES DIFFERENCE;

ACYLATION; ANIMALS; CAENORHABDITIS ELEGANS; CELL DIVISION; CELL SURVIVAL; DROSOPHILA MELANOGASTER; EUKARYOTIC CELLS; GLYCOSYLATION; HOST CELL FACTOR C1; HUMANS; MAMMALS; MICE; MODELS, MOLECULAR; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECIES SPECIFICITY;

EID: 84974715560     PISSN: 00664154     EISSN: 15454509     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-060713-035344     Document Type: Article

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