Hexosamines as mediators of nutrient sensing and regulation in diabetes

Journal of Diabetes and its Complications

Volumn 16, Issue 1, 2002, Pages 72-80

  McClain, Donald A ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Hexosamine; Insulin resistance; Type 2 diabetes

Indexed keywords

6 PHOSPHOFRUCTOKINASE; GLUCOSAMINE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; GLYCOGEN; HEXOSAMINE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOSYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; GLYCOSYLATION; HYPERINSULINEMIA; INSULIN RESISTANCE; LIVER METABOLISM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ANIMALS; DIABETES MELLITUS; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HEXOSAMINES; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIVER; MICE; MICE, TRANSGENIC; TRIGLYCERIDES;

EID: 0036181947     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8727(01)00188-X     Document Type: Conference Paper

References (55)

1. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
2. Glucosamine induces insulin resistance in vivo by affecting GLUT4 translocation in skeletal muscle. Implications for glucose toxicity
3. Glucosamine-induced inhibition of glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production
4. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
5. Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene
6. O-linked glycosylation of human cytokeratin
7. c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas
8. O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate
9. Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine: fructose-6-phosphate amidotransferase
10. Glutamine: fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and NIDDM subjects and regulation by glucose and insulin
11. Glucose regulation of transforming growth factor alpha expression is mediated by products of the hexosamine biosynthetic pathway
12. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat
13. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
14. Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys
15. O-linked N-acetyl glucosamine: the 'yin-yang' of Ser/Thr phosphorylation?
16. Glycosylation in the nucleus and cytoplasm
17. Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level
18. Role of the glucosamine pathway in fat-induced insulin resistance
19. Overexpression of glutamine: fructose-6-phosphate amidotransferase in transgenic mice causes insulin resistance
20. The subcellular distribution of terminal GlcN moieties
21. Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes
22. O-glycosylation of eucaryotic transcription factors
23. SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis
24. Insights into insulin resistance and type 2 diabetes from knockout mice
25. Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance
26. Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteins
27. RNA polymerase II is a glycoprotein: modification of the COOH-terminal domain by O-GlcNAc
28. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
29. Glucosamine infusion in rats impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
30. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
31. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
32. Progressive decline in insulin levels in Rabson-Mendenhall syndrome
33. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system
34. Hexosamines stimulate leptin production in transgenic mice
35. Effects of glucosamine on insulin secretion and insulin action
36. Activation of the hexosamine pathway by glucosamine induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle
37. Fasting hyperinsulinemia predicts diabetes independent of insulin resistance and is associated with a polymorphism in PPARg
38. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor
39. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
40. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
41. The O-GlcNAc transferase gene is essential for embryonic stem cell viability and mouse ontogeny
42. Glucosamine infusion in rats mimics the b-cell dysfunction of non-insulin-dependent diabetes mellitus
43. SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II
44. Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus
45. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
46. Increased hexosamine flux in b-cells of transgenic mice results in hyperinsulinemia and peripheral insulin resistance
47. Regulation of hepatic glycogen metabolism in transgenic mice overexpressing glutamine: fructose-6-phosphate amidotransferase
48. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues
49. Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus. Influence of body weight
50. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
51. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
52. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young
53. UDP-N-acetyl glucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues
54. Differential effects of troglitazone and D-chiroinositol on glucosamine-induced insulin resistance in vivo in rats
55. Targeted disruption of GLUT4 selectively in muscle causes insulin resistance and glucose intolerance