Insights into O-linked N-acetylglucosamine (O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15395-15408

  Shen, David L ^a   Gloster, Tracey M ^a   Yuzwa, Scott A ^a   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIVERSE PROTEINS; DYNAMIC EQUILIBRIA; FINE TUNING; IN-VITRO; KINETIC ACTIVITY; KINETIC ANALYSIS; KINETIC EVIDENCE; KINETIC STUDY; MODIFIED PROTEINS; N-ACETYLGLUCOSAMINE; O-LINKED; PROTEIN SUBSTRATE; SPECIFIC ACTIVITY; TARGET PROTEINS; UPPER LIMITS;

ENZYMES; KINETICS; PHOSPHORYLATION; STOICHIOMETRY; SUBSTRATES;

PROTEINS;

N ACETYLGLUCOSAMINE; O LINKED N ACETYLGLUCOSAMINE; TAU PROTEIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYL DEXTRO GLUCOSAMINE POLYPEPTIDYLTRANSFERASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ACETYLGLUCOSAMINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BETA-N-ACETYLHEXOSAMINIDASES; BLOTTING, WESTERN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 4; GLYCOSYLATION; HUMANS; KINETICS; MASS SPECTROMETRY; MEMBRANE GLYCOPROTEINS; MUTATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; NUCLEAR PORE COMPLEX PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-ARGININE N-METHYLTRANSFERASES; PROTEINS; RECOMBINANT PROTEINS; SERINE; SUBSTRATE SPECIFICITY; TAU PROTEINS;

EID: 84860871127     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.310664     Document Type: Article

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