Concerted activity of host cell factor subregions in promoting stable VP16 complex assembly and preventing interference by the acidic activation domain

Molecular and Cellular Biology

Volumn 17, Issue 12, 1997, Pages 7108-7118

  Laboissière, Sylvie ^a   Walker, Stephen ^b   O'Hare, Peter ^a  

^a MARIE CURIE RESEARCH INSTITUTE   (United Kingdom)

^b Department of Surgery   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; GENETIC TRANSCRIPTION; HOST CELL; HOUSEKEEPING GENE; MAMMAL CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRION; YEAST;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0030667738     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.12.7108     Document Type: Article

References (58)

1. Ace, C. I., M. A. Dalrymple, F. H. Ramsay, V. G. Preston, and C. M. Preston. 1988. Mutational analysis of the herpes simplex virus type 1 trans-inducing factor Vmw65. J. Gen. Virol. 69:2595-2605.
2. apRhys, C. M., D. M. Ciufo, E. A. O'Neill, T. J. Kelly, and G. S. Hayward. 1989. Overlapping octamer and TAATGARAT motifs in the VF65-response elements in herpes simplex virus immediate-early promoters represent independent binding sites for cellular nuclear factor III. J. Virol. 63:2798-2812.
3. Bork, P., and R. F. Doolittle. 1994. Drosophila kelch motif is derived from a common enzyme fold. J. Mol. Biol. 236:1277-1282.
4. Breim, A., K. Ohbo, and H. Scholer. 1997. The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain. Mol. Cell. Biol. 17:154-162.
5. Campbell, M. E., J. W. Palfreyman, and C. M. Preston. 1984. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J. Mol. Biol. 180:1-19.
6. Cepek, K. L., D. L. Chasman, and P. A. Sharp. 1996. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes Dev. 10:2079-2088.
7. Cousens, D. J., R. Greaves, C. R. Goding, and P. O'Hare. 1989. The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimcric DNA-binding proteins. EMBO J. 8:2337-2342.
8. Eichinger, L., L. Bomblies, J. Vanderkerckhove, M. Schleicher, and J. Gettemans. 1996. A novel type of protein kinase phosphorylates actin in the actin-fragmin complex. EMBO J. 15:5547-5556.
9. Gerster, T., and R. G. Roeder. 1988. A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins. Proc. Natl. Acad. Sci. USA 85:6347-6351.
10. Greaves, R., and P. O'Hare. 1989. Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65. J. Virol. 63:1641-1650.
11. Greaves, R. F., and P. O'Hare. 1990. Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences. J. Virol. 64: 2716-2724.
12. Gstaiger, M., O. Georgiev, H. van Leeuwen, P. van der Vliet, and W. Schaffner. 1996. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. EMBO J. 15:2781-2790.
13. Hayes, S., and P. O'Hare. 1993. Mapping of a major surface exposed site in the herpes simplex virus protein Vmw65 to a region of direct interaction in a transcription complex assembly. J. Virol. 67:852-862.
14. 13a.He, X., R. Gerrero, D. M. Simmons, R. E. Park, C. R. Lin, L. W. Swanson, and M. G. Rosenfeld. 1991. Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule Po. Mol. Cell. Biol. 11:1739-1744.
15. Herr, W., R. A. Sturm, R. G. Clerc, L. M. Corcoran, D. Baltimore, P. A. Sharpe, H. A. Ingraham, M. G. Rosenfeld, M. Finney, G. Ruvken, and H. R. Horvitz. 1988. The POU domain: a large conserved region in the mammalian pit-1, ocl-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2:1513-1516.
16. Hill, C. S., J. Wynne, and R. Treisman. 1994. Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain. EMBO J. 13:5421-5432.
17. Hinkley, C. S., J. F. Martin, D. Leibham, and M. Perry. 1992. Sequential expression of multiple POU proteins during amphibian early development. Mol. Cell. Biol. 12:638-649.
18. Ho, N., S. E. Philips, K. D. S. Yadav, and P. F. Knowles. 1994. Crystal structure of a free radical enzyme, galactose oxidase. J. Mol. Biol. 238:794-814.
19. Johnson, W. A., and J. Hirsh. 1990. Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons. Nature 343:467-470.
20. Katan, M., A. Haigh, C. P. Verrijzer, P. C. van der Vliet, and P. O'Hare. 1990. Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex. Nucleic Acids Res. 18:6871-6880.
21. Kemler, I., E. Bucher, K. Seipel, M. M. Muller-Immergluck, and W. Schaffner. 1991. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Res. 19:237-242.
22. Kristie, T. M., J. H. LeBowitz, and P. A. Sharp. 1989. The octamer-binding proteins form multi-protein-DNA complexes with the HSV alpha TIF regulatory protein. EMBO J. 8:4229-4238.
23. Kristie, T. M., J. L. Pomerantz, T. C. Twomey, S. A. Parent, and P. A. Sharp. 1995. The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. J. Biol. Chem. 270:4387-4394.
24. Kristie, T. M., and P. A. Sharp. 1993. Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus α-trans-induction factor (VP16). J. Biol. Chem. 268:6525-6534.
25. Lai, J. S., M. A. Cleary, and W. Herr. 1992. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. Genes Dev. 6:2058-2065.
26. Lefstin, J. A., J. R. Thomas, and K. R. Yamamoto. 1994. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev. 8:2842-2856.
27. Luo, Y., and R. G. Roeder. 1995. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15:4115-4124.
28. Mackem, S., and B. Roizman. 1982. Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes. J. Virol. 44:939-949.
29. Monuki, E. S., R. Kuhn, and G. Lemke. 1993. Repression of the myelin P0 gene by the POU transcription factor SCIP. Mech. Dev. 42:15-32.
30. Morris, P. J., T. Theil, C. J. A. Ring, K. A. Lillycrop, T. Moroy, and D. S. Latchman. 1994. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol. Cell. Biol. 14:6907-6914.
31. O'Hare, P. 1993. The virion transactivator of herpes simplex. Semin. Virol. 4:145-155.
32. O'Hare, P., and C. R. Goding. 1988. Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation. Cell 52:435-445.
33. O'Hare, P., C. R. Goding, and A. Haigh. 1988. Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression. EMBO J. 7:4231-1238.
34. O'Reilly, D., O. Hanscombe, and P. O'Hare. 1997. A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II. EMBO J. 16:2420-2430.
35. Pfisterer, P., S. Zwilling, J. Hess, and T. Wirth. 1995. Functional characterisation of the murine homolog of the B-cell-specinc coactivator BOB.1/ OBF.1. J. Biol. Chem. 270:29870-29880.
36. Pomerantz, J. L., T. M. Kristie, and P. A. Sharp. 1992. Recognition of the surface of a homeo domain protein. Genes Dev. 6:2047-2057.
37. Post, L. E., S. Mackem, and B. Roizman. 1981. Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. Cell 24:555-565.
38. Preston, C. M., M. G. Cordingley, and N. D. Stow. 1984. Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene. J. Virol. 50:708-716.
39. Preston, C. M., M. C. Frame, and M. E. Campbell. 1988. A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence. Cell 52:425-434.
40. Rosenfeld, M. 1991. POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev. 5:897-907.
41. Ruvkun, G., and M. Finney. 1991. Regulation of transcription and cell identity by POU domain proteins. Cell 64:475-176.
42. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335:563-564.
43. Simmen, K. A., A. Newell, M. Robinson, J. S. Mills, G. Canning, R. Handa, K. Parkes, N. Borkakoti, and R. Jupp. 1997. Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements. J. Virol. 71:3886-3894.
44. Stern, S., and W. Herr. 1991. The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain. Genes Dev. 5:2555-2566.
45. Stern, S., M. Tanaka, and W. Herr. 1989. The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature 341:624-630.
46. Strubin, M., J. W. Newell, and P. Matthias. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497-506.
47. Thompson, C., and S. McKnight. 1992. Anatomy of an enhancer. Trends Genet. 8:232-236.
48. Triezenberg, S. J., K. L. LaMarco, and S. L. McKnight. 1988. Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16. Genes Dev. 2:730-742.
49. Verrijzer, C. P., J. van Oosterhout, and P. C. van der Vliet. 1992. The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins. Mol. Cell. Biol. 12:542-551.
50. Verrijzer, C. P., and P. C. van der Vliet. 1993. POU domain transcription factors. Biochim. Biophys. Acta 1173:1-21.
51. Walker, S., S. Hayes, and P. O'Hare. 1994. Site-specific conformational alteration of the Oct-1 POU domain-DNA complex as the basis for the differential recognition by Vmw65 (VP16). Cell 79:841-852.
52. Wegner, M., D. W. Drolet, and M. G. Rosenfeld. 1993. POU-domain proteins: structure and function of developmental regulators. Curr. Opin. Cell Biol. 5:488-498.
53. Werstuck, G., and J. P. Capone. 1989. Mutational analysis of the herpes simplex virus trans-inducing factor Vmw65. Gene 75:213-224.
54. Wilson, A., M. G. Peterson, and W. Herr. 1995. The HCF repeat is an unusual proteolytic cleavage signal. Genes Dev. 9:2445-2458.
55. Wilson, A. C., M. A. Cleary, J. S. Lai, K. LaMarco, M. G. Peterson, and W. Herr. 1993. Combinatorial control of transcription: the herpes simplex virus VP16-induced complex. Cold Spring Harbor Symp. Quant. Biol. 58:167-178.
56. Wilson, A. C., K. LaMarco, M. G. Peterson, and W. Herr. 1993. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell 74:115-125.
57. Xiao, P., and J. P. Capone. 1990. A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1. Mol. Cell. Biol. 10:4974-4977.
58. Xue, F., and L. Cooley. 1993. Kelch encodes a component of intercellular bridges in Drosophila egg chambers. Cell 72:681-693.